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Q8NA54

- IQUB_HUMAN

UniProt

Q8NA54 - IQUB_HUMAN

Protein

IQ and ubiquitin-like domain-containing protein

Gene

IQUB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May play roles in cilia formation and/or maintenance.By similarity

    GO - Biological processi

    1. cilium morphogenesis Source: Ensembl

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    IQ and ubiquitin-like domain-containing protein
    Gene namesi
    Name:IQUB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21995. IQUB.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. motile cilium Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162392258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 791791IQ and ubiquitin-like domain-containing proteinPRO_0000274601Add
    BLAST

    Proteomic databases

    PaxDbiQ8NA54.
    PRIDEiQ8NA54.

    PTM databases

    PhosphoSiteiQ8NA54.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NA54.
    BgeeiQ8NA54.
    CleanExiHS_IQUB.
    GenevestigatoriQ8NA54.

    Organism-specific databases

    HPAiHPA020621.
    HPA049626.

    Interactioni

    Protein-protein interaction databases

    BioGridi127562. 1 interaction.
    MINTiMINT-1469252.

    Structurei

    Secondary structure

    1
    791
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi131 – 1377
    Turni138 – 1403
    Beta strandi143 – 1486
    Beta strandi150 – 1523
    Helixi154 – 16512
    Turni169 – 1713
    Beta strandi172 – 1765
    Beta strandi179 – 1813
    Helixi187 – 1904
    Beta strandi197 – 2059
    Turni207 – 2093

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DAFNMR-A123-227[»]
    ProteinModelPortaliQ8NA54.
    SMRiQ8NA54. Positions 123-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8NA54.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 20777Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini338 – 36730IQAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IQ domain.Curated
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG85200.
    HOVERGENiHBG081805.
    InParanoidiQ8NA54.
    OMAiTVKEHEC.
    OrthoDBiEOG7CZK5F.
    PhylomeDBiQ8NA54.
    TreeFamiTF323180.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NA54-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE    50
    QFSESHAIHV EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA 100
    MQRPNDDSLA FLDKIKSVKE SLQESVEDSL ATVKVVLIPV GQEIVIPFKV 150
    DTILKYLKDH FSHLLGIPHS VLQIRYSGKI LKNNETLVQH GVKPQEIVQV 200
    EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP VEIVKSDFHK 250
    PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT 300
    TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR 350
    QWHAKIFVEN LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN 400
    EDFEFLYNAL EFWRQEELTR INQSFTGAER KAALCELLEK ETQIIASIGR 450
    HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP NGKTIEMDTQ FTIRARELQN 500
    IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL IDREVDLMMR 550
    GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF 600
    CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ 650
    LYYTEADYED DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR 700
    WNKSLEWSPW NCILLTKDEA AAHLKLTSIE EGYERSFIHK IKHKHILAKN 750
    YFSQVPVLAS FILDDGEIDE IRWKYHSDTT PKIIESQRPP H 791
    Length:791
    Mass (Da):92,581
    Last modified:February 6, 2007 - v2
    Checksum:i3D16F8BF4BAED522
    GO
    Isoform 2 (identifier: Q8NA54-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         587-680: VPQDPLKFYK...QDIQYLTENI → MGGEYLSMAL
         681-791: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:596
    Mass (Da):69,382
    Checksum:i0F99A639616E100E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41Q → R in BAC04074. (PubMed:14702039)Curated
    Sequence conflicti252 – 2521F → S in BAC04074. (PubMed:14702039)Curated
    Sequence conflicti343 – 3431I → T in BAC04074. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti126 – 1261V → M.1 Publication
    Corresponds to variant rs10255061 [ dbSNP | Ensembl ].
    VAR_030332
    Natural varianti691 – 6911D → N.
    Corresponds to variant rs17146009 [ dbSNP | Ensembl ].
    VAR_030333
    Natural varianti735 – 7351R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036291
    Natural varianti735 – 7351R → P.
    Corresponds to variant rs1525626 [ dbSNP | Ensembl ].
    VAR_030334

