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Protein

Fibrous sheath-interacting protein 1

Gene

FSIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150667-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrous sheath-interacting protein 1
Gene namesi
Name:FSIP1
ORF Names:HSD10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:21674. FSIP1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi161835.
OpenTargetsiENSG00000150667.
PharmGKBiPA142671750.

Polymorphism and mutation databases

BioMutaiFSIP1.
DMDMi74729808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003149181 – 581Fibrous sheath-interacting protein 1Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NA03.
MaxQBiQ8NA03.
PaxDbiQ8NA03.
PeptideAtlasiQ8NA03.
PRIDEiQ8NA03.

PTM databases

iPTMnetiQ8NA03.
PhosphoSitePlusiQ8NA03.

Expressioni

Gene expression databases

BgeeiENSG00000150667.
CleanExiHS_FSIP1.
ExpressionAtlasiQ8NA03. baseline and differential.
GenevisibleiQ8NA03. HS.

Organism-specific databases

HPAiHPA041002.

Interactioni

Protein-protein interaction databases

BioGridi127805. 2 interactors.
IntActiQ8NA03. 1 interactor.
STRINGi9606.ENSP00000280236.

Structurei

3D structure databases

ProteinModelPortaliQ8NA03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili105 – 153Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the FSIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J06C. Eukaryota.
ENOG41120JM. LUCA.
GeneTreeiENSGT00390000013879.
HOGENOMiHOG000112659.
HOVERGENiHBG098301.
InParanoidiQ8NA03.
OMAiKCLQFSK.
OrthoDBiEOG091G0A36.
PhylomeDBiQ8NA03.
TreeFamiTF351151.

Family and domain databases

InterProiIPR026246. Fsip1.
[Graphical view]
PANTHERiPTHR22012. PTHR22012. 1 hit.
PfamiPF15554. FSIP1. 1 hit.
[Graphical view]
PRINTSiPR02075. FIBSHEATHIP1.

Sequencei

Sequence statusi: Complete.

Q8NA03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIKGNLDG ISKPASNSRI RPGSRSSNAS LEVLSTEPGS FKVDTASNLN
60 70 80 90 100
SGKEDHSESS NTENRRTSND DKQESCSEKI KLAEEGSDED LDLVQHQIIS
110 120 130 140 150
ECSDEPKLKE LDSQLQDAIQ KMKKLDKILA KKQRREKEIK KQGLEMRIKL
160 170 180 190 200
WEEIKSAKYS EAWQSKEEME NTKKFLSLTA VSEETVGPSH EEEDTFSSVF
210 220 230 240 250
HTQIPPEEYE MQMQKLNKDF TCDVERNESL IKSGKKPFSN TEKIELRGKH
260 270 280 290 300
NQDFIKRNIE LAKESRNPVV MVDREKKRLV ELLKDLDEKD SGLSSSEGDQ
310 320 330 340 350
SGWVVPVKGY ELAVTQHQQL AEIDIKLQEL SAASPTISSF SPRLENRNNQ
360 370 380 390 400
KPDRDGERNM EVTPGEKILR NTKEQRDLHN RLREIDEKLK MMKENVLEST
410 420 430 440 450
SCLSEEQLKC LLDECILKQK SIIKLSSERK KEDIEDVTPV FPQLSRSIIS
460 470 480 490 500
KLLNESETKV QKTEVEDADM LESEECEASK GYYLTKALTG HNMSEALVTE
510 520 530 540 550
AENMKCLQFS KDVIISDTKD YFMSKTLGIG RLKRPSFLDD PLYGISVSLS
560 570 580
SEDQHLKLSS PENTIADEQE TKDAAEECKE P
Length:581
Mass (Da):66,121
Last modified:October 1, 2002 - v1
Checksum:i979A8B4DE2177C74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75S → R in AAP20066 (Ref. 1) Curated1
Sequence conflicti574A → G in AAP20066 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03812464N → D.Corresponds to variant rs1166719dbSNPEnsembl.1
Natural variantiVAR_038125354R → H.1 PublicationCorresponds to variant rs937961dbSNPEnsembl.1
Natural variantiVAR_038126374E → G.Corresponds to variant rs16969673dbSNPEnsembl.1
Natural variantiVAR_038127402C → R.1 PublicationCorresponds to variant rs10152640dbSNPEnsembl.1
Natural variantiVAR_038128411L → F.Corresponds to variant rs12908846dbSNPEnsembl.1
Natural variantiVAR_038129528G → A.Corresponds to variant rs16969386dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260140 mRNA. Translation: AAP20066.1.
AK093308 mRNA. Translation: BAC04128.1.
CH471125 Genomic DNA. Translation: EAW92382.1.
BC045191 mRNA. Translation: AAH45191.1.
CCDSiCCDS10050.1.
RefSeqiNP_001311267.1. NM_001324338.1.
NP_689810.3. NM_152597.4.
XP_011519607.1. XM_011521305.2.
XP_011519608.1. XM_011521306.1.
UniGeneiHs.129598.

