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Q8NAC3 (I17RC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor C

Short name=IL-17 receptor C
Short name=IL-17RC
Alternative name(s):
Interleukin-17 receptor homolog
Short name=IL17Rhom
Interleukin-17 receptor-like protein
Short name=IL-17RL
ZcytoR14
Gene names
Name:IL17RC
ORF Names:UNQ6118/PRO20040/PRO38901
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length791 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein. Note: Soluble isoforms may be produced.

Tissue specificity

Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta. Ref.7

Induction

By HGF and VEGF. Ref.8

Sequence similarities

Contains 1 SEFIR domain.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q8NAC3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q8NAC3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
Isoform 3 (identifier: Q8NAC3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8NAC3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.
     579-624: AAARGRAALL...VAVDLWSRRE → GEWEQALGGG...PRGSAPLLSR
     625-791: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q8NAC3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     566-578: Missing.
Note: Gene prediction based on EST data.
Isoform 6 (identifier: Q8NAC3-6)

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.
     425-441: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.6
Chain21 – 791771Interleukin-17 receptor C
PRO_0000011034

Regions

Topological domain21 – 538518Extracellular Potential
Transmembrane539 – 55921Helical; Potential
Topological domain560 – 791232Cytoplasmic Potential
Domain583 – 735153SEFIR

Amino acid modifications

Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Glycosylation3241N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Potential
Glycosylation4431N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence36 – 10671Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_014138
Alternative sequence264 – 27815Missing in isoform 3, isoform 4 and isoform 6.
VSP_014139
Alternative sequence425 – 44117Missing in isoform 6.
VSP_047291
Alternative sequence566 – 57813Missing in isoform 5.
VSP_047292
Alternative sequence579 – 62446AAARG…WSRRE → GEWEQALGGGPPPGSQACAS SPLPSPSVFSGSGRQGPRGS APLLSR in isoform 4.
VSP_014140
Alternative sequence625 – 791167Missing in isoform 4.
VSP_014141
Natural variant1821S → L. Ref.1 Ref.3
Corresponds to variant rs708567 [ dbSNP | Ensembl ].
VAR_022680

Experimental info

Sequence conflict2411E → G in AAQ89199. Ref.2
Sequence conflict3781Q → R in AAM77569. Ref.1
Sequence conflict3781Q → R in AAQ89199. Ref.2
Sequence conflict3781Q → R in AAQ89456. Ref.2
Sequence conflict3781Q → R in BAC04001. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: E9A4032C17ECD4AF

FASTA79186,240
        10         20         30         40         50         60 
MPVPWFLLSL ALGRSPVVLS LERLVGPQDA THCSPVSLEP WGDEERLRVQ FLAQQSLSLA 

        70         80         90        100        110        120 
PVTAATARTA LSGLSGADGR REERGRGKSW VCLSLGGSGN TEPQKKGLSC RLWDSDILCL 

       130        140        150        160        170        180 
PGDIVPAPGP VLAPTHLQTE LVLRCQKETD CDLCLRVAVH LAVHGHWEEP EDEEKFGGAA 

       190        200        210        220        230        240 
DSGVEEPRNA SLQAQVVLSF QAYPTARCVL LEVQVPAALV QFGQSVGSVV YDCFEAALGS 

       250        260        270        280        290        300 
EVRIWSYTQP RYEKELNHTQ QLPDCRGLEV WNSIPSCWAL PWLNVSADGD NVHLVLNVSE 

       310        320        330        340        350        360 
EQHFGLSLYW NQVQGPPKPR WHKNLTGPQI ITLNHTDLVP CLCIQVWPLE PDSVRTNICP 

       370        380        390        400        410        420 
FREDPRAHQN LWQAARLQLL TLQSWLLDAP CSLPAEAALC WRAPGGDPCQ PLVPPLSWEN 

       430        440        450        460        470        480 
VTVDKVLEFP LLKGHPNLCV QVNSSEKLQL QECLWADSLG PLKDDVLLLE TRGPQDNRSL 

       490        500        510        520        530        540 
CALEPSGCTS LPSKASTRAA RLGEYLLQDL QSGQCLQLWD DDLGALWACP MDKYIHKRWA 

       550        560        570        580        590        600 
LVWLACLLFA AALSLILLLK KDHAKGWLRL LKQDVRSGAA ARGRAALLLY SADDSGFERL 

       610        620        630        640        650        660 
VGALASALCQ LPLRVAVDLW SRRELSAQGP VAWFHAQRRQ TLQEGGVVVL LFSPGAVALC 

       670        680        690        700        710        720 
SEWLQDGVSG PGAHGPHDAF RASLSCVLPD FLQGRAPGSY VGACFDRLLH PDAVPALFRT 

       730        740        750        760        770        780 
VPVFTLPSQL PDFLGALQQP RAPRSGRLQE RAEQVSRALQ PALDSYFHPP GTPAPGRGVG 

       790 
PGAGPGAGDG T 

« Hide

Isoform 2 [UniParc].

