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Protein

Probable E3 ubiquitin-protein ligase TRIML1

Gene

TRIML1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32843-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase TRIML1 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 209
Tripartite motif family-like protein 1
Gene namesi
Name:TRIML1
Synonyms:RNF209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26698. TRIML1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184108.
PharmGKBiPA162407030.

Polymorphism and mutation databases

BioMutaiTRIML1.
DMDMi74729772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745981 – 468Probable E3 ubiquitin-protein ligase TRIML1Add BLAST468

Proteomic databases

EPDiQ8N9V2.
PaxDbiQ8N9V2.
PeptideAtlasiQ8N9V2.
PRIDEiQ8N9V2.

PTM databases

iPTMnetiQ8N9V2.
PhosphoSitePlusiQ8N9V2.

Expressioni

Gene expression databases

BgeeiENSG00000184108.
CleanExiHS_TRIML1.
GenevisibleiQ8N9V2. HS.

Interactioni

Subunit structurei

Interacts with USP5.By similarity

Protein-protein interaction databases

BioGridi130974. 4 interactors.
IntActiQ8N9V2. 2 interactors.
STRINGi9606.ENSP00000327738.

Structurei

3D structure databases

ProteinModelPortaliQ8N9V2.
SMRiQ8N9V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 468B30.2/SPRYPROSITE-ProRule annotationAdd BLAST202

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili133 – 158Sequence analysisAdd BLAST26
Coiled coili184 – 237Sequence analysisAdd BLAST54

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129725.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8N9V2.
KOiK12038.
OMAiEETKACK.
OrthoDBiEOG091G05W2.
PhylomeDBiQ8N9V2.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N9V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTADLMENL REELTCFICL DYFSSPVTTE CGHSFCLVCL LRSWEEHNTP
60 70 80 90 100
LSCPECWRTL EGPHFQSNER LGRLASIARQ LRSQVLQSED EQGSYGRMPT
110 120 130 140 150
TAKALSDDEQ GGSAFVAQSH GANRVHLSSE AEEHHREKLQ EILNLLRVRR
160 170 180 190 200
KEAQAVLTHE KERVKLCQEE TKTCKQVVVS EYMKMHQFLK EEEQLQLQLL
210 220 230 240 250
EQEEKENMRK LRNNEIKLTQ QIRSLSKMIA QIESSSQSSA FESLEEVRGA
260 270 280 290 300
LERSEPLLLQ CPEATTTELS LCRITGMKEM LRKFSTEITL DPATANAYLV
310 320 330 340 350
LSEDLKSVKY GGSRQQLPDN PERFDQSATV LGTQIFTSGR HYWEVEVGNK
360 370 380 390 400
TEWEVGICKD SVSRKGNLPK PPGDLFSLIG LKIGDDYSLW VSSPLKGQHV
410 420 430 440 450
REPVCKVGVF LDYESGHIAF YNGTDESLIY SFPQASFQEA LRPIFSPCLP
460
NEGTNTDPLT ICSLNSHV
Length:468
Mass (Da):53,002
Last modified:October 1, 2002 - v1
Checksum:i66F9E2DABC5C96B8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03596321D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_052145132E → K.Corresponds to variant rs13131525dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093499 mRNA. Translation: BAC04185.1.
AC138781 Genomic DNA. No translation available.
BC015684 mRNA. Translation: AAH15684.1.
BC113860 mRNA. Translation: AAI13861.1.
BC114469 mRNA. Translation: AAI14470.1.
CCDSiCCDS3851.1.
RefSeqiNP_848651.2. NM_178556.4.
UniGeneiHs.348618.

Genome annotation databases

EnsembliENST00000332517; ENSP00000327738; ENSG00000184108.
GeneIDi339976.
KEGGihsa:339976.
UCSCiuc003izm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093499 mRNA. Translation: BAC04185.1.
AC138781 Genomic DNA. No translation available.
BC015684 mRNA. Translation: AAH15684.1.
BC113860 mRNA. Translation: AAI13861.1.
BC114469 mRNA. Translation: AAI14470.1.
CCDSiCCDS3851.1.
RefSeqiNP_848651.2. NM_178556.4.
UniGeneiHs.348618.

3D structure databases

ProteinModelPortaliQ8N9V2.
SMRiQ8N9V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130974. 4 interactors.
IntActiQ8N9V2. 2 interactors.
STRINGi9606.ENSP00000327738.

PTM databases

iPTMnetiQ8N9V2.
PhosphoSitePlusiQ8N9V2.

Polymorphism and mutation databases

BioMutaiTRIML1.
DMDMi74729772.

Proteomic databases

EPDiQ8N9V2.
PaxDbiQ8N9V2.
PeptideAtlasiQ8N9V2.
PRIDEiQ8N9V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332517; ENSP00000327738; ENSG00000184108.
GeneIDi339976.
KEGGihsa:339976.
UCSCiuc003izm.2. human.

Organism-specific databases

CTDi339976.
GeneCardsiTRIML1.
HGNCiHGNC:26698. TRIML1.
neXtProtiNX_Q8N9V2.
OpenTargetsiENSG00000184108.
PharmGKBiPA162407030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129725.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8N9V2.
KOiK12038.
OMAiEETKACK.
OrthoDBiEOG091G05W2.
PhylomeDBiQ8N9V2.
TreeFamiTF338674.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:G66-32843-MONOMER.

Miscellaneous databases

GenomeRNAii339976.
PROiQ8N9V2.

Gene expression databases

BgeeiENSG00000184108.
CleanExiHS_TRIML1.
GenevisibleiQ8N9V2. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRIML_HUMAN
AccessioniPrimary (citable) accession number: Q8N9V2
Secondary accession number(s): Q96BE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.