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Q8N9V3

- WSDU1_HUMAN

UniProt

Q8N9V3 - WSDU1_HUMAN

Protein

WD repeat, SAM and U-box domain-containing protein 1

Gene

WDSUB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: InterPro

    Enzyme and pathway databases

    SignaLinkiQ8N9V3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat, SAM and U-box domain-containing protein 1
    Gene namesi
    Name:WDSUB1
    Synonyms:WDSAM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:26697. WDSUB1.

    Subcellular locationi

    GO - Cellular componenti

    1. ubiquitin ligase complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394761.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476WD repeat, SAM and U-box domain-containing protein 1PRO_0000278608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei458 – 4581Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N9V3.
    PaxDbiQ8N9V3.
    PRIDEiQ8N9V3.

    PTM databases

    PhosphoSiteiQ8N9V3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N9V3.
    BgeeiQ8N9V3.
    CleanExiHS_WDSUB1.
    GenevestigatoriQ8N9V3.

    Organism-specific databases

    HPAiHPA036840.

    Interactioni

    Protein-protein interaction databases

    BioGridi127386. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N9V3.
    SMRiQ8N9V3. Positions 3-378, 401-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati10 – 4738WD 1Add
    BLAST
    Repeati52 – 9140WD 2Add
    BLAST
    Repeati95 – 13440WD 3Add
    BLAST
    Repeati137 – 17640WD 4Add
    BLAST
    Repeati178 – 22851WD 5Add
    BLAST
    Repeati237 – 27640WD 6Add
    BLAST
    Repeati279 – 31840WD 7Add
    BLAST
    Domaini332 – 39665SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini403 – 47674U-boxAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
    Contains 1 U-box domain.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000231980.
    HOVERGENiHBG080511.
    InParanoidiQ8N9V3.
    OMAiSCGQDCQ.
    OrthoDBiEOG7K9K25.
    PhylomeDBiQ8N9V3.
    TreeFamiTF328991.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.130.10.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR003613. Ubox_domain.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF07647. SAM_2. 1 hit.
    PF04564. U-box. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00454. SAM. 1 hit.
    SM00504. Ubox. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF50998. SSF50998. 1 hit.
    PROSITEiPS50105. SAM_DOMAIN. 1 hit.
    PS51698. U_BOX. 1 hit.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N9V3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL    50
    KFHTYAVHCC CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV 100
    RVCQFSPDST CLASGAADGT VVLWNAQSYK LYRCGSVKDG SLAACAFSPN 150
    GSFFVTGSSC GDLTVWDDKM RCPHSEKAHD LGITCCDFSS QPVSDGEQGL 200
    QFFRLASCGQ DCQVKIWIVS FTHILGFELK YKSTLSGHCA PVLACAFSHD 250
    GQMLVSGSVD KSVIVYDTNT ENILHTLTQH TRYVTTCAFA PNTLLLATGS 300
    MDKTVNIWQF DLETLCQARR TEHQLKQFTE DWSEEDVSTW LCAQDLKDLV 350
    GIFKMNNIDG KELLNLTKES LADDLKIESL GLRSKVLRKI EELRTKVKSL 400
    SSGIPDEFIC PITRELMKDP VIASDGYSYE KEAMENWISK KKRTSPMTNL 450
    VLPSAVLTPN RTLKMAINRW LETHQK 476
    Length:476
    Mass (Da):52,817
    Last modified:May 5, 2009 - v3
    Checksum:iF53C643A768B6622
    GO
    Isoform 2 (identifier: Q8N9V3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         226-317: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:384
    Mass (Da):42,722
    Checksum:iD23E018257ED0EBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731P → L in BAC04184. (PubMed:14702039)Curated
    Sequence conflicti173 – 1731P → L in AAH29520. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti215 – 2151K → T.
    Corresponds to variant rs16843852 [ dbSNP | Ensembl ].
    VAR_030791
    Natural varianti223 – 2231H → D.1 Publication
    Corresponds to variant rs17852677 [ dbSNP | Ensembl ].
    VAR_030792
    Natural varianti320 – 3201R → S.1 Publication
    Corresponds to variant rs7591849 [ dbSNP | Ensembl ].
    VAR_030793

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei226 – 31792Missing in isoform 2. 1 PublicationVSP_023337Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093494 mRNA. Translation: BAC04184.1.
    AC008277 Genomic DNA. No translation available.
    AC009307 Genomic DNA. Translation: AAX93043.1.
    BC029520 mRNA. Translation: AAH29520.1.
    CCDSiCCDS2208.1. [Q8N9V3-1]
    RefSeqiNP_001121684.1. NM_001128212.1.
    NP_689741.2. NM_152528.2.
    UniGeneiHs.20848.

    Genome annotation databases

    EnsembliENST00000358147; ENSP00000350866; ENSG00000196151. [Q8N9V3-2]
    ENST00000359774; ENSP00000352820; ENSG00000196151. [Q8N9V3-1]
    ENST00000392796; ENSP00000376545; ENSG00000196151. [Q8N9V3-1]
    ENST00000409990; ENSP00000387078; ENSG00000196151. [Q8N9V3-1]
    GeneIDi151525.
    KEGGihsa:151525.
    UCSCiuc010foo.3. human. [Q8N9V3-2]

    Polymorphism databases

    DMDMi229463016.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093494 mRNA. Translation: BAC04184.1 .
    AC008277 Genomic DNA. No translation available.
    AC009307 Genomic DNA. Translation: AAX93043.1 .
    BC029520 mRNA. Translation: AAH29520.1 .
    CCDSi CCDS2208.1. [Q8N9V3-1 ]
    RefSeqi NP_001121684.1. NM_001128212.1.
    NP_689741.2. NM_152528.2.
    UniGenei Hs.20848.

    3D structure databases

    ProteinModelPortali Q8N9V3.
    SMRi Q8N9V3. Positions 3-378, 401-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127386. 2 interactions.

    PTM databases

    PhosphoSitei Q8N9V3.

    Polymorphism databases

    DMDMi 229463016.

    Proteomic databases

    MaxQBi Q8N9V3.
    PaxDbi Q8N9V3.
    PRIDEi Q8N9V3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358147 ; ENSP00000350866 ; ENSG00000196151 . [Q8N9V3-2 ]
    ENST00000359774 ; ENSP00000352820 ; ENSG00000196151 . [Q8N9V3-1 ]
    ENST00000392796 ; ENSP00000376545 ; ENSG00000196151 . [Q8N9V3-1 ]
    ENST00000409990 ; ENSP00000387078 ; ENSG00000196151 . [Q8N9V3-1 ]
    GeneIDi 151525.
    KEGGi hsa:151525.
    UCSCi uc010foo.3. human. [Q8N9V3-2 ]

    Organism-specific databases

    CTDi 151525.
    GeneCardsi GC02M160092.
    HGNCi HGNC:26697. WDSUB1.
    HPAi HPA036840.
    neXtProti NX_Q8N9V3.
    PharmGKBi PA128394761.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000231980.
    HOVERGENi HBG080511.
    InParanoidi Q8N9V3.
    OMAi SCGQDCQ.
    OrthoDBi EOG7K9K25.
    PhylomeDBi Q8N9V3.
    TreeFami TF328991.

    Enzyme and pathway databases

    SignaLinki Q8N9V3.

    Miscellaneous databases

    GenomeRNAii 151525.
    NextBioi 86717.
    PROi Q8N9V3.

    Gene expression databases

    ArrayExpressi Q8N9V3.
    Bgeei Q8N9V3.
    CleanExi HS_WDSUB1.
    Genevestigatori Q8N9V3.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.130.10.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR011047. Quinonprotein_ADH-like_supfam.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR003613. Ubox_domain.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF07647. SAM_2. 1 hit.
    PF04564. U-box. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00454. SAM. 1 hit.
    SM00504. Ubox. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF50998. SSF50998. 1 hit.
    PROSITEi PS50105. SAM_DOMAIN. 1 hit.
    PS51698. U_BOX. 1 hit.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-320.
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-223.
      Tissue: Brain.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiWSDU1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N9V3
    Secondary accession number(s): Q53TI9, Q8N6N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3