Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 610

Gene

ZNF610

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 610
Gene namesi
Name:ZNF610
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26687. ZNF610.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963099.

Polymorphism and mutation databases

BioMutaiZNF610.
DMDMi229462790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Zinc finger protein 610PRO_0000234595Add
BLAST

Proteomic databases

MaxQBiQ8N9Z0.
PaxDbiQ8N9Z0.
PRIDEiQ8N9Z0.

PTM databases

iPTMnetiQ8N9Z0.
PhosphoSiteiQ8N9Z0.

Expressioni

Gene expression databases

BgeeiQ8N9Z0.
CleanExiHS_ZNF610.
ExpressionAtlasiQ8N9Z0. baseline and differential.
GenevisibleiQ8N9Z0. HS.

Organism-specific databases

HPAiHPA055771.

Interactioni

Protein-protein interaction databases

BioGridi127832. 3 interactions.
IntActiQ8N9Z0. 1 interaction.
STRINGi9606.ENSP00000324441.

Structurei

3D structure databases

ProteinModelPortaliQ8N9Z0.
SMRiQ8N9Z0. Positions 24-64, 204-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N9Z0.
KOiK09228.
OMAiVNTGRSC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N9Z0.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9Z0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCDEEAQKR KAKESGMALP QGRLTFMDVA IEFSQEEWKS LDPGQRALYR
60 70 80 90 100
DVMLENYRNL VFLGICLPDL SIISMLKQRR EPLILQSQVK IVKNTDGREC
110 120 130 140 150
VRSVNTGRSC VLGSNAENKP IKNQLGLTLE AHLSELQLFQ AGRKIYRSNQ
160 170 180 190 200
VEKFTNHRSS VSPLQKISSS FTTHIFNKYR NDLIDFPLLP QEEKAYIRGK
210 220 230 240 250
SYEYECSEDG EVFRVRASLT NHQVIHTAEK PYKCTECGKV FSRNSHLVEH
260 270 280 290 300
WRIHTGQKPY KCSECDKVFN RNSNLARHQR IHTGEKPHKC NECGKAFREC
310 320 330 340 350
SGLTTHLVIH TGEKPYKCNE CGKNFRHKFS LTNHQRSHTA EKPYKCNECG
360 370 380 390 400
KVFSLLSYLA RHQIIHSTEK PYKCNECGRA FHKRPGLMAH LLIHTGEKPY
410 420 430 440 450
KCNECDKVFG RKLYLTNHQR IHTGERPYKC NACGKVFNQN PHLSRHRKIH
460
AGENSLRTLQ ME
Length:462
Mass (Da):53,489
Last modified:May 5, 2009 - v2
Checksum:i610D482D57C7A65D
GO
Isoform 2 (identifier: Q8N9Z0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-107: Missing.

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):48,654
Checksum:iDA66FC1C296014AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041V → M.
Corresponds to variant rs3815905 [ dbSNP | Ensembl ].
VAR_052873
Natural varianti131 – 1311A → S.2 Publications
Corresponds to variant rs2241586 [ dbSNP | Ensembl ].
VAR_052874
Natural varianti216 – 2161R → P.2 Publications
Corresponds to variant rs321937 [ dbSNP | Ensembl ].
VAR_033582
Natural varianti298 – 2981R → I.
Corresponds to variant rs7343101 [ dbSNP | Ensembl ].
VAR_052875

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei65 – 10743Missing in isoform 2. 1 PublicationVSP_018387Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290888 mRNA. Translation: BAF83577.1.
AK093359 mRNA. Translation: BAC04144.1.
AC010320 Genomic DNA. No translation available.
BC039903 mRNA. Translation: AAH39903.1.
BC105967 mRNA. Translation: AAI05968.1.
AL831871 mRNA. Translation: CAD38559.1.
CCDSiCCDS12851.1. [Q8N9Z0-1]
CCDS54309.1. [Q8N9Z0-2]
RefSeqiNP_001154897.1. NM_001161425.1. [Q8N9Z0-1]
NP_001154898.1. NM_001161426.1. [Q8N9Z0-1]
NP_001154899.1. NM_001161427.1. [Q8N9Z0-2]
NP_775801.2. NM_173530.2. [Q8N9Z0-1]
XP_011524862.1. XM_011526560.1. [Q8N9Z0-1]
XP_011524863.1. XM_011526561.1. [Q8N9Z0-1]
XP_011524864.1. XM_011526562.1. [Q8N9Z0-1]
UniGeneiHs.147025.

