Q8NA54 (IQUB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
IQ and ubiquitin-like domain-containing protein

Gene names

Name:

IQUB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	791 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play roles in cilia formation and/or maintenance By similarity.
Sequence similarities	Contains 1 IQ domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NA54-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NA54-2)

The sequence of this isoform differs from the canonical sequence as follows:
     587-680: VPQDPLKFYK...QDIQYLTENI → MGGEYLSMAL
     681-791: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 791

791

IQ and ubiquitin-like domain-containing protein

PRO_0000274601

Regions

Domain

131 – 207

77

Ubiquitin-like

Domain

338 – 367

30

IQ

Natural variations

Alternative sequence

587 – 680

94

VPQDP…LTENI → MGGEYLSMAL in isoform 2.

VSP_022830

Alternative sequence

681 – 791

111

Missing in isoform 2.

VSP_022831

Natural variant

126

1

V → M. Ref.3
Corresponds to variant rs10255061 [ dbSNP | Ensembl ].

VAR_030332

Natural variant

691

1

D → N.
Corresponds to variant rs17146009 [ dbSNP | Ensembl ].

VAR_030333

Natural variant

735

1

R → H in a colorectal cancer sample; somatic mutation. Ref.5

VAR_036291

Natural variant

735

1

R → P.
Corresponds to variant rs1525626 [ dbSNP | Ensembl ].

VAR_030334

Experimental info

Sequence conflict

4

1

Q → R in BAC04074. Ref.1

Sequence conflict

252

1

F → S in BAC04074. Ref.1

Sequence conflict

343

1

I → T in BAC04074. Ref.1

Secondary structure

1

.

.

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.

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.

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.

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.

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791

Helix Strand Turn

Details...

Beta strand

131 – 137

7

Turn

138 – 140

3

Beta strand

143 – 148

6

Beta strand

150 – 152

3

Helix

154 – 165

12

Turn

169 – 171

3

Beta strand

172 – 176

5

Beta strand

179 – 181

3

Helix

187 – 190

4

Beta strand

197 – 205

9

Turn

207 – 209

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 3D16F8BF4BAED522	FASTA	791	92,581
	10 20 30 40 50 60 MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV 70 80 90 100 110 120 EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE 130 140 150 160 170 180 SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI 190 200 210 220 230 240 LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP 250 260 270 280 290 300 VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT 310 320 330 340 350 360 TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN 370 380 390 400 410 420 LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR 430 440 450 460 470 480 INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP 490 500 510 520 530 540 NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL 550 560 570 580 590 600 IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF 610 620 630 640 650 660 CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ LYYTEADYED 670 680 690 700 710 720 DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR WNKSLEWSPW NCILLTKDEA 730 740 750 760 770 780 AAHLKLTSIE EGYERSFIHK IKHKHILAKN YFSQVPVLAS FILDDGEIDE IRWKYHSDTT 790 PKIIESQRPP H
	Isoform 2 [UniParc]. Checksum: 0F99A639616E100E	FASTA	596	69,382
	10 20 30 40 50 60 MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV 70 80 90 100 110 120 EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE 130 140 150 160 170 180 SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI 190 200 210 220 230 240 LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP 250 260 270 280 290 300 VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT 310 320 330 340 350 360 TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN 370 380 390 400 410 420 LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR 430 440 450 460 470 480 INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP 490 500 510 520 530 540 NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL 550 560 570 580 590 IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKMGGE YLSMAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-126. Tissue: Testis.
[4]	"Solution structure of the novel identified ubiquitin-like domain in the human hypothetical protein FLJ35834." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 121-227.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-735.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK093153 mRNA. Translation: BAC04074.1.
AK093393 mRNA. Translation: BAC04153.1.
CH236947 Genomic DNA. Translation: EAL24336.1.
BC026173 mRNA. Translation: AAH26173.1.
BC036121 mRNA. Translation: AAH36121.1.
BC091520 mRNA. Translation: AAH91520.1.
BC128181 mRNA. Translation: AAI28182.1.

IPI

IPI00167908.
IPI00828017.

RefSeq

NP_849149.3. NM_178827.4.

UniGene

Hs.159650.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DAF	NMR	-	A	123-227	[»]

ProteinModelPortal

Q8NA54.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-1469252.

PTM databases

PhosphoSite

Q8NA54.

Polymorphism databases

DMDM

125950212.

Proteomic databases

PaxDb

Q8NA54.

PRIDE

Q8NA54.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000324698; ENSP00000324882; ENSG00000164675.
ENST00000434450; ENSP00000388498; ENSG00000164675.
ENST00000466202; ENSP00000417769; ENSG00000164675.
ENST00000484508; ENSP00000417285; ENSG00000164675.

GeneID

154865.

KEGG

hsa:154865.

UCSC

uc003vkn.3. human.
uc003vkp.1. human.

Organism-specific databases

CTD

154865.

GeneCards

GC07M123092.

HGNC

HGNC:21995. IQUB.

HPA

HPA020621.

neXtProt

NX_Q8NA54.

PharmGKB

PA162392258.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG85200.

HOVERGEN

HBG081805.

InParanoid

Q8NA54.

OMA

CSAPKIW.

OrthoDB

EOG47D9FN.

PhylomeDB

Q8NA54.

Gene expression databases

ArrayExpress

Q8NA54.

Bgee

Q8NA54.

CleanEx

HS_IQUB.

Genevestigator

Q8NA54.

Family and domain databases

InterPro

IPR000626. Ubiquitin.
IPR019955. Ubiquitin_supergroup.
[Graphical view]

Pfam

PF00240. ubiquitin. 1 hit.
[Graphical view]

PROSITE

PS50096. IQ. False negative.
PS00299. UBIQUITIN_1. False negative.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8NA54.

GenomeRNAi

154865.

NextBio

87328.

Entry information

Entry name

IQUB_HUMAN

Accession

Primary (citable) accession number: Q8NA54
Secondary accession number(s): A4D0X0 , Q49AL6, Q4G189, Q5BJD9, Q6NUH6, Q8N9Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.