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Protein

Zinc finger protein 579

Gene

ZNF579

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 66C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179943-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 579
Gene namesi
Name:ZNF579
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26646. ZNF579.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000218891.
PharmGKBiPA134930711.

Polymorphism and mutation databases

BioMutaiZNF579.
DMDMi296453047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476691 – 562Zinc finger protein 579Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92Omega-N-methylarginineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8NAF0.
MaxQBiQ8NAF0.
PaxDbiQ8NAF0.
PeptideAtlasiQ8NAF0.
PRIDEiQ8NAF0.

PTM databases

iPTMnetiQ8NAF0.
PhosphoSitePlusiQ8NAF0.

Expressioni

Gene expression databases

BgeeiENSG00000218891.
CleanExiHS_ZNF579.
ExpressionAtlasiQ8NAF0. baseline and differential.
GenevisibleiQ8NAF0. HS.

Organism-specific databases

HPAiHPA062812.

Interactioni

Protein-protein interaction databases

BioGridi127842. 37 interactors.
IntActiQ8NAF0. 13 interactors.
MINTiMINT-8247391.
STRINGi9606.ENSP00000320188.

Structurei

3D structure databases

ProteinModelPortaliQ8NAF0.
SMRiQ8NAF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi331 – 370Gly-richAdd BLAST40
Compositional biasi481 – 525Pro-richAdd BLAST45

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 66C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 123C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132444.
HOGENOMiHOG000054202.
HOVERGENiHBG098620.
InParanoidiQ8NAF0.
OMAiQDEGVEQ.
OrthoDBiEOG091G0766.
PhylomeDBiQ8NAF0.
TreeFamiTF331849.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NAF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQPPPPAQ GSPPHRGRGR GRGRGRGRGR GRGRGGAGAP RAPLPCPTCG
60 70 80 90 100
RLFRFPYYLS RHRLSHSGLR PHACPLCPKA FRRPAHLSRH LRGHGPQPPL
110 120 130 140 150
RCAACPRTFP EPAQLRRHLA QEHAGGEVEL AIERVAKETA EPSWGPQDEG
160 170 180 190 200
SEPPTTAAAG ATEEEAVAAW PETWPAGEPS TLAAPTSAAE PRESESEEAE
210 220 230 240 250
AGAAELRAEL ALAAGRQEEK QVLLQADWTL LCLRCREAFA TKGELKAHPC
260 270 280 290 300
LRPEGEQEGE GGPPPRPKRH QCSICLKAFA RPWSLSRHRL VHSTDRPFVC
310 320 330 340 350
PDCGLAFRLA SYLRQHRRVH GPLSLLAPLP AAGKKDDKAS GARNSAKGPE
360 370 380 390 400
GGEGAECGGA SEGGEGQNGG DAAPARPPAG EPRFWCPECG KGFRRRAHLR
410 420 430 440 450
QHGVTHSGAR PFQCVRCQRE FKRLADLARH AQVHAGGPAP HPCPRCPRRF
460 470 480 490 500
SRAYSLLRHQ RCHRAELERA AALQALQAQA PTSPPPPPPP LKAEQEEEGL
510 520 530 540 550
PLPLANIKEE PPSPGTPPQS PPAPPVFLSA SCFDSQDHSA FEMEEEEVDS
560
KAHLRGLGGL AS
Length:562
Mass (Da):60,509
Last modified:May 18, 2010 - v2
Checksum:i9A1C83911B9F20A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228W → R in BAC03972 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061956353E → D.Corresponds to variant rs10403008dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092772 mRNA. Translation: BAC03972.1.
AC008735 Genomic DNA. No translation available.
CCDSiCCDS12927.1.
RefSeqiNP_689813.2. NM_152600.2.
UniGeneiHs.112529.

Genome annotation databases

EnsembliENST00000325421; ENSP00000320188; ENSG00000218891.
GeneIDi163033.
KEGGihsa:163033.
UCSCiuc002qlh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092772 mRNA. Translation: BAC03972.1.
AC008735 Genomic DNA. No translation available.
CCDSiCCDS12927.1.
RefSeqiNP_689813.2. NM_152600.2.
UniGeneiHs.112529.

3D structure databases

ProteinModelPortaliQ8NAF0.
SMRiQ8NAF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127842. 37 interactors.
IntActiQ8NAF0. 13 interactors.
MINTiMINT-8247391.
STRINGi9606.ENSP00000320188.

PTM databases

iPTMnetiQ8NAF0.
PhosphoSitePlusiQ8NAF0.

Polymorphism and mutation databases

BioMutaiZNF579.
DMDMi296453047.

Proteomic databases

EPDiQ8NAF0.
MaxQBiQ8NAF0.
PaxDbiQ8NAF0.
PeptideAtlasiQ8NAF0.
PRIDEiQ8NAF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325421; ENSP00000320188; ENSG00000218891.
GeneIDi163033.
KEGGihsa:163033.
UCSCiuc002qlh.4. human.

Organism-specific databases

CTDi163033.
GeneCardsiZNF579.
HGNCiHGNC:26646. ZNF579.
HPAiHPA062812.
neXtProtiNX_Q8NAF0.
OpenTargetsiENSG00000218891.
PharmGKBiPA134930711.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132444.
HOGENOMiHOG000054202.
HOVERGENiHBG098620.
InParanoidiQ8NAF0.
OMAiQDEGVEQ.
OrthoDBiEOG091G0766.
PhylomeDBiQ8NAF0.
TreeFamiTF331849.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179943-MONOMER.

Miscellaneous databases

GenomeRNAii163033.
PROiQ8NAF0.

Gene expression databases

BgeeiENSG00000218891.
CleanExiHS_ZNF579.
ExpressionAtlasiQ8NAF0. baseline and differential.
GenevisibleiQ8NAF0. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN579_HUMAN
AccessioniPrimary (citable) accession number: Q8NAF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.