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Protein

DDB1- and CUL4-associated factor 4-like protein 2

Gene

DCAF4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8NA75.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 4-like protein 2
Alternative name(s):
WD repeat-containing protein 21C
Gene namesi
Name:DCAF4L2
Synonyms:WDR21C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26657. DCAF4L2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585467.

Polymorphism and mutation databases

BioMutaiDCAF4L2.
DMDMi74760061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395DDB1- and CUL4-associated factor 4-like protein 2PRO_0000245503Add
BLAST

Proteomic databases

EPDiQ8NA75.
PaxDbiQ8NA75.
PeptideAtlasiQ8NA75.
PRIDEiQ8NA75.

PTM databases

iPTMnetiQ8NA75.
PhosphoSiteiQ8NA75.

Expressioni

Gene expression databases

BgeeiENSG00000176566.
CleanExiHS_WDR21C.
GenevisibleiQ8NA75. HS.

Organism-specific databases

HPAiHPA067584.

Interactioni

Protein-protein interaction databases

BioGridi126496. 6 interactions.
IntActiQ8NA75. 1 interaction.
STRINGi9606.ENSP00000316496.

Structurei

3D structure databases

ProteinModelPortaliQ8NA75.
SMRiQ8NA75. Positions 221-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati268 – 30740WD 1Add
BLAST
Repeati312 – 35140WD 2Add
BLAST

Sequence similaritiesi

Contains 2 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2695. Eukaryota.
ENOG410XQIU. LUCA.
GeneTreeiENSGT00390000009546.
HOGENOMiHOG000065756.
HOVERGENiHBG054724.
InParanoidiQ8NA75.
OMAiDAWSCAW.
OrthoDBiEOG091G06QG.
PhylomeDBiQ8NA75.
TreeFamiTF332050.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NA75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKRPRLLE EADKQKKTVR VGLNAPSMLR KNQLGFLRFA NYCRIARELR
60 70 80 90 100
VSCMQRKKVQ IHSWDPSSLA SDRFNRILAN TNTDQLFTVN QVEAGGSKYG
110 120 130 140 150
IITMRGLTTP ELRVYPHKTL YVPNRKVNSM CWASLNHLDS HLLLCFVGLA
160 170 180 190 200
DTPSCAVLLP ASLFIGSFPG MRRPGMLCSF QIPDAWSCAW SLSIHAYHSF
210 220 230 240 250
STGLSQQVLL TNVVTGHQQS FGTSSDVLAQ QFAIMTPLLF NGCRSGEIFG
260 270 280 290 300
IDLRCGNQGS GWKAICLSHD SAVTSLQILQ DGQFLVSSDM TGTIKLWDLR
310 320 330 340 350
ATKCVTQYEG HVNNSAYLPV HVNEEEGVVA AVGQDCYTRI WSLRHGHLLT
360 370 380 390
TIPSPYPASE NDIPSVAFSS RLGGFRGAPG LLMAVREDLY CFSYG
Length:395
Mass (Da):43,747
Last modified:October 1, 2002 - v1
Checksum:i676EF30CDD8348B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093094 mRNA. Translation: BAC04051.1.
BC111778 mRNA. Translation: AAI11779.1.
CCDSiCCDS6245.1.
RefSeqiNP_689631.1. NM_152418.3.
UniGeneiHs.371738.

Genome annotation databases

EnsembliENST00000319675; ENSP00000316496; ENSG00000176566.
GeneIDi138009.
KEGGihsa:138009.
UCSCiuc003ydz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093094 mRNA. Translation: BAC04051.1.
BC111778 mRNA. Translation: AAI11779.1.
CCDSiCCDS6245.1.
RefSeqiNP_689631.1. NM_152418.3.
UniGeneiHs.371738.

3D structure databases

ProteinModelPortaliQ8NA75.
SMRiQ8NA75. Positions 221-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126496. 6 interactions.
IntActiQ8NA75. 1 interaction.
STRINGi9606.ENSP00000316496.

PTM databases

iPTMnetiQ8NA75.
PhosphoSiteiQ8NA75.

Polymorphism and mutation databases

BioMutaiDCAF4L2.
DMDMi74760061.

Proteomic databases

EPDiQ8NA75.
PaxDbiQ8NA75.
PeptideAtlasiQ8NA75.
PRIDEiQ8NA75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319675; ENSP00000316496; ENSG00000176566.
GeneIDi138009.
KEGGihsa:138009.
UCSCiuc003ydz.3. human.

Organism-specific databases

CTDi138009.
GeneCardsiDCAF4L2.
H-InvDBHIX0007633.
HGNCiHGNC:26657. DCAF4L2.
HPAiHPA067584.
neXtProtiNX_Q8NA75.
PharmGKBiPA165585467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2695. Eukaryota.
ENOG410XQIU. LUCA.
GeneTreeiENSGT00390000009546.
HOGENOMiHOG000065756.
HOVERGENiHBG054724.
InParanoidiQ8NA75.
OMAiDAWSCAW.
OrthoDBiEOG091G06QG.
PhylomeDBiQ8NA75.
TreeFamiTF332050.

Enzyme and pathway databases

SignaLinkiQ8NA75.

Miscellaneous databases

GenomeRNAii138009.
PROiQ8NA75.

Gene expression databases

BgeeiENSG00000176566.
CleanExiHS_WDR21C.
GenevisibleiQ8NA75. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDC4L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NA75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.