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Protein

Spermatid-associated protein

Gene

SPERT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid-associated protein
Alternative name(s):
Protein chibby homolog 2
Gene namesi
Name:SPERT
Synonyms:CBY2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:30720. SPERT.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596272.

Polymorphism and mutation databases

BioMutaiSPERT.
DMDMi74751135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Spermatid-associated proteinPRO_0000307291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei86 – 861PhosphoserineBy similarity
Modified residuei89 – 891PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei148 – 1481PhosphoserineBy similarity
Modified residuei150 – 1501PhosphoserineBy similarity
Modified residuei212 – 2121PhosphoserineBy similarity
Modified residuei225 – 2251PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei338 – 3381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NA61.
PeptideAtlasiQ8NA61.
PRIDEiQ8NA61.

PTM databases

iPTMnetiQ8NA61.
PhosphoSiteiQ8NA61.

Expressioni

Gene expression databases

BgeeiENSG00000174015.
CleanExiHS_SPERT.
ExpressionAtlasiQ8NA61. baseline and differential.
GenevisibleiQ8NA61. HS.

Organism-specific databases

HPAiHPA039359.
HPA040046.

Interactioni

Subunit structurei

Homodimer. Binds to NEK1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R6J33EBI-741724,EBI-10175524
ACTN1P128143EBI-741724,EBI-351710
ARHGEF40Q8TER5-23EBI-741724,EBI-10275150
ARMC7Q9H6L43EBI-741724,EBI-742909
C14orf105Q17R993EBI-741724,EBI-10238351
C19orf44Q9H6X53EBI-741724,EBI-7112211
C1orf109Q9NX043EBI-741724,EBI-8643161
CCDC146Q8IYE0-23EBI-741724,EBI-10247802
CCNG1P519593EBI-741724,EBI-3905829
CDC23Q9UJX23EBI-741724,EBI-396137
CEP44Q9C0F14EBI-741724,EBI-744115
CEP57L1Q8IYX8-23EBI-741724,EBI-10181988
CEP95Q96GE43EBI-741724,EBI-372775
CHCHD3Q9NX633EBI-741724,EBI-743375
CHIC2Q9UKJ53EBI-741724,EBI-741528
CKS1BP610243EBI-741724,EBI-456371
CNNM3Q8NE013EBI-741724,EBI-741032
CTNNAL1Q9UBT73EBI-741724,EBI-514206
DKFZp451B226Q5HYH73EBI-741724,EBI-10173842
DUSP14O951473EBI-741724,EBI-3922653
DZIP1LQ8IYY43EBI-741724,EBI-10264440
EIF4E2O605733EBI-741724,EBI-398610
ENKD1Q9H0I23EBI-741724,EBI-744099
FAM161AQ3B8203EBI-741724,EBI-719941
FRS3O435593EBI-741724,EBI-725515
GOLGA6L2Q8N9W4-23EBI-741724,EBI-10268729
HAUS1Q96CS23EBI-741724,EBI-2514791
KIFC3Q9BVG85EBI-741724,EBI-2125614
KLC3Q6P5973EBI-741724,EBI-1643885
LATS1Q6PJG33EBI-741724,EBI-10253976
LENG1Q96BZ83EBI-741724,EBI-726510
LMO1P258003EBI-741724,EBI-8639312
LMO2P257913EBI-741724,EBI-739696
LMO3Q8TAP43EBI-741724,EBI-742259
LNX1Q8TBB14EBI-11524851,EBI-739832
MED28Q9H2043EBI-741724,EBI-514199
METTL17Q9H7H03EBI-741724,EBI-749353
MLH1P406924EBI-741724,EBI-744248
MOSP005403EBI-741724,EBI-1757866
PID1Q7Z2X43EBI-741724,EBI-10256685
PIN1Q135263EBI-741724,EBI-714158
PLEKHN1Q494U13EBI-741724,EBI-10241513
PPP1R18Q6NYC83EBI-741724,EBI-2557469
RPL9P9P329693EBI-741724,EBI-358122
RTP5Q14D333EBI-741724,EBI-10217913
RUNX1T1Q06455-43EBI-741724,EBI-10224192
SCNM1Q9BWG63EBI-741724,EBI-748391
SH3RF2Q08AM83EBI-741724,EBI-10225873
SYCE1Q8N0S23EBI-741724,EBI-6872807
TCEANCQ8N8B73EBI-741724,EBI-954696
TCEB3Q142413EBI-741724,EBI-742350
TEX11Q8IYF33EBI-741724,EBI-742397
TRIM42A1L4B63EBI-741724,EBI-10172216
TSGA10Q9BZW73EBI-741724,EBI-744794
TXLNAP402223EBI-741724,EBI-359793
ZC2HC1CQ53FD03EBI-741724,EBI-740767
ZMAT2Q96NC03EBI-741724,EBI-2682299
ZNF564Q8TBZ83EBI-741724,EBI-10273713
ZNF581Q9P0T43EBI-741724,EBI-745520
ZNF655Q8N7203EBI-741724,EBI-625509

Protein-protein interaction databases

BioGridi128627. 72 interactions.
IntActiQ8NA61. 74 interactions.
STRINGi9606.ENSP00000309189.

Structurei

3D structure databases

ProteinModelPortaliQ8NA61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili164 – 19835Sequence analysisAdd
BLAST
Coiled coili242 – 26726Sequence analysisAdd
BLAST
Coiled coili356 – 41459Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the chibby family. SPERT subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVSP. Eukaryota.
ENOG41116VI. LUCA.
GeneTreeiENSGT00510000049023.
HOGENOMiHOG000154381.
HOVERGENiHBG108507.
InParanoidiQ8NA61.
OMAiSRPNFTR.
OrthoDBiEOG091G0BYF.
PhylomeDBiQ8NA61.
TreeFamiTF324419.

Family and domain databases

InterProiIPR028118. Chibby_fam.
IPR026655. SPERT.
[Graphical view]
PANTHERiPTHR21533:SF13. PTHR21533:SF13. 2 hits.
PfamiPF14645. Chibby. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL
60 70 80 90 100
PQRGTAEPFP RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL
110 120 130 140 150
DPMERPMSQA DLELDYNPPR VQLSDEMFVF QDGRWVNENC RLQSPYFSPS
160 170 180 190 200
ASFHHKLHHK RLAKECMLQE ENKSLREENK ALREENRMLS KENKILQVFW
210 220 230 240 250
EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR GKEDSTLQLL
260 270 280 290 300
REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ
310 320 330 340 350
GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP
360 370 380 390 400
DGCQPLQLLR EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL
410 420 430 440
WENNKLKLQQ KLVIDTVTEV TARMEMLIEE LYAFMPARSQ DPKKPSRV
Length:448
Mass (Da):51,570
Last modified:October 1, 2002 - v1
Checksum:iD59271CFE59F8863
GO
Isoform 2 (identifier: Q8NA61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-52: TRSESLEIPISVVLPQ → MQPEGLKCRMEESNAE

Show »
Length:412
Mass (Da):47,289
Checksum:i6EC3B47EF08CDE10
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti329 – 3291K → E.
Corresponds to variant rs7317245 [ dbSNP | Ensembl ].
VAR_054064

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2. 2 PublicationsVSP_028673Add
BLAST
Alternative sequencei37 – 5216TRSES…VVLPQ → MQPEGLKCRMEESNAE in isoform 2. 2 PublicationsVSP_028674Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093129 mRNA. Translation: BAC04067.1.
AK292350 mRNA. Translation: BAF85039.1.
AL139320 Genomic DNA. Translation: CAH70637.1.
AL139320 Genomic DNA. Translation: CAH70638.1.
BC027609 mRNA. Translation: AAH27609.1.
CCDSiCCDS66540.1. [Q8NA61-2]
CCDS9399.1. [Q8NA61-1]
RefSeqiNP_001273270.1. NM_001286341.1.
NP_001273271.1. NM_001286342.1. [Q8NA61-2]
NP_689932.1. NM_152719.2. [Q8NA61-1]
UniGeneiHs.186363.

Genome annotation databases

EnsembliENST00000310521; ENSP00000309189; ENSG00000174015. [Q8NA61-1]
ENST00000378966; ENSP00000368249; ENSG00000174015. [Q8NA61-2]
ENST00000610924; ENSP00000480148; ENSG00000174015. [Q8NA61-2]
GeneIDi220082.
KEGGihsa:220082.
UCSCiuc001van.3. human. [Q8NA61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093129 mRNA. Translation: BAC04067.1.
AK292350 mRNA. Translation: BAF85039.1.
AL139320 Genomic DNA. Translation: CAH70637.1.
AL139320 Genomic DNA. Translation: CAH70638.1.
BC027609 mRNA. Translation: AAH27609.1.
CCDSiCCDS66540.1. [Q8NA61-2]
CCDS9399.1. [Q8NA61-1]
RefSeqiNP_001273270.1. NM_001286341.1.
NP_001273271.1. NM_001286342.1. [Q8NA61-2]
NP_689932.1. NM_152719.2. [Q8NA61-1]
UniGeneiHs.186363.

3D structure databases

ProteinModelPortaliQ8NA61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128627. 72 interactions.
IntActiQ8NA61. 74 interactions.
STRINGi9606.ENSP00000309189.

PTM databases

iPTMnetiQ8NA61.
PhosphoSiteiQ8NA61.

Polymorphism and mutation databases

BioMutaiSPERT.
DMDMi74751135.

Proteomic databases

PaxDbiQ8NA61.
PeptideAtlasiQ8NA61.
PRIDEiQ8NA61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310521; ENSP00000309189; ENSG00000174015. [Q8NA61-1]
ENST00000378966; ENSP00000368249; ENSG00000174015. [Q8NA61-2]
ENST00000610924; ENSP00000480148; ENSG00000174015. [Q8NA61-2]
GeneIDi220082.
KEGGihsa:220082.
UCSCiuc001van.3. human. [Q8NA61-1]

Organism-specific databases

CTDi220082.
GeneCardsiSPERT.
HGNCiHGNC:30720. SPERT.
HPAiHPA039359.
HPA040046.
neXtProtiNX_Q8NA61.
PharmGKBiPA144596272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVSP. Eukaryota.
ENOG41116VI. LUCA.
GeneTreeiENSGT00510000049023.
HOGENOMiHOG000154381.
HOVERGENiHBG108507.
InParanoidiQ8NA61.
OMAiSRPNFTR.
OrthoDBiEOG091G0BYF.
PhylomeDBiQ8NA61.
TreeFamiTF324419.

Miscellaneous databases

GenomeRNAii220082.
PROiQ8NA61.

Gene expression databases

BgeeiENSG00000174015.
CleanExiHS_SPERT.
ExpressionAtlasiQ8NA61. baseline and differential.
GenevisibleiQ8NA61. HS.

Family and domain databases

InterProiIPR028118. Chibby_fam.
IPR026655. SPERT.
[Graphical view]
PANTHERiPTHR21533:SF13. PTHR21533:SF13. 2 hits.
PfamiPF14645. Chibby. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPERT_HUMAN
AccessioniPrimary (citable) accession number: Q8NA61
Secondary accession number(s): A8K8I5, Q8NHV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.