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Protein

Centrosomal protein POC5

Gene

POC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the assembly of the distal half of centrioles, required for centriole elongation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein POC5
Alternative name(s):
Protein of centriole 5
Short name:
hPOC5
Gene namesi
Name:POC5
Synonyms:C5orf37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26658. POC5.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB-SubCell
  • centrosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi134359.
OpenTargetsiENSG00000152359.
PharmGKBiPA165660427.

Polymorphism and mutation databases

BioMutaiPOC5.
DMDMi143955298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002819081 – 575Centrosomal protein POC5Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei538N6-acetyllysineCombined sources1
Modified residuei564PhosphoserineCombined sources1

Post-translational modificationi

Hyperphosphorylated during recruitment to procentrioles in G2/M phase.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NA72.
MaxQBiQ8NA72.
PaxDbiQ8NA72.
PeptideAtlasiQ8NA72.
PRIDEiQ8NA72.

PTM databases

iPTMnetiQ8NA72.
PhosphoSitePlusiQ8NA72.

Expressioni

Gene expression databases

BgeeiENSG00000152359.
CleanExiHS_C5orf37.
ExpressionAtlasiQ8NA72. baseline and differential.
GenevisibleiQ8NA72. HS.

Organism-specific databases

HPAiHPA037509.
HPA037510.
HPA061521.

Interactioni

Subunit structurei

Interacts with CETN2 and CETN3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CETN1Q127984EBI-11751537,EBI-2512818
CETN2P412087EBI-2561090,EBI-1789926
CETN3O151824EBI-11751537,EBI-712959
FAM161AQ3B8204EBI-2561090,EBI-719941

Protein-protein interaction databases

BioGridi126396. 77 interactors.
IntActiQ8NA72. 69 interactors.
STRINGi9606.ENSP00000410216.

Structurei

3D structure databases

ProteinModelPortaliQ8NA72.
SMRiQ8NA72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati142 – 173Centrin-binding (CBR) 1Add BLAST32
Repeati231 – 262Centrin-binding (CBR) 2Add BLAST32
Repeati263 – 295Centrin-binding (CBR) 3Add BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili191 – 222Sequence analysisAdd BLAST32
Coiled coili316 – 355Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the POC5 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IF7G. Eukaryota.
ENOG410XRU9. LUCA.
GeneTreeiENSGT00390000004454.
HOGENOMiHOG000294169.
HOVERGENiHBG102627.
InParanoidiQ8NA72.
KOiK16483.
OMAiKQLCNQI.
OrthoDBiEOG091G0J96.
PhylomeDBiQ8NA72.
TreeFamiTF329296.

Family and domain databases

InterProiIPR033351. POC5.
[Graphical view]
PANTHERiPTHR28618. PTHR28618. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDEEKYSL PVVQNDSSRG SSVSSNLQEE YEELLHYAIV TPNIEPCASQ
60 70 80 90 100
SSHPKGELVP DVRISTIHDI LHSQGNNSEV RETAIEVGKG CDFHISSHSK
110 120 130 140 150
TDESSPVLSP RKPSHPVMDF FSSHLLADSS SPATNSSHTD AHEILVSDFL
160 170 180 190 200
VSDENLQKME NVLDLWSSGL KTNIISELSK WRLNFIDWHR MEMRKEKEKH
210 220 230 240 250
AAHLKQLCNQ INELKELQKT FEISIGRKDE VISSLSHAIG KQKEKIELMR
260 270 280 290 300
TFFHWRIGHV RARQDVYEGK LADQYYQRTL LKKVWKVWRS VVQKQWKDVV
310 320 330 340 350
ERACQARAEE VCIQISNDYE AKVAMLSGAL ENAKAEIQRM QHEKEHFEDS
360 370 380 390 400
MKKAFMRGVC ALNLEAMTIF QNRNDAGIDS TNNKKEEYGP GVQGKEHSAH
410 420 430 440 450
LDPSAPPMPL PVTSPLLPSP PAAVGGASAT AVPSAASMTS TRAASASSVH
460 470 480 490 500
VPVSALGAGS AATAASEEMY VPRVVTSAQQ KAGRTITARI TGRCDFASKN
510 520 530 540 550
RISSSLAIMG VSPPMSSVVV EKHHPVTVQT IPQATAAKYP RTIHPESSTS
560 570
ASRSLGTRSA HTQSLTSVHS IKVVD
Length:575
Mass (Da):63,351
Last modified:April 3, 2007 - v2
Checksum:i0B544DD102B35D80
GO
Isoform 2 (identifier: Q8NA72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     470-528: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):44,255
Checksum:iD306448E1E4BFFB3
GO
Isoform 3 (identifier: Q8NA72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MSSDEEKYSLPVVQNDSSRGSSVSSNLQ → MKW

Note: No experimental confirmation available.Curated
Show »
Length:550
Mass (Da):60,784
Checksum:i1D0B8B349B00F227
GO

Sequence cautioni

The sequence BC101328 differs from that shown. Reason: Frameshift at position 195.Curated
Isoform 3 : The sequence BC101328 differs from that shown. Reason: Frameshift at positions 3 and 195.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41T → A in AAH65750 (PubMed:15489334).Curated1
Sequence conflicti47C → R in BAC04054 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03132436H → R.2 PublicationsCorresponds to variant rs2307111dbSNPEnsembl.1
Natural variantiVAR_03132585I → T.1 PublicationCorresponds to variant rs17672542dbSNPEnsembl.1
Natural variantiVAR_050778446A → T.Corresponds to variant rs34678567dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0240981 – 117Missing in isoform 2. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_0240991 – 28MSSDE…SSNLQ → MKW in isoform 3. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_024100470 – 528Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093098 mRNA. Translation: BAC04054.1.
AK296071 mRNA. Translation: BAG58829.1.
BC065750 mRNA. Translation: AAH65750.1. Different termination.
BC101326 mRNA. Translation: AAI01327.1.
BC101325 mRNA. Translation: AAI01326.1.
BC101327 mRNA. Translation: AAI01328.1.
BC101328 mRNA. No translation available.
CCDSiCCDS47236.1. [Q8NA72-1]
CCDS47237.1. [Q8NA72-3]
RefSeqiNP_001092741.1. NM_001099271.1. [Q8NA72-1]
NP_689621.2. NM_152408.2. [Q8NA72-3]
UniGeneiHs.432726.

Genome annotation databases

EnsembliENST00000428202; ENSP00000410216; ENSG00000152359. [Q8NA72-1]
ENST00000446329; ENSP00000399481; ENSG00000152359. [Q8NA72-3]
ENST00000510798; ENSP00000426796; ENSG00000152359. [Q8NA72-2]
GeneIDi134359.
KEGGihsa:134359.
UCSCiuc003keg.5. human. [Q8NA72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093098 mRNA. Translation: BAC04054.1.
AK296071 mRNA. Translation: BAG58829.1.
BC065750 mRNA. Translation: AAH65750.1. Different termination.
BC101326 mRNA. Translation: AAI01327.1.
BC101325 mRNA. Translation: AAI01326.1.
BC101327 mRNA. Translation: AAI01328.1.
BC101328 mRNA. No translation available.
CCDSiCCDS47236.1. [Q8NA72-1]
CCDS47237.1. [Q8NA72-3]
RefSeqiNP_001092741.1. NM_001099271.1. [Q8NA72-1]
NP_689621.2. NM_152408.2. [Q8NA72-3]
UniGeneiHs.432726.

3D structure databases

ProteinModelPortaliQ8NA72.
SMRiQ8NA72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126396. 77 interactors.
IntActiQ8NA72. 69 interactors.
STRINGi9606.ENSP00000410216.

PTM databases

iPTMnetiQ8NA72.
PhosphoSitePlusiQ8NA72.

Polymorphism and mutation databases

BioMutaiPOC5.
DMDMi143955298.

Proteomic databases

EPDiQ8NA72.
MaxQBiQ8NA72.
PaxDbiQ8NA72.
PeptideAtlasiQ8NA72.
PRIDEiQ8NA72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428202; ENSP00000410216; ENSG00000152359. [Q8NA72-1]
ENST00000446329; ENSP00000399481; ENSG00000152359. [Q8NA72-3]
ENST00000510798; ENSP00000426796; ENSG00000152359. [Q8NA72-2]
GeneIDi134359.
KEGGihsa:134359.
UCSCiuc003keg.5. human. [Q8NA72-1]

Organism-specific databases

CTDi134359.
DisGeNETi134359.
GeneCardsiPOC5.
HGNCiHGNC:26658. POC5.
HPAiHPA037509.
HPA037510.
HPA061521.
neXtProtiNX_Q8NA72.
OpenTargetsiENSG00000152359.
PharmGKBiPA165660427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF7G. Eukaryota.
ENOG410XRU9. LUCA.
GeneTreeiENSGT00390000004454.
HOGENOMiHOG000294169.
HOVERGENiHBG102627.
InParanoidiQ8NA72.
KOiK16483.
OMAiKQLCNQI.
OrthoDBiEOG091G0J96.
PhylomeDBiQ8NA72.
TreeFamiTF329296.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152359-MONOMER.

Miscellaneous databases

GenomeRNAii134359.
PROiQ8NA72.

Gene expression databases

BgeeiENSG00000152359.
CleanExiHS_C5orf37.
ExpressionAtlasiQ8NA72. baseline and differential.
GenevisibleiQ8NA72. HS.

Family and domain databases

InterProiIPR033351. POC5.
[Graphical view]
PANTHERiPTHR28618. PTHR28618. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPOC5_HUMAN
AccessioniPrimary (citable) accession number: Q8NA72
Secondary accession number(s): B4DJG7
, Q494X7, Q494X9, Q6P085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.