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Q8NA75 (DC4L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DDB1- and CUL4-associated factor 4-like protein 2
Alternative name(s):
WD repeat-containing protein 21C
Gene names
Name:DCAF4L2
Synonyms:WDR21C
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 2 WD repeats.

Ontologies

Keywords
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395DDB1- and CUL4-associated factor 4-like protein 2
PRO_0000245503

Regions

Repeat268 – 30740WD 1
Repeat312 – 35140WD 2

Amino acid modifications

Modified residue1151Phosphotyrosine Ref.3
Modified residue1191Phosphothreonine Ref.3
Modified residue1211Phosphotyrosine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8NA75 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 676EF30CDD8348B0

FASTA39543,747
        10         20         30         40         50         60 
MESKRPRLLE EADKQKKTVR VGLNAPSMLR KNQLGFLRFA NYCRIARELR VSCMQRKKVQ 

        70         80         90        100        110        120 
IHSWDPSSLA SDRFNRILAN TNTDQLFTVN QVEAGGSKYG IITMRGLTTP ELRVYPHKTL 

       130        140        150        160        170        180 
YVPNRKVNSM CWASLNHLDS HLLLCFVGLA DTPSCAVLLP ASLFIGSFPG MRRPGMLCSF 

       190        200        210        220        230        240 
QIPDAWSCAW SLSIHAYHSF STGLSQQVLL TNVVTGHQQS FGTSSDVLAQ QFAIMTPLLF 

       250        260        270        280        290        300 
NGCRSGEIFG IDLRCGNQGS GWKAICLSHD SAVTSLQILQ DGQFLVSSDM TGTIKLWDLR 

       310        320        330        340        350        360 
ATKCVTQYEG HVNNSAYLPV HVNEEEGVVA AVGQDCYTRI WSLRHGHLLT TIPSPYPASE 

       370        380        390 
NDIPSVAFSS RLGGFRGAPG LLMAVREDLY CFSYG

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-115; THR-119 AND TYR-121, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK093094 mRNA. Translation: BAC04051.1.
BC111778 mRNA. Translation: AAI11779.1.
IPIIPI00167925.
RefSeqNP_689631.1. NM_152418.3.
UniGeneHs.371738.

3D structure databases

ProteinModelPortalQ8NA75.
SMRQ8NA75. Positions 185-371.
ModBaseSearch...

PTM databases

PhosphoSiteQ8NA75.

Polymorphism databases

DMDM74760061.

Proteomic databases

PRIDEQ8NA75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319675; ENSP00000316496; ENSG00000176566.
GeneID138009.
KEGGhsa:138009.
UCSCuc003ydz.1. human.

Organism-specific databases

CTD138009.
GeneCardsGC08M088954.
H-InvDBHIX0007633.
HGNCHGNC:26657. DCAF4L2.
neXtProtNX_Q8NA75.
PharmGKBPA142670606.
PA165585467.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00390000009546.
HOGENOMHBG445161.
HOVERGENHBG054724.
InParanoidQ8NA75.
OMADAWSCAW.
OrthoDBEOG4N8R4Q.
PhylomeDBQ8NA75.

Gene expression databases

ArrayExpressQ8NA75.
BgeeQ8NA75.
CleanExHS_WDR21C.
GenevestigatorQ8NA75.
GermOnlineENSG00000176566. Homo sapiens.

Family and domain databases

InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio83721.

Entry information

Entry nameDC4L2_HUMAN
AccessionPrimary (citable) accession number: Q8NA75
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents