Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Autophagy-related protein 16-2

Gene

ATG16L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in autophagy.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ8NAA4.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 16-2
Alternative name(s):
APG16-like 2
WD repeat-containing protein 80
Gene namesi
Name:ATG16L2
Synonyms:WDR80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25464. ATG16L2.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Localizes also to discrete punctae along the ciliary axoneme.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672575.

Polymorphism and mutation databases

BioMutaiATG16L2.
DMDMi189027648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Autophagy-related protein 16-2PRO_0000337110Add
BLAST

Proteomic databases

EPDiQ8NAA4.
PaxDbiQ8NAA4.
PRIDEiQ8NAA4.

PTM databases

iPTMnetiQ8NAA4.
PhosphoSiteiQ8NAA4.

Expressioni

Gene expression databases

BgeeiQ8NAA4.
CleanExiHS_ATG16L2.
ExpressionAtlasiQ8NAA4. baseline and differential.
GenevisibleiQ8NAA4. HS.

Organism-specific databases

HPAiHPA045444.
HPA050312.

Interactioni

Protein-protein interaction databases

BioGridi124620. 4 interactions.
IntActiQ8NAA4. 5 interactions.
MINTiMINT-8247605.
STRINGi9606.ENSP00000326340.

Structurei

3D structure databases

ProteinModelPortaliQ8NAA4.
SMRiQ8NAA4. Positions 297-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati334 – 37340WD 1Add
BLAST
Repeati378 – 41740WD 2Add
BLAST
Repeati420 – 45435WD 3Add
BLAST
Repeati455 – 49844WD 4Add
BLAST
Repeati500 – 53940WD 5Add
BLAST
Repeati546 – 58540WD 6Add
BLAST
Repeati589 – 61931WD 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 227112Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat ATG16 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IMNZ. Eukaryota.
ENOG410YFNR. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000112569.
HOVERGENiHBG050534.
InParanoidiQ8NAA4.
KOiK17890.
OrthoDBiEOG70CR6M.
PhylomeDBiQ8NAA4.
TreeFamiTF315541.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08614. ATG16. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NAA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPGVPGAP AARWKRHIVR QLRLRDRTQK ALFLELVPAY NHLLEKAELL
60 70 80 90 100
DKFSKKLQPE PNSVTPTTHQ GPWEESELDS DQVPSLVALR VKWQEEEEGL
110 120 130 140 150
RLVCGEMAYQ VVEKGAALGT LESELQQRQS RLAALEARVA QLREARAQQA
160 170 180 190 200
QQVEEWRAQN AVQRAAYEAL RAHVGLREAA LRRLQEEARD LLERLVQRKA
210 220 230 240 250
RAAAERNLRN ERRERAKQAR VSQELKKAAK RTVSISEGPD TLGDGMRERR
260 270 280 290 300
ETLALAPEPE PLEKEACEKW KRPFRSASAT SLTLSHCVDV VKGLLDFKKR
310 320 330 340 350
RGHSIGGAPE QRYQIIPVCV AARLPTRAQD VLDAHLSEVN AVRFGPNSSL
360 370 380 390 400
LATGGADRLI HLWNVVGSRL EANQTLEGAG GSITSVDFDP SGYQVLAATY
410 420 430 440 450
NQAAQLWKVG EAQSKETLSG HKDKVTAAKF KLTRHQAVTG SRDRTVKEWD
460 470 480 490 500
LGRAYCSRTI NVLSYCNDVV CGDHIIISGH NDQKIRFWDS RGPHCTQVIP
510 520 530 540 550
VQGRVTSLSL SHDQLHLLSC SRDNTLKVID LRVSNIRQVF RADGFKCGSD
560 570 580 590 600
WTKAVFSPDR SYALAGSCDG ALYIWDVDTG KLESRLQGPH CAAVNAVAWC
610
YSGSHMVSVD QGRKVVLWQ
Length:619
Mass (Da):68,998
Last modified:May 20, 2008 - v2
Checksum:i7F2962AA3C6BB850
GO
Isoform 2 (identifier: Q8NAA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.
Show »
Length:513
Mass (Da):56,955
Checksum:iBC41BEBE478C9F55
GO
Isoform 3 (identifier: Q8NAA4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-619: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):31,445
Checksum:i09BEED7D259D9E04
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241E → G in BAC03485 (PubMed:14702039).Curated
Sequence conflicti256 – 2561A → V in AAH36713 (PubMed:15489334).Curated
Sequence conflicti343 – 3431R → G in BAC03485 (PubMed:14702039).Curated
Sequence conflicti492 – 4921G → E in BAC04021 (PubMed:14702039).Curated
Sequence conflicti508 – 5081L → R in CAH56355 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201R → W.
Corresponds to variant rs11235604 [ dbSNP | Ensembl ].
VAR_043605

