Q8NA61 (SPERT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermatid-associated protein

Alternative name(s):
Protein chibby homolog 2

Gene names

Name:	SPERT
Synonyms:	CBY2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homodimer. Binds to NEK1 By similarity.
Sequence similarities	Belongs to the chibby family. SPERT subfamily.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NA61-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NA61-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-52: TRSESLEIPISVVLPQ → MQPEGLKCRMEESNAE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Spermatid-associated protein		PRO_0000307291
Regions
	Coiled coil	164 – 198	35	Potential
	Coiled coil	242 – 267	26	Potential
	Coiled coil	356 – 414	59	Potential
Natural variations
	Alternative sequence	1 – 36	36	Missing in isoform 2.		VSP_028673
	Alternative sequence	37 – 52	16	TRSES…VVLPQ → MQPEGLKCRMEESNAE in isoform 2.		VSP_028674
	Natural variant	329	1	K → E. Corresponds to variant rs7317245 [ dbSNP | Ensembl ].		VAR_054064

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D59271CFE59F8863	FASTA	448	51,570
	10 20 30 40 50 60 MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL PQRGTAEPFP 70 80 90 100 110 120 RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL DPMERPMSQA DLELDYNPPR 130 140 150 160 170 180 VQLSDEMFVF QDGRWVNENC RLQSPYFSPS ASFHHKLHHK RLAKECMLQE ENKSLREENK 190 200 210 220 230 240 ALREENRMLS KENKILQVFW EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR 250 260 270 280 290 300 GKEDSTLQLL REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ 310 320 330 340 350 360 GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP DGCQPLQLLR 370 380 390 400 410 420 EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL WENNKLKLQQ KLVIDTVTEV 430 440 TARMEMLIEE LYAFMPARSQ DPKKPSRV
	Isoform 2 [UniParc]. Checksum: 6EC3B47EF08CDE10	FASTA	412	47,289
	10 20 30 40 50 60 MQPEGLKCRM EESNAERGTA EPFPRLHNLY STPRCAQQAA LPRLSRRMAS QHSYPLNRFS 70 80 90 100 110 120 SVPLDPMERP MSQADLELDY NPPRVQLSDE MFVFQDGRWV NENCRLQSPY FSPSASFHHK 130 140 150 160 170 180 LHHKRLAKEC MLQEENKSLR EENKALREEN RMLSKENKIL QVFWEEHKAS LGREESRAPS 190 200 210 220 230 240 PLLHKDSASL EVVKKDHVAL QVPRGKEDST LQLLREENRA LQQLLEQKQA YWAQAEDTAA 250 260 270 280 290 300 PAEESKPAPS PHEEPCSPGL LQDQGSGLSS RFEEPKGPPA RQEDSKELRA LRKMVSNMSG 310 320 330 340 350 360 PSGEEEAKVG PGLPDGCQPL QLLREMRQAL QALLKENRLL QEENRTLQVL RAEHRGFQEE 370 380 390 400 410 NKALWENNKL KLQQKLVIDT VTEVTARMEM LIEELYAFMP ARSQDPKKPS RV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093129 mRNA. Translation: BAC04067.1. AK292350 mRNA. Translation: BAF85039.1. AL139320 Genomic DNA. Translation: CAH70637.1. AL139320 Genomic DNA. Translation: CAH70638.1. BC027609 mRNA. Translation: AAH27609.1.
IPI	IPI00167913. IPI00641475.
RefSeq	NP_689932.1. NM_152719.1.
UniGene	Hs.186363.
3D structure databases
ProteinModelPortal	Q8NA61.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NA61. 4 interactions.
STRING	Q8NA61.
Polymorphism databases
DMDM	74751135.
Proteomic databases
PRIDE	Q8NA61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310521; ENSP00000309189; ENSG00000174015.
GeneID	220082.
KEGG	hsa:220082.
UCSC	uc001van.1. human. uc001vao.2. human.
Organism-specific databases
CTD	220082.
GeneCards	GC13P046276.
HGNC	HGNC:30720. SPERT.
HPA	HPA039359. HPA040046.
neXtProt	NX_Q8NA61.
PharmGKB	PA144596272.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18268.
GeneTree	ENSGT00510000049023.
HOGENOM	HBG125375.
HOVERGEN	HBG108507.
InParanoid	Q8NA61.
OMA	LQVFWEE.
OrthoDB	EOG40VVQZ.
PhylomeDB	Q8NA61.
Gene expression databases
ArrayExpress	Q8NA61.
Bgee	Q8NA61.
CleanEx	HS_SPERT.
Genevestigator	Q8NA61.
Family and domain databases
ProtoNet	Search...
Other
NextBio	90987.

Entry information

Entry name

SPERT_HUMAN

Accession

Primary (citable) accession number: Q8NA61
Secondary accession number(s): A8K8I5, Q8NHV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.