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Q8N9V3

- WSDU1_HUMAN

UniProt

Q8N9V3 - WSDU1_HUMAN

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Protein

WD repeat, SAM and U-box domain-containing protein 1

Gene
WDSUB1, WDSAM1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N9V3.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat, SAM and U-box domain-containing protein 1
Gene namesi
Name:WDSUB1
Synonyms:WDSAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26697. WDSUB1.

Subcellular locationi

GO - Cellular componenti

  1. ubiquitin ligase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476WD repeat, SAM and U-box domain-containing protein 1PRO_0000278608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei458 – 4581Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N9V3.
PaxDbiQ8N9V3.
PRIDEiQ8N9V3.

PTM databases

PhosphoSiteiQ8N9V3.

Expressioni

Gene expression databases

ArrayExpressiQ8N9V3.
BgeeiQ8N9V3.
CleanExiHS_WDSUB1.
GenevestigatoriQ8N9V3.

Organism-specific databases

HPAiHPA036840.

Interactioni

Protein-protein interaction databases

BioGridi127386. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8N9V3.
SMRiQ8N9V3. Positions 3-378, 401-474.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 4738WD 1Add
BLAST
Repeati52 – 9140WD 2Add
BLAST
Repeati95 – 13440WD 3Add
BLAST
Repeati137 – 17640WD 4Add
BLAST
Repeati178 – 22851WD 5Add
BLAST
Repeati237 – 27640WD 6Add
BLAST
Repeati279 – 31840WD 7Add
BLAST
Domaini332 – 39665SAMAdd
BLAST
Domaini403 – 47674U-boxAdd
BLAST

Sequence similaritiesi

Contains 1 U-box domain.
Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000231980.
HOVERGENiHBG080511.
InParanoidiQ8N9V3.
OMAiSCGQDCQ.
OrthoDBiEOG7K9K25.
PhylomeDBiQ8N9V3.
TreeFamiTF328991.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR003613. Ubox_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF04564. U-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00454. SAM. 1 hit.
SM00504. Ubox. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS51698. U_BOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N9V3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL    50
KFHTYAVHCC CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV 100
RVCQFSPDST CLASGAADGT VVLWNAQSYK LYRCGSVKDG SLAACAFSPN 150
GSFFVTGSSC GDLTVWDDKM RCPHSEKAHD LGITCCDFSS QPVSDGEQGL 200
QFFRLASCGQ DCQVKIWIVS FTHILGFELK YKSTLSGHCA PVLACAFSHD 250
GQMLVSGSVD KSVIVYDTNT ENILHTLTQH TRYVTTCAFA PNTLLLATGS 300
MDKTVNIWQF DLETLCQARR TEHQLKQFTE DWSEEDVSTW LCAQDLKDLV 350
GIFKMNNIDG KELLNLTKES LADDLKIESL GLRSKVLRKI EELRTKVKSL 400
SSGIPDEFIC PITRELMKDP VIASDGYSYE KEAMENWISK KKRTSPMTNL 450
VLPSAVLTPN RTLKMAINRW LETHQK 476
Length:476
Mass (Da):52,817
Last modified:May 5, 2009 - v3
Checksum:iF53C643A768B6622
GO
Isoform 2 (identifier: Q8N9V3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-317: Missing.

Note: No experimental confirmation available.

Show »
Length:384
Mass (Da):42,722
Checksum:iD23E018257ED0EBA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151K → T.
Corresponds to variant rs16843852 [ dbSNP | Ensembl ].
VAR_030791
Natural varianti223 – 2231H → D.1 Publication
Corresponds to variant rs17852677 [ dbSNP | Ensembl ].
VAR_030792
Natural varianti320 – 3201R → S.1 Publication
Corresponds to variant rs7591849 [ dbSNP | Ensembl ].
VAR_030793

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei226 – 31792Missing in isoform 2. VSP_023337Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731P → L in BAC04184. 1 Publication
Sequence conflicti173 – 1731P → L in AAH29520. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093494 mRNA. Translation: BAC04184.1.
AC008277 Genomic DNA. No translation available.
AC009307 Genomic DNA. Translation: AAX93043.1.
BC029520 mRNA. Translation: AAH29520.1.
CCDSiCCDS2208.1. [Q8N9V3-1]
RefSeqiNP_001121684.1. NM_001128212.1.
NP_689741.2. NM_152528.2.
UniGeneiHs.20848.

Genome annotation databases

EnsembliENST00000358147; ENSP00000350866; ENSG00000196151. [Q8N9V3-2]
ENST00000359774; ENSP00000352820; ENSG00000196151. [Q8N9V3-1]
ENST00000392796; ENSP00000376545; ENSG00000196151. [Q8N9V3-1]
ENST00000409990; ENSP00000387078; ENSG00000196151. [Q8N9V3-1]
GeneIDi151525.
KEGGihsa:151525.
UCSCiuc010foo.3. human. [Q8N9V3-2]

Polymorphism databases

DMDMi229463016.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093494 mRNA. Translation: BAC04184.1 .
AC008277 Genomic DNA. No translation available.
AC009307 Genomic DNA. Translation: AAX93043.1 .
BC029520 mRNA. Translation: AAH29520.1 .
CCDSi CCDS2208.1. [Q8N9V3-1 ]
RefSeqi NP_001121684.1. NM_001128212.1.
NP_689741.2. NM_152528.2.
UniGenei Hs.20848.

3D structure databases

ProteinModelPortali Q8N9V3.
SMRi Q8N9V3. Positions 3-378, 401-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127386. 2 interactions.

PTM databases

PhosphoSitei Q8N9V3.

Polymorphism databases

DMDMi 229463016.

Proteomic databases

MaxQBi Q8N9V3.
PaxDbi Q8N9V3.
PRIDEi Q8N9V3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358147 ; ENSP00000350866 ; ENSG00000196151 . [Q8N9V3-2 ]
ENST00000359774 ; ENSP00000352820 ; ENSG00000196151 . [Q8N9V3-1 ]
ENST00000392796 ; ENSP00000376545 ; ENSG00000196151 . [Q8N9V3-1 ]
ENST00000409990 ; ENSP00000387078 ; ENSG00000196151 . [Q8N9V3-1 ]
GeneIDi 151525.
KEGGi hsa:151525.
UCSCi uc010foo.3. human. [Q8N9V3-2 ]

Organism-specific databases

CTDi 151525.
GeneCardsi GC02M160092.
HGNCi HGNC:26697. WDSUB1.
HPAi HPA036840.
neXtProti NX_Q8N9V3.
PharmGKBi PA128394761.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000231980.
HOVERGENi HBG080511.
InParanoidi Q8N9V3.
OMAi SCGQDCQ.
OrthoDBi EOG7K9K25.
PhylomeDBi Q8N9V3.
TreeFami TF328991.

Enzyme and pathway databases

SignaLinki Q8N9V3.

Miscellaneous databases

GenomeRNAii 151525.
NextBioi 86717.
PROi Q8N9V3.

Gene expression databases

ArrayExpressi Q8N9V3.
Bgeei Q8N9V3.
CleanExi HS_WDSUB1.
Genevestigatori Q8N9V3.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR003613. Ubox_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF07647. SAM_2. 1 hit.
PF04564. U-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00454. SAM. 1 hit.
SM00504. Ubox. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEi PS50105. SAM_DOMAIN. 1 hit.
PS51698. U_BOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-320.
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-223.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiWSDU1_HUMAN
AccessioniPrimary (citable) accession number: Q8N9V3
Secondary accession number(s): Q53TI9, Q8N6N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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