Q8NA23 (WDR31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 31

Gene names

Name:

WDR31

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 5 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NA23-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NA23-2)

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	WD repeat-containing protein 31		PRO_0000051380
Regions
	Repeat	60 – 100	41	WD 1
	Repeat	101 – 140	40	WD 2
	Repeat	144 – 183	40	WD 3
	Repeat	186 – 225	40	WD 4
	Repeat	276 – 319	44	WD 5
Natural variations
	Alternative sequence	40	1	Missing in isoform 2.		VSP_010418
	Natural variant	113	1	P → S. Corresponds to variant rs10817479 [ dbSNP | Ensembl ].		VAR_053426

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 57B317C3164749CA	FASTA	367	40,840
	10 20 30 40 50 60 MLLLRCQLKQ APPQKVSFRF CVVMGKQQSK LKHSTYKYGR PDEIIEERIQ TKAFQEYSPA 70 80 90 100 110 120 HMDTVSVVAA LNSDLCVSGG KDKTVVAYNW KTGNVVKRFK GHEHEITKVA CIPKSSQFFS 130 140 150 160 170 180 ASRDRMVMMW DLHGSSQPRQ QLCGHAMVVT GLAVSPDSSQ LCTGSRDNTL LLWDVVTGQS 190 200 210 220 230 240 VERASVSRNV VTHLCWVPRE PYILQTSEDK TLRLWDSRGL QVAHMFPAKQ HIQTYCEVSV 250 260 270 280 290 300 DGHKCISCSN GFGGEGCEAT LWDLRQTRNR ICEYKGHFQT VASCVFLPRA LALMPLIATS 310 320 330 340 350 360 SHDCKVKIWN QDTGACLFTL SLDGSGPLTS LAVGDAISLL CASFNRGIHL LRMDHSQGLE LQEVAAF
	Isoform 2 [UniParc]. Checksum: 0013969CA733BACB	FASTA	366	40,684
	10 20 30 40 50 60 MLLLRCQLKQ APPQKVSFRF CVVMGKQQSK LKHSTYKYGP DEIIEERIQT KAFQEYSPAH 70 80 90 100 110 120 MDTVSVVAAL NSDLCVSGGK DKTVVAYNWK TGNVVKRFKG HEHEITKVAC IPKSSQFFSA 130 140 150 160 170 180 SRDRMVMMWD LHGSSQPRQQ LCGHAMVVTG LAVSPDSSQL CTGSRDNTLL LWDVVTGQSV 190 200 210 220 230 240 ERASVSRNVV THLCWVPREP YILQTSEDKT LRLWDSRGLQ VAHMFPAKQH IQTYCEVSVD 250 260 270 280 290 300 GHKCISCSNG FGGEGCEATL WDLRQTRNRI CEYKGHFQTV ASCVFLPRAL ALMPLIATSS 310 320 330 340 350 360 HDCKVKIWNQ DTGACLFTLS LDGSGPLTSL AVGDAISLLC ASFNRGIHLL RMDHSQGLEL QEVAAF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093240 mRNA. Translation: BAC04106.1. AL137066, AL449305 Genomic DNA. Translation: CAH70096.1. AL449305, AL137066 Genomic DNA. Translation: CAI10961.1. CH471090 Genomic DNA. Translation: EAW87368.1. BC012352 mRNA. Translation: AAH12352.1.
IPI	IPI00329568. IPI00396427.
RefSeq	NP_001012361.1. NM_001012361.2. NP_660284.1. NM_145241.3.
UniGene	Hs.133331.
3D structure databases
ProteinModelPortal	Q8NA23.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363308.
Polymorphism databases
DMDM	47606186.
Proteomic databases
PaxDb	Q8NA23.
PRIDE	Q8NA23.
Protocols and materials databases
DNASU	114987.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341761; ENSP00000345027; ENSG00000148225. ENST00000374193; ENSP00000363308; ENSG00000148225.
GeneID	114987.
KEGG	hsa:114987.
UCSC	uc004bhc.3. human. uc004bhd.3. human.
Organism-specific databases
CTD	114987.
GeneCards	GC09M116077.
HGNC	HGNC:21421. WDR31.
HPA	HPA019340. HPA019347.
neXtProt	NX_Q8NA23.
PharmGKB	PA134959062.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000290168.
HOVERGEN	HBG072917.
InParanoid	Q8NA23.
OMA	EERIQTK.
OrthoDB	EOG49GKGV.
Enzyme and pathway databases
SignaLink	Q8NA23.
Gene expression databases
ArrayExpress	Q8NA23.
Bgee	Q8NA23.
CleanEx	HS_WDR31.
Genevestigator	Q8NA23.
GermOnline	ENSG00000148225. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 4 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	114987.
NextBio	79472.

Entry information

Entry name

WDR31_HUMAN

Accession

Primary (citable) accession number: Q8NA23
Secondary accession number(s): Q5W0T9, Q96EG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.