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Q8NAA5

- LR75A_HUMAN

UniProt

Q8NAA5 - LR75A_HUMAN

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Protein

Leucine-rich repeat-containing protein 75A

Gene

LRRC75A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 75A
Alternative name(s):
Leucine-rich repeat-containing protein FAM211A
Gene namesi
Name:LRRC75A
Synonyms:C17orf76, FAM211A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:32403. LRRC75A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Leucine-rich repeat-containing protein 75APRO_0000286624Add
BLAST

Proteomic databases

MaxQBiQ8NAA5.
PaxDbiQ8NAA5.
PRIDEiQ8NAA5.

PTM databases

PhosphoSiteiQ8NAA5.

Expressioni

Gene expression databases

BgeeiQ8NAA5.
CleanExiHS_C17orf76.
GenevestigatoriQ8NAA5.

Organism-specific databases

HPAiHPA028528.

Structurei

3D structure databases

ProteinModelPortaliQ8NAA5.
SMRiQ8NAA5. Positions 165-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati204 – 21714LRR 1Add
BLAST
Repeati229 – 24214LRR 2Add
BLAST

Sequence similaritiesi

Belongs to the LRRC75 family.Curated
Contains 2 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG41786.
GeneTreeiENSGT00390000004841.
HOGENOMiHOG000111942.
HOVERGENiHBG066484.
InParanoidiQ8NAA5.
OMAiKFPSVTW.
OrthoDBiEOG7RZ5RM.
PhylomeDBiQ8NAA5.
TreeFamiTF332831.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NAA5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTRQTKGSL AERASPGAAP GPRRERPDFW ASLLLRAGDK AGRAGAGMPP
60 70 80 90 100
YHRRVGMVQE LLRMVRQGRR EEAGTLLQHL RQDLGMESTS LDDVLYRYAS
110 120 130 140 150
FRNLVDPITH DLIISLARYI HCPKPEGDAL GAMEKLCRQL TYHLSPHSQW
160 170 180 190 200
RRHRGLVKRK PQACLKAVLA GSPPDNTVDL SGIPLTSRDL ERVTSYLQRC
210 220 230 240 250
GEQVDSVELG FTGLTDDMVL QLLPALSTLP RLTTLALNGN RLTRAVLRDL
260 270 280 290 300
TDILKDPSKF PNVTWIDLGN NVDIFSLPQP FLLSLRKRSP KQGHLPTILE
310 320 330 340
LGEGPGSGEE VREGTVGQED PGGGPVAPAE DHHEGKETVA AAQT
Length:344
Mass (Da):37,780
Last modified:May 15, 2007 - v2
Checksum:iE76D268A6D393A0C
GO
Isoform 2 (identifier: Q8NAA5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-212: EGDALGAMEK...QVDSVELGFT → PQGCPGRKPP...VDPGRAARPH
     213-344: Missing.

Show »
Length:212
Mass (Da):23,031
Checksum:i26D91F09C3814BEE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 21287EGDAL…ELGFT → PQGCPGRKPPRQHSGPVGNP TDLPRPGAGDQLPTALWGAG RQRGAGLHRPHGRHGPAAAA STQHPAPPHHTGTQWQPVDP GRAARPH in isoform 2. 1 PublicationVSP_025134Add
BLAST
Alternative sequencei213 – 344132Missing in isoform 2. 1 PublicationVSP_025135Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127540 Genomic DNA. No translation available.
AC093484 Genomic DNA. No translation available.
AK093015 mRNA. Translation: BAC04020.1.
CCDSiCCDS11178.2. [Q8NAA5-2]
CCDS45620.1. [Q8NAA5-1]
RefSeqiNP_001107039.1. NM_001113567.2. [Q8NAA5-1]
NP_997270.2. NM_207387.3. [Q8NAA5-2]
UniGeneiHs.25425.

Genome annotation databases

EnsembliENST00000409083; ENSP00000386504; ENSG00000181350. [Q8NAA5-2]
ENST00000470794; ENSP00000419502; ENSG00000181350. [Q8NAA5-1]
GeneIDi388341.
KEGGihsa:388341.
UCSCiuc002gqh.3. human. [Q8NAA5-2]
uc010cph.2. human. [Q8NAA5-1]

Polymorphism databases

DMDMi147640319.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127540 Genomic DNA. No translation available.
AC093484 Genomic DNA. No translation available.
AK093015 mRNA. Translation: BAC04020.1 .
CCDSi CCDS11178.2. [Q8NAA5-2 ]
CCDS45620.1. [Q8NAA5-1 ]
RefSeqi NP_001107039.1. NM_001113567.2. [Q8NAA5-1 ]
NP_997270.2. NM_207387.3. [Q8NAA5-2 ]
UniGenei Hs.25425.

3D structure databases

ProteinModelPortali Q8NAA5.
SMRi Q8NAA5. Positions 165-271.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8NAA5.

Polymorphism databases

DMDMi 147640319.

Proteomic databases

MaxQBi Q8NAA5.
PaxDbi Q8NAA5.
PRIDEi Q8NAA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409083 ; ENSP00000386504 ; ENSG00000181350 . [Q8NAA5-2 ]
ENST00000470794 ; ENSP00000419502 ; ENSG00000181350 . [Q8NAA5-1 ]
GeneIDi 388341.
KEGGi hsa:388341.
UCSCi uc002gqh.3. human. [Q8NAA5-2 ]
uc010cph.2. human. [Q8NAA5-1 ]

Organism-specific databases

CTDi 388341.
GeneCardsi GC17M016346.
HGNCi HGNC:32403. LRRC75A.
HPAi HPA028528.
neXtProti NX_Q8NAA5.
PharmGKBi PA143485400.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41786.
GeneTreei ENSGT00390000004841.
HOGENOMi HOG000111942.
HOVERGENi HBG066484.
InParanoidi Q8NAA5.
OMAi KFPSVTW.
OrthoDBi EOG7RZ5RM.
PhylomeDBi Q8NAA5.
TreeFami TF332831.

Miscellaneous databases

GenomeRNAii 388341.
NextBioi 101984.
PROi Q8NAA5.

Gene expression databases

Bgeei Q8NAA5.
CleanExi HS_C17orf76.
Genevestigatori Q8NAA5.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-344 (ISOFORM 2).
    Tissue: Spleen.

Entry informationi

Entry nameiLR75A_HUMAN
AccessioniPrimary (citable) accession number: Q8NAA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3