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Protein

Tetratricopeptide repeat protein 29

Gene

TTC29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 29
Short name:
TPR repeat protein 29
Alternative name(s):
Protein TBPP2A
Testis development protein NYD-SP14
Gene namesi
Name:TTC29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29936. TTC29.

Pathology & Biotechi

Organism-specific databases

DisGeNETi83894.
OpenTargetsiENSG00000137473.
PharmGKBiPA145147799.

Polymorphism and mutation databases

BioMutaiTTC29.
DMDMi152112335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944351 – 475Tetratricopeptide repeat protein 29Add BLAST475

Proteomic databases

PaxDbiQ8NA56.
PeptideAtlasiQ8NA56.
PRIDEiQ8NA56.

PTM databases

iPTMnetiQ8NA56.
PhosphoSitePlusiQ8NA56.

Expressioni

Gene expression databases

BgeeiENSG00000137473.
CleanExiHS_TTC29.
ExpressionAtlasiQ8NA56. baseline and differential.
GenevisibleiQ8NA56. HS.

Organism-specific databases

HPAiHPA037006.
HPA061473.

Interactioni

Protein-protein interaction databases

BioGridi123805. 16 interactors.
STRINGi9606.ENSP00000316740.

Structurei

3D structure databases

ProteinModelPortaliQ8NA56.
SMRiQ8NA56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati182 – 215TPR 1Add BLAST34
Repeati234 – 267TPR 2Add BLAST34
Repeati274 – 307TPR 3Add BLAST34
Repeati314 – 347TPR 4Add BLAST34
Repeati354 – 387TPR 5Add BLAST34

Sequence similaritiesi

Contains 5 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFVK. Eukaryota.
ENOG410XPVA. LUCA.
GeneTreeiENSGT00390000008611.
HOGENOMiHOG000067965.
HOVERGENiHBG108611.
InParanoidiQ8NA56.
PhylomeDBiQ8NA56.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTLPPLPMT RPKLTALARQ KLPCSSRKIP RSQLIKEKDD IDHYLEVNFK
60 70 80 90 100
GLSKEEVAAY RNSYKKNICV DMLRDGYHKS FTELFALMER WDALREAARV
110 120 130 140 150
RSLFWLQKPL EEQPDKLDYL YHYLTRAEDA ERKESFEDVH NNLYALACYF
160 170 180 190 200
NNSEDKWVRN HFYERCFKIA QLIKIDCGKK EAEAHMHMGL LYEEDGQLLE
210 220 230 240 250
AAEHYEAFHQ LTQGRIWKDE TGRSLNLLAC ESLLRTYRLL SDKMLENKEY
260 270 280 290 300
KQAIKILIKA SEIAKEGSDK KMEAEASYYL GLAHLAAEEY ETALTVLDTY
310 320 330 340 350
CKISTDLDDD LSLGRGYEAI AKVLQSQGEM TEAIKYLKKF VKIARNNFQS
360 370 380 390 400
LDLVRASTML GDIYNEKGYY NKASECFQQA FDTTVELMSM PLMDETKVHY
410 420 430 440 450
GIAKAHQMML TVNNYIESAD LTSLNYLLSW KESRGNIEPD PVTEEFRGST
460 470
VEAVSQNSER LEELSRFPGD QKNET
Length:475
Mass (Da):55,082
Last modified:July 10, 2007 - v2
Checksum:i09BF33E42330C53A
GO
Isoform 2 (identifier: Q8NA56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIPMFTVTLEDSGTLWKSLHSSSESE

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):57,846
Checksum:i3073D5287BA44F0C
GO

Sequence cautioni

The sequence AAK29064 differs from that shown. Reason: Frameshift at position 467.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239L → F in BAC04072 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03317994L → P.Corresponds to variant rs35123039dbSNPEnsembl.1
Natural variantiVAR_033180140H → Y.2 PublicationsCorresponds to variant rs17610219dbSNPEnsembl.1
Natural variantiVAR_033181276A → T.2 PublicationsCorresponds to variant rs10013280dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0266381M → MIPMFTVTLEDSGTLWKSLH SSSESE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345910 mRNA. Translation: AAK29064.1. Frameshift.
EF432564 mRNA. Translation: ABO31099.1.
AK093145 mRNA. Translation: BAC04072.1.
AC092435 Genomic DNA. No translation available.
AC097497 Genomic DNA. No translation available.
AC093887 Genomic DNA. No translation available.
CCDSiCCDS47141.1. [Q8NA56-1]
RefSeqiNP_001287690.1. NM_001300761.2.
NP_001304735.1. NM_001317806.1.
NP_114162.2. NM_031956.3. [Q8NA56-1]
UniGeneiHs.378893.

Genome annotation databases

EnsembliENST00000325106; ENSP00000316740; ENSG00000137473. [Q8NA56-1]
GeneIDi83894.
KEGGihsa:83894.
UCSCiuc003ikw.5. human. [Q8NA56-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345910 mRNA. Translation: AAK29064.1. Frameshift.
EF432564 mRNA. Translation: ABO31099.1.
AK093145 mRNA. Translation: BAC04072.1.
AC092435 Genomic DNA. No translation available.
AC097497 Genomic DNA. No translation available.
AC093887 Genomic DNA. No translation available.
CCDSiCCDS47141.1. [Q8NA56-1]
RefSeqiNP_001287690.1. NM_001300761.2.
NP_001304735.1. NM_001317806.1.
NP_114162.2. NM_031956.3. [Q8NA56-1]
UniGeneiHs.378893.

3D structure databases

ProteinModelPortaliQ8NA56.
SMRiQ8NA56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123805. 16 interactors.
STRINGi9606.ENSP00000316740.

PTM databases

iPTMnetiQ8NA56.
PhosphoSitePlusiQ8NA56.

Polymorphism and mutation databases

BioMutaiTTC29.
DMDMi152112335.

Proteomic databases

PaxDbiQ8NA56.
PeptideAtlasiQ8NA56.
PRIDEiQ8NA56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325106; ENSP00000316740; ENSG00000137473. [Q8NA56-1]
GeneIDi83894.
KEGGihsa:83894.
UCSCiuc003ikw.5. human. [Q8NA56-1]

Organism-specific databases

CTDi83894.
DisGeNETi83894.
GeneCardsiTTC29.
HGNCiHGNC:29936. TTC29.
HPAiHPA037006.
HPA061473.
neXtProtiNX_Q8NA56.
OpenTargetsiENSG00000137473.
PharmGKBiPA145147799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFVK. Eukaryota.
ENOG410XPVA. LUCA.
GeneTreeiENSGT00390000008611.
HOGENOMiHOG000067965.
HOVERGENiHBG108611.
InParanoidiQ8NA56.
PhylomeDBiQ8NA56.
TreeFamiTF328344.

Miscellaneous databases

ChiTaRSiTTC29. human.
GenomeRNAii83894.
PROiQ8NA56.

Gene expression databases

BgeeiENSG00000137473.
CleanExiHS_TTC29.
ExpressionAtlasiQ8NA56. baseline and differential.
GenevisibleiQ8NA56. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC29_HUMAN
AccessioniPrimary (citable) accession number: Q8NA56
Secondary accession number(s): A4GU95, Q9BXB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.