Genome annotation databases

EnsembliENST00000350221; ENSP00000280236; ENSG00000150667.
GeneIDi161835.
KEGGihsa:161835.
UCSCiuc001zki.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260140 mRNA. Translation: AAP20066.1.
AK093308 mRNA. Translation: BAC04128.1.
CH471125 Genomic DNA. Translation: EAW92382.1.
BC045191 mRNA. Translation: AAH45191.1.
CCDSiCCDS10050.1.
RefSeqiNP_001311267.1. NM_001324338.1.
NP_689810.3. NM_152597.4.
XP_011519607.1. XM_011521305.2.
XP_011519608.1. XM_011521306.1.
UniGeneiHs.129598.

3D structure databases

ProteinModelPortaliQ8NA03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127805. 2 interactors.
IntActiQ8NA03. 1 interactor.
STRINGi9606.ENSP00000280236.

PTM databases

iPTMnetiQ8NA03.
PhosphoSitePlusiQ8NA03.

Polymorphism and mutation databases

BioMutaiFSIP1.
DMDMi74729808.

Proteomic databases

EPDiQ8NA03.
MaxQBiQ8NA03.
PaxDbiQ8NA03.
PeptideAtlasiQ8NA03.
PRIDEiQ8NA03.

Protocols and materials databases

DNASUi161835.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350221; ENSP00000280236; ENSG00000150667.
GeneIDi161835.
KEGGihsa:161835.
UCSCiuc001zki.4. human.

Organism-specific databases

CTDi161835.
DisGeNETi161835.
GeneCardsiFSIP1.
HGNCiHGNC:21674. FSIP1.
HPAiHPA041002.
MIMi615795. gene.
neXtProtiNX_Q8NA03.
OpenTargetsiENSG00000150667.
PharmGKBiPA142671750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J06C. Eukaryota.
ENOG41120JM. LUCA.
GeneTreeiENSGT00390000013879.
HOGENOMiHOG000112659.
HOVERGENiHBG098301.
InParanoidiQ8NA03.
OMAiKCLQFSK.
OrthoDBiEOG091G0A36.
PhylomeDBiQ8NA03.
TreeFamiTF351151.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150667-MONOMER.

Miscellaneous databases

ChiTaRSiFSIP1. human.
GenomeRNAii161835.
PROiQ8NA03.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150667.
CleanExiHS_FSIP1.
ExpressionAtlasiQ8NA03. baseline and differential.
GenevisibleiQ8NA03. HS.

Family and domain databases

InterProiIPR026246. Fsip1.
[Graphical view]
PANTHERiPTHR22012. PTHR22012. 1 hit.
PfamiPF15554. FSIP1. 1 hit.
[Graphical view]
PRINTSiPR02075. FIBSHEATHIP1.
ProtoNetiSearch...

Entry informationi

Entry nameiFSIP1_HUMAN
AccessioniPrimary (citable) accession number: Q8NA03
Secondary accession number(s): Q6X2C8, Q86Y89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.