Q8NAC3 (I17RC_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Interleukin-17 receptor C Short name=IL-17 receptor C Short name=IL-17RC Alternative name(s): Interleukin-17 receptor homolog Short name=IL17Rhom Interleukin-17 receptor-like protein Short name=IL-17RL ZcytoR14 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 791 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Note: Soluble isoforms may be produced. |
| Tissue specificity | Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta. Ref.7 |
| Induction | By HGF and VEGF. Ref.8 |
| Sequence similarities | Contains 1 SEFIR domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal Transmembrane Transmembrane helix |
| Molecular function | Receptor |
| PTM | Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | positive regulation of cytokine production involved in inflammatory response Inferred from electronic annotation. Source: Compara |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | interleukin-17 receptor activity Inferred from direct assay PubMed 17911633. Source: MGI |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist. | ||||||
| Isoform 1 (identifier: Q8NAC3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 2 (identifier: Q8NAC3-2) The sequence of this isoform differs from the canonical sequence as follows: 36-106: Missing. | ||||||
| Isoform 3 (identifier: Q8NAC3-3) The sequence of this isoform differs from the canonical sequence as follows: 36-106: Missing. 264-278: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 4 (identifier: Q8NAC3-4) The sequence of this isoform differs from the canonical sequence as follows: 36-106: Missing. 264-278: Missing. 579-624: AAARGRAALL...VAVDLWSRRE → GEWEQALGGG...PRGSAPLLSR 625-791: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Ref.6 | ||||||
| Chain | 21 – 791 | 771 | Interleukin-17 receptor C | PRO_0000011034 | |||||
Regions | |||||||||
| Topological domain | 21 – 538 | 518 | Extracellular Potential | ||||||
| Transmembrane | 539 – 559 | 21 | Helical; Potential | ||||||
| Topological domain | 560 – 791 | 232 | Cytoplasmic Potential | ||||||
| Domain | 583 – 735 | 153 | SEFIR | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 189 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 257 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 284 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 297 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 324 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 334 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 420 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 443 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 477 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 36 – 106 | 71 | Missing in isoform 2, isoform 3 and isoform 4. | VSP_014138 | |||||
| Alternative sequence | 264 – 278 | 15 | Missing in isoform 3 and isoform 4. | VSP_014139 | |||||
| Alternative sequence | 579 – 624 | 46 | AAARG…WSRRE → GEWEQALGGGPPPGSQACAS SPLPSPSVFSGSGRQGPRGS APLLSR in isoform 4. | VSP_014140 | |||||
| Alternative sequence | 625 – 791 | 167 | Missing in isoform 4. | VSP_014141 | |||||
| Natural variant | 182 | 1 | S → L. Ref.1 Ref.3 Corresponds to variant rs708567 [ dbSNP | Ensembl ]. | VAR_022680 | |||||
Experimental info | |||||||||
| Sequence conflict | 241 | 1 | E → G in AAQ89199. Ref.2 | ||||||
| Sequence conflict | 378 | 1 | Q → R in AAM77569. Ref.1 | ||||||
| Sequence conflict | 378 | 1 | Q → R in AAQ89199. Ref.2 | ||||||
| Sequence conflict | 378 | 1 | Q → R in AAQ89456. Ref.2 | ||||||
| Sequence conflict | 378 | 1 | Q → R in BAC04001. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of novel IL-17 related receptors." Gilbert J.M., Gorman D.M. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-182. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-182. Tissue: Spleen. |
| [4] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Uterus. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35. |
| [7] | "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer." Haudenschild D., Moseley T., Rose L., Reddi A.H. J. Biol. Chem. 277:4309-4316(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY. |
| [8] | "Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells." Gerritsen M.E., Tomlinson J.E., Zlot C., Ziman M., Hwang S. Br. J. Pharmacol. 140:595-610(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY HGF AND VEGF. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF458065 mRNA. Translation: AAM77569.1. AY358840 mRNA. Translation: AAQ89199.1. AY359098 mRNA. Translation: AAQ89456.1. AK092907 mRNA. Translation: BAC04001.1. AC018809 Genomic DNA. No translation available. BC006411 mRNA. No translation available. |
| IPI | IPI00013761. IPI00300564. IPI00303074. IPI00607747. |
| RefSeq | NP_001190192.1. NM_001203263.1. NP_001190193.1. NM_001203264.1. NP_001190194.1. NM_001203265.1. NP_116121.2. NM_032732.5. NP_703190.1. NM_153460.3. NP_703191.1. NM_153461.3. |
| UniGene | Hs.129959. |
3D structure databases | |
| ProteinModelPortal | Q8NAC3. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000295981. |
PTM databases | |
| PhosphoSite | Q8NAC3. |
Polymorphism databases | |
| DMDM | 229462881. |
Proteomic databases | |
| PaxDb | Q8NAC3. |
| PRIDE | Q8NAC3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000295981; ENSP00000295981; ENSG00000163702. ENST00000383812; ENSP00000373323; ENSG00000163702. ENST00000403601; ENSP00000384969; ENSG00000163702. |
| GeneID | 84818. |
| KEGG | hsa:84818. |
| UCSC | uc003btz.3. human. uc003bua.3. human. uc003bub.3. human. uc011atq.2. human. |
Organism-specific databases | |
| CTD | 84818. |
| GeneCards | GC03P009958. |
| HGNC | HGNC:18358. IL17RC. |
| HPA | CAB026255. HPA019885. |
| MIM | 610925. gene. |
| neXtProt | NX_Q8NAC3. |
| PharmGKB | PA134986616. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG45936. |
| HOGENOM | HOG000112986. |
| HOVERGEN | HBG081776. |
| InParanoid | Q8NAC3. |
| KO | K05166. |
| OMA | GQCLQLW. |
Gene expression databases | |
| ArrayExpress | Q8NAC3. |
| Bgee | Q8NAC3. |
| CleanEx | HS_IL17RC. |
| Genevestigator | Q8NAC3. |
| GermOnline | ENSG00000163702. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013568. SEFIR. [Graphical view] |
| Pfam | PF08357. SEFIR. 1 hit. [Graphical view] |
| PROSITE | PS51534. SEFIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 84818. |
| NextBio | 75014. |
| SOURCE | Search... |
Entry information
| Entry name | I17RC_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NAC3 Secondary accession number(s): Q6UVY3 Q9BR97 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
