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Protein

Zinc finger protein 383

Gene

ZNF383

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 383
Gene namesi
Name:ZNF383
ORF Names:HSD17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18609. ZNF383.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903145.

Polymorphism and mutation databases

BioMutaiZNF383.
DMDMi74760056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Zinc finger protein 383PRO_0000047550Add
BLAST

Proteomic databases

PaxDbiQ8NA42.
PRIDEiQ8NA42.

PTM databases

iPTMnetiQ8NA42.
PhosphoSiteiQ8NA42.

Expressioni

Tissue specificityi

Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.1 Publication

Developmental stagei

In tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lower expression levels in kidney, intestines and prostate.1 Publication

Gene expression databases

BgeeiQ8NA42.
CleanExiHS_ZNF383.
ExpressionAtlasiQ8NA42. baseline and differential.
GenevisibleiQ8NA42. HS.

Organism-specific databases

HPAiHPA063945.

Interactioni

Protein-protein interaction databases

BioGridi127849. 2 interactions.
STRINGi9606.ENSP00000340132.

Structurei

3D structure databases

ProteinModelPortaliQ8NA42.
SMRiQ8NA42. Positions 6-46, 139-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Domaini

The KRAB domain is responsible for the transcriptional repressor activity.

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NA42.
KOiK09228.
OMAiLEYRNHF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NA42.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NA42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYG NLVSMGLYTP
60 70 80 90 100
KPQVISLLEQ GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC
110 120 130 140 150
QREIMGLTKH GLEYSSFGDV LEYRSHLAKQ LGYPNGHFSQ EIFTPEYMPT
160 170 180 190 200
FIQQTFLTLH QIINNEDRPY ECKKCGKAFS QNSQFIQHQR IHIGEKSYEC
210 220 230 240 250
KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY LSQHQRIHTG
260 270 280 290 300
KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYECKVCGKA FTKSSQLFQH
310 320 330 340 350
ARIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG
360 370 380 390 400
SALTNHQRIH TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG
410 420 430 440 450
KAFTQNSQLF QHQRIHTDEK PYECNECGKA FNKCSNLTRH LRIHTGEKPY
460 470
NCKECGKAFS SGSDLIRHQG IHTNK
Length:475
Mass (Da):54,613
Last modified:October 1, 2002 - v1
Checksum:i2F47070F5C2E582B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111V → A in AAP20067 (Ref. 2) Curated
Sequence conflicti114 – 1141Y → H in AAP20067 (Ref. 2) Curated
Sequence conflicti443 – 4431I → V in AAP20067 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY438646 mRNA. Translation: AAR14184.1.
AY260141 mRNA. Translation: AAP20067.1.
AK093182 mRNA. Translation: BAC04086.1.
CCDSiCCDS12501.1.
RefSeqiNP_689817.1. NM_152604.1.
XP_005258642.1. XM_005258585.1.
XP_005258644.1. XM_005258587.1.
XP_005258645.1. XM_005258588.1.
XP_011524888.1. XM_011526586.1.
XP_011524889.1. XM_011526587.1.
XP_011524890.1. XM_011526588.1.
XP_011524891.1. XM_011526589.1.
XP_011524892.1. XM_011526590.1.
UniGeneiHs.590975.

Genome annotation databases

EnsembliENST00000352998; ENSP00000340132; ENSG00000188283.
ENST00000589413; ENSP00000464871; ENSG00000188283.
ENST00000590503; ENSP00000466101; ENSG00000188283.
GeneIDi163087.
KEGGihsa:163087.
UCSCiuc002oft.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY438646 mRNA. Translation: AAR14184.1.
AY260141 mRNA. Translation: AAP20067.1.
AK093182 mRNA. Translation: BAC04086.1.
CCDSiCCDS12501.1.
RefSeqiNP_689817.1. NM_152604.1.
XP_005258642.1. XM_005258585.1.
XP_005258644.1. XM_005258587.1.
XP_005258645.1. XM_005258588.1.
XP_011524888.1. XM_011526586.1.
XP_011524889.1. XM_011526587.1.
XP_011524890.1. XM_011526588.1.
XP_011524891.1. XM_011526589.1.
XP_011524892.1. XM_011526590.1.
UniGeneiHs.590975.

3D structure databases

ProteinModelPortaliQ8NA42.
SMRiQ8NA42. Positions 6-46, 139-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127849. 2 interactions.
STRINGi9606.ENSP00000340132.

PTM databases

iPTMnetiQ8NA42.
PhosphoSiteiQ8NA42.

Polymorphism and mutation databases

BioMutaiZNF383.
DMDMi74760056.

Proteomic databases

PaxDbiQ8NA42.
PRIDEiQ8NA42.

Protocols and materials databases

DNASUi163087.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352998; ENSP00000340132; ENSG00000188283.
ENST00000589413; ENSP00000464871; ENSG00000188283.
ENST00000590503; ENSP00000466101; ENSG00000188283.
GeneIDi163087.
KEGGihsa:163087.
UCSCiuc002oft.2. human.

Organism-specific databases

CTDi163087.
GeneCardsiZNF383.
HGNCiHGNC:18609. ZNF383.
HPAiHPA063945.
neXtProtiNX_Q8NA42.
PharmGKBiPA134903145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NA42.
KOiK09228.
OMAiLEYRNHF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NA42.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163087.
PROiQ8NA42.

Gene expression databases

BgeeiQ8NA42.
CleanExiHS_ZNF383.
ExpressionAtlasiQ8NA42. baseline and differential.
GenevisibleiQ8NA42. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."
    Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.
    Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryonic heart.
  2. "A new spermatogenesis-related gene."
    Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN383_HUMAN
AccessioniPrimary (citable) accession number: Q8NA42
Secondary accession number(s): Q6X2C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.