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Protein

Sorting nexin-31

Gene

SNX31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi9.A.3.1.2 the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-31
Gene namesi
Name:SNX31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000174226.8
HGNCiHGNC:28605 SNX31
neXtProtiNX_Q8N9S9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi169166
OpenTargetsiENSG00000174226
PharmGKBiPA162404313

Polymorphism and mutation databases

BioMutaiSNX31
DMDMi269849658

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316031 – 440Sorting nexin-31Add BLAST440

Proteomic databases

PaxDbiQ8N9S9
PeptideAtlasiQ8N9S9
PRIDEiQ8N9S9

PTM databases

iPTMnetiQ8N9S9
PhosphoSitePlusiQ8N9S9

Expressioni

Gene expression databases

BgeeiENSG00000174226
CleanExiHS_SNX31
ExpressionAtlasiQ8N9S9 baseline and differential
GenevisibleiQ8N9S9 HS

Organism-specific databases

HPAiHPA024284
HPA053466

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LZTS2Q9BRK43EBI-9380649,EBI-741037

Protein-protein interaction databases

BioGridi127977, 1 interactor
IntActiQ8N9S9, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8N9S9
SMRiQ8N9S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG3784 Eukaryota
ENOG410XT9I LUCA
GeneTreeiENSGT00530000063147
HOGENOMiHOG000007722
HOVERGENiHBG061207
InParanoidiQ8N9S9
KOiK17937
OMAiCWQVTFL
OrthoDBiEOG091G0BES
PhylomeDBiQ8N9S9
TreeFamiTF318398

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR037831 SNX17/27/31
PANTHERiPTHR12431 PTHR12431, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMHFCIPVS QQRSDALGGR YVLYSVHLDG FLFCRVRYSQ LHGWNEQLRR
60 70 80 90 100
VFGNCLPPFP PKYYLAMTTA MADERRDQLE QYLQNVTMDP NVLRSDVFVE
110 120 130 140 150
FLKLAQLNTF DIATKKAYLD IFLPNEQSIR IEIITSDTAE RVLEVVSHKI
160 170 180 190 200
GLCRELLGYF GLFLIRFGKE GKLSVVKKLA DFELPYVSLG SSEVENCKVG
210 220 230 240 250
LRKWYMAPSL DSVLMDCRVA VDLLYMQAIQ DIEKGWAKPT QAQRQKLEAF
260 270 280 290 300
QKEDSQTKFL ELAREVRHYG YLQLDPCTCD YPESGSGAVL SVGNNEISCC
310 320 330 340 350
ITLPDSQTQD IVFQMSRVKC WQVTFLGTLL DTDGPQRTLN QNLELRFQYS
360 370 380 390 400
EDSCWQWFVI YTKQAFLLSS CLKKMISEKM VKLAAENTEM QIEVPEQSKS
410 420 430 440
KKYHIQQSQQ KDYSSFLSRK SKIKIAKDDC VFGNIKEEDL
Length:440
Mass (Da):50,802
Last modified:November 24, 2009 - v3
Checksum:iB4B5671DC5593D85
GO
Isoform 2 (identifier: Q8N9S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-107: EFLKLAQL → MLGNTENW

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):39,145
Checksum:i2B650D0A82339F0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174S → P in BAC04249 (PubMed:14702039).Curated1
Sequence conflicti338T → A in BAC04249 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04290073D → H1 PublicationCorresponds to variant dbSNP:rs2187016Ensembl.1
Natural variantiVAR_042901309Q → R. Corresponds to variant dbSNP:rs2248609Ensembl.1
Natural variantiVAR_042902428D → G1 PublicationCorresponds to variant dbSNP:rs2022923Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0332611 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_033262100 – 107EFLKLAQL → MLGNTENW in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093906 mRNA Translation: BAC04249.1
AP000424 Genomic DNA No translation available.
AP001205 Genomic DNA No translation available.
BC031260 mRNA Translation: AAH31260.1
CCDSiCCDS6288.1 [Q8N9S9-1]
RefSeqiNP_689841.3, NM_152628.3 [Q8N9S9-1]
XP_005250872.1, XM_005250815.3 [Q8N9S9-2]
UniGeneiHs.567758

Genome annotation databases

EnsembliENST00000311812; ENSP00000312368; ENSG00000174226 [Q8N9S9-1]
ENST00000428383; ENSP00000405024; ENSG00000174226 [Q8N9S9-2]
GeneIDi169166
KEGGihsa:169166
UCSCiuc003yjr.4 human [Q8N9S9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNX31_HUMAN
AccessioniPrimary (citable) accession number: Q8N9S9
Secondary accession number(s): C9J6L9, Q8N0U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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