Q8NA47 (CCD63_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 63

Gene names

Name:

CCDC63

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAH44815.1 differs from that shown. Reason: Frameshift at position 241.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Coiled-coil domain-containing protein 63		PRO_0000288874
Regions
	Coiled coil	18 – 201	184	Potential
	Coiled coil	233 – 291	59	Potential
	Coiled coil	341 – 422	82	Potential
Natural variations
	Natural variant	212	1	L → S. Corresponds to variant rs12371434 [ dbSNP | Ensembl ].		VAR_050758
Experimental info
	Sequence conflict	35 – 60	26	RQQFR…IASQY → VGSAVAAAVGQAARAATDKQ SGPRHC in AAH64580. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NA47 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 55FF11018BB9B2DC	FASTA	563	66,250
	10 20 30 40 50 60 MSVLKKNRRK DSDTPQEPSE KAKEQQAEAE LRKLRQQFRK MVESRKSFKF RNQQKIASQY 70 80 90 100 110 120 KEIKTLKTEQ DEITLLLSLM KSSRNMNRSE KNYMELRLLL QTKEDYEALI KSLKVLLAEL 130 140 150 160 170 180 DEKILQMEKK IANQKQIFAK MQEANNPRKL QKQIHILETR LNLVTVHFDK MLTTNAKLRK 190 200 210 220 230 240 EIEDLRFEKA AYDNVYQQLQ HCLLMEKKTM NLAIEQSSQA YEQRVEAMAR MAAMKDRQKK 250 260 270 280 290 300 DTSQYNLEIR ELERLYAHES KLKSFLLVKL NDRNEFEEQA KREEALKAKK HVKKNRGESF 310 320 330 340 350 360 ESYEVAHLRL LKLAESGNLN QLIEDFLAKE EKNFARFTYV TELNNDMEMM HKRTQRIQDE 370 380 390 400 410 420 IILLRSQQKL SHDDNHSVLR QLEDKLRKTT EEADMYESKY GEVSKTLDLL KNSVEKLFKK 430 440 450 460 470 480 INCDATKILV QLGETGKVTD INLPQYFAII EKKTNDLLLL ETYRRILEVE GAEAEIPPPF 490 500 510 520 530 540 INPFWGGSAL LKPPEPIKVI PPVLGADPFS DRLDDVEQPL DHSSLRQLVL DNYILKENRS 550 560 KEVRGDSLPE KVDDFRSRKK VTM

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093162 mRNA. Translation: BAC04081.1. BC044815 mRNA. Translation: AAH44815.1. Frameshift. BC064580 mRNA. Translation: AAH64580.1. BC073147 mRNA. Translation: AAH73147.1.
IPI	IPI00167904.
RefSeq	NP_689804.1. NM_152591.1.
UniGene	Hs.437141.
3D structure databases
ProteinModelPortal	Q8NA47.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000312399.
PTM databases
PhosphoSite	Q8NA47.
Polymorphism databases
DMDM	74729832.
Proteomic databases
PaxDb	Q8NA47.
PRIDE	Q8NA47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308208; ENSP00000312399; ENSG00000173093.
GeneID	160762.
KEGG	hsa:160762.
UCSC	uc001trv.1. human.
Organism-specific databases
CTD	160762.
GeneCards	GC12P111284.
HGNC	HGNC:26669. CCDC63.
HPA	HPA041765. HPA043927.
neXtProt	NX_Q8NA47.
PharmGKB	PA143485415.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85245.
HOGENOM	HOG000111427.
HOVERGEN	HBG107616.
InParanoid	Q8NA47.
OMA	FINPFWG.
OrthoDB	EOG4DR9D0.
PhylomeDB	Q8NA47.
Gene expression databases
ArrayExpress	Q8NA47.
Bgee	Q8NA47.
CleanEx	HS_CCDC63.
Genevestigator	Q8NA47.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	160762.
NextBio	87991.

Entry information

Entry name

CCD63_HUMAN

Accession

Primary (citable) accession number: Q8NA47
Secondary accession number(s): Q0P603, Q6P2E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.