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Q8NA29

- NLS1_HUMAN

UniProt

Q8NA29 - NLS1_HUMAN

Protein

Sodium-dependent lysophosphatidylcholine symporter 1

Gene

MFSD2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis By similarity. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732).By similarity3 Publications

    GO - Molecular functioni

    1. phospholipid transporter activity Source: UniProtKB
    2. symporter activity Source: UniProtKB

    GO - Biological processi

    1. establishment of blood-brain barrier Source: UniProtKB
    2. fatty acid transport Source: UniProtKB
    3. lipid transport across blood brain barrier Source: UniProtKB
    4. phospholipid transport Source: GOC
    5. transcytosis Source: UniProtKB
    6. transmembrane transport Source: GOC

    Keywords - Biological processi

    Lipid transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.2.3.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent lysophosphatidylcholine symporter 1
    Short name:
    NLS1
    Short name:
    Sodium-dependent LPC symporter 1
    Alternative name(s):
    Major facilitator superfamily domain-containing protein 2A
    Gene namesi
    Name:MFSD2A
    Synonyms:MFSD2, NLS1
    ORF Names:HMFN0656, PP9177, UNQ300/PRO341
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25897. MFSD2A.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Curated
    Note: Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane.1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: UniProtKB
    4. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi103 – 1031R → A: No effect on cell sensitivity toward tunicamycin. 1 Publication
    Mutagenesisi106 – 1061D → A: No effect on cell sensitivity toward tunicamycin. 1 Publication
    Mutagenesisi110 – 1101D → A: Drastic loss of cell sensitivity toward tunicamycin. 1 Publication
    Mutagenesisi230 – 2301N → Q: Loss of glycosylation; when associated with Q-240. 1 Publication
    Mutagenesisi240 – 2401N → Q: Loss of glycosylation; when associated with Q-230. 1 Publication
    Mutagenesisi449 – 4491K → A: Loss of plasma membrane localization. Loss of cell sensitivity toward tunicamycin. 1 Publication

    Organism-specific databases

    PharmGKBiPA165751549.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Sodium-dependent lysophosphatidylcholine symporter 1PRO_0000273387Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi230 – 2301N-linked (GlcNAc...)1 Publication
    Glycosylationi240 – 2401N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NA29.
    PRIDEiQ8NA29.

    PTM databases

    PhosphoSiteiQ8NA29.

    Expressioni

    Tissue specificityi

    In placenta, associated with trophoblast cells.1 Publication

    Gene expression databases

    ArrayExpressiQ8NA29.
    BgeeiQ8NA29.
    CleanExiHS_MFSD2.
    GenevestigatoriQ8NA29.

    Organism-specific databases

    HPAiHPA043107.

    Interactioni

    Subunit structurei

    Interacts with ERVFRD-1/syncytin-2.1 Publication

    Protein-protein interaction databases

    DIPiDIP-47306N.
    IntActiQ8NA29. 1 interaction.
    STRINGi9606.ENSP00000361895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NA29.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini102 – 12827ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini150 – 16011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini182 – 25675ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini278 – 31033CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini332 – 34413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini366 – 3705CytoplasmicSequence Analysis
    Topological domaini392 – 3932ExtracellularSequence Analysis
    Topological domaini415 – 43723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini459 – 48022ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini502 – 54342CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 384Poly-Lys

    Sequence similaritiesi

    Belongs to the major facilitator superfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2211.
    HOGENOMiHOG000294186.
    HOVERGENiHBG080097.
    InParanoidiQ8NA29.
    OMAiRGCSQPK.
    OrthoDBiEOG7QRQTT.
    PhylomeDBiQ8NA29.
    TreeFamiTF331194.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NA29-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKGEGAESG SAAGLLPTSI LQSTERPAQV KKEPKKKKQQ LSVCNKLCYA    50
    LGGAPYQVTG CALGFFLQIY LLDVAQKDEE VVFCFSSFQV GPFSASIILF 100
    VGRAWDAITD PLVGLCISKS PWTCLGRLMP WIIFSTPLAV IAYFLIWFVP 150
    DFPHGQTYWY LLFYCLFETM VTCFHVPYSA LTMFISTEQT ERDSATAYRM 200
    TVEVLGTVLG TAIQGQIVGQ ADTPCFQDLN SSTVASQSAN HTHGTTSHRE 250
    TQKAYLLAAG VIVCIYIICA VILILGVREQ REPYEAQQSE PIAYFRGLRL 300
    VMSHGPYIKL ITGFLFTSLA FMLVEGNFVL FCTYTLGFRN EFQNLLLAIM 350
    LSATLTIPIW QWFLTRFGKK TAVYVGISSA VPFLILVALM ESNLIITYAV 400
    AVAAGISVAA AFLLPWSMLP DVIDDFHLKQ PHFHGTEPIF FSFYVFFTKF 450
    ASGVSLGIST LSLDFAGYQT RGCSQPERVK FTLNMLVTMA PIVLILLGLL 500
    LFKMYPIDEE RRRQNKKALQ ALRDEASSSG CSETDSTELA SIL 543
    Length:543
    Mass (Da):60,170
    Last modified:October 1, 2002 - v1
    Checksum:iC9933B79335BFBDE
    GO
    Isoform 2 (identifier: Q8NA29-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-89: Missing.

    Show »
    Length:530
    Mass (Da):58,624
    Checksum:i3B6978F4EA92C763
    GO
    Isoform 3 (identifier: Q8NA29-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-186: MAKGEGAESG...PYSALTMFIS → MWLRWALSLP...PTRLSPCSSA

    Note: No experimental confirmation available.

    Show »
    Length:458
    Mass (Da):50,230
    Checksum:i4C470B6380870E38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti229 – 2291L → F in AAQ88999. (PubMed:12975309)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 186186MAKGE…TMFIS → MWLRWALSLPPSSCLWAEPG MPSQTPWWASASANPPGPAW VALCPGSSSPRPWPSLPTSS SGSCPTSHTARPIGTCFSIA SLKQWSRVSMFPTRLSPCSS A in isoform 3. 1 PublicationVSP_022540Add
    BLAST
    Alternative sequencei77 – 8913Missing in isoform 2. 5 PublicationsVSP_022539Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358636 mRNA. Translation: AAQ88999.1.
    AK093223 mRNA. Translation: BAC04100.1.
    AB073383 mRNA. Translation: BAD38634.1.
    AF289609 mRNA. Translation: AAL55793.1.
    AK075183 mRNA. Translation: BAC11456.1.
    AK291540 mRNA. Translation: BAF84229.1.
    AL663070 Genomic DNA. Translation: CAI20268.1.
    AL663070 Genomic DNA. Translation: CAI20269.1.
    CH471059 Genomic DNA. Translation: EAX07248.1.
    BC006353 mRNA. Translation: AAH06353.2.
    BC011587 mRNA. Translation: AAH11587.1.
    BC092414 mRNA. Translation: AAH92414.1.
    CCDSiCCDS44118.1. [Q8NA29-1]
    CCDS446.1. [Q8NA29-2]
    RefSeqiNP_001129965.1. NM_001136493.2. [Q8NA29-1]
    NP_001274737.1. NM_001287808.1.
    NP_001274738.1. NM_001287809.1.
    NP_116182.2. NM_032793.4. [Q8NA29-2]
    UniGeneiHs.655177.

    Genome annotation databases

    EnsembliENST00000372809; ENSP00000361895; ENSG00000168389. [Q8NA29-1]
    ENST00000372811; ENSP00000361898; ENSG00000168389. [Q8NA29-2]
    GeneIDi84879.
    KEGGihsa:84879.
    UCSCiuc001ceu.3. human. [Q8NA29-2]
    uc001cev.3. human. [Q8NA29-1]

    Polymorphism databases

    DMDMi74751132.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358636 mRNA. Translation: AAQ88999.1 .
    AK093223 mRNA. Translation: BAC04100.1 .
    AB073383 mRNA. Translation: BAD38634.1 .
    AF289609 mRNA. Translation: AAL55793.1 .
    AK075183 mRNA. Translation: BAC11456.1 .
    AK291540 mRNA. Translation: BAF84229.1 .
    AL663070 Genomic DNA. Translation: CAI20268.1 .
    AL663070 Genomic DNA. Translation: CAI20269.1 .
    CH471059 Genomic DNA. Translation: EAX07248.1 .
    BC006353 mRNA. Translation: AAH06353.2 .
    BC011587 mRNA. Translation: AAH11587.1 .
    BC092414 mRNA. Translation: AAH92414.1 .
    CCDSi CCDS44118.1. [Q8NA29-1 ]
    CCDS446.1. [Q8NA29-2 ]
    RefSeqi NP_001129965.1. NM_001136493.2. [Q8NA29-1 ]
    NP_001274737.1. NM_001287808.1.
    NP_001274738.1. NM_001287809.1.
    NP_116182.2. NM_032793.4. [Q8NA29-2 ]
    UniGenei Hs.655177.

    3D structure databases

    ProteinModelPortali Q8NA29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-47306N.
    IntActi Q8NA29. 1 interaction.
    STRINGi 9606.ENSP00000361895.

    Protein family/group databases

    TCDBi 2.A.2.3.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

    PTM databases

    PhosphoSitei Q8NA29.

    Polymorphism databases

    DMDMi 74751132.

    Proteomic databases

    PaxDbi Q8NA29.
    PRIDEi Q8NA29.

    Protocols and materials databases

    DNASUi 84879.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372809 ; ENSP00000361895 ; ENSG00000168389 . [Q8NA29-1 ]
    ENST00000372811 ; ENSP00000361898 ; ENSG00000168389 . [Q8NA29-2 ]
    GeneIDi 84879.
    KEGGi hsa:84879.
    UCSCi uc001ceu.3. human. [Q8NA29-2 ]
    uc001cev.3. human. [Q8NA29-1 ]

    Organism-specific databases

    CTDi 84879.
    GeneCardsi GC01P040421.
    HGNCi HGNC:25897. MFSD2A.
    HPAi HPA043107.
    MIMi 614397. gene.
    neXtProti NX_Q8NA29.
    PharmGKBi PA165751549.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2211.
    HOGENOMi HOG000294186.
    HOVERGENi HBG080097.
    InParanoidi Q8NA29.
    OMAi RGCSQPK.
    OrthoDBi EOG7QRQTT.
    PhylomeDBi Q8NA29.
    TreeFami TF331194.

    Miscellaneous databases

    ChiTaRSi mfsd2a. human.
    GeneWikii MFSD2.
    GenomeRNAii 84879.
    NextBioi 75189.
    PROi Q8NA29.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NA29.
    Bgeei Q8NA29.
    CleanExi HS_MFSD2.
    Genevestigatori Q8NA29.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Testis.
    3. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hepatoblastoma.
    4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye, Muscle and Testis.
    9. "Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis."
      Angers M., Uldry M., Kong D., Gimble J.M., Jetten A.M.
      Biochem. J. 416:347-355(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    10. "A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2."
      Esnault C., Priet S., Ribet D., Vernochet C., Bruls T., Lavialle C., Weissenbach J., Heidmann T.
      Proc. Natl. Acad. Sci. U.S.A. 105:17532-17537(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, TISSUE SPECIFICITY, INTERACTION WITH ERVFRD-1.
    11. "A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin."
      Reiling J.H., Clish C.B., Carette J.E., Varadarajan M., Brummelkamp T.R., Sabatini D.M.
      Proc. Natl. Acad. Sci. U.S.A. 108:11756-11765(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-230 AND ASN-240, MUTAGENESIS OF ARG-103; ASP-106; ASP-110; ASN-230; ASN-240 AND LYS-449.
    12. "MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion."
      Toufaily C., Vargas A., Lemire M., Lafond J., Rassart E., Barbeau B.
      Placenta 34:85-88(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNLS1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NA29
    Secondary accession number(s): A8K675
    , Q6UWU5, Q96F59, Q9BRC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3