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Protein

Sodium-dependent lysophosphatidylcholine symporter 1

Gene

MFSD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Symport, Transport

Protein family/group databases

TCDBi2.A.2.3.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent lysophosphatidylcholine symporter 1
Short name:
NLS1
Short name:
Sodium-dependent LPC symporter 1
Alternative name(s):
Major facilitator superfamily domain-containing protein 2A
Gene namesi
Name:MFSD2A
Synonyms:MFSD2, NLS1
ORF Names:HMFN0656, PP9177, UNQ300/PRO341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25897. MFSD2A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Topological domaini68 – 8013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 12827ExtracellularSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Topological domaini150 – 16011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Topological domaini182 – 25675ExtracellularSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 31033CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Topological domaini332 – 34413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Topological domaini366 – 3705CytoplasmicSequence Analysis
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST
Topological domaini392 – 3932ExtracellularSequence Analysis
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Topological domaini415 – 43723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Topological domaini459 – 48022ExtracellularSequence AnalysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence AnalysisAdd
BLAST
Topological domaini502 – 54342CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi103 – 1031R → A: No effect on cell sensitivity toward tunicamycin. 1 Publication
Mutagenesisi106 – 1061D → A: No effect on cell sensitivity toward tunicamycin. 1 Publication
Mutagenesisi110 – 1101D → A: Drastic loss of cell sensitivity toward tunicamycin. 1 Publication
Mutagenesisi230 – 2301N → Q: Loss of glycosylation; when associated with Q-240. 1 Publication
Mutagenesisi240 – 2401N → Q: Loss of glycosylation; when associated with Q-230. 1 Publication
Mutagenesisi449 – 4491K → A: Loss of plasma membrane localization. Loss of cell sensitivity toward tunicamycin. 1 Publication

Organism-specific databases

PharmGKBiPA165751549.

Polymorphism and mutation databases

BioMutaiMFSD2A.
DMDMi74751132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Sodium-dependent lysophosphatidylcholine symporter 1PRO_0000273387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi230 – 2301N-linked (GlcNAc...)1 Publication
Glycosylationi240 – 2401N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NA29.
PRIDEiQ8NA29.

PTM databases

PhosphoSiteiQ8NA29.

Expressioni

Tissue specificityi

In placenta, associated with trophoblast cells.1 Publication

Gene expression databases

BgeeiQ8NA29.
CleanExiHS_MFSD2.
ExpressionAtlasiQ8NA29. baseline and differential.
GenevisibleiQ8NA29. HS.

Organism-specific databases

HPAiHPA043107.

Interactioni

Subunit structurei

Interacts with ERVFRD-1/syncytin-2.1 Publication

Protein-protein interaction databases

DIPiDIP-47306N.
IntActiQ8NA29. 1 interaction.
STRINGi9606.ENSP00000361895.

Structurei

3D structure databases

ProteinModelPortaliQ8NA29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 384Poly-Lys

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2211.
GeneTreeiENSGT00390000005318.
HOGENOMiHOG000294186.
HOVERGENiHBG080097.
InParanoidiQ8NA29.
OMAiAGCNMIG.
OrthoDBiEOG7QRQTT.
PhylomeDBiQ8NA29.
TreeFamiTF331194.

Family and domain databases

InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKGEGAESG SAAGLLPTSI LQSTERPAQV KKEPKKKKQQ LSVCNKLCYA
60 70 80 90 100
LGGAPYQVTG CALGFFLQIY LLDVAQKDEE VVFCFSSFQV GPFSASIILF
110 120 130 140 150
VGRAWDAITD PLVGLCISKS PWTCLGRLMP WIIFSTPLAV IAYFLIWFVP
160 170 180 190 200
DFPHGQTYWY LLFYCLFETM VTCFHVPYSA LTMFISTEQT ERDSATAYRM
210 220 230 240 250
TVEVLGTVLG TAIQGQIVGQ ADTPCFQDLN SSTVASQSAN HTHGTTSHRE
260 270 280 290 300
TQKAYLLAAG VIVCIYIICA VILILGVREQ REPYEAQQSE PIAYFRGLRL
310 320 330 340 350
VMSHGPYIKL ITGFLFTSLA FMLVEGNFVL FCTYTLGFRN EFQNLLLAIM
360 370 380 390 400
LSATLTIPIW QWFLTRFGKK TAVYVGISSA VPFLILVALM ESNLIITYAV
410 420 430 440 450
AVAAGISVAA AFLLPWSMLP DVIDDFHLKQ PHFHGTEPIF FSFYVFFTKF
460 470 480 490 500
ASGVSLGIST LSLDFAGYQT RGCSQPERVK FTLNMLVTMA PIVLILLGLL
510 520 530 540
LFKMYPIDEE RRRQNKKALQ ALRDEASSSG CSETDSTELA SIL
Length:543
Mass (Da):60,170
Last modified:October 1, 2002 - v1
Checksum:iC9933B79335BFBDE
GO
Isoform 2 (identifier: Q8NA29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-89: Missing.

