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Protein

Tetratricopeptide repeat protein 29

Gene

TTC29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 29
Short name:
TPR repeat protein 29
Alternative name(s):
Protein TBPP2A
Testis development protein NYD-SP14
Gene namesi
Name:TTC29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29936. TTC29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147799.

Polymorphism and mutation databases

BioMutaiTTC29.
DMDMi152112335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Tetratricopeptide repeat protein 29PRO_0000294435Add
BLAST

Proteomic databases

EPDiQ8NA56.
PaxDbiQ8NA56.
PRIDEiQ8NA56.

PTM databases

PhosphoSiteiQ8NA56.

Expressioni

Gene expression databases

BgeeiQ8NA56.
CleanExiHS_TTC29.
ExpressionAtlasiQ8NA56. baseline and differential.
GenevisibleiQ8NA56. HS.

Interactioni

Protein-protein interaction databases

BioGridi123805. 16 interactions.
STRINGi9606.ENSP00000316740.

Structurei

3D structure databases

ProteinModelPortaliQ8NA56.
SMRiQ8NA56. Positions 182-301, 314-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati182 – 21534TPR 1Add
BLAST
Repeati234 – 26734TPR 2Add
BLAST
Repeati274 – 30734TPR 3Add
BLAST
Repeati314 – 34734TPR 4Add
BLAST
Repeati354 – 38734TPR 5Add
BLAST

Sequence similaritiesi

Contains 5 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFVK. Eukaryota.
ENOG410XPVA. LUCA.
GeneTreeiENSGT00390000008611.
HOGENOMiHOG000067965.
HOVERGENiHBG108611.
InParanoidiQ8NA56.
OrthoDBiEOG751NGB.
PhylomeDBiQ8NA56.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTLPPLPMT RPKLTALARQ KLPCSSRKIP RSQLIKEKDD IDHYLEVNFK
60 70 80 90 100
GLSKEEVAAY RNSYKKNICV DMLRDGYHKS FTELFALMER WDALREAARV
110 120 130 140 150
RSLFWLQKPL EEQPDKLDYL YHYLTRAEDA ERKESFEDVH NNLYALACYF
160 170 180 190 200
NNSEDKWVRN HFYERCFKIA QLIKIDCGKK EAEAHMHMGL LYEEDGQLLE
210 220 230 240 250
AAEHYEAFHQ LTQGRIWKDE TGRSLNLLAC ESLLRTYRLL SDKMLENKEY
260 270 280 290 300
KQAIKILIKA SEIAKEGSDK KMEAEASYYL GLAHLAAEEY ETALTVLDTY
310 320 330 340 350
CKISTDLDDD LSLGRGYEAI AKVLQSQGEM TEAIKYLKKF VKIARNNFQS
360 370 380 390 400
LDLVRASTML GDIYNEKGYY NKASECFQQA FDTTVELMSM PLMDETKVHY
410 420 430 440 450
GIAKAHQMML TVNNYIESAD LTSLNYLLSW KESRGNIEPD PVTEEFRGST
460 470
VEAVSQNSER LEELSRFPGD QKNET
Length:475
Mass (Da):55,082
Last modified:July 10, 2007 - v2
Checksum:i09BF33E42330C53A
GO
Isoform 2 (identifier: Q8NA56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIPMFTVTLEDSGTLWKSLHSSSESE

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):57,846
Checksum:i3073D5287BA44F0C
GO

Sequence cautioni

The sequence AAK29064.1 differs from that shown. Reason: Frameshift at position 467. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391L → F in BAC04072 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941L → P.
Corresponds to variant rs35123039 [ dbSNP | Ensembl ].
VAR_033179
Natural varianti140 – 1401H → Y.2 Publications
Corresponds to variant rs17610219 [ dbSNP | Ensembl ].
VAR_033180
Natural varianti276 – 2761A → T.2 Publications
Corresponds to variant rs10013280 [ dbSNP | Ensembl ].
VAR_033181

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MIPMFTVTLEDSGTLWKSLH SSSESE in isoform 2. 1 PublicationVSP_026638

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345910 mRNA. Translation: AAK29064.1. Frameshift.
EF432564 mRNA. Translation: ABO31099.1.
AK093145 mRNA. Translation: BAC04072.1.
AC092435 Genomic DNA. No translation available.
AC097497 Genomic DNA. No translation available.
AC093887 Genomic DNA. No translation available.
CCDSiCCDS47141.1. [Q8NA56-1]
RefSeqiNP_001287690.1. NM_001300761.2.
NP_001304735.1. NM_001317806.1.
NP_114162.2. NM_031956.3. [Q8NA56-1]
UniGeneiHs.378893.

Genome annotation databases

EnsembliENST00000325106; ENSP00000316740; ENSG00000137473. [Q8NA56-1]
GeneIDi83894.
UCSCiuc003ikw.5. human. [Q8NA56-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345910 mRNA. Translation: AAK29064.1. Frameshift.
EF432564 mRNA. Translation: ABO31099.1.
AK093145 mRNA. Translation: BAC04072.1.
AC092435 Genomic DNA. No translation available.
AC097497 Genomic DNA. No translation available.
AC093887 Genomic DNA. No translation available.
CCDSiCCDS47141.1. [Q8NA56-1]
RefSeqiNP_001287690.1. NM_001300761.2.
NP_001304735.1. NM_001317806.1.
NP_114162.2. NM_031956.3. [Q8NA56-1]
UniGeneiHs.378893.

3D structure databases

ProteinModelPortaliQ8NA56.
SMRiQ8NA56. Positions 182-301, 314-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123805. 16 interactions.
STRINGi9606.ENSP00000316740.

PTM databases

PhosphoSiteiQ8NA56.

Polymorphism and mutation databases

BioMutaiTTC29.
DMDMi152112335.

Proteomic databases

EPDiQ8NA56.
PaxDbiQ8NA56.
PRIDEiQ8NA56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325106; ENSP00000316740; ENSG00000137473. [Q8NA56-1]
GeneIDi83894.
UCSCiuc003ikw.5. human. [Q8NA56-1]

Organism-specific databases

CTDi83894.
GeneCardsiTTC29.
HGNCiHGNC:29936. TTC29.
neXtProtiNX_Q8NA56.
PharmGKBiPA145147799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFVK. Eukaryota.
ENOG410XPVA. LUCA.
GeneTreeiENSGT00390000008611.
HOGENOMiHOG000067965.
HOVERGENiHBG108611.
InParanoidiQ8NA56.
OrthoDBiEOG751NGB.
PhylomeDBiQ8NA56.
TreeFamiTF328344.

Miscellaneous databases

ChiTaRSiTTC29. human.
GenomeRNAii83894.
NextBioi72991.
PROiQ8NA56.

Gene expression databases

BgeeiQ8NA56.
CleanExiHS_TTC29.
ExpressionAtlasiQ8NA56. baseline and differential.
GenevisibleiQ8NA56. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of a novel gene related development gene NYD-SP14."
    Sha J.H.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS TYR-140 AND THR-276.
    Tissue: Testis.
  2. Li J.M., Cheng J., Wang Q.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS TYR-140 AND THR-276.
    Tissue: Mammary cancer.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTTC29_HUMAN
AccessioniPrimary (citable) accession number: Q8NA56
Secondary accession number(s): A4GU95, Q9BXB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.