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Protein

Uncharacterized protein C12orf50

Gene

C12orf50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf50
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26665. C12orf50.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485379.

Polymorphism and mutation databases

BioMutaiC12orf50.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Uncharacterized protein C12orf50PRO_0000295234Add
BLAST

Proteomic databases

PaxDbiQ8NA57.
PRIDEiQ8NA57.

PTM databases

iPTMnetiQ8NA57.
PhosphoSiteiQ8NA57.

Expressioni

Gene expression databases

BgeeiENSG00000165805.
CleanExiHS_C12orf50.
ExpressionAtlasiQ8NA57. baseline and differential.
GenevisibleiQ8NA57. HS.

Organism-specific databases

HPAiCAB002778.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-10268935,EBI-618309

Protein-protein interaction databases

BioGridi127758. 2 interactions.
IntActiQ8NA57. 1 interaction.
STRINGi9606.ENSP00000298699.

Structurei

3D structure databases

ProteinModelPortaliQ8NA57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4791. Eukaryota.
ENOG41101ZI. LUCA.
GeneTreeiENSGT00730000111331.
HOGENOMiHOG000111761.
HOVERGENiHBG107707.
InParanoidiQ8NA57.
OMAiMNDVQPV.
OrthoDBiEOG091G07FZ.
PhylomeDBiQ8NA57.
TreeFamiTF335608.

Sequencei

Sequence statusi: Complete.

Q8NA57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMQQNCSIS CFWETQPLGC VKISCIFYHS KPRNINGLFL PPSSNITLQK
60 70 80 90 100
EIQEGIPLQS QSQEPLKPQE NISRPIHHPL VLKTNFEEEE EVDEQNDASS
110 120 130 140 150
LWTKTPEEIE EKRAIKEMCY KSGEYYRFHT PPDILSSKSM TPTAEKQLEK
160 170 180 190 200
PLENGSELQE GDSLTVPTKL SQYERQGEIK TSLHGKPKTD IAAFENGGGD
210 220 230 240 250
CYVPQRVIFL GVDESEALTE EKEITISKCS NTKDNKDSPH PKHSLTTRLV
260 270 280 290 300
PTTHVLNATE NISMKCREDP SSMNDVQPVK KPHFKGVKKR KWIYDEPQNF
310 320 330 340 350
PNSGMQRAVQ APRPQNKMSY HRNNKNRNAE NASYIHVQRD AVRTVALNAP
360 370 380 390 400
SRSRPTHGSY NKVHANREPK PNLSPDKYTS TSYNDSAWRK RIPFSKTYSK
410
SEKIYPEPRR NGSK
Length:414
Mass (Da):47,326
Last modified:October 1, 2002 - v1
Checksum:iB8DA1067481EAB8D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061Q → R.
Corresponds to variant rs10777084 [ dbSNP | Ensembl ].
VAR_033266
Natural varianti322 – 3221R → H.
Corresponds to variant rs11104703 [ dbSNP | Ensembl ].
VAR_033267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093140 mRNA. Translation: BAC04071.1.
BC038413 mRNA. Translation: AAH38413.1.
BC062424 mRNA. Translation: AAH62424.1. Sequence problems.
CCDSiCCDS9031.1.
RefSeqiNP_689802.1. NM_152589.1.
UniGeneiHs.112930.

Genome annotation databases

EnsembliENST00000298699; ENSP00000298699; ENSG00000165805.
GeneIDi160419.
KEGGihsa:160419.
UCSCiuc001tam.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093140 mRNA. Translation: BAC04071.1.
BC038413 mRNA. Translation: AAH38413.1.
BC062424 mRNA. Translation: AAH62424.1. Sequence problems.
CCDSiCCDS9031.1.
RefSeqiNP_689802.1. NM_152589.1.
UniGeneiHs.112930.

3D structure databases

ProteinModelPortaliQ8NA57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127758. 2 interactions.
IntActiQ8NA57. 1 interaction.
STRINGi9606.ENSP00000298699.

PTM databases

iPTMnetiQ8NA57.
PhosphoSiteiQ8NA57.

Polymorphism and mutation databases

BioMutaiC12orf50.

Proteomic databases

PaxDbiQ8NA57.
PRIDEiQ8NA57.

Protocols and materials databases

DNASUi160419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298699; ENSP00000298699; ENSG00000165805.
GeneIDi160419.
KEGGihsa:160419.
UCSCiuc001tam.2. human.

Organism-specific databases

CTDi160419.
GeneCardsiC12orf50.
HGNCiHGNC:26665. C12orf50.
HPAiCAB002778.
neXtProtiNX_Q8NA57.
PharmGKBiPA143485379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4791. Eukaryota.
ENOG41101ZI. LUCA.
GeneTreeiENSGT00730000111331.
HOGENOMiHOG000111761.
HOVERGENiHBG107707.
InParanoidiQ8NA57.
OMAiMNDVQPV.
OrthoDBiEOG091G07FZ.
PhylomeDBiQ8NA57.
TreeFamiTF335608.

Miscellaneous databases

GenomeRNAii160419.
PROiQ8NA57.

Gene expression databases

BgeeiENSG00000165805.
CleanExiHS_C12orf50.
ExpressionAtlasiQ8NA57. baseline and differential.
GenevisibleiQ8NA57. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCL050_HUMAN
AccessioniPrimary (citable) accession number: Q8NA57
Secondary accession number(s): Q6P674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.