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Protein

WD repeat-containing protein 31

Gene

WDR31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8NA23.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 31
Gene namesi
Name:WDR31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21421. WDR31.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959062.

Polymorphism and mutation databases

BioMutaiWDR31.
DMDMi47606186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367WD repeat-containing protein 31PRO_0000051380Add
BLAST

Proteomic databases

PaxDbiQ8NA23.
PRIDEiQ8NA23.

Expressioni

Gene expression databases

BgeeiQ8NA23.
CleanExiHS_WDR31.
ExpressionAtlasiQ8NA23. baseline and differential.
GenevisibleiQ8NA23. HS.

Organism-specific databases

HPAiHPA019340.
HPA019347.

Interactioni

Protein-protein interaction databases

IntActiQ8NA23. 1 interaction.
STRINGi9606.ENSP00000363308.

Structurei

3D structure databases

ProteinModelPortaliQ8NA23.
SMRiQ8NA23. Positions 60-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 9038WD 1Add
BLAST
Repeati94 – 13239WD 2Add
BLAST
Repeati137 – 17539WD 3Add
BLAST
Repeati179 – 21739WD 4Add
BLAST
Repeati221 – 26444WD 5Add
BLAST
Repeati269 – 31143WD 6Add
BLAST
Repeati315 – 35339WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000290168.
HOVERGENiHBG072917.
InParanoidiQ8NA23.
OMAiVAHMFPA.
OrthoDBiEOG7P2XS8.
PhylomeDBiQ8NA23.
TreeFamiTF312936.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NA23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLRCQLKQ APPQKVSFRF CVVMGKQQSK LKHSTYKYGR PDEIIEERIQ
60 70 80 90 100
TKAFQEYSPA HMDTVSVVAA LNSDLCVSGG KDKTVVAYNW KTGNVVKRFK
110 120 130 140 150
GHEHEITKVA CIPKSSQFFS ASRDRMVMMW DLHGSSQPRQ QLCGHAMVVT
160 170 180 190 200
GLAVSPDSSQ LCTGSRDNTL LLWDVVTGQS VERASVSRNV VTHLCWVPRE
210 220 230 240 250
PYILQTSEDK TLRLWDSRGL QVAHMFPAKQ HIQTYCEVSV DGHKCISCSN
260 270 280 290 300
GFGGEGCEAT LWDLRQTRNR ICEYKGHFQT VASCVFLPRA LALMPLIATS
310 320 330 340 350
SHDCKVKIWN QDTGACLFTL SLDGSGPLTS LAVGDAISLL CASFNRGIHL
360
LRMDHSQGLE LQEVAAF
Length:367
Mass (Da):40,840
Last modified:October 1, 2002 - v1
Checksum:i57B317C3164749CA
GO
Isoform 2 (identifier: Q8NA23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):40,684
Checksum:i0013969CA733BACB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131P → S.
Corresponds to variant rs10817479 [ dbSNP | Ensembl ].
VAR_053426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei40 – 401Missing in isoform 2. 1 PublicationVSP_010418

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093240 mRNA. Translation: BAC04106.1.
AL137066, AL449305 Genomic DNA. Translation: CAH70096.1.
AL449305, AL137066 Genomic DNA. Translation: CAI10961.1.
CH471090 Genomic DNA. Translation: EAW87368.1.
BC012352 mRNA. Translation: AAH12352.1.
CCDSiCCDS35110.1. [Q8NA23-1]
CCDS6792.1. [Q8NA23-2]
RefSeqiNP_001012361.1. NM_001012361.3. [Q8NA23-1]
NP_660284.1. NM_145241.4. [Q8NA23-2]
UniGeneiHs.133331.

Genome annotation databases

EnsembliENST00000341761; ENSP00000345027; ENSG00000148225. [Q8NA23-2]
ENST00000374193; ENSP00000363308; ENSG00000148225. [Q8NA23-1]
ENST00000374195; ENSP00000363310; ENSG00000148225. [Q8NA23-2]
GeneIDi114987.
KEGGihsa:114987.
UCSCiuc004bhc.4. human. [Q8NA23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093240 mRNA. Translation: BAC04106.1.
AL137066, AL449305 Genomic DNA. Translation: CAH70096.1.
AL449305, AL137066 Genomic DNA. Translation: CAI10961.1.
CH471090 Genomic DNA. Translation: EAW87368.1.
BC012352 mRNA. Translation: AAH12352.1.
CCDSiCCDS35110.1. [Q8NA23-1]
CCDS6792.1. [Q8NA23-2]
RefSeqiNP_001012361.1. NM_001012361.3. [Q8NA23-1]
NP_660284.1. NM_145241.4. [Q8NA23-2]
UniGeneiHs.133331.

3D structure databases

ProteinModelPortaliQ8NA23.
SMRiQ8NA23. Positions 60-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NA23. 1 interaction.
STRINGi9606.ENSP00000363308.

Polymorphism and mutation databases

BioMutaiWDR31.
DMDMi47606186.

Proteomic databases

PaxDbiQ8NA23.
PRIDEiQ8NA23.

Protocols and materials databases

DNASUi114987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341761; ENSP00000345027; ENSG00000148225. [Q8NA23-2]
ENST00000374193; ENSP00000363308; ENSG00000148225. [Q8NA23-1]
ENST00000374195; ENSP00000363310; ENSG00000148225. [Q8NA23-2]
GeneIDi114987.
KEGGihsa:114987.
UCSCiuc004bhc.4. human. [Q8NA23-1]

Organism-specific databases

CTDi114987.
GeneCardsiWDR31.
HGNCiHGNC:21421. WDR31.
HPAiHPA019340.
HPA019347.
neXtProtiNX_Q8NA23.
PharmGKBiPA134959062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000290168.
HOVERGENiHBG072917.
InParanoidiQ8NA23.
OMAiVAHMFPA.
OrthoDBiEOG7P2XS8.
PhylomeDBiQ8NA23.
TreeFamiTF312936.

Enzyme and pathway databases

SignaLinkiQ8NA23.

Miscellaneous databases

ChiTaRSiWDR31. human.
GenomeRNAii114987.
NextBioi79472.
PROiQ8NA23.

Gene expression databases

BgeeiQ8NA23.
CleanExiHS_WDR31.
ExpressionAtlasiQ8NA23. baseline and differential.
GenevisibleiQ8NA23. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.

Entry informationi

Entry nameiWDR31_HUMAN
AccessioniPrimary (citable) accession number: Q8NA23
Secondary accession number(s): Q5W0T9, Q96EG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.