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Protein

DDB1- and CUL4-associated factor 4-like protein 2

Gene

DCAF4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8NA75.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 4-like protein 2
Alternative name(s):
WD repeat-containing protein 21C
Gene namesi
Name:DCAF4L2
Synonyms:WDR21C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000176566.4.
HGNCiHGNC:26657. DCAF4L2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176566.
PharmGKBiPA165585467.

Polymorphism and mutation databases

BioMutaiDCAF4L2.
DMDMi74760061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455031 – 395DDB1- and CUL4-associated factor 4-like protein 2Add BLAST395

Proteomic databases

EPDiQ8NA75.
PaxDbiQ8NA75.
PeptideAtlasiQ8NA75.
PRIDEiQ8NA75.

PTM databases

iPTMnetiQ8NA75.
PhosphoSitePlusiQ8NA75.

Expressioni

Gene expression databases

BgeeiENSG00000176566.
CleanExiHS_WDR21C.
GenevisibleiQ8NA75. HS.

Organism-specific databases

HPAiHPA067584.

Interactioni

Protein-protein interaction databases

BioGridi126496. 6 interactors.
IntActiQ8NA75. 1 interactor.
STRINGi9606.ENSP00000316496.

Structurei

3D structure databases

ProteinModelPortaliQ8NA75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati268 – 307WD 1Add BLAST40
Repeati312 – 351WD 2Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2695. Eukaryota.
ENOG410XQIU. LUCA.
GeneTreeiENSGT00390000009546.
HOGENOMiHOG000065756.
HOVERGENiHBG054724.
InParanoidiQ8NA75.
OMAiDAWSCAW.
OrthoDBiEOG091G06QG.
PhylomeDBiQ8NA75.
TreeFamiTF332050.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 2 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NA75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKRPRLLE EADKQKKTVR VGLNAPSMLR KNQLGFLRFA NYCRIARELR
60 70 80 90 100
VSCMQRKKVQ IHSWDPSSLA SDRFNRILAN TNTDQLFTVN QVEAGGSKYG
110 120 130 140 150
IITMRGLTTP ELRVYPHKTL YVPNRKVNSM CWASLNHLDS HLLLCFVGLA
160 170 180 190 200
DTPSCAVLLP ASLFIGSFPG MRRPGMLCSF QIPDAWSCAW SLSIHAYHSF
210 220 230 240 250
STGLSQQVLL TNVVTGHQQS FGTSSDVLAQ QFAIMTPLLF NGCRSGEIFG
260 270 280 290 300
IDLRCGNQGS GWKAICLSHD SAVTSLQILQ DGQFLVSSDM TGTIKLWDLR
310 320 330 340 350
ATKCVTQYEG HVNNSAYLPV HVNEEEGVVA AVGQDCYTRI WSLRHGHLLT
360 370 380 390
TIPSPYPASE NDIPSVAFSS RLGGFRGAPG LLMAVREDLY CFSYG
Length:395
Mass (Da):43,747
Last modified:October 1, 2002 - v1
Checksum:i676EF30CDD8348B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093094 mRNA. Translation: BAC04051.1.
BC111778 mRNA. Translation: AAI11779.1.
CCDSiCCDS6245.1.
RefSeqiNP_689631.1. NM_152418.3.
UniGeneiHs.371738.

Genome annotation databases

EnsembliENST00000319675; ENSP00000316496; ENSG00000176566.
GeneIDi138009.
KEGGihsa:138009.
UCSCiuc003ydz.3. human.

Similar proteinsi

Entry informationi

Entry nameiDC4L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NA75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM