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Q8N9V2

- TRIML_HUMAN

UniProt

Q8N9V2 - TRIML_HUMAN

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Protein
Probable E3 ubiquitin-protein ligase TRIML1
Gene
TRIML1, RNF209
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 5742RING-type
Add
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase TRIML1 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 209
Tripartite motif family-like protein 1
Gene namesi
Name:TRIML1
Synonyms:RNF209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:26698. TRIML1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Probable E3 ubiquitin-protein ligase TRIML1
PRO_0000274598Add
BLAST

Proteomic databases

PaxDbiQ8N9V2.
PeptideAtlasiQ8N9V2.
PRIDEiQ8N9V2.

PTM databases

PhosphoSiteiQ8N9V2.

Expressioni

Gene expression databases

BgeeiQ8N9V2.
CleanExiHS_TRIML1.
GenevestigatoriQ8N9V2.

Organism-specific databases

HPAiHPA037769.

Interactioni

Subunit structurei

Interacts with USP5 By similarity.

Protein-protein interaction databases

BioGridi130974. 4 interactions.
IntActiQ8N9V2. 2 interactions.
STRINGi9606.ENSP00000327738.

Structurei

3D structure databases

ProteinModelPortaliQ8N9V2.
SMRiQ8N9V2. Positions 7-56, 288-464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 468202B30.2/SPRY
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili133 – 15826 Reviewed prediction
Add
BLAST
Coiled coili184 – 23754 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG267050.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8N9V2.
KOiK12038.
OMAiELTLCRI.
OrthoDBiEOG7M3J02.
PhylomeDBiQ8N9V2.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N9V2-1 [UniParc]FASTAAdd to Basket

« Hide

MSTADLMENL REELTCFICL DYFSSPVTTE CGHSFCLVCL LRSWEEHNTP    50
LSCPECWRTL EGPHFQSNER LGRLASIARQ LRSQVLQSED EQGSYGRMPT 100
TAKALSDDEQ GGSAFVAQSH GANRVHLSSE AEEHHREKLQ EILNLLRVRR 150
KEAQAVLTHE KERVKLCQEE TKTCKQVVVS EYMKMHQFLK EEEQLQLQLL 200
EQEEKENMRK LRNNEIKLTQ QIRSLSKMIA QIESSSQSSA FESLEEVRGA 250
LERSEPLLLQ CPEATTTELS LCRITGMKEM LRKFSTEITL DPATANAYLV 300
LSEDLKSVKY GGSRQQLPDN PERFDQSATV LGTQIFTSGR HYWEVEVGNK 350
TEWEVGICKD SVSRKGNLPK PPGDLFSLIG LKIGDDYSLW VSSPLKGQHV 400
REPVCKVGVF LDYESGHIAF YNGTDESLIY SFPQASFQEA LRPIFSPCLP 450
NEGTNTDPLT ICSLNSHV 468
Length:468
Mass (Da):53,002
Last modified:October 1, 2002 - v1
Checksum:i66F9E2DABC5C96B8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211D → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_035963
Natural varianti132 – 1321E → K.
Corresponds to variant rs13131525 [ dbSNP | Ensembl ].
VAR_052145

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093499 mRNA. Translation: BAC04185.1.
AC138781 Genomic DNA. No translation available.
BC015684 mRNA. Translation: AAH15684.1.
BC113860 mRNA. Translation: AAI13861.1.
BC114469 mRNA. Translation: AAI14470.1.
CCDSiCCDS3851.1.
RefSeqiNP_848651.2. NM_178556.3.
UniGeneiHs.348618.

Genome annotation databases

EnsembliENST00000332517; ENSP00000327738; ENSG00000184108.
GeneIDi339976.
KEGGihsa:339976.
UCSCiuc003izm.1. human.

Polymorphism databases

DMDMi74729772.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093499 mRNA. Translation: BAC04185.1 .
AC138781 Genomic DNA. No translation available.
BC015684 mRNA. Translation: AAH15684.1 .
BC113860 mRNA. Translation: AAI13861.1 .
BC114469 mRNA. Translation: AAI14470.1 .
CCDSi CCDS3851.1.
RefSeqi NP_848651.2. NM_178556.3.
UniGenei Hs.348618.

3D structure databases

ProteinModelPortali Q8N9V2.
SMRi Q8N9V2. Positions 7-56, 288-464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130974. 4 interactions.
IntActi Q8N9V2. 2 interactions.
STRINGi 9606.ENSP00000327738.

PTM databases

PhosphoSitei Q8N9V2.

Polymorphism databases

DMDMi 74729772.

Proteomic databases

PaxDbi Q8N9V2.
PeptideAtlasi Q8N9V2.
PRIDEi Q8N9V2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332517 ; ENSP00000327738 ; ENSG00000184108 .
GeneIDi 339976.
KEGGi hsa:339976.
UCSCi uc003izm.1. human.

Organism-specific databases

CTDi 339976.
GeneCardsi GC04P189060.
HGNCi HGNC:26698. TRIML1.
HPAi HPA037769.
neXtProti NX_Q8N9V2.
PharmGKBi PA162407030.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267050.
HOGENOMi HOG000234133.
HOVERGENi HBG001357.
InParanoidi Q8N9V2.
KOi K12038.
OMAi ELTLCRI.
OrthoDBi EOG7M3J02.
PhylomeDBi Q8N9V2.
TreeFami TF338674.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GenomeRNAii 339976.
NextBioi 97650.
PROi Q8N9V2.

Gene expression databases

Bgeei Q8N9V2.
CleanExi HS_TRIML1.
Genevestigatori Q8N9V2.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-21.

Entry informationi

Entry nameiTRIML_HUMAN
AccessioniPrimary (citable) accession number: Q8N9V2
Secondary accession number(s): Q96BE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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