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Protein

Cyclic nucleotide-binding domain-containing protein 1

Gene

CNBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi322 – 436cNMPAdd BLAST115

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-binding domain-containing protein 1
Gene namesi
Name:CNBD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26663. CNBD1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi168975.
OpenTargetsiENSG00000176571.
PharmGKBiPA142672090.

Polymorphism and mutation databases

BioMutaiCNBD1.
DMDMi74729846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917771 – 436Cyclic nucleotide-binding domain-containing protein 1Add BLAST436

Proteomic databases

PaxDbiQ8NA66.
PeptideAtlasiQ8NA66.
PRIDEiQ8NA66.

PTM databases

iPTMnetiQ8NA66.
PhosphoSitePlusiQ8NA66.

Expressioni

Gene expression databases

BgeeiENSG00000176571.
CleanExiHS_CNBD1.
ExpressionAtlasiQ8NA66. baseline and differential.
GenevisibleiQ8NA66. HS.

Organism-specific databases

HPAiHPA025037.
HPA027469.
HPA027786.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000430073.

Structurei

3D structure databases

ProteinModelPortaliQ8NA66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 24Poly-Pro4

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIAY. Eukaryota.
ENOG4111GJP. LUCA.
GeneTreeiENSGT00390000001688.
HOGENOMiHOG000171012.
HOVERGENiHBG072652.
InParanoidiQ8NA66.
OMAiISETWIK.
OrthoDBiEOG091G0GYX.
PhylomeDBiQ8NA66.
TreeFamiTF337630.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NA66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMSSLPAAI LSHMTAINNV PPPPLHSIPN LKKSKHINYG QLNALCHIRG
60 70 80 90 100
QHSRSMSNIL SAHDTFMKQY PKVFLHQKPR LPKLFKQEEQ RELNEGKEES
110 120 130 140 150
QHQQPDDSNN IAVHVQRAHG GHILYRPKRA TEKFEEFLAI LKKLPIHRTP
160 170 180 190 200
YEHKTVWKFL KTIPDLTFQL NDKHLKTLSK TVFSETWLKG STVVANDGFY
210 220 230 240 250
VILKGLARPQ TNVYKNLIEG SDSPDSFISQ SFHSFIWSEE FKNSTLAEMY
260 270 280 290 300
LPSYDSMLSK WSTFGTLEVM PQNESETQMF SVVTEDDCEI LKIPAKGYAK
310 320 330 340 350
IKEEKIKLEN MQKLKLIRMC PYYEEWPTLS IYELIALLKW KKFPPGHVIV
360 370 380 390 400
ESGNIISFVG YINSGCCNIY RSIIGFVKLR SNKVKRSQKL VYMGKLKEKE
410 420 430
SFGEISVLLQ VPFTCTIITK KEVEMAIIED KDLFVA
Length:436
Mass (Da):50,224
Last modified:October 1, 2002 - v1
Checksum:i16ABA68561881EA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03285964D → N.Corresponds to variant rs10504829dbSNPEnsembl.1
Natural variantiVAR_03286069Q → K.Corresponds to variant rs16894901dbSNPEnsembl.1
Natural variantiVAR_061108257M → V.Corresponds to variant rs60556175dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093121 mRNA. Translation: BAC04062.1.
BC117326 mRNA. Translation: AAI17327.1.
BC117328 mRNA. Translation: AAI17329.1.
CCDSiCCDS55259.1.
RefSeqiNP_775809.1. NM_173538.2.
UniGeneiHs.246284.

Genome annotation databases

EnsembliENST00000518476; ENSP00000430073; ENSG00000176571.
GeneIDi168975.
KEGGihsa:168975.
UCSCiuc003ydy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093121 mRNA. Translation: BAC04062.1.
BC117326 mRNA. Translation: AAI17327.1.
BC117328 mRNA. Translation: AAI17329.1.
CCDSiCCDS55259.1.
RefSeqiNP_775809.1. NM_173538.2.
UniGeneiHs.246284.

3D structure databases

ProteinModelPortaliQ8NA66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000430073.

PTM databases

iPTMnetiQ8NA66.
PhosphoSitePlusiQ8NA66.

Polymorphism and mutation databases

BioMutaiCNBD1.
DMDMi74729846.

Proteomic databases

PaxDbiQ8NA66.
PeptideAtlasiQ8NA66.
PRIDEiQ8NA66.

Protocols and materials databases

DNASUi168975.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518476; ENSP00000430073; ENSG00000176571.
GeneIDi168975.
KEGGihsa:168975.
UCSCiuc003ydy.3. human.

Organism-specific databases

CTDi168975.
DisGeNETi168975.
GeneCardsiCNBD1.
HGNCiHGNC:26663. CNBD1.
HPAiHPA025037.
HPA027469.
HPA027786.
neXtProtiNX_Q8NA66.
OpenTargetsiENSG00000176571.
PharmGKBiPA142672090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIAY. Eukaryota.
ENOG4111GJP. LUCA.
GeneTreeiENSGT00390000001688.
HOGENOMiHOG000171012.
HOVERGENiHBG072652.
InParanoidiQ8NA66.
OMAiISETWIK.
OrthoDBiEOG091G0GYX.
PhylomeDBiQ8NA66.
TreeFamiTF337630.

Miscellaneous databases

ChiTaRSiCNBD1. human.
GenomeRNAii168975.
PROiQ8NA66.

Gene expression databases

BgeeiENSG00000176571.
CleanExiHS_CNBD1.
ExpressionAtlasiQ8NA66. baseline and differential.
GenevisibleiQ8NA66. HS.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNBD1_HUMAN
AccessioniPrimary (citable) accession number: Q8NA66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.