Checksum: 598203CD77A72647
Show »

FASTA72078,689
Isoform 3 [UniParc].

Checksum: E665E2494E795EFF
Show »

FASTA70576,942
Isoform 4 [UniParc].

Checksum: 55E6359DA6A5AF4B
Show »

FASTA53859,100
Isoform 5 [UniParc].

Checksum: 3BED07CC5C11A8B3
Show »

FASTA70777,179
Isoform 6 [UniParc].

Checksum: A3A8A825FDD77893
Show »

FASTA68875,025

References

« Hide 'large scale' references
[1]"Identification of novel IL-17 related receptors."
Gilbert J.M., Gorman D.M.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-182.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-182.
Tissue: Spleen.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Uterus.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-35.
[7]"Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer."
Haudenschild D., Moseley T., Rose L., Reddi A.H.
J. Biol. Chem. 277:4309-4316(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[8]"Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells."
Gerritsen M.E., Tomlinson J.E., Zlot C., Ziman M., Hwang S.
Br. J. Pharmacol. 140:595-610(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY HGF AND VEGF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF458065 mRNA. Translation: AAM77569.1.
AY358840 mRNA. Translation: AAQ89199.1.
AY359098 mRNA. Translation: AAQ89456.1.
AK092907 mRNA. Translation: BAC04001.1.
AC018809 Genomic DNA. No translation available.
BC006411 mRNA. No translation available.
RefSeqNP_001190192.1. NM_001203263.1.
NP_001190193.1. NM_001203264.1.
NP_001190194.1. NM_001203265.1.
NP_116121.2. NM_032732.5.
NP_703190.1. NM_153460.3.
NP_703191.1. NM_153461.3.
UniGeneHs.129959.

3D structure databases

ProteinModelPortalQ8NAC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124278. 1 interaction.
STRING9606.ENSP00000295981.

PTM databases

PhosphoSiteQ8NAC3.

Polymorphism databases

DMDM229462881.

Proteomic databases

PaxDbQ8NAC3.
PRIDEQ8NAC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295981; ENSP00000295981; ENSG00000163702. [Q8NAC3-1]
ENST00000383812; ENSP00000373323; ENSG00000163702. [Q8NAC3-3]
ENST00000403601; ENSP00000384969; ENSG00000163702. [Q8NAC3-2]
ENST00000413608; ENSP00000396064; ENSG00000163702. [Q8NAC3-5]
ENST00000455057; ENSP00000407894; ENSG00000163702. [Q8NAC3-6]
GeneID84818.
KEGGhsa:84818.
UCSCuc003btz.3. human. [Q8NAC3-2]
uc003bua.3. human. [Q8NAC3-1]
uc003bub.3. human. [Q8NAC3-3]
uc011atq.2. human. [Q8NAC3-4]

Organism-specific databases

CTD84818.
GeneCardsGC03P009958.
HGNCHGNC:18358. IL17RC.
HPACAB026255.
HPA019885.
MIM610925. gene.
neXtProtNX_Q8NAC3.
PharmGKBPA134986616.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45936.
HOGENOMHOG000112986.
HOVERGENHBG081776.
InParanoidQ8NAC3.
KOK05166.
OMAGQCLQLW.
OrthoDBEOG7J4466.
PhylomeDBQ8NAC3.
TreeFamTF335852.

Gene expression databases

ArrayExpressQ8NAC3.
BgeeQ8NAC3.
CleanExHS_IL17RC.
GenevestigatorQ8NAC3.

Family and domain databases

InterProIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR.
[Graphical view]
PfamPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIL17RC.
GenomeRNAi84818.
NextBio35502048.
PROQ8NAC3.
SOURCESearch...

Entry information

Entry nameI17RC_HUMAN
AccessionPrimary (citable) accession number: Q8NAC3
Secondary accession number(s): E9PHG1 expand/collapse secondary AC list , E9PHJ6, Q6UVY3, Q6UWD4, Q8NFS1, Q9BR97
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM