Q8N9V2 (TRIML_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable E3 ubiquitin-protein ligase TRIML1
EC=6.3.2.-

Alternative name(s):
RING finger protein 209
Tripartite motif family-like protein 1

Gene names

Name:	TRIML1
Synonyms:	RNF209

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with USP5 By similarity.
Sequence similarities	Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Developmental protein Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ligase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Probable E3 ubiquitin-protein ligase TRIML1		PRO_0000274598
Regions
	Domain	267 – 468	202	B30.2/SPRY
	Zinc finger	16 – 57	42	RING-type
	Coiled coil	133 – 158	26	Potential
	Coiled coil	184 – 237	54	Potential
Natural variations
	Natural variant	21	1	D → H in a breast cancer sample; somatic mutation. Ref.4		VAR_035963
	Natural variant	132	1	E → K. Corresponds to variant rs13131525 [ dbSNP | Ensembl ].		VAR_052145

Sequences

	Sequence		Length	Mass (Da)
	Q8N9V2 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 66F9E2DABC5C96B8	FASTA	468	53,002
	10 20 30 40 50 60 MSTADLMENL REELTCFICL DYFSSPVTTE CGHSFCLVCL LRSWEEHNTP LSCPECWRTL 70 80 90 100 110 120 EGPHFQSNER LGRLASIARQ LRSQVLQSED EQGSYGRMPT TAKALSDDEQ GGSAFVAQSH 130 140 150 160 170 180 GANRVHLSSE AEEHHREKLQ EILNLLRVRR KEAQAVLTHE KERVKLCQEE TKTCKQVVVS 190 200 210 220 230 240 EYMKMHQFLK EEEQLQLQLL EQEEKENMRK LRNNEIKLTQ QIRSLSKMIA QIESSSQSSA 250 260 270 280 290 300 FESLEEVRGA LERSEPLLLQ CPEATTTELS LCRITGMKEM LRKFSTEITL DPATANAYLV 310 320 330 340 350 360 LSEDLKSVKY GGSRQQLPDN PERFDQSATV LGTQIFTSGR HYWEVEVGNK TEWEVGICKD 370 380 390 400 410 420 SVSRKGNLPK PPGDLFSLIG LKIGDDYSLW VSSPLKGQHV REPVCKVGVF LDYESGHIAF 430 440 450 460 YNGTDESLIY SFPQASFQEA LRPIFSPCLP NEGTNTDPLT ICSLNSHV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-21.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093499 mRNA. Translation: BAC04185.1. AC138781 Genomic DNA. No translation available. BC015684 mRNA. Translation: AAH15684.1. BC113860 mRNA. Translation: AAI13861.1. BC114469 mRNA. Translation: AAI14470.1.
IPI	IPI00167821.
RefSeq	NP_848651.2. NM_178556.3.
UniGene	Hs.348618.
3D structure databases
HSSP	HSSP built from PDB template 2CKL based on UniProtKB Q9CQJ4.
ProteinModelPortal	Q8N9V2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N9V2. 2 interactions.
STRING	9606.ENSP00000327738.
PTM databases
PhosphoSite	Q8N9V2.
Polymorphism databases
DMDM	74729772.
Proteomic databases
PaxDb	Q8N9V2.
PeptideAtlas	Q8N9V2.
PRIDE	Q8N9V2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332517; ENSP00000327738; ENSG00000184108.
GeneID	339976.
KEGG	hsa:339976.
UCSC	uc003izm.1. human.
Organism-specific databases
CTD	339976.
GeneCards	GC04P189060.
HGNC	HGNC:26698. TRIML1.
HPA	HPA037769.
neXtProt	NX_Q8N9V2.
PharmGKB	PA162407030.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267050.
HOGENOM	HOG000234133.
HOVERGEN	HBG001357.
InParanoid	Q8N9V2.
KO	K12038.
OMA	GSYGRMP.
OrthoDB	EOG41C6W4.
PhylomeDB	Q8N9V2.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Bgee	Q8N9V2.
CleanEx	HS_TRIML1.
Genevestigator	Q8N9V2.
Family and domain databases
Gene3D	3.30.40.10. 2 hits.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR006574. PRY. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00589. PRY. 1 hit. SM00184. RING. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	339976.
NextBio	97650.

Entry information

Entry name

TRIML_HUMAN

Accession

Primary (citable) accession number: Q8N9V2
Secondary accession number(s): Q96BE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.