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Protein

IQ and ubiquitin-like domain-containing protein

Gene

IQUB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play roles in cilia formation and/or maintenance.By similarity

GO - Biological processi

  1. cilium morphogenesis Source: Ensembl
  2. smoothened signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
IQ and ubiquitin-like domain-containing protein
Gene namesi
Name:IQUB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21995. IQUB.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. motile cilium Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392258.

Polymorphism and mutation databases

BioMutaiIQUB.
DMDMi125950212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791IQ and ubiquitin-like domain-containing proteinPRO_0000274601Add
BLAST

Proteomic databases

PaxDbiQ8NA54.
PRIDEiQ8NA54.

PTM databases

PhosphoSiteiQ8NA54.

Expressioni

Gene expression databases

BgeeiQ8NA54.
CleanExiHS_IQUB.
ExpressionAtlasiQ8NA54. baseline and differential.
GenevestigatoriQ8NA54.

Organism-specific databases

HPAiHPA020621.
HPA049626.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BLZF1Q9H2G93EBI-10220600,EBI-2548012
CCDC36Q8IYA83EBI-10220600,EBI-8638439
DYNLL1P631673EBI-10220600,EBI-349105
KRT40Q6A1623EBI-10220600,EBI-10171697
KRTAP10-7P604093EBI-10220600,EBI-10172290
KRTAP10-9P604113EBI-10220600,EBI-10172052
KRTAP12-4P603293EBI-10220600,EBI-10176396
MAGEA6P433603EBI-10220600,EBI-1045155
SYCE1Q8N0S23EBI-10220600,EBI-6872807
TMCC2Q7Z6C63EBI-10220600,EBI-10177480
TRAF2Q129333EBI-10220600,EBI-355744
TRIM23P364063EBI-10220600,EBI-740098
TRIM27P143733EBI-10220600,EBI-719493
TRIM42A1L4B63EBI-10220600,EBI-10172216
TRIM54Q9BYV23EBI-10220600,EBI-2130429

Protein-protein interaction databases

BioGridi127562. 18 interactions.
IntActiQ8NA54. 15 interactions.
MINTiMINT-1469252.

Structurei

Secondary structure

1
791
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi131 – 1377Combined sources
Turni138 – 1403Combined sources
Beta strandi143 – 1486Combined sources
Beta strandi150 – 1523Combined sources
Helixi154 – 16512Combined sources
Turni169 – 1713Combined sources
Beta strandi172 – 1765Combined sources
Beta strandi179 – 1813Combined sources
Helixi187 – 1904Combined sources
Beta strandi197 – 2059Combined sources
Turni207 – 2093Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAFNMR-A123-227[»]
ProteinModelPortaliQ8NA54.
SMRiQ8NA54. Positions 123-228.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NA54.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 20777Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini338 – 36730IQAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG85200.
GeneTreeiENSGT00390000014326.
HOVERGENiHBG081805.
InParanoidiQ8NA54.
OMAiTVKEHEC.
OrthoDBiEOG7CZK5F.
PhylomeDBiQ8NA54.
TreeFamiTF323180.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE
60 70 80 90 100
QFSESHAIHV EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA
110 120 130 140 150
MQRPNDDSLA FLDKIKSVKE SLQESVEDSL ATVKVVLIPV GQEIVIPFKV
160 170 180 190 200
DTILKYLKDH FSHLLGIPHS VLQIRYSGKI LKNNETLVQH GVKPQEIVQV
210 220 230 240 250
EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP VEIVKSDFHK
260 270 280 290 300
PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT
310 320 330 340 350
TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR
360 370 380 390 400
QWHAKIFVEN LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN
410 420 430 440 450
EDFEFLYNAL EFWRQEELTR INQSFTGAER KAALCELLEK ETQIIASIGR
460 470 480 490 500
HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP NGKTIEMDTQ FTIRARELQN
510 520 530 540 550
IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL IDREVDLMMR
560 570 580 590 600
GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF
610 620 630 640 650
CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ
660 670 680 690 700
LYYTEADYED DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR
710 720 730 740 750
WNKSLEWSPW NCILLTKDEA AAHLKLTSIE EGYERSFIHK IKHKHILAKN
760 770 780 790
YFSQVPVLAS FILDDGEIDE IRWKYHSDTT PKIIESQRPP H
Length:791
Mass (Da):92,581
Last modified:February 6, 2007 - v2
Checksum:i3D16F8BF4BAED522
GO
Isoform 2 (identifier: Q8NA54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-680: VPQDPLKFYK...QDIQYLTENI → MGGEYLSMAL
     681-791: Missing.

Note: No experimental confirmation available.