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei587 – 68094VPQDP…LTENI → MGGEYLSMAL in isoform 2. 1 PublicationVSP_022830Add
    BLAST
    Alternative sequencei681 – 791111Missing in isoform 2. 1 PublicationVSP_022831Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093153 mRNA. Translation: BAC04074.1.
    AK093393 mRNA. Translation: BAC04153.1.
    CH236947 Genomic DNA. Translation: EAL24336.1.
    BC026173 mRNA. Translation: AAH26173.1.
    BC036121 mRNA. Translation: AAH36121.1.
    BC091520 mRNA. Translation: AAH91520.1.
    BC128181 mRNA. Translation: AAI28182.1.
    CCDSiCCDS5787.1. [Q8NA54-1]
    RefSeqiNP_001269784.1. NM_001282855.1. [Q8NA54-1]
    NP_849149.3. NM_178827.4. [Q8NA54-1]
    XP_005250217.1. XM_005250160.2. [Q8NA54-1]
    XP_005250218.1. XM_005250161.2. [Q8NA54-1]
    UniGeneiHs.159650.

    Genome annotation databases

    EnsembliENST00000324698; ENSP00000324882; ENSG00000164675. [Q8NA54-1]
    ENST00000466202; ENSP00000417769; ENSG00000164675. [Q8NA54-1]
    ENST00000484508; ENSP00000417285; ENSG00000164675. [Q8NA54-2]
    GeneIDi154865.
    KEGGihsa:154865.
    UCSCiuc003vkn.3. human. [Q8NA54-1]
    uc003vkp.1. human. [Q8NA54-2]

    Polymorphism databases

    DMDMi125950212.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093153 mRNA. Translation: BAC04074.1 .
    AK093393 mRNA. Translation: BAC04153.1 .
    CH236947 Genomic DNA. Translation: EAL24336.1 .
    BC026173 mRNA. Translation: AAH26173.1 .
    BC036121 mRNA. Translation: AAH36121.1 .
    BC091520 mRNA. Translation: AAH91520.1 .
    BC128181 mRNA. Translation: AAI28182.1 .
    CCDSi CCDS5787.1. [Q8NA54-1 ]
    RefSeqi NP_001269784.1. NM_001282855.1. [Q8NA54-1 ]
    NP_849149.3. NM_178827.4. [Q8NA54-1 ]
    XP_005250217.1. XM_005250160.2. [Q8NA54-1 ]
    XP_005250218.1. XM_005250161.2. [Q8NA54-1 ]
    UniGenei Hs.159650.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DAF NMR - A 123-227 [» ]
    ProteinModelPortali Q8NA54.
    SMRi Q8NA54. Positions 123-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127562. 1 interaction.
    MINTi MINT-1469252.

    PTM databases

    PhosphoSitei Q8NA54.

    Polymorphism databases

    DMDMi 125950212.

    Proteomic databases

    PaxDbi Q8NA54.
    PRIDEi Q8NA54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324698 ; ENSP00000324882 ; ENSG00000164675 . [Q8NA54-1 ]
    ENST00000466202 ; ENSP00000417769 ; ENSG00000164675 . [Q8NA54-1 ]
    ENST00000484508 ; ENSP00000417285 ; ENSG00000164675 . [Q8NA54-2 ]
    GeneIDi 154865.
    KEGGi hsa:154865.
    UCSCi uc003vkn.3. human. [Q8NA54-1 ]
    uc003vkp.1. human. [Q8NA54-2 ]

    Organism-specific databases

    CTDi 154865.
    GeneCardsi GC07M123092.
    HGNCi HGNC:21995. IQUB.
    HPAi HPA020621.
    HPA049626.
    neXtProti NX_Q8NA54.
    PharmGKBi PA162392258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85200.
    HOVERGENi HBG081805.
    InParanoidi Q8NA54.
    OMAi TVKEHEC.
    OrthoDBi EOG7CZK5F.
    PhylomeDBi Q8NA54.
    TreeFami TF323180.

    Miscellaneous databases

    EvolutionaryTracei Q8NA54.
    GenomeRNAii 154865.
    NextBioi 87328.
    PROi Q8NA54.

    Gene expression databases

    ArrayExpressi Q8NA54.
    Bgeei Q8NA54.
    CleanExi HS_IQUB.
    Genevestigatori Q8NA54.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-126.
      Tissue: Testis.
    4. "Solution structure of the novel identified ubiquitin-like domain in the human hypothetical protein FLJ35834."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 121-227.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-735.

    Entry informationi

    Entry nameiIQUB_HUMAN
    AccessioniPrimary (citable) accession number: Q8NA54
    Secondary accession number(s): A4D0X0
    , Q49AL6, Q4G189, Q5BJD9, Q6NUH6, Q8N9Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3