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Protein

WD repeat, SAM and U-box domain-containing protein 1

Gene

WDSUB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N9V3.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat, SAM and U-box domain-containing protein 1
Gene namesi
Name:WDSUB1
Synonyms:WDSAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26697. WDSUB1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394761.

Polymorphism and mutation databases

BioMutaiWDSUB1.
DMDMi229463016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476WD repeat, SAM and U-box domain-containing protein 1PRO_0000278608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei458 – 4581Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N9V3.
PaxDbiQ8N9V3.
PRIDEiQ8N9V3.

PTM databases

PhosphoSiteiQ8N9V3.

Expressioni

Gene expression databases

BgeeiQ8N9V3.
CleanExiHS_WDSUB1.
ExpressionAtlasiQ8N9V3. baseline and differential.
GenevisibleiQ8N9V3. HS.

Organism-specific databases

HPAiHPA036840.

Interactioni

Protein-protein interaction databases

BioGridi127386. 1 interaction.
STRINGi9606.ENSP00000352820.

Structurei

3D structure databases

ProteinModelPortaliQ8N9V3.
SMRiQ8N9V3. Positions 3-376, 401-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 4738WD 1Add
BLAST
Repeati52 – 9140WD 2Add
BLAST
Repeati95 – 13440WD 3Add
BLAST
Repeati137 – 17640WD 4Add
BLAST
Repeati178 – 22851WD 5Add
BLAST
Repeati237 – 27640WD 6Add
BLAST
Repeati279 – 31840WD 7Add
BLAST
Domaini332 – 39665SAMPROSITE-ProRule annotationAdd
BLAST
Domaini403 – 47674U-boxAdd
BLAST

Sequence similaritiesi

Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 U-box domain.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000231980.
HOVERGENiHBG080511.
InParanoidiQ8N9V3.
OrthoDBiEOG7K9K25.
PhylomeDBiQ8N9V3.
TreeFamiTF328991.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR003613. Ubox_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF04564. U-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00454. SAM. 1 hit.
SM00504. Ubox. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS51698. U_BOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9V3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL
60 70 80 90 100
KFHTYAVHCC CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV
110 120 130 140 150
RVCQFSPDST CLASGAADGT VVLWNAQSYK LYRCGSVKDG SLAACAFSPN
160 170 180 190 200
GSFFVTGSSC GDLTVWDDKM RCPHSEKAHD LGITCCDFSS QPVSDGEQGL
210 220 230 240 250
QFFRLASCGQ DCQVKIWIVS FTHILGFELK YKSTLSGHCA PVLACAFSHD
260 270 280 290 300
GQMLVSGSVD KSVIVYDTNT ENILHTLTQH TRYVTTCAFA PNTLLLATGS
310 320 330 340 350
MDKTVNIWQF DLETLCQARR TEHQLKQFTE DWSEEDVSTW LCAQDLKDLV
360 370 380 390 400
GIFKMNNIDG KELLNLTKES LADDLKIESL GLRSKVLRKI EELRTKVKSL
410 420 430 440 450
SSGIPDEFIC PITRELMKDP VIASDGYSYE KEAMENWISK KKRTSPMTNL
460 470
VLPSAVLTPN RTLKMAINRW LETHQK
Length:476
Mass (Da):52,817
Last modified:May 5, 2009 - v3
Checksum:iF53C643A768B6622
GO
Isoform 2 (identifier: Q8N9V3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-317: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,722
Checksum:iD23E018257ED0EBA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731P → L in BAC04184 (PubMed:14702039).Curated
Sequence conflicti173 – 1731P → L in AAH29520 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151K → T.
Corresponds to variant rs16843852 [ dbSNP | Ensembl ].
VAR_030791
Natural varianti223 – 2231H → D.1 Publication
Corresponds to variant rs17852677 [ dbSNP | Ensembl ].
VAR_030792
Natural varianti320 – 3201R → S.1 Publication
Corresponds to variant rs7591849 [ dbSNP | Ensembl ].
VAR_030793

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei226 – 31792Missing in isoform 2. 1 PublicationVSP_023337Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093494 mRNA. Translation: BAC04184.1.
AC008277 Genomic DNA. No translation available.
AC009307 Genomic DNA. Translation: AAX93043.1.
BC029520 mRNA. Translation: AAH29520.1.
CCDSiCCDS2208.1. [Q8N9V3-1]
CCDS77477.1. [Q8N9V3-2]
RefSeqiNP_001121684.1. NM_001128212.2.
NP_001294923.1. NM_001307994.1.
NP_689741.2. NM_152528.2.
UniGeneiHs.20848.

Genome annotation databases

EnsembliENST00000358147; ENSP00000350866; ENSG00000196151.
ENST00000359774; ENSP00000352820; ENSG00000196151.
ENST00000392796; ENSP00000376545; ENSG00000196151.
ENST00000409990; ENSP00000387078; ENSG00000196151.
GeneIDi151525.
KEGGihsa:151525.
UCSCiuc010foo.3. human. [Q8N9V3-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093494 mRNA. Translation: BAC04184.1.
AC008277 Genomic DNA. No translation available.
AC009307 Genomic DNA. Translation: AAX93043.1.
BC029520 mRNA. Translation: AAH29520.1.
CCDSiCCDS2208.1. [Q8N9V3-1]
CCDS77477.1. [Q8N9V3-2]
RefSeqiNP_001121684.1. NM_001128212.2.
NP_001294923.1. NM_001307994.1.
NP_689741.2. NM_152528.2.
UniGeneiHs.20848.

3D structure databases

ProteinModelPortaliQ8N9V3.
SMRiQ8N9V3. Positions 3-376, 401-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127386. 1 interaction.
STRINGi9606.ENSP00000352820.

PTM databases

PhosphoSiteiQ8N9V3.

Polymorphism and mutation databases

BioMutaiWDSUB1.
DMDMi229463016.

Proteomic databases

MaxQBiQ8N9V3.
PaxDbiQ8N9V3.
PRIDEiQ8N9V3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358147; ENSP00000350866; ENSG00000196151.
ENST00000359774; ENSP00000352820; ENSG00000196151.
ENST00000392796; ENSP00000376545; ENSG00000196151.
ENST00000409990; ENSP00000387078; ENSG00000196151.
GeneIDi151525.
KEGGihsa:151525.
UCSCiuc010foo.3. human. [Q8N9V3-2]

Organism-specific databases

CTDi151525.
GeneCardsiGC02M160092.
HGNCiHGNC:26697. WDSUB1.
HPAiHPA036840.
neXtProtiNX_Q8N9V3.
PharmGKBiPA128394761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000231980.
HOVERGENiHBG080511.
InParanoidiQ8N9V3.
OrthoDBiEOG7K9K25.
PhylomeDBiQ8N9V3.
TreeFamiTF328991.

Enzyme and pathway databases

SignaLinkiQ8N9V3.

Miscellaneous databases

ChiTaRSiWDSUB1. human.
GenomeRNAii151525.
NextBioi86717.
PROiQ8N9V3.

Gene expression databases

BgeeiQ8N9V3.
CleanExiHS_WDSUB1.
ExpressionAtlasiQ8N9V3. baseline and differential.
GenevisibleiQ8N9V3. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR003613. Ubox_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF04564. U-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00454. SAM. 1 hit.
SM00504. Ubox. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS51698. U_BOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-320.
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-223.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiWSDU1_HUMAN
AccessioniPrimary (citable) accession number: Q8N9V3
Secondary accession number(s): Q53TI9, Q8N6N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 5, 2009
Last modified: July 22, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.