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Protein

Uncharacterized protein C19orf45

Gene

C19orf45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24745. C19orf45.

Pathology & Biotechi

Organism-specific databases

DisGeNETi374877.
OpenTargetsiENSG00000198723.
PharmGKBiPA145149520.

Polymorphism and mutation databases

BioMutaiC19orf45.
DMDMi156630490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976601 – 505Uncharacterized protein C19orf45Add BLAST505

Proteomic databases

PaxDbiQ8NA69.
PeptideAtlasiQ8NA69.
PRIDEiQ8NA69.

PTM databases

iPTMnetiQ8NA69.
PhosphoSitePlusiQ8NA69.

Expressioni

Gene expression databases

BgeeiENSG00000198723.
CleanExiHS_C19orf45.
ExpressionAtlasiQ8NA69. baseline and differential.
GenevisibleiQ8NA69. HS.

Organism-specific databases

HPAiHPA066278.

Interactioni

Protein-protein interaction databases

BioGridi131928. 14 interactors.
IntActiQ8NA69. 1 interactor.
STRINGi9606.ENSP00000355241.

Structurei

3D structure databases

ProteinModelPortaliQ8NA69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ35. Eukaryota.
ENOG4111PU5. LUCA.
GeneTreeiENSGT00390000014215.
HOGENOMiHOG000111991.
HOVERGENiHBG071731.
InParanoidiQ8NA69.
OMAiFQESHVP.
OrthoDBiEOG091G0V2R.
PhylomeDBiQ8NA69.
TreeFamiTF336162.

Family and domain databases

InterProiIPR028001. DUF4601.
[Graphical view]
PfamiPF15373. DUF4601. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NA69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGALLPCS RPCPMSRLDF LKASHFSLGP DLRLHEGTMR TTSHRDFAYP
60 70 80 90 100
AATREPPSLQ PPPALLFPMD PRWDREERVS EAHRAFPPPS TPPWELLQAQ
110 120 130 140 150
ARERTLAMQA GNLHLHEDAH AGIGLSNAHA AYGWPELPAR TRERIRGARL
160 170 180 190 200
IFDRDSLPPG DRDKLRIPPT THQALFPPHD ARPQPRAPSC HLGGPNTLKW
210 220 230 240 250
DYTRQDGTSY QRQFQALPGP PALRCKRASS GVELGDCKIS YGSTCSEQKQ
260 270 280 290 300
AYRPQDLPED RYDKAQATAH IHCVNIRPGD GLFRDRTTKA EHFYAREPEP
310 320 330 340 350
FVLHHDQTPE SHILKGNWCP GPGSLDTFMQ YFYGQPPPPT QPPSRHVPHE
360 370 380 390 400
KLQSHVTLGE PKLLKRFFKT TMGSDYCPSE WRQVQKAPNL HLQQSYLPRG
410 420 430 440 450
TGEFDFLTMN QKMLKPHRTP PAPVTEEMLQ RCKYSHMEPP LGGLRFFSTQ
460 470 480 490 500
YKDEFPFKYQ GPAALRLKNP QEGFVPLGTP HQRGCREKID PLVPQPPMYL

CPSQQ
Length:505
Mass (Da):57,331
Last modified:August 21, 2007 - v2
Checksum:i39F780DF2B525E94
GO

Sequence cautioni

The sequence AAH29824 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH34779 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38T → A in BAC04057 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034664256D → G.1 PublicationCorresponds to variant rs484870dbSNPEnsembl.1
Natural variantiVAR_034665396Y → N.1 PublicationCorresponds to variant rs3826736dbSNPEnsembl.1
Natural variantiVAR_034666434Y → N.1 PublicationCorresponds to variant rs475923dbSNPEnsembl.1
Natural variantiVAR_034667497P → S.1 PublicationCorresponds to variant rs1133378dbSNPEnsembl.1
Natural variantiVAR_034668500L → P.1 PublicationCorresponds to variant rs608144dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093103 mRNA. Translation: BAC04057.1.
BC029824 mRNA. Translation: AAH29824.1. Different initiation.
BC034779 mRNA. Translation: AAH34779.1. Different initiation.
CCDSiCCDS12179.2.
RefSeqiNP_940936.2. NM_198534.2.
XP_005272530.1. XM_005272473.3.
UniGeneiHs.631862.

Genome annotation databases

EnsembliENST00000361664; ENSP00000355241; ENSG00000198723.
GeneIDi374877.
KEGGihsa:374877.
UCSCiuc002mgm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093103 mRNA. Translation: BAC04057.1.
BC029824 mRNA. Translation: AAH29824.1. Different initiation.
BC034779 mRNA. Translation: AAH34779.1. Different initiation.
CCDSiCCDS12179.2.
RefSeqiNP_940936.2. NM_198534.2.
XP_005272530.1. XM_005272473.3.
UniGeneiHs.631862.

3D structure databases

ProteinModelPortaliQ8NA69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131928. 14 interactors.
IntActiQ8NA69. 1 interactor.
STRINGi9606.ENSP00000355241.

PTM databases

iPTMnetiQ8NA69.
PhosphoSitePlusiQ8NA69.

Polymorphism and mutation databases

BioMutaiC19orf45.
DMDMi156630490.

Proteomic databases

PaxDbiQ8NA69.
PeptideAtlasiQ8NA69.
PRIDEiQ8NA69.

Protocols and materials databases

DNASUi374877.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361664; ENSP00000355241; ENSG00000198723.
GeneIDi374877.
KEGGihsa:374877.
UCSCiuc002mgm.2. human.

Organism-specific databases

CTDi374877.
DisGeNETi374877.
GeneCardsiC19orf45.
HGNCiHGNC:24745. C19orf45.
HPAiHPA066278.
neXtProtiNX_Q8NA69.
OpenTargetsiENSG00000198723.
PharmGKBiPA145149520.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ35. Eukaryota.
ENOG4111PU5. LUCA.
GeneTreeiENSGT00390000014215.
HOGENOMiHOG000111991.
HOVERGENiHBG071731.
InParanoidiQ8NA69.
OMAiFQESHVP.
OrthoDBiEOG091G0V2R.
PhylomeDBiQ8NA69.
TreeFamiTF336162.

Enzyme and pathway databases

BioCyciZFISH:G66-31759-MONOMER.

Miscellaneous databases

GenomeRNAii374877.
PROiQ8NA69.

Gene expression databases

BgeeiENSG00000198723.
CleanExiHS_C19orf45.
ExpressionAtlasiQ8NA69. baseline and differential.
GenevisibleiQ8NA69. HS.

Family and domain databases

InterProiIPR028001. DUF4601.
[Graphical view]
PfamiPF15373. DUF4601. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCS045_HUMAN
AccessioniPrimary (citable) accession number: Q8NA69
Secondary accession number(s): Q8N115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 30, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.