Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NAA5 (LR75A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 75A
Alternative name(s):
Leucine-rich repeat-containing protein FAM211A
Gene names
Name:LRRC75A
Synonyms:C17orf76, FAM211A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the LRRC75 family.

Contains 2 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NAA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NAA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     126-212: EGDALGAMEK...QVDSVELGFT → PQGCPGRKPP...VDPGRAARPH
     213-344: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Leucine-rich repeat-containing protein 75A
PRO_0000286624

Regions

Repeat204 – 21714LRR 1
Repeat229 – 24214LRR 2

Natural variations

Alternative sequence126 – 21287EGDAL…ELGFT → PQGCPGRKPPRQHSGPVGNP TDLPRPGAGDQLPTALWGAG RQRGAGLHRPHGRHGPAAAA STQHPAPPHHTGTQWQPVDP GRAARPH in isoform 2.
VSP_025134
Alternative sequence213 – 344132Missing in isoform 2.
VSP_025135

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: E76D268A6D393A0C

FASTA34437,780
        10         20         30         40         50         60 
MGTRQTKGSL AERASPGAAP GPRRERPDFW ASLLLRAGDK AGRAGAGMPP YHRRVGMVQE 

        70         80         90        100        110        120 
LLRMVRQGRR EEAGTLLQHL RQDLGMESTS LDDVLYRYAS FRNLVDPITH DLIISLARYI 

       130        140        150        160        170        180 
HCPKPEGDAL GAMEKLCRQL TYHLSPHSQW RRHRGLVKRK PQACLKAVLA GSPPDNTVDL 

       190        200        210        220        230        240 
SGIPLTSRDL ERVTSYLQRC GEQVDSVELG FTGLTDDMVL QLLPALSTLP RLTTLALNGN 

       250        260        270        280        290        300 
RLTRAVLRDL TDILKDPSKF PNVTWIDLGN NVDIFSLPQP FLLSLRKRSP KQGHLPTILE 

       310        320        330        340 
LGEGPGSGEE VREGTVGQED PGGGPVAPAE DHHEGKETVA AAQT 

« Hide

Isoform 2 [UniParc].

Checksum: 26D91F09C3814BEE
Show »

FASTA21223,031

References

[1]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-344 (ISOFORM 2).
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC127540 Genomic DNA. No translation available.
AC093484 Genomic DNA. No translation available.
AK093015 mRNA. Translation: BAC04020.1.
CCDSCCDS11178.2. [Q8NAA5-2]
CCDS45620.1. [Q8NAA5-1]
RefSeqNP_001107039.1. NM_001113567.2. [Q8NAA5-1]
NP_997270.2. NM_207387.3. [Q8NAA5-2]
UniGeneHs.25425.

3D structure databases

ProteinModelPortalQ8NAA5.
SMRQ8NAA5. Positions 175-271.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8NAA5.

Polymorphism databases

DMDM147640319.

Proteomic databases

MaxQBQ8NAA5.
PaxDbQ8NAA5.
PRIDEQ8NAA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409083; ENSP00000386504; ENSG00000181350. [Q8NAA5-2]
ENST00000470794; ENSP00000419502; ENSG00000181350. [Q8NAA5-1]
GeneID388341.
KEGGhsa:388341.
UCSCuc002gqh.3. human. [Q8NAA5-2]
uc010cph.2. human. [Q8NAA5-1]

Organism-specific databases

CTD388341.
GeneCardsGC17M016344.
HGNCHGNC:32403. LRRC75A.
HPAHPA028528.
neXtProtNX_Q8NAA5.
PharmGKBPA143485400.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41786.
HOGENOMHOG000111942.
HOVERGENHBG066484.
InParanoidQ8NAA5.
OMAKFPSVTW.
OrthoDBEOG7RZ5RM.
PhylomeDBQ8NAA5.
TreeFamTF332831.

Gene expression databases

BgeeQ8NAA5.
CleanExHS_C17orf76.
GenevestigatorQ8NAA5.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi388341.
NextBio101984.
PROQ8NAA5.

Entry information

Entry nameLR75A_HUMAN
AccessionPrimary (citable) accession number: Q8NAA5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM