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Protein

WD repeat, SAM and U-box domain-containing protein 1

Gene

WDSUB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiQ8N9V3

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat, SAM and U-box domain-containing protein 1
Gene namesi
Name:WDSUB1
Synonyms:WDSAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000196151.10
HGNCiHGNC:26697 WDSUB1
neXtProtiNX_Q8N9V3

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394761

Polymorphism and mutation databases

BioMutaiWDSUB1
DMDMi229463016

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786081 – 476WD repeat, SAM and U-box domain-containing protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei458PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9V3
MaxQBiQ8N9V3
PaxDbiQ8N9V3
PeptideAtlasiQ8N9V3
PRIDEiQ8N9V3

PTM databases

iPTMnetiQ8N9V3
PhosphoSitePlusiQ8N9V3

Expressioni

Gene expression databases

BgeeiENSG00000196151
CleanExiHS_WDSUB1
ExpressionAtlasiQ8N9V3 baseline and differential
GenevisibleiQ8N9V3 HS

Organism-specific databases

HPAiHPA036840
HPA058172

Interactioni

Protein-protein interaction databases

BioGridi127386, 1 interactor
STRINGi9606.ENSP00000352820

Structurei

3D structure databases

ProteinModelPortaliQ8N9V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 47WD 1Add BLAST38
Repeati52 – 91WD 2Add BLAST40
Repeati95 – 134WD 3Add BLAST40
Repeati137 – 176WD 4Add BLAST40
Repeati178 – 228WD 5Add BLAST51
Repeati237 – 276WD 6Add BLAST40
Repeati279 – 318WD 7Add BLAST40
Domaini332 – 396SAMPROSITE-ProRule annotationAdd BLAST65
Domaini403 – 476U-boxAdd BLAST74

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410ISIY Eukaryota
ENOG410XRM4 LUCA
HOGENOMiHOG000231980
HOVERGENiHBG080511
InParanoidiQ8N9V3
OrthoDBiEOG091G0F4M
PhylomeDBiQ8N9V3
TreeFamiTF328991

Family and domain databases

Gene3Di2.130.10.10, 3 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR003613 Ubox_domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF04564 U-box, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SM00504 Ubox, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS51698 U_BOX, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9V3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL
60 70 80 90 100
KFHTYAVHCC CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV
110 120 130 140 150
RVCQFSPDST CLASGAADGT VVLWNAQSYK LYRCGSVKDG SLAACAFSPN
160 170 180 190 200
GSFFVTGSSC GDLTVWDDKM RCPHSEKAHD LGITCCDFSS QPVSDGEQGL
210 220 230 240 250
QFFRLASCGQ DCQVKIWIVS FTHILGFELK YKSTLSGHCA PVLACAFSHD
260 270 280 290 300
GQMLVSGSVD KSVIVYDTNT ENILHTLTQH TRYVTTCAFA PNTLLLATGS
310 320 330 340 350
MDKTVNIWQF DLETLCQARR TEHQLKQFTE DWSEEDVSTW LCAQDLKDLV
360 370 380 390 400
GIFKMNNIDG KELLNLTKES LADDLKIESL GLRSKVLRKI EELRTKVKSL
410 420 430 440 450
SSGIPDEFIC PITRELMKDP VIASDGYSYE KEAMENWISK KKRTSPMTNL
460 470
VLPSAVLTPN RTLKMAINRW LETHQK
Length:476
Mass (Da):52,817
Last modified:May 5, 2009 - v3
Checksum:iF53C643A768B6622
GO
Isoform 2 (identifier: Q8N9V3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-317: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,722
Checksum:iD23E018257ED0EBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173P → L in BAC04184 (PubMed:14702039).Curated1
Sequence conflicti173P → L in AAH29520 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030791215K → T. Corresponds to variant dbSNP:rs16843852Ensembl.1
Natural variantiVAR_030792223H → D1 PublicationCorresponds to variant dbSNP:rs17852677Ensembl.1
Natural variantiVAR_030793320R → S1 PublicationCorresponds to variant dbSNP:rs7591849Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023337226 – 317Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093494 mRNA Translation: BAC04184.1
AC008277 Genomic DNA No translation available.
AC009307 Genomic DNA Translation: AAX93043.1
BC029520 mRNA Translation: AAH29520.1
CCDSiCCDS2208.1 [Q8N9V3-1]
CCDS77477.1 [Q8N9V3-2]
RefSeqiNP_001121684.1, NM_001128212.2
NP_001294923.1, NM_001307994.1
NP_689741.2, NM_152528.2
UniGeneiHs.20848

Genome annotation databases

EnsembliENST00000358147; ENSP00000350866; ENSG00000196151
ENST00000359774; ENSP00000352820; ENSG00000196151
ENST00000392796; ENSP00000376545; ENSG00000196151
ENST00000409990; ENSP00000387078; ENSG00000196151
GeneIDi151525
KEGGihsa:151525
UCSCiuc002uaj.5 human [Q8N9V3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWSDU1_HUMAN
AccessioniPrimary (citable) accession number: Q8N9V3
Secondary accession number(s): Q53TI9, Q8N6N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 5, 2009
Last modified: April 25, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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