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Protein

Tandem C2 domains nuclear protein

Gene

TC2N

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • regulation of blood coagulation Source: UniProtKB
  • regulation of gene expression Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tandem C2 domains nuclear protein
Alternative name(s):
Membrane targeting tandem C2 domain-containing protein 1
Tandem C2 protein in nucleus
Short name:
Tac2-N
Gene namesi
Name:TC2N
Synonyms:C14orf47, MTAC2D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165929.12.
HGNCiHGNC:19859. TC2N.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165929.
PharmGKBiPA162405395.

Polymorphism and mutation databases

BioMutaiTC2N.
DMDMi317373282.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724141 – 490Tandem C2 domains nuclear proteinAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei218PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9U0.
MaxQBiQ8N9U0.
PaxDbiQ8N9U0.
PeptideAtlasiQ8N9U0.
PRIDEiQ8N9U0.

PTM databases

iPTMnetiQ8N9U0.
PhosphoSitePlusiQ8N9U0.
SwissPalmiQ8N9U0.

Expressioni

Gene expression databases

BgeeiENSG00000165929.
CleanExiHS_TC2N.
ExpressionAtlasiQ8N9U0. baseline and differential.
GenevisibleiQ8N9U0. HS.

Organism-specific databases

HPAiHPA027549.

Interactioni

Protein-protein interaction databases

BioGridi125812. 4 interactors.
STRINGi9606.ENSP00000343199.

Structurei

3D structure databases

ProteinModelPortaliQ8N9U0.
SMRiQ8N9U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini353 – 456C2PROSITE-ProRule annotationAdd BLAST104

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi447 – 449Nuclear localization signalSequence analysis3

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00390000009196.
HOGENOMiHOG000133064.
HOVERGENiHBG056511.
InParanoidiQ8N9U0.
KOiK17287.
OMAiMETFVFA.
OrthoDBiEOG091G06AP.
PhylomeDBiQ8N9U0.
TreeFamiTF317035.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR030542. Tac2-N.
PANTHERiPTHR10024:SF5. PTHR10024:SF5. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
SMARTiView protein in SMART
SM00239. C2. 2 hits.
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEFIKSCC GGCFYGETEK HNFSVERDFK AAVPNSQNAT ISVPPLTSVS
60 70 80 90 100
VKPQLGCTED YLLSKLPSDG KEVPFVVPKF KLSYIQPRTQ ETPSHLEELE
110 120 130 140 150
GSARASFGDR KVELSSSSQH GPSYDVYNPF YMYQHISPDL SRRFPPRSEV
160 170 180 190 200
KRLYGSVCDL RTNKLPGSPG LSKSMFDLTN SSQRFIQRHD SLSSVPSSSS
210 220 230 240 250
SRKNSQGSNR SLDTITLSGD ERDFGRLNVK LFYNSSVEQI WITVLQCRDL
260 270 280 290 300
SWPSSYGDTP TVSIKGILTL PKPVHFKSSA KEGSNAIEFM ETFVFAIKLQ
310 320 330 340 350
NLQTVRLVFK IQTQTPRKKT IGECSMSLRT LSTQEMDYSL DITPPSKISV
360 370 380 390 400
CHAELELGTC FQAVNSRIQL QILEARYLPS SSTPLTLSFF VKVGMFSSGE
410 420 430 440 450
LIYKKKTRLL KASNGRVKWG ETMIFPLIQS EKEIVFLIKL YSRSSVRRKH
460 470 480 490
FVGQIWISED SNNIEAVNQW KETVINPEKV VIRWHKLNPS
Length:490
Mass (Da):55,284
Last modified:January 11, 2011 - v2
Checksum:i5606E022D6584200
GO
Isoform 2 (identifier: Q8N9U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-349: Missing.

Note: No experimental confirmation available.
Show »
Length:426
Mass (Da):47,948
Checksum:iD86D1D04A985223D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60D → G in BAC86538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051405151K → T2 PublicationsCorresponds to variant dbSNP:rs2402073Ensembl.1
Natural variantiVAR_051406172S → N. Corresponds to variant dbSNP:rs8020529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008572286 – 349Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093876 mRNA. Translation: BAC04238.1.
AK126359 mRNA. Translation: BAC86538.1.
AL121839 Genomic DNA. No translation available.
BC040503 mRNA. Translation: AAH40503.1.
CCDSiCCDS73679.1. [Q8N9U0-2]
CCDS9897.1. [Q8N9U0-1]
RefSeqiNP_001122067.1. NM_001128595.2.
NP_001122068.1. NM_001128596.2.
NP_001276063.1. NM_001289134.1.
NP_689545.1. NM_152332.5.
UniGeneiHs.510262.

Genome annotation databases

EnsembliENST00000340892; ENSP00000343199; ENSG00000165929. [Q8N9U0-1]
ENST00000360594; ENSP00000353802; ENSG00000165929. [Q8N9U0-1]
ENST00000435962; ENSP00000387882; ENSG00000165929. [Q8N9U0-1]
ENST00000556018; ENSP00000451317; ENSG00000165929. [Q8N9U0-2]
ENST00000610758; ENSP00000483305; ENSG00000276776. [Q8N9U0-1]
ENST00000620359; ENSP00000478127; ENSG00000276776. [Q8N9U0-1]
ENST00000632584; ENSP00000487608; ENSG00000276776. [Q8N9U0-1]
ENST00000634120; ENSP00000488431; ENSG00000276776. [Q8N9U0-2]
GeneIDi123036.
KEGGihsa:123036.
UCSCiuc001xzt.6. human. [Q8N9U0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAC2N_HUMAN
AccessioniPrimary (citable) accession number: Q8N9U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 11, 2011
Last modified: October 25, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations