Q8NA58 (PNDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly(A)-specific ribonuclease PARN-like domain-containing protein 1

Gene names

Name:

PNLDC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type IV membrane protein Potential.
Sequence similarities	Belongs to the CAF1 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NA58-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NA58-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MFCTRGLLFFAFLA → MDVGADEFEESLPLLQELVQEADFV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 520	502	Poly(A)-specific ribonuclease PARN-like domain-containing protein 1		PRO_0000311365
Regions
	Topological domain	19 – 494	476	Cytoplasmic Potential
	Transmembrane	495 – 515	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	516 – 520	5	Extracellular Potential
Natural variations
	Alternative sequence	1 – 14	14	MFCTR…FAFLA → MDVGADEFEESLPLLQELVQ EADFV in isoform 2.		VSP_029552

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 02DEB5953BE88448	FASTA	520	60,124
	10 20 30 40 50 60 MFCTRGLLFF AFLAGLDIEF TGLRSNLSGP QQISLFDLPS EWYLKTRQSV QQFTVCQIGL 70 80 90 100 110 120 SVFSAIEGEA NKYIAHSCNF YLFPTTFGIL DSEFSFQASS VQFLNQYGFN YNKFLKNGIP 130 140 150 160 170 180 YMNEEQEKKI RHDILTGNWR VRSSPDKDQI KVVIDEVTRW LELAKEGDWM TLPGITGFQA 190 200 210 220 230 240 FEVQLVLRQA LPNIWTVLKD EGVVVKKVSK QHRWYLQNTS CDRESCWKEN ILLSARGFSV 250 260 270 280 290 300 FFQMLVKAQK PLVGHNMMMD LLHLHEKFFR PLPESYDQFK QNIHSLFPVL IDTKSVTKDI 310 320 330 340 350 360 WKEMNFPRVS NLSEVYEVLN SDLNPTKNSG PEIVHASRCE KYVETKCPHE AAYDAFLCGS 370 380 390 400 410 420 VLLKVAHLLL QKIYHIDPVP ESSFPQYLDV LAPYVNQVNL IRAGVPKINF SGPDYPSIRP 430 440 450 460 470 480 PILILSVKRW PGVSEQQVYH KFQNLCKFDV RRLTRSQFLL LTNKFKDARN ILKEYRDHPT 490 500 510 520 LCISLYRYWR HSPNVNCLLQ VCGIVTAWAL LAFILGRSGT
	Isoform 2 [UniParc]. Checksum: 033C43041E6EBB39	FASTA	531	61,311
	10 20 30 40 50 60 MDVGADEFEE SLPLLQELVQ EADFVGLDIE FTGLRSNLSG PQQISLFDLP SEWYLKTRQS 70 80 90 100 110 120 VQQFTVCQIG LSVFSAIEGE ANKYIAHSCN FYLFPTTFGI LDSEFSFQAS SVQFLNQYGF 130 140 150 160 170 180 NYNKFLKNGI PYMNEEQEKK IRHDILTGNW RVRSSPDKDQ IKVVIDEVTR WLELAKEGDW 190 200 210 220 230 240 MTLPGITGFQ AFEVQLVLRQ ALPNIWTVLK DEGVVVKKVS KQHRWYLQNT SCDRESCWKE 250 260 270 280 290 300 NILLSARGFS VFFQMLVKAQ KPLVGHNMMM DLLHLHEKFF RPLPESYDQF KQNIHSLFPV 310 320 330 340 350 360 LIDTKSVTKD IWKEMNFPRV SNLSEVYEVL NSDLNPTKNS GPEIVHASRC EKYVETKCPH 370 380 390 400 410 420 EAAYDAFLCG SVLLKVAHLL LQKIYHIDPV PESSFPQYLD VLAPYVNQVN LIRAGVPKIN 430 440 450 460 470 480 FSGPDYPSIR PPILILSVKR WPGVSEQQVY HKFQNLCKFD VRRLTRSQFL LLTNKFKDAR 490 500 510 520 530 NILKEYRDHP TLCISLYRYW RHSPNVNCLL QVCGIVTAWA LLAFILGRSG T

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093139 mRNA. Translation: BAC04070.1. AK097559 mRNA. Translation: BAC05101.1. AL139045 Genomic DNA. Translation: CAI19750.2. AL139045 Genomic DNA. Translation: CAM27947.1. CH471051 Genomic DNA. Translation: EAW47612.1. CH471051 Genomic DNA. Translation: EAW47613.1. BC112246 mRNA. Translation: AAI12247.1.
IPI	IPI00167911. IPI00797928.
RefSeq	NP_775787.1. NM_173516.1.
UniGene	Hs.349077.
3D structure databases
HSSP	HSSP built from PDB template 2A1S based on UniProtKB O95453.
ProteinModelPortal	Q8NA58.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000275275.
PTM databases
PhosphoSite	Q8NA58.
Polymorphism databases
DMDM	160419239.
Proteomic databases
PaxDb	Q8NA58.
PRIDE	Q8NA58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275275; ENSP00000275275; ENSG00000146453. ENST00000392167; ENSP00000376007; ENSG00000146453.
GeneID	154197.
KEGG	hsa:154197.
UCSC	uc003qsx.1. human. uc003qsy.1. human.
Organism-specific databases
CTD	154197.
GeneCards	GC06P160221.
HGNC	HGNC:21185. PNLDC1.
HPA	HPA052026.
neXtProt	NX_Q8NA58.
PharmGKB	PA134892245.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145331.
HOGENOM	HOG000115590.
HOVERGEN	HBG101204.
OMA	SCDRESC.
OrthoDB	EOG40P46K.
PhylomeDB	Q8NA58.
Gene expression databases
Bgee	Q8NA58.
CleanEx	HS_PNLDC1.
Genevestigator	Q8NA58.
Family and domain databases
InterPro	IPR006941. RNase_CAF1. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF04857. CAF1. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	154197.
NextBio	87251.

Entry information

Entry name

PNDC1_HUMAN

Accession

Primary (citable) accession number: Q8NA58
Secondary accession number(s): Q5TAP7, Q8N7X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.