Genome annotation databases

EnsembliENST00000321287; ENSP00000324441; ENSG00000167554. [Q8N9Z0-1]
ENST00000327920; ENSP00000327597; ENSG00000167554. [Q8N9Z0-1]
ENST00000403906; ENSP00000383922; ENSG00000167554. [Q8N9Z0-1]
ENST00000601151; ENSP00000471021; ENSG00000167554. [Q8N9Z0-2]
ENST00000613461; ENSP00000477617; ENSG00000167554. [Q8N9Z0-2]
ENST00000616431; ENSP00000485001; ENSG00000167554. [Q8N9Z0-1]
GeneIDi162963.
KEGGihsa:162963.
UCSCiuc002pyx.5. human. [Q8N9Z0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290888 mRNA. Translation: BAF83577.1.
AK093359 mRNA. Translation: BAC04144.1.
AC010320 Genomic DNA. No translation available.
BC039903 mRNA. Translation: AAH39903.1.
BC105967 mRNA. Translation: AAI05968.1.
AL831871 mRNA. Translation: CAD38559.1.
CCDSiCCDS12851.1. [Q8N9Z0-1]
CCDS54309.1. [Q8N9Z0-2]
RefSeqiNP_001154897.1. NM_001161425.1. [Q8N9Z0-1]
NP_001154898.1. NM_001161426.1. [Q8N9Z0-1]
NP_001154899.1. NM_001161427.1. [Q8N9Z0-2]
NP_775801.2. NM_173530.2. [Q8N9Z0-1]
XP_011524862.1. XM_011526560.1. [Q8N9Z0-1]
XP_011524863.1. XM_011526561.1. [Q8N9Z0-1]
XP_011524864.1. XM_011526562.1. [Q8N9Z0-1]
UniGeneiHs.147025.

3D structure databases

ProteinModelPortaliQ8N9Z0.
SMRiQ8N9Z0. Positions 24-64, 204-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127832. 3 interactions.
IntActiQ8N9Z0. 1 interaction.
STRINGi9606.ENSP00000324441.

PTM databases

iPTMnetiQ8N9Z0.
PhosphoSiteiQ8N9Z0.

Polymorphism and mutation databases

BioMutaiZNF610.
DMDMi229462790.

Proteomic databases

MaxQBiQ8N9Z0.
PaxDbiQ8N9Z0.
PRIDEiQ8N9Z0.

Protocols and materials databases

DNASUi162963.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321287; ENSP00000324441; ENSG00000167554. [Q8N9Z0-1]
ENST00000327920; ENSP00000327597; ENSG00000167554. [Q8N9Z0-1]
ENST00000403906; ENSP00000383922; ENSG00000167554. [Q8N9Z0-1]
ENST00000601151; ENSP00000471021; ENSG00000167554. [Q8N9Z0-2]
ENST00000613461; ENSP00000477617; ENSG00000167554. [Q8N9Z0-2]
ENST00000616431; ENSP00000485001; ENSG00000167554. [Q8N9Z0-1]
GeneIDi162963.
KEGGihsa:162963.
UCSCiuc002pyx.5. human. [Q8N9Z0-1]

Organism-specific databases

CTDi162963.
GeneCardsiZNF610.
HGNCiHGNC:26687. ZNF610.
HPAiHPA055771.
neXtProtiNX_Q8N9Z0.
PharmGKBiPA134963099.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N9Z0.
KOiK09228.
OMAiVNTGRSC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N9Z0.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii162963.
NextBioi88227.
PROiQ8N9Z0.

Gene expression databases

BgeeiQ8N9Z0.
CleanExiHS_ZNF610.
ExpressionAtlasiQ8N9Z0. baseline and differential.
GenevisibleiQ8N9Z0. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-131 AND PRO-216.
    Tissue: Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-131.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-216.
    Tissue: Eye and Skin.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 247-462.
    Tissue: Brain.

Entry informationi

Entry nameiZN610_HUMAN
AccessioniPrimary (citable) accession number: Q8N9Z0
Secondary accession number(s): A8K4C3, Q86YH8, Q8NDS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 5, 2009
Last modified: March 16, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.