Q8NA39 (Q8NA39_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ35870 fis, clone TESTI2007998, highly similar to SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1 EMBL BAC04089.1
Organism	Homo sapiens (Human) EMBL BAC04089.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354

Ontologies

Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: InterPro
Molecular function	signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NA39 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 93C3ABB1BF01C207	FASTA	412	43,743
	10 20 30 40 50 60 MKGGAVAADG RIEPGDMLLQ VNDVNFENMS NDDAVRVLRE IVSQTGPISL TVAKCWDPTP 70 80 90 100 110 120 RSYFTVPRAD PVRPIDPAAW LSHTAALTGA LPRYGTSPCS SAVTRTSSSS LTSSVPGAPQ 130 140 150 160 170 180 LEEAPLTVKS DMSAVVRVMQ LPDSGLEIRD RMWLKITIAN AVIGADVVDW LYTHVEGFKE 190 200 210 220 230 240 RREARKYASS LLKHGFLRHT VNKITFSEQC YYVFGDLCSN LATLNLNSGS SGTSDQDTLA 250 260 270 280 290 300 PLPHPAAPWP LGQGYPYQYP GPPPCFPPAY QDPGFSYGSG STGSQQSEGS KSSGSTRSSR 310 320 330 340 350 360 RAPVREKERR AAGAGGSGSE SDHTAPSGVG SSWRERPAGQ LSRGSSPRSQ ASATAPGLPP 370 380 390 400 410 PHPTTKAYTV VGGPPGGPPV RELAAVPPEL TGSRQSFQKA MGNPCEFFVD IM

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL BAC04089.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093189 mRNA. Translation: BAC04089.1.
IPI	IPI00023100.
UniGene	Hs.74375.
3D structure databases
HSSP	HSSP built from PDB template 1FSH based on UniProtKB P51141.
ProteinModelPortal	Q8NA39.
SMR	Q8NA39. Positions 1-62, 123-216.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NA39.
Proteomic databases
PRIDE	Q8NA39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc001aeq.1. human.
Phylogenomic databases
GeneTree	ENSGT00390000013552.
HOVERGEN	HBG005542.
Gene expression databases
ArrayExpress	Q8NA39.
Family and domain databases
InterPro	IPR000591. DEP_dom. IPR008339. Dishevelled. IPR008340. Dishevelled_1. IPR024580. Dishevelled_C-dom. IPR015506. Dsh. IPR001478. PDZ/DHR/GLGF. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR10878:SF5. Dishevelled_1. 1 hit. PTHR10878. Dsh. 1 hit.
Pfam	PF00610. DEP. 1 hit. PF12316. Dsh_C. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR01760. DISHEVELLED. PR01761. DISHEVELLED1.
SMART	SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50186. DEP. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8NA39_HUMAN

Accession

Primary (citable) accession number: Q8NA39

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.