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Protein

Protein FAM71D

Gene

FAM71D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM71D
Gene namesi
Name:FAM71D
Synonyms:C14orf54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20101. FAM71D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387759.

Polymorphism and mutation databases

BioMutaiFAM71D.
DMDMi116241304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Protein FAM71DPRO_0000089895Add
BLAST

Proteomic databases

PaxDbiQ8N9W8.
PRIDEiQ8N9W8.

PTM databases

iPTMnetiQ8N9W8.
PhosphoSiteiQ8N9W8.

Expressioni

Gene expression databases

BgeeiQ8N9W8.
CleanExiHS_FAM71D.
ExpressionAtlasiQ8N9W8. baseline and differential.
GenevisibleiQ8N9W8. HS.

Organism-specific databases

HPAiHPA001206.
HPA004739.

Interactioni

Protein-protein interaction databases

BioGridi127772. 3 interactions.
IntActiQ8N9W8. 1 interaction.
STRINGi9606.ENSP00000431905.

Structurei

3D structure databases

ProteinModelPortaliQ8N9W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

eggNOGiENOG410IKU8. Eukaryota.
ENOG4111C4W. LUCA.
GeneTreeiENSGT00530000063078.
HOVERGENiHBG051011.
InParanoidiQ8N9W8.
OMAiENMRLKV.
PhylomeDBiQ8N9W8.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKNTSKTTM RINKQDALCT PHSHDPRDLQ NMLDGGEYAP FVSPPMLESN
60 70 80 90 100
FIQVNRRGES IYLHNRANWV TVGICFSSST HKIPNVMLLA HLTPGAQKDT
110 120 130 140 150
ETLFKSLLTS PPAEKLVLTR FLPLQFVTLS VHDAENMSLK VKLVSGRAYY
160 170 180 190 200
LQLCTSAYKQ DTLFSQWVAL ISLLNQEKAK VSKVSEVSSL SGITNSTDIT
210 220 230 240 250
GSMDVTDVTT FTAILTPYMY AGTGPEHVRD SIDFPEFTDI TDITDVTDLP
260 270 280 290 300
ENEVPEVPDV RIVTEVIEVR EATEVTDSSD ITNCSGVTVV FENNDLIRAK
310 320 330 340 350
QEEKEKLKNI LKPGCLQDTK SKSELKESSK HVTISNITLT FEGKRYFQTT
360 370 380 390 400
LTPVESEANT SKEMKDKTSE EKMPDFQSTA LKAEESRSLR TESNTSVLSP
410 420
HIKSPSNFLK LVPHLSAPFS RE
Length:422
Mass (Da):47,076
Last modified:October 17, 2006 - v2
Checksum:iEDD1E7A0ADED9C8F
GO
Isoform 2 (identifier: Q8N9W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-343: Missing.

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):44,646
Checksum:i455658C8FE246A88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921L → P in BAC04169 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei322 – 34322Missing in isoform 2. 1 PublicationVSP_009298Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093449 mRNA. Translation: BAC04169.1.
BC050401 mRNA. Translation: AAH50401.1.
CCDSiCCDS9778.1. [Q8N9W8-1]
RefSeqiNP_775797.2. NM_173526.3. [Q8N9W8-1]
XP_011534802.1. XM_011536500.1. [Q8N9W8-1]
XP_011534803.1. XM_011536501.1. [Q8N9W8-1]
XP_011534804.1. XM_011536502.1. [Q8N9W8-1]
XP_011534805.1. XM_011536503.1. [Q8N9W8-1]
UniGeneiHs.412818.
Hs.733286.

Genome annotation databases

EnsembliENST00000311864; ENSP00000431905; ENSG00000172717. [Q8N9W8-1]
ENST00000534174; ENSP00000432195; ENSG00000172717. [Q8N9W8-2]
ENST00000612183; ENSP00000483154; ENSG00000172717. [Q8N9W8-1]
GeneIDi161142.
KEGGihsa:161142.
UCSCiuc001xja.2. human. [Q8N9W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093449 mRNA. Translation: BAC04169.1.
BC050401 mRNA. Translation: AAH50401.1.
CCDSiCCDS9778.1. [Q8N9W8-1]
RefSeqiNP_775797.2. NM_173526.3. [Q8N9W8-1]
XP_011534802.1. XM_011536500.1. [Q8N9W8-1]
XP_011534803.1. XM_011536501.1. [Q8N9W8-1]
XP_011534804.1. XM_011536502.1. [Q8N9W8-1]
XP_011534805.1. XM_011536503.1. [Q8N9W8-1]
UniGeneiHs.412818.
Hs.733286.

3D structure databases

ProteinModelPortaliQ8N9W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127772. 3 interactions.
IntActiQ8N9W8. 1 interaction.
STRINGi9606.ENSP00000431905.

PTM databases

iPTMnetiQ8N9W8.
PhosphoSiteiQ8N9W8.

Polymorphism and mutation databases

BioMutaiFAM71D.
DMDMi116241304.

Proteomic databases

PaxDbiQ8N9W8.
PRIDEiQ8N9W8.

Protocols and materials databases

DNASUi161142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311864; ENSP00000431905; ENSG00000172717. [Q8N9W8-1]
ENST00000534174; ENSP00000432195; ENSG00000172717. [Q8N9W8-2]
ENST00000612183; ENSP00000483154; ENSG00000172717. [Q8N9W8-1]
GeneIDi161142.
KEGGihsa:161142.
UCSCiuc001xja.2. human. [Q8N9W8-1]

Organism-specific databases

CTDi161142.
GeneCardsiFAM71D.
HGNCiHGNC:20101. FAM71D.
HPAiHPA001206.
HPA004739.
neXtProtiNX_Q8N9W8.
PharmGKBiPA162387759.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKU8. Eukaryota.
ENOG4111C4W. LUCA.
GeneTreeiENSGT00530000063078.
HOVERGENiHBG051011.
InParanoidiQ8N9W8.
OMAiENMRLKV.
PhylomeDBiQ8N9W8.

Miscellaneous databases

GenomeRNAii161142.
NextBioi88019.
PROiQ8N9W8.

Gene expression databases

BgeeiQ8N9W8.
CleanExiHS_FAM71D.
ExpressionAtlasiQ8N9W8. baseline and differential.
GenevisibleiQ8N9W8. HS.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiFA71D_HUMAN
AccessioniPrimary (citable) accession number: Q8N9W8
Secondary accession number(s): Q86VN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: February 17, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.