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Protein

Zinc finger protein 579

Gene

ZNF579

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 66C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 579
Gene namesi
Name:ZNF579
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000218891.4
HGNCiHGNC:26646 ZNF579
neXtProtiNX_Q8NAF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000218891
PharmGKBiPA134930711

Polymorphism and mutation databases

BioMutaiZNF579
DMDMi296453047

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476691 – 562Zinc finger protein 579Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92Omega-N-methylarginineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8NAF0
MaxQBiQ8NAF0
PaxDbiQ8NAF0
PeptideAtlasiQ8NAF0
PRIDEiQ8NAF0

PTM databases

iPTMnetiQ8NAF0
PhosphoSitePlusiQ8NAF0

Expressioni

Gene expression databases

BgeeiENSG00000218891
CleanExiHS_ZNF579
ExpressionAtlasiQ8NAF0 baseline and differential
GenevisibleiQ8NAF0 HS

Organism-specific databases

HPAiHPA062812

Interactioni

Protein-protein interaction databases

BioGridi127842, 46 interactors
IntActiQ8NAF0, 13 interactors
MINTiQ8NAF0
STRINGi9606.ENSP00000320188

Structurei

3D structure databases

ProteinModelPortaliQ8NAF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi331 – 370Gly-richAdd BLAST40
Compositional biasi481 – 525Pro-richAdd BLAST45

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 66C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141245
HOGENOMiHOG000054202
HOVERGENiHBG098620
InParanoidiQ8NAF0
OMAiQDEGVEQ
OrthoDBiEOG091G0766
PhylomeDBiQ8NAF0
TreeFamiTF331849

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

Q8NAF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQPPPPAQ GSPPHRGRGR GRGRGRGRGR GRGRGGAGAP RAPLPCPTCG
60 70 80 90 100
RLFRFPYYLS RHRLSHSGLR PHACPLCPKA FRRPAHLSRH LRGHGPQPPL
110 120 130 140 150
RCAACPRTFP EPAQLRRHLA QEHAGGEVEL AIERVAKETA EPSWGPQDEG
160 170 180 190 200
SEPPTTAAAG ATEEEAVAAW PETWPAGEPS TLAAPTSAAE PRESESEEAE
210 220 230 240 250
AGAAELRAEL ALAAGRQEEK QVLLQADWTL LCLRCREAFA TKGELKAHPC
260 270 280 290 300
LRPEGEQEGE GGPPPRPKRH QCSICLKAFA RPWSLSRHRL VHSTDRPFVC
310 320 330 340 350
PDCGLAFRLA SYLRQHRRVH GPLSLLAPLP AAGKKDDKAS GARNSAKGPE
360 370 380 390 400
GGEGAECGGA SEGGEGQNGG DAAPARPPAG EPRFWCPECG KGFRRRAHLR
410 420 430 440 450
QHGVTHSGAR PFQCVRCQRE FKRLADLARH AQVHAGGPAP HPCPRCPRRF
460 470 480 490 500
SRAYSLLRHQ RCHRAELERA AALQALQAQA PTSPPPPPPP LKAEQEEEGL
510 520 530 540 550
PLPLANIKEE PPSPGTPPQS PPAPPVFLSA SCFDSQDHSA FEMEEEEVDS
560
KAHLRGLGGL AS
Length:562
Mass (Da):60,509
Last modified:May 18, 2010 - v2
Checksum:i9A1C83911B9F20A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228W → R in BAC03972 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061956353E → D. Corresponds to variant dbSNP:rs10403008Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092772 mRNA Translation: BAC03972.1
AC008735 Genomic DNA No translation available.
CCDSiCCDS12927.1
RefSeqiNP_689813.2, NM_152600.2
UniGeneiHs.112529

Genome annotation databases

EnsembliENST00000325421; ENSP00000320188; ENSG00000218891
GeneIDi163033
KEGGihsa:163033
UCSCiuc002qlh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN579_HUMAN
AccessioniPrimary (citable) accession number: Q8NAF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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