Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

THAP domain-containing protein 8

Gene

THAP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8585THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 8
Gene namesi
Name:THAP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23191. THAP8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973337.

Polymorphism and mutation databases

BioMutaiTHAP8.
DMDMi29839559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274THAP domain-containing protein 8PRO_0000068650Add
BLAST

Proteomic databases

MaxQBiQ8NA92.
PaxDbiQ8NA92.
PRIDEiQ8NA92.

PTM databases

iPTMnetiQ8NA92.
PhosphoSiteiQ8NA92.

Expressioni

Gene expression databases

BgeeiENSG00000161277.
CleanExiHS_THAP8.
ExpressionAtlasiQ8NA92. baseline and differential.
GenevisibleiQ8NA92. HS.

Organism-specific databases

HPAiCAB021094.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFIP11Q9UBB93EBI-717429,EBI-1105213

Protein-protein interaction databases

BioGridi128269. 9 interactions.
IntActiQ8NA92. 6 interactions.
MINTiMINT-1376020.
STRINGi9606.ENSP00000292894.

Structurei

3D structure databases

ProteinModelPortaliQ8NA92.
SMRiQ8NA92. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8585THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J6A3. Eukaryota.
ENOG4111Z0Y. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000154565.
HOVERGENiHBG079251.
InParanoidiQ8NA92.
OMAiFQWRWGV.
OrthoDBiEOG091G034R.
PhylomeDBiQ8NA92.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026522. THAP8.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF13. PTHR23080:SF13. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NA92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKYCRAPNC SNTAGRLGAD NRPVSFYKFP LKDGPRLQAW LQHMGCEHWV
60 70 80 90 100
PSCHQHLCSE HFTPSCFQWR WGVRYLRPDA VPSIFSRGPP AKSQRRTRST
110 120 130 140 150
QKPVSPPPPL QKNTPLPQSP AIPVSGPVRL VVLGPTSGSP KTVATMLLTP
160 170 180 190 200
LAPAPTPERS QPEVPAQQAQ TGLGPVLGAL QRRVRRLQRC QERHQAQLQA
210 220 230 240 250
LERLAQQLHG ESLLARARRG LQRLTTAQTL GPEESQTFTI ICGGPDIAMV
260 270
LAQDPAPATV DAKPELLDTR IPSA
Length:274
Mass (Da):30,082
Last modified:October 1, 2002 - v1
Checksum:iED820002E426E81A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701R → H.
Corresponds to variant rs3810449 [ dbSNP | Ensembl ].
VAR_034552
Natural varianti112 – 1121K → R.
Corresponds to variant rs3810450 [ dbSNP | Ensembl ].
VAR_020264
Natural varianti157 – 1571P → S.1 Publication
Corresponds to variant rs34250145 [ dbSNP | Ensembl ].
VAR_034553
Natural varianti185 – 1851R → Q.1 Publication
Corresponds to variant rs10421966 [ dbSNP | Ensembl ].
VAR_052288
Natural varianti189 – 1891R → W.1 Publication
Corresponds to variant rs10420353 [ dbSNP | Ensembl ].
VAR_052289

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057453 mRNA. Translation: BAB71493.1.
AK093048 mRNA. Translation: BAC04034.1.
BC046207 mRNA. Translation: AAH46207.1.
BC072416 mRNA. Translation: AAH72416.1.
CCDSiCCDS33000.1.
RefSeqiNP_689871.1. NM_152658.2.
UniGeneiHs.350209.

Genome annotation databases

EnsembliENST00000292894; ENSP00000292894; ENSG00000161277.
GeneIDi199745.
KEGGihsa:199745.
UCSCiuc002oda.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057453 mRNA. Translation: BAB71493.1.
AK093048 mRNA. Translation: BAC04034.1.
BC046207 mRNA. Translation: AAH46207.1.
BC072416 mRNA. Translation: AAH72416.1.
CCDSiCCDS33000.1.
RefSeqiNP_689871.1. NM_152658.2.
UniGeneiHs.350209.

3D structure databases

ProteinModelPortaliQ8NA92.
SMRiQ8NA92. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128269. 9 interactions.
IntActiQ8NA92. 6 interactions.
MINTiMINT-1376020.
STRINGi9606.ENSP00000292894.

PTM databases

iPTMnetiQ8NA92.
PhosphoSiteiQ8NA92.

Polymorphism and mutation databases

BioMutaiTHAP8.
DMDMi29839559.

Proteomic databases

MaxQBiQ8NA92.
PaxDbiQ8NA92.
PRIDEiQ8NA92.

Protocols and materials databases

DNASUi199745.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292894; ENSP00000292894; ENSG00000161277.
GeneIDi199745.
KEGGihsa:199745.
UCSCiuc002oda.1. human.

Organism-specific databases

CTDi199745.
GeneCardsiTHAP8.
HGNCiHGNC:23191. THAP8.
HPAiCAB021094.
MIMi612536. gene.
neXtProtiNX_Q8NA92.
PharmGKBiPA134973337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6A3. Eukaryota.
ENOG4111Z0Y. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000154565.
HOVERGENiHBG079251.
InParanoidiQ8NA92.
OMAiFQWRWGV.
OrthoDBiEOG091G034R.
PhylomeDBiQ8NA92.
TreeFamiTF330127.

Miscellaneous databases

GenomeRNAii199745.
PROiQ8NA92.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161277.
CleanExiHS_THAP8.
ExpressionAtlasiQ8NA92. baseline and differential.
GenevisibleiQ8NA92. HS.

Family and domain databases

InterProiIPR026522. THAP8.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF13. PTHR23080:SF13. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP8_HUMAN
AccessioniPrimary (citable) accession number: Q8NA92
Secondary accession number(s): Q0P5Z7, Q96M21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.