Unreviewed, UniProtKB/TrEMBL Q8NAM2 (Q8NAM2_HUMAN)

Names and origin

Protein names	Submitted name:     cDNA FLJ35118 fis, clone PLACE6007436, highly similar to Homo sapiens hairy and enhancer of split related-1 (HESR-1) mRNA EMBL BAC03890.1
Organism	Homo sapiens (Human) EMBL BAC03890.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus By similarity. Spearmint SPM003650
Sequence similarities	Contains 1 Orange domain. Spearmint SPM003650 Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367V1 Spearmint SPM003650

Ontologies

Keywords
Biological process	Transcription Transcription regulation Spearmint SPM003650
Cellular component	Nucleus Spearmint SPM003650
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro transcription regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NAM2-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: F5A47C6EB2DAD7E8	FASTA	308	33,084
	10 20 30 40 50 60 MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR KRRRGIIEKR 70 80 90 100 110 120 RRDRINNSLS ELRRLVPSAF EKQVMEQGSA KLEKAEILQM TVDHLKMLHT AGGKGYFDAH 130 140 150 160 170 180 ALAMDYRSLG FRECLAEVAR YLSIIEGLDA SDPLRVRLVS HLNNYASQRE AASGAHAGLG 190 200 210 220 230 240 HIPWGTVFGH HPHIAHPLLL PQNGHGNAGT TASPTEPHHQ GRLGSAHPEA PALRAPPSGS 250 260 270 280 290 300 PGPVLPVVTS ASKLSPPLLS SVASLSAFPF SFGSFHLLSP NALSPSAPTQ AANLGKPYRP WGTEIGAF

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAC03890.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK092437 mRNA. Translation: BAC03890.1.
IPI	IPI00550054.
UniGene	Hs.234434
3D structure databases
SMR	Q8NAM2. Positions 115-169.
ModBase	Search...
Proteomic databases
PRIDE	Q8NAM2.
Genome annotation databases
Ensembl	ENSG00000164683. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:4880. HEY1.
Phylogenomic databases
HOGENOM	Q8NAM2.
HOVERGEN	Q8NAM2.
Gene expression databases
ArrayExpress	Q8NAM2.
Bgee	Q8NAM2.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. IPR003650. Orange. IPR018352. Orange_subgroup. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. PS51054. ORANGE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8NAM2_HUMAN

Accession

Primary (citable) accession number: Q8NAM2

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	April 14, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)