Show »
Length:596
Mass (Da):69,382
Checksum:i0F99A639616E100E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41Q → R in BAC04074 (PubMed:14702039).Curated
Sequence conflicti252 – 2521F → S in BAC04074 (PubMed:14702039).Curated
Sequence conflicti343 – 3431I → T in BAC04074 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261V → M.1 Publication
Corresponds to variant rs10255061 [ dbSNP | Ensembl ].
VAR_030332
Natural varianti691 – 6911D → N.
Corresponds to variant rs17146009 [ dbSNP | Ensembl ].
VAR_030333
Natural varianti735 – 7351R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036291
Natural varianti735 – 7351R → P.
Corresponds to variant rs1525626 [ dbSNP | Ensembl ].
VAR_030334

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei587 – 68094VPQDP…LTENI → MGGEYLSMAL in isoform 2. 1 PublicationVSP_022830Add
BLAST
Alternative sequencei681 – 791111Missing in isoform 2. 1 PublicationVSP_022831Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093153 mRNA. Translation: BAC04074.1.
AK093393 mRNA. Translation: BAC04153.1.
CH236947 Genomic DNA. Translation: EAL24336.1.
BC026173 mRNA. Translation: AAH26173.1.
BC036121 mRNA. Translation: AAH36121.1.
BC091520 mRNA. Translation: AAH91520.1.
BC128181 mRNA. Translation: AAI28182.1.
CCDSiCCDS5787.1. [Q8NA54-1]
RefSeqiNP_001269784.1. NM_001282855.1. [Q8NA54-1]
NP_849149.3. NM_178827.4. [Q8NA54-1]
XP_005250218.1. XM_005250161.3. [Q8NA54-1]
UniGeneiHs.159650.

Genome annotation databases

EnsembliENST00000324698; ENSP00000324882; ENSG00000164675. [Q8NA54-1]
ENST00000466202; ENSP00000417769; ENSG00000164675. [Q8NA54-1]
ENST00000484508; ENSP00000417285; ENSG00000164675. [Q8NA54-2]
GeneIDi154865.
KEGGihsa:154865.
UCSCiuc003vkn.3. human. [Q8NA54-1]
uc003vkp.1. human. [Q8NA54-2]

Polymorphism and mutation databases

BioMutaiIQUB.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093153 mRNA. Translation: BAC04074.1.
AK093393 mRNA. Translation: BAC04153.1.
CH236947 Genomic DNA. Translation: EAL24336.1.
BC026173 mRNA. Translation: AAH26173.1.
BC036121 mRNA. Translation: AAH36121.1.
BC091520 mRNA. Translation: AAH91520.1.
BC128181 mRNA. Translation: AAI28182.1.
CCDSiCCDS5787.1. [Q8NA54-1]
RefSeqiNP_001269784.1. NM_001282855.1. [Q8NA54-1]
NP_849149.3. NM_178827.4. [Q8NA54-1]
XP_005250218.1. XM_005250161.3. [Q8NA54-1]
UniGeneiHs.159650.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAFNMR-A123-227[»]
ProteinModelPortaliQ8NA54.
SMRiQ8NA54. Positions 123-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127562. 18 interactions.
IntActiQ8NA54. 15 interactions.
MINTiMINT-1469252.

PTM databases

PhosphoSiteiQ8NA54.

Polymorphism and mutation databases

BioMutaiIQUB.
DMDMi125950212.

Proteomic databases

PaxDbiQ8NA54.
PRIDEiQ8NA54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324698; ENSP00000324882; ENSG00000164675. [Q8NA54-1]
ENST00000466202; ENSP00000417769; ENSG00000164675. [Q8NA54-1]
ENST00000484508; ENSP00000417285; ENSG00000164675. [Q8NA54-2]
GeneIDi154865.
KEGGihsa:154865.
UCSCiuc003vkn.3. human. [Q8NA54-1]
uc003vkp.1. human. [Q8NA54-2]

Organism-specific databases

CTDi154865.
GeneCardsiGC07M123092.
HGNCiHGNC:21995. IQUB.
HPAiHPA020621.
HPA049626.
neXtProtiNX_Q8NA54.
PharmGKBiPA162392258.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85200.
GeneTreeiENSGT00390000014326.
HOVERGENiHBG081805.
InParanoidiQ8NA54.
OMAiTVKEHEC.
OrthoDBiEOG7CZK5F.
PhylomeDBiQ8NA54.
TreeFamiTF323180.

Miscellaneous databases

EvolutionaryTraceiQ8NA54.
GenomeRNAii154865.
NextBioi87328.
PROiQ8NA54.

Gene expression databases

BgeeiQ8NA54.
CleanExiHS_IQUB.
ExpressionAtlasiQ8NA54. baseline and differential.
GenevestigatoriQ8NA54.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-126.
    Tissue: Testis.
  4. "Solution structure of the novel identified ubiquitin-like domain in the human hypothetical protein FLJ35834."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 121-227.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-735.

Entry informationi

Entry nameiIQUB_HUMAN
AccessioniPrimary (citable) accession number: Q8NA54
Secondary accession number(s): A4D0X0
, Q49AL6, Q4G189, Q5BJD9, Q6NUH6, Q8N9Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 29, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.