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Protein

Protein KRI1 homolog

Gene

KRI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KRI1 homolog
Gene namesi
Name:KRI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25769. KRI1.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393682.

Polymorphism and mutation databases

BioMutaiKRI1.
DMDMi550544300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989761 – 703Protein KRI1 homologAdd BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphothreonineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei622PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9T8.
MaxQBiQ8N9T8.
PaxDbiQ8N9T8.
PeptideAtlasiQ8N9T8.
PRIDEiQ8N9T8.

PTM databases

iPTMnetiQ8N9T8.
PhosphoSitePlusiQ8N9T8.

Expressioni

Gene expression databases

BgeeiENSG00000129347.
CleanExiHS_KRI1.
ExpressionAtlasiQ8N9T8. baseline and differential.
GenevisibleiQ8N9T8. HS.

Organism-specific databases

HPAiHPA043110.
HPA043574.

Interactioni

Protein-protein interaction databases

BioGridi122394. 38 interactors.
IntActiQ8N9T8. 17 interactors.
MINTiMINT-2810961.
STRINGi9606.ENSP00000320917.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 423Glu-richAdd BLAST326

Sequence similaritiesi

Belongs to the KRI1 family.Curated

Phylogenomic databases

eggNOGiKOG2409. Eukaryota.
ENOG410XR4G. LUCA.
HOVERGENiHBG108077.
InParanoidiQ8N9T8.
KOiK14786.
OrthoDBiEOG091G08XW.
TreeFamiTF320278.

Family and domain databases

InterProiView protein in InterPro
IPR018034. Kri1.
IPR024626. Kri1-like_C.
PANTHERiPTHR14490. PTHR14490. 1 hit.
PfamiView protein in Pfam
PF05178. Kri1. 1 hit.
PF12936. Kri1_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N9T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPRGSSQL RVNAAFAARY NRYREREELQ RLKDRYGDRD SSSDSSSESD
60 70 80 90 100
SSDERVEFDP QQERDFYKTL SLLKKKDPRI YQKDATFYNR TASSSDSEED
110 120 130 140 150
PEALEKQKKV RPMYLKDYER KVILEKAGKY VDEENSDGET SNHRLQETSS
160 170 180 190 200
QSYVEEQKQL KESFRAFVED SEDEDGAGEG GSSLLQKRAK TRQEKAQEEA
210 220 230 240 250
DYIEWLKGQK EIRNPDSLKE LTHLKEYWND PELDEGERFL RDYILNKRYE
260 270 280 290 300
EEEEEEEDEE EMEEEEGVHG PPVQLAVDDS SDEGELFLKK QEDFEQKYNF
310 320 330 340 350
RFEEPDSASV KTYPRSIASS VRRKDERRKE KREETRERKK REKAKKQEEL
360 370 380 390 400
KQLKNLKRKE ILAKLEKLRK VTGNEMLGLE EGDLEDDFDP AQHDQLMQKC
410 420 430 440 450
FGDEYYGAVE EEKPQFEEEE GLEDDWNWDT WDGPEQEGDW SQQELHCEDP
460 470 480 490 500
NFNMDADYDP SQPRKKKREA PLTGKKKRKS PFAAAVGQEK PVFEPGDKTF
510 520 530 540 550
EEYLDEYYRL DYEDIIDDLP CRFKYRTVVP CDFGLSTEEI LAADDKELNR
560 570 580 590 600
WCSLKKTCMY RSEQEELRDK RAYSQKAQNS WKKRQVFKSL CREEAETPAE
610 620 630 640 650
ATGKPQRDEA GPQRQLPALD GSLMGPESPP AQEEEAPVSP HKKPAPQKRR
660 670 680 690 700
RAKKARLLGP TVMLGGCEFS RQRLQAFGLN PKRLHFRQLG RQRRKQQGPK

NSS
Length:703
Mass (Da):82,598
Last modified:October 16, 2013 - v3
Checksum:i0C34E54AB1250141
GO

Sequence cautioni

The sequence BAB14357 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15278 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04240 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165R → W in BAC04240 (PubMed:14702039).Curated1
Sequence conflicti252E → G in BAB14357 (PubMed:14702039).Curated1
Sequence conflicti279D → G in BAB14357 (PubMed:14702039).Curated1
Sequence conflicti316S → N in BAC04240 (PubMed:14702039).Curated1
Sequence conflicti345K → E in BAC04240 (PubMed:14702039).Curated1
Sequence conflicti556K → E in BAB15278 (PubMed:14702039).Curated1
Sequence conflicti627E → G in BAB15278 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034751138G → R1 PublicationCorresponds to variant dbSNP:rs12984043Ensembl.1
Natural variantiVAR_034752179E → A. Corresponds to variant dbSNP:rs11545166Ensembl.1
Natural variantiVAR_034753266E → KCombined sources2 PublicationsCorresponds to variant dbSNP:rs3745249Ensembl.1
Natural variantiVAR_034754309S → L. Corresponds to variant dbSNP:rs34743532Ensembl.1
Natural variantiVAR_034755336R → W. Corresponds to variant dbSNP:rs33999611Ensembl.1
Natural variantiVAR_034756349E → Q2 PublicationsCorresponds to variant dbSNP:rs3826709Ensembl.1
Natural variantiVAR_034757445L → P. Corresponds to variant dbSNP:rs1982074Ensembl.1
Natural variantiVAR_034758703S → P2 PublicationsCorresponds to variant dbSNP:rs3087689Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023011 mRNA. Translation: BAB14357.1. Different initiation.
AK025907 mRNA. Translation: BAB15278.1. Different initiation.
AK093879 mRNA. Translation: BAC04240.1. Sequence problems.
AC011461 Genomic DNA. No translation available.
AC011475 Genomic DNA. No translation available.
BC002890 mRNA. Translation: AAH02890.3.
BC009876 mRNA. Translation: AAH09876.2.
BC112249 mRNA. Translation: AAI12250.1.
BC112251 mRNA. Translation: AAI12252.1.
RefSeqiNP_075384.3. NM_023008.3.
UniGeneiHs.709967.

Genome annotation databases

EnsembliENST00000312962; ENSP00000320917; ENSG00000129347.
GeneIDi65095.
KEGGihsa:65095.
UCSCiuc002moy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRI1_HUMAN
AccessioniPrimary (citable) accession number: Q8N9T8
Secondary accession number(s): Q2M1R5
, Q2M1R7, Q7L5J7, Q96G92, Q9BU50, Q9H6I1, Q9H978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 16, 2013
Last modified: August 30, 2017
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families