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 2. 1 PublicationVSP_033904Add
BLAST
Alternative sequencei276 – 619344Missing in isoform 3. 1 PublicationVSP_033905Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093017 mRNA. Translation: BAC04021.1.
AK090597 mRNA. Translation: BAC03485.1.
CH471076 Genomic DNA. Translation: EAW74876.1.
CH471076 Genomic DNA. Translation: EAW74874.1.
BC036713 mRNA. Translation: AAH36713.1.
BC137489 mRNA. Translation: AAI37490.1.
BC137490 mRNA. Translation: AAI37491.1.
BC142718 mRNA. Translation: AAI42719.1.
BC146660 mRNA. Translation: AAI46661.1.
AL832974 mRNA. Translation: CAH56355.1.
CCDSiCCDS31634.1. [Q8NAA4-1]
RefSeqiNP_001305695.1. NM_001318766.1. [Q8NAA4-2]
NP_203746.1. NM_033388.1. [Q8NAA4-1]
XP_011543635.1. XM_011545333.1. [Q8NAA4-2]
XP_011543636.1. XM_011545334.1. [Q8NAA4-2]
UniGeneiHs.653186.

Genome annotation databases

EnsembliENST00000321297; ENSP00000326340; ENSG00000168010. [Q8NAA4-1]
GeneIDi89849.
KEGGihsa:89849.
UCSCiuc001otd.4. human. [Q8NAA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093017 mRNA. Translation: BAC04021.1.
AK090597 mRNA. Translation: BAC03485.1.
CH471076 Genomic DNA. Translation: EAW74876.1.
CH471076 Genomic DNA. Translation: EAW74874.1.
BC036713 mRNA. Translation: AAH36713.1.
BC137489 mRNA. Translation: AAI37490.1.
BC137490 mRNA. Translation: AAI37491.1.
BC142718 mRNA. Translation: AAI42719.1.
BC146660 mRNA. Translation: AAI46661.1.
AL832974 mRNA. Translation: CAH56355.1.
CCDSiCCDS31634.1. [Q8NAA4-1]
RefSeqiNP_001305695.1. NM_001318766.1. [Q8NAA4-2]
NP_203746.1. NM_033388.1. [Q8NAA4-1]
XP_011543635.1. XM_011545333.1. [Q8NAA4-2]
XP_011543636.1. XM_011545334.1. [Q8NAA4-2]
UniGeneiHs.653186.

3D structure databases

ProteinModelPortaliQ8NAA4.
SMRiQ8NAA4. Positions 297-618.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124620. 4 interactions.
IntActiQ8NAA4. 5 interactions.
MINTiMINT-8247605.
STRINGi9606.ENSP00000326340.

PTM databases

iPTMnetiQ8NAA4.
PhosphoSiteiQ8NAA4.

Polymorphism and mutation databases

BioMutaiATG16L2.
DMDMi189027648.

Proteomic databases

EPDiQ8NAA4.
PaxDbiQ8NAA4.
PRIDEiQ8NAA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321297; ENSP00000326340; ENSG00000168010. [Q8NAA4-1]
GeneIDi89849.
KEGGihsa:89849.
UCSCiuc001otd.4. human. [Q8NAA4-1]

Organism-specific databases

CTDi89849.
GeneCardsiATG16L2.
H-InvDBHIX0009913.
HGNCiHGNC:25464. ATG16L2.
HPAiHPA045444.
HPA050312.
neXtProtiNX_Q8NAA4.
PharmGKBiPA142672575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMNZ. Eukaryota.
ENOG410YFNR. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000112569.
HOVERGENiHBG050534.
InParanoidiQ8NAA4.
KOiK17890.
OrthoDBiEOG70CR6M.
PhylomeDBiQ8NAA4.
TreeFamiTF315541.

Enzyme and pathway databases

SignaLinkiQ8NAA4.

Miscellaneous databases

ChiTaRSiATG16L2. human.
GenomeRNAii89849.
PROiQ8NAA4.

Gene expression databases

BgeeiQ8NAA4.
CleanExiHS_ATG16L2.
ExpressionAtlasiQ8NAA4. baseline and differential.
GenevisibleiQ8NAA4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08614. ATG16. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Astrocyte and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Eye.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-619.
    Tissue: Stomach.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiA16L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NAA4
Secondary accession number(s): A5PL30
, B2RPK5, Q658V4, Q6PID3, Q8NBG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.