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Q8NA54 (IQUB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
IQ and ubiquitin-like domain-containing protein
Gene names
Name:IQUB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length791 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play roles in cilia formation and/or maintenance By similarity.

Sequence similarities

Contains 1 IQ domain.

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Biological processCilium biogenesis/degradation
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcilium morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentacrosomal vesicle

Inferred from electronic annotation. Source: Ensembl

motile cilium

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NA54-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NA54-2)

The sequence of this isoform differs from the canonical sequence as follows:
     587-680: VPQDPLKFYK...QDIQYLTENI → MGGEYLSMAL
     681-791: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 791791IQ and ubiquitin-like domain-containing protein
PRO_0000274601

Regions

Domain131 – 20777Ubiquitin-like
Domain338 – 36730IQ

Natural variations

Alternative sequence587 – 68094VPQDP…LTENI → MGGEYLSMAL in isoform 2.
VSP_022830
Alternative sequence681 – 791111Missing in isoform 2.
VSP_022831
Natural variant1261V → M. Ref.3
Corresponds to variant rs10255061 [ dbSNP | Ensembl ].
VAR_030332
Natural variant6911D → N.
Corresponds to variant rs17146009 [ dbSNP | Ensembl ].
VAR_030333
Natural variant7351R → H in a colorectal cancer sample; somatic mutation. Ref.5
VAR_036291
Natural variant7351R → P.
Corresponds to variant rs1525626 [ dbSNP | Ensembl ].
VAR_030334

Experimental info

Sequence conflict41Q → R in BAC04074. Ref.1
Sequence conflict2521F → S in BAC04074. Ref.1
Sequence conflict3431I → T in BAC04074. Ref.1

Secondary structure

..................... 791
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: 3D16F8BF4BAED522

FASTA79192,581
        10         20         30         40         50         60 
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV 

        70         80         90        100        110        120 
EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE 

       130        140        150        160        170        180 
SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI 

       190        200        210        220        230        240 
LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP 

       250        260        270        280        290        300 
VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT 

       310        320        330        340        350        360 
TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN 

       370        380        390        400        410        420 
LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR 

       430        440        450        460        470        480 
INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP 

       490        500        510        520        530        540 
NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL 

       550        560        570        580        590        600 
IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF 

       610        620        630        640        650        660 
CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ LYYTEADYED 

       670        680        690        700        710        720 
DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR WNKSLEWSPW NCILLTKDEA 

       730        740        750        760        770        780 
AAHLKLTSIE EGYERSFIHK IKHKHILAKN YFSQVPVLAS FILDDGEIDE IRWKYHSDTT 

       790 
PKIIESQRPP H 

« Hide

Isoform 2 [UniParc].

Checksum: 0F99A639616E100E
Show »

FASTA59669,382

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-126.
Tissue: Testis.
[4]"Solution structure of the novel identified ubiquitin-like domain in the human hypothetical protein FLJ35834."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 121-227.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-735.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK093153 mRNA. Translation: BAC04074.1.
AK093393 mRNA. Translation: BAC04153.1.
CH236947 Genomic DNA. Translation: EAL24336.1.
BC026173 mRNA. Translation: AAH26173.1.
BC036121 mRNA. Translation: AAH36121.1.
BC091520 mRNA. Translation: AAH91520.1.
BC128181 mRNA. Translation: AAI28182.1.
RefSeqNP_001269784.1. NM_001282855.1.
NP_849149.3. NM_178827.4.
XP_005250217.1. XM_005250160.2.
XP_005250218.1. XM_005250161.2.
UniGeneHs.159650.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAFNMR-A123-227[»]
ProteinModelPortalQ8NA54.
SMRQ8NA54. Positions 123-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127562. 1 interaction.
MINTMINT-1469252.

PTM databases

PhosphoSiteQ8NA54.

Polymorphism databases

DMDM125950212.

Proteomic databases

PaxDbQ8NA54.
PRIDEQ8NA54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324698; ENSP00000324882; ENSG00000164675. [Q8NA54-1]
ENST00000434450; ENSP00000388498; ENSG00000164675. [Q8NA54-2]
ENST00000466202; ENSP00000417769; ENSG00000164675. [Q8NA54-1]
ENST00000484508; ENSP00000417285; ENSG00000164675. [Q8NA54-2]
GeneID154865.
KEGGhsa:154865.
UCSCuc003vkn.3. human. [Q8NA54-1]
uc003vkp.1. human. [Q8NA54-2]

Organism-specific databases

CTD154865.
GeneCardsGC07M123092.
HGNCHGNC:21995. IQUB.
HPAHPA020621.
HPA049626.
neXtProtNX_Q8NA54.
PharmGKBPA162392258.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85200.
HOVERGENHBG081805.
InParanoidQ8NA54.
OMATVKEHEC.
OrthoDBEOG7CZK5F.
PhylomeDBQ8NA54.
TreeFamTF323180.

Gene expression databases

ArrayExpressQ8NA54.
BgeeQ8NA54.
CleanExHS_IQUB.
GenevestigatorQ8NA54.

Family and domain databases

InterProIPR000626. Ubiquitin-like.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
[Graphical view]
PROSITEPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8NA54.
GenomeRNAi154865.
NextBio87328.
PROQ8NA54.

Entry information

Entry nameIQUB_HUMAN
AccessionPrimary (citable) accession number: Q8NA54
Secondary accession number(s): A4D0X0 expand/collapse secondary AC list , Q49AL6, Q4G189, Q5BJD9, Q6NUH6, Q8N9Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM