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Q8N9V2

- TRIML_HUMAN

UniProt

Q8N9V2 - TRIML_HUMAN

Protein

Probable E3 ubiquitin-protein ligase TRIML1

Gene

TRIML1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Developmental protein, Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIML1 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 209
    Tripartite motif family-like protein 1
    Gene namesi
    Name:TRIML1
    Synonyms:RNF209
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26698. TRIML1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162407030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Probable E3 ubiquitin-protein ligase TRIML1PRO_0000274598Add
    BLAST

    Proteomic databases

    PaxDbiQ8N9V2.
    PeptideAtlasiQ8N9V2.
    PRIDEiQ8N9V2.

    PTM databases

    PhosphoSiteiQ8N9V2.

    Expressioni

    Gene expression databases

    BgeeiQ8N9V2.
    CleanExiHS_TRIML1.
    GenevestigatoriQ8N9V2.

    Organism-specific databases

    HPAiHPA037769.

    Interactioni

    Subunit structurei

    Interacts with USP5.By similarity

    Protein-protein interaction databases

    BioGridi130974. 4 interactions.
    IntActiQ8N9V2. 2 interactions.
    STRINGi9606.ENSP00000327738.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N9V2.
    SMRiQ8N9V2. Positions 7-56, 288-464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini267 – 468202B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili133 – 15826Sequence AnalysisAdd
    BLAST
    Coiled coili184 – 23754Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 5742RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG267050.
    HOGENOMiHOG000234133.
    HOVERGENiHBG001357.
    InParanoidiQ8N9V2.
    KOiK12038.
    OMAiELTLCRI.
    OrthoDBiEOG7M3J02.
    PhylomeDBiQ8N9V2.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N9V2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTADLMENL REELTCFICL DYFSSPVTTE CGHSFCLVCL LRSWEEHNTP    50
    LSCPECWRTL EGPHFQSNER LGRLASIARQ LRSQVLQSED EQGSYGRMPT 100
    TAKALSDDEQ GGSAFVAQSH GANRVHLSSE AEEHHREKLQ EILNLLRVRR 150
    KEAQAVLTHE KERVKLCQEE TKTCKQVVVS EYMKMHQFLK EEEQLQLQLL 200
    EQEEKENMRK LRNNEIKLTQ QIRSLSKMIA QIESSSQSSA FESLEEVRGA 250
    LERSEPLLLQ CPEATTTELS LCRITGMKEM LRKFSTEITL DPATANAYLV 300
    LSEDLKSVKY GGSRQQLPDN PERFDQSATV LGTQIFTSGR HYWEVEVGNK 350
    TEWEVGICKD SVSRKGNLPK PPGDLFSLIG LKIGDDYSLW VSSPLKGQHV 400
    REPVCKVGVF LDYESGHIAF YNGTDESLIY SFPQASFQEA LRPIFSPCLP 450
    NEGTNTDPLT ICSLNSHV 468
    Length:468
    Mass (Da):53,002
    Last modified:October 1, 2002 - v1
    Checksum:i66F9E2DABC5C96B8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211D → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035963
    Natural varianti132 – 1321E → K.
    Corresponds to variant rs13131525 [ dbSNP | Ensembl ].
    VAR_052145

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093499 mRNA. Translation: BAC04185.1.
    AC138781 Genomic DNA. No translation available.
    BC015684 mRNA. Translation: AAH15684.1.
    BC113860 mRNA. Translation: AAI13861.1.
    BC114469 mRNA. Translation: AAI14470.1.
    CCDSiCCDS3851.1.
    RefSeqiNP_848651.2. NM_178556.3.
    UniGeneiHs.348618.

    Genome annotation databases

    EnsembliENST00000332517; ENSP00000327738; ENSG00000184108.
    GeneIDi339976.
    KEGGihsa:339976.
    UCSCiuc003izm.1. human.

    Polymorphism databases

    DMDMi74729772.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093499 mRNA. Translation: BAC04185.1 .
    AC138781 Genomic DNA. No translation available.
    BC015684 mRNA. Translation: AAH15684.1 .
    BC113860 mRNA. Translation: AAI13861.1 .
    BC114469 mRNA. Translation: AAI14470.1 .
    CCDSi CCDS3851.1.
    RefSeqi NP_848651.2. NM_178556.3.
    UniGenei Hs.348618.

    3D structure databases

    ProteinModelPortali Q8N9V2.
    SMRi Q8N9V2. Positions 7-56, 288-464.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130974. 4 interactions.
    IntActi Q8N9V2. 2 interactions.
    STRINGi 9606.ENSP00000327738.

    PTM databases

    PhosphoSitei Q8N9V2.

    Polymorphism databases

    DMDMi 74729772.

    Proteomic databases

    PaxDbi Q8N9V2.
    PeptideAtlasi Q8N9V2.
    PRIDEi Q8N9V2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332517 ; ENSP00000327738 ; ENSG00000184108 .
    GeneIDi 339976.
    KEGGi hsa:339976.
    UCSCi uc003izm.1. human.

    Organism-specific databases

    CTDi 339976.
    GeneCardsi GC04P189060.
    HGNCi HGNC:26698. TRIML1.
    HPAi HPA037769.
    neXtProti NX_Q8N9V2.
    PharmGKBi PA162407030.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267050.
    HOGENOMi HOG000234133.
    HOVERGENi HBG001357.
    InParanoidi Q8N9V2.
    KOi K12038.
    OMAi ELTLCRI.
    OrthoDBi EOG7M3J02.
    PhylomeDBi Q8N9V2.
    TreeFami TF338674.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GenomeRNAii 339976.
    NextBioi 97650.
    PROi Q8N9V2.

    Gene expression databases

    Bgeei Q8N9V2.
    CleanExi HS_TRIML1.
    Genevestigatori Q8N9V2.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-21.

    Entry informationi

    Entry nameiTRIML_HUMAN
    AccessioniPrimary (citable) accession number: Q8N9V2
    Secondary accession number(s): Q96BE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3