Show »
Length:530
Mass (Da):58,624
Checksum:i3B6978F4EA92C763
GO
Isoform 3 (identifier: Q8NA29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: MAKGEGAESG...PYSALTMFIS → MWLRWALSLP...PTRLSPCSSA

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):50,230
Checksum:i4C470B6380870E38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291L → F in AAQ88999 (PubMed:12975309).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 186186MAKGE…TMFIS → MWLRWALSLPPSSCLWAEPG MPSQTPWWASASANPPGPAW VALCPGSSSPRPWPSLPTSS SGSCPTSHTARPIGTCFSIA SLKQWSRVSMFPTRLSPCSS A in isoform 3. 1 PublicationVSP_022540Add
BLAST
Alternative sequencei77 – 8913Missing in isoform 2. 5 PublicationsVSP_022539Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358636 mRNA. Translation: AAQ88999.1.
AK093223 mRNA. Translation: BAC04100.1.
AB073383 mRNA. Translation: BAD38634.1.
AF289609 mRNA. Translation: AAL55793.1.
AK075183 mRNA. Translation: BAC11456.1.
AK291540 mRNA. Translation: BAF84229.1.
AL663070 Genomic DNA. Translation: CAI20268.1.
AL663070 Genomic DNA. Translation: CAI20269.1.
CH471059 Genomic DNA. Translation: EAX07248.1.
BC006353 mRNA. Translation: AAH06353.2.
BC011587 mRNA. Translation: AAH11587.1.
BC092414 mRNA. Translation: AAH92414.1.
CCDSiCCDS44118.1. [Q8NA29-1]
CCDS446.1. [Q8NA29-2]
RefSeqiNP_001129965.1. NM_001136493.2. [Q8NA29-1]
NP_001274737.1. NM_001287808.1.
NP_001274738.1. NM_001287809.1.
NP_116182.2. NM_032793.4. [Q8NA29-2]
UniGeneiHs.655177.

Genome annotation databases

EnsembliENST00000372809; ENSP00000361895; ENSG00000168389. [Q8NA29-1]
ENST00000372811; ENSP00000361898; ENSG00000168389. [Q8NA29-2]
GeneIDi84879.
KEGGihsa:84879.
UCSCiuc001ceu.3. human. [Q8NA29-2]
uc001cev.3. human. [Q8NA29-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358636 mRNA. Translation: AAQ88999.1.
AK093223 mRNA. Translation: BAC04100.1.
AB073383 mRNA. Translation: BAD38634.1.
AF289609 mRNA. Translation: AAL55793.1.
AK075183 mRNA. Translation: BAC11456.1.
AK291540 mRNA. Translation: BAF84229.1.
AL663070 Genomic DNA. Translation: CAI20268.1.
AL663070 Genomic DNA. Translation: CAI20269.1.
CH471059 Genomic DNA. Translation: EAX07248.1.
BC006353 mRNA. Translation: AAH06353.2.
BC011587 mRNA. Translation: AAH11587.1.
BC092414 mRNA. Translation: AAH92414.1.
CCDSiCCDS44118.1. [Q8NA29-1]
CCDS446.1. [Q8NA29-2]
RefSeqiNP_001129965.1. NM_001136493.2. [Q8NA29-1]
NP_001274737.1. NM_001287808.1.
NP_001274738.1. NM_001287809.1.
NP_116182.2. NM_032793.4. [Q8NA29-2]
UniGeneiHs.655177.

3D structure databases

ProteinModelPortaliQ8NA29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47306N.
IntActiQ8NA29. 1 interaction.
STRINGi9606.ENSP00000361895.

Protein family/group databases

TCDBi2.A.2.3.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

PhosphoSiteiQ8NA29.

Polymorphism and mutation databases

BioMutaiMFSD2A.
DMDMi74751132.

Proteomic databases

PaxDbiQ8NA29.
PRIDEiQ8NA29.

Protocols and materials databases

DNASUi84879.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372809; ENSP00000361895; ENSG00000168389. [Q8NA29-1]
ENST00000372811; ENSP00000361898; ENSG00000168389. [Q8NA29-2]
GeneIDi84879.
KEGGihsa:84879.
UCSCiuc001ceu.3. human. [Q8NA29-2]
uc001cev.3. human. [Q8NA29-1]

Organism-specific databases

CTDi84879.
GeneCardsiGC01P040421.
HGNCiHGNC:25897. MFSD2A.
HPAiHPA043107.
MIMi614397. gene.
neXtProtiNX_Q8NA29.
PharmGKBiPA165751549.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2211.
GeneTreeiENSGT00390000005318.
HOGENOMiHOG000294186.
HOVERGENiHBG080097.
InParanoidiQ8NA29.
OMAiAGCNMIG.
OrthoDBiEOG7QRQTT.
PhylomeDBiQ8NA29.
TreeFamiTF331194.

Miscellaneous databases

ChiTaRSiMFSD2A. human.
GeneWikiiMFSD2.
GenomeRNAii84879.
NextBioi75189.
PROiQ8NA29.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NA29.
CleanExiHS_MFSD2.
ExpressionAtlasiQ8NA29. baseline and differential.
GenevisibleiQ8NA29. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Testis.
  3. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hepatoblastoma.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye, Muscle and Testis.
  9. "Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis."
    Angers M., Uldry M., Kong D., Gimble J.M., Jetten A.M.
    Biochem. J. 416:347-355(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  10. "A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2."
    Esnault C., Priet S., Ribet D., Vernochet C., Bruls T., Lavialle C., Weissenbach J., Heidmann T.
    Proc. Natl. Acad. Sci. U.S.A. 105:17532-17537(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, TISSUE SPECIFICITY, INTERACTION WITH ERVFRD-1.
  11. "A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin."
    Reiling J.H., Clish C.B., Carette J.E., Varadarajan M., Brummelkamp T.R., Sabatini D.M.
    Proc. Natl. Acad. Sci. U.S.A. 108:11756-11765(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-230 AND ASN-240, MUTAGENESIS OF ARG-103; ASP-106; ASP-110; ASN-230; ASN-240 AND LYS-449.
  12. "MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion."
    Toufaily C., Vargas A., Lemire M., Lafond J., Rassart E., Barbeau B.
    Placenta 34:85-88(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNLS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NA29
Secondary accession number(s): A8K675
, Q6UWU5, Q96F59, Q9BRC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.