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Protein

Protein FAM47B

Gene

FAM47B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM47B
Gene namesi
Name:FAM47B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26659. FAM47B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969396.

Polymorphism and mutation databases

BioMutaiFAM47B.
DMDMi71151884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 645645Protein FAM47BPRO_0000187038Add
BLAST

Proteomic databases

PaxDbiQ8NA70.
PRIDEiQ8NA70.

PTM databases

PhosphoSiteiQ8NA70.

Expressioni

Gene expression databases

BgeeiQ8NA70.
CleanExiHS_FAM47B.
GenevisibleiQ8NA70. HS.

Organism-specific databases

HPAiHPA046829.
HPA050996.

Interactioni

Protein-protein interaction databases

BioGridi127993. 1 interaction.
IntActiQ8NA70. 1 interaction.
STRINGi9606.ENSP00000328307.

Structurei

3D structure databases

ProteinModelPortaliQ8NA70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi189 – 324136Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM47 family.Curated

Phylogenomic databases

eggNOGiNOG83278.
GeneTreeiENSGT00400000022396.
HOGENOMiHOG000112475.
HOVERGENiHBG076577.
InParanoidiQ8NA70.
OMAiPFESRMP.
OrthoDBiEOG7K0ZBC.
PhylomeDBiQ8NA70.
TreeFamiTF340932.

Sequencei

Sequence statusi: Complete.

Q8NA70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRRPQDRP RSQGMDSKPW YCDKPPSKYF AKRKHRRLRF PPVDTQNWVF
60 70 80 90 100
VTEGMDDFRY ACQSPEDTLV CRRDEFLLPK ISLRGPQADR KSRKKKLLKK
110 120 130 140 150
AALFSELSPV QPARKAFVEE VEAQLMTKHP LAMYPNLGKD MPPDLLLQVL
160 170 180 190 200
KQLDPERKLE DAWARCEARE KTTEVPTESG KYPCGESCPR PPETPVSRLR
210 220 230 240 250
PQLPKTPVSS RRPEPPKTRV SSLRPEPPKT RVSSLHPEPP ETRASHLRVD
260 270 280 290 300
PPETGVSHLC PEPPKTLVSS VHPEPPDTGA SHLCPEPPET RVSHLHPEPP
310 320 330 340 350
ETGVSHLRPE PSKTQVSSLC PEPPEAGVSH LCLEPPNTHR VSSFLLQVLK
360 370 380 390 400
LDSEKKLEDA RARCEGQEMT TEELTKPGKY HFWESCPRPF ESRMPHLRLV
410 420 430 440 450
LPITRRMASL CLKPPKTRRV SSLCPEPTKT GASHLKELFQ EDTPSTMECV
460 470 480 490 500
SDSLQRRHTS RKLRDFKWAG DLGVNEESIS SLFDFTPECR TTDQDQKIKK
510 520 530 540 550
ANECASRLMY GMELDDMDEV EFLRIKYWDR RRRAAPHSYS AQRGRIRYGP
560 570 580 590 600
WYFEPKLGKK LRSDEPLIDP KPVLEKPDEP DILDGLYGPI AFKDFILSKG
610 620 630 640
YRMPGVIEKL FAKKGWTYDS VKTPIQRAVQ VYKYKEDVTD ASKED
Length:645
Mass (Da):73,945
Last modified:July 19, 2005 - v2
Checksum:iF49BACE4627E3C5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021Q → H in AAH35026 (PubMed:15489334).Curated
Sequence conflicti220 – 2212VS → AP in BAC04056 (PubMed:14702039).Curated
Sequence conflicti299 – 2991P → S in BAC04056 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093101 mRNA. Translation: BAC04056.1.
AL645585 Genomic DNA. Translation: CAI41598.1.
BC035026 mRNA. Translation: AAH35026.1.
CCDSiCCDS14236.1.
RefSeqiNP_689844.2. NM_152631.2.
UniGeneiHs.197801.

Genome annotation databases

EnsembliENST00000329357; ENSP00000328307; ENSG00000189132.
GeneIDi170062.
KEGGihsa:170062.
UCSCiuc004ddi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093101 mRNA. Translation: BAC04056.1.
AL645585 Genomic DNA. Translation: CAI41598.1.
BC035026 mRNA. Translation: AAH35026.1.
CCDSiCCDS14236.1.
RefSeqiNP_689844.2. NM_152631.2.
UniGeneiHs.197801.

3D structure databases

ProteinModelPortaliQ8NA70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127993. 1 interaction.
IntActiQ8NA70. 1 interaction.
STRINGi9606.ENSP00000328307.

PTM databases

PhosphoSiteiQ8NA70.

Polymorphism and mutation databases

BioMutaiFAM47B.
DMDMi71151884.

Proteomic databases

PaxDbiQ8NA70.
PRIDEiQ8NA70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329357; ENSP00000328307; ENSG00000189132.
GeneIDi170062.
KEGGihsa:170062.
UCSCiuc004ddi.2. human.

Organism-specific databases

CTDi170062.
GeneCardsiGC0XP034870.
HGNCiHGNC:26659. FAM47B.
HPAiHPA046829.
HPA050996.
neXtProtiNX_Q8NA70.
PharmGKBiPA134969396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG83278.
GeneTreeiENSGT00400000022396.
HOGENOMiHOG000112475.
HOVERGENiHBG076577.
InParanoidiQ8NA70.
OMAiPFESRMP.
OrthoDBiEOG7K0ZBC.
PhylomeDBiQ8NA70.
TreeFamiTF340932.

Miscellaneous databases

GenomeRNAii170062.
NextBioi88858.
PROiQ8NA70.

Gene expression databases

BgeeiQ8NA70.
CleanExiHS_FAM47B.
GenevisibleiQ8NA70. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFA47B_HUMAN
AccessioniPrimary (citable) accession number: Q8NA70
Secondary accession number(s): Q5JQN5, Q6PIG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 22, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.