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Protein

Sorting nexin-31

Gene

SNX31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174226-MONOMER.

Protein family/group databases

TCDBi9.A.3.1.2. the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-31
Gene namesi
Name:SNX31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28605. SNX31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi169166.
OpenTargetsiENSG00000174226.
PharmGKBiPA162404313.

Polymorphism and mutation databases

BioMutaiSNX31.
DMDMi269849658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316031 – 440Sorting nexin-31Add BLAST440

Proteomic databases

PaxDbiQ8N9S9.
PRIDEiQ8N9S9.

PTM databases

iPTMnetiQ8N9S9.
PhosphoSitePlusiQ8N9S9.

Expressioni

Gene expression databases

BgeeiENSG00000174226.
CleanExiHS_SNX31.
ExpressionAtlasiQ8N9S9. baseline and differential.
GenevisibleiQ8N9S9. HS.

Organism-specific databases

HPAiHPA024284.
HPA053466.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LZTS2Q9BRK43EBI-9380649,EBI-741037

Protein-protein interaction databases

BioGridi127977. 1 interactor.
IntActiQ8N9S9. 4 interactors.
STRINGi9606.ENSP00000312368.

Structurei

3D structure databases

ProteinModelPortaliQ8N9S9.
SMRiQ8N9S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ8N9S9.
KOiK17937.
OMAiRVKCWQV.
OrthoDBiEOG091G0BES.
PhylomeDBiQ8N9S9.
TreeFamiTF318398.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMHFCIPVS QQRSDALGGR YVLYSVHLDG FLFCRVRYSQ LHGWNEQLRR
60 70 80 90 100
VFGNCLPPFP PKYYLAMTTA MADERRDQLE QYLQNVTMDP NVLRSDVFVE
110 120 130 140 150
FLKLAQLNTF DIATKKAYLD IFLPNEQSIR IEIITSDTAE RVLEVVSHKI
160 170 180 190 200
GLCRELLGYF GLFLIRFGKE GKLSVVKKLA DFELPYVSLG SSEVENCKVG
210 220 230 240 250
LRKWYMAPSL DSVLMDCRVA VDLLYMQAIQ DIEKGWAKPT QAQRQKLEAF
260 270 280 290 300
QKEDSQTKFL ELAREVRHYG YLQLDPCTCD YPESGSGAVL SVGNNEISCC
310 320 330 340 350
ITLPDSQTQD IVFQMSRVKC WQVTFLGTLL DTDGPQRTLN QNLELRFQYS
360 370 380 390 400
EDSCWQWFVI YTKQAFLLSS CLKKMISEKM VKLAAENTEM QIEVPEQSKS
410 420 430 440
KKYHIQQSQQ KDYSSFLSRK SKIKIAKDDC VFGNIKEEDL
Length:440
Mass (Da):50,802
Last modified:November 24, 2009 - v3
Checksum:iB4B5671DC5593D85
GO
Isoform 2 (identifier: Q8N9S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-107: EFLKLAQL → MLGNTENW

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):39,145
Checksum:i2B650D0A82339F0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174S → P in BAC04249 (PubMed:14702039).Curated1
Sequence conflicti338T → A in BAC04249 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04290073D → H.1 PublicationCorresponds to variant rs2187016dbSNPEnsembl.1
Natural variantiVAR_042901309Q → R.Corresponds to variant rs2248609dbSNPEