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Q8N9V3 (WSDU1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat, SAM and U-box domain-containing protein 1
Gene names
Name:WDSUB1
Synonyms:WDSAM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 SAM (sterile alpha motif) domain.

Contains 1 U-box domain.

Contains 7 WD repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentubiquitin ligase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionubiquitin-protein transferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N9V3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N9V3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     226-317: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476WD repeat, SAM and U-box domain-containing protein 1
PRO_0000278608

Regions

Repeat10 – 4738WD 1
Repeat52 – 9140WD 2
Repeat95 – 13440WD 3
Repeat137 – 17640WD 4
Repeat178 – 22851WD 5
Repeat237 – 27640WD 6
Repeat279 – 31840WD 7
Domain332 – 39665SAM
Domain403 – 47674U-box

Amino acid modifications

Modified residue4581Phosphothreonine Ref.4

Natural variations

Alternative sequence226 – 31792Missing in isoform 2.
VSP_023337
Natural variant2151K → T.
Corresponds to variant rs16843852 [ dbSNP | Ensembl ].
VAR_030791
Natural variant2231H → D. Ref.3
Corresponds to variant rs17852677 [ dbSNP | Ensembl ].
VAR_030792
Natural variant3201R → S. Ref.1
Corresponds to variant rs7591849 [ dbSNP | Ensembl ].
VAR_030793

Experimental info

Sequence conflict1731P → L in BAC04184. Ref.1
Sequence conflict1731P → L in AAH29520. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: F53C643A768B6622

FASTA47652,817
        10         20         30         40         50         60 
MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL KFHTYAVHCC 

        70         80         90        100        110        120 
CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV RVCQFSPDST CLASGAADGT 

       130        140        150        160        170        180 
VVLWNAQSYK LYRCGSVKDG SLAACAFSPN GSFFVTGSSC GDLTVWDDKM RCPHSEKAHD 

       190        200        210        220        230        240 
LGITCCDFSS QPVSDGEQGL QFFRLASCGQ DCQVKIWIVS FTHILGFELK YKSTLSGHCA 

       250        260        270        280        290        300 
PVLACAFSHD GQMLVSGSVD KSVIVYDTNT ENILHTLTQH TRYVTTCAFA PNTLLLATGS 

       310        320        330        340        350        360 
MDKTVNIWQF DLETLCQARR TEHQLKQFTE DWSEEDVSTW LCAQDLKDLV GIFKMNNIDG 

       370        380        390        400        410        420 
KELLNLTKES LADDLKIESL GLRSKVLRKI EELRTKVKSL SSGIPDEFIC PITRELMKDP 

       430        440        450        460        470 
VIASDGYSYE KEAMENWISK KKRTSPMTNL VLPSAVLTPN RTLKMAINRW LETHQK 

« Hide

Isoform 2 [UniParc].

Checksum: D23E018257ED0EBA
Show »

FASTA38442,722

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-320.
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-223.
Tissue: Brain.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK093494 mRNA. Translation: BAC04184.1.
AC008277 Genomic DNA. No translation available.
AC009307 Genomic DNA. Translation: AAX93043.1.
BC029520 mRNA. Translation: AAH29520.1.
CCDSCCDS2208.1. [Q8N9V3-1]
RefSeqNP_001121684.1. NM_001128212.1.
NP_689741.2. NM_152528.2.
UniGeneHs.20848.

3D structure databases

ProteinModelPortalQ8N9V3.
SMRQ8N9V3. Positions 3-378, 401-474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127386. 2 interactions.

PTM databases

PhosphoSiteQ8N9V3.

Polymorphism databases

DMDM229463016.

Proteomic databases

MaxQBQ8N9V3.
PaxDbQ8N9V3.
PRIDEQ8N9V3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358147; ENSP00000350866; ENSG00000196151. [Q8N9V3-2]
ENST00000359774; ENSP00000352820; ENSG00000196151. [Q8N9V3-1]
ENST00000392796; ENSP00000376545; ENSG00000196151. [Q8N9V3-1]
ENST00000409990; ENSP00000387078; ENSG00000196151. [Q8N9V3-1]
GeneID151525.
KEGGhsa:151525.
UCSCuc010foo.3. human. [Q8N9V3-2]

Organism-specific databases

CTD151525.
GeneCardsGC02M160092.
HGNCHGNC:26697. WDSUB1.
HPAHPA036840.
neXtProtNX_Q8N9V3.
PharmGKBPA128394761.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000231980.
HOVERGENHBG080511.
InParanoidQ8N9V3.
OMASCGQDCQ.
OrthoDBEOG7K9K25.
PhylomeDBQ8N9V3.
TreeFamTF328991.

Enzyme and pathway databases

SignaLinkQ8N9V3.

Gene expression databases

ArrayExpressQ8N9V3.
BgeeQ8N9V3.
CleanExHS_WDSUB1.
GenevestigatorQ8N9V3.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR003613. Ubox_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF07647. SAM_2. 1 hit.
PF04564. U-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00454. SAM. 1 hit.
SM00504. Ubox. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEPS50105. SAM_DOMAIN. 1 hit.
PS51698. U_BOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi151525.
NextBio86717.
PROQ8N9V3.

Entry information

Entry nameWSDU1_HUMAN
AccessionPrimary (citable) accession number: Q8N9V3
Secondary accession number(s): Q53TI9, Q8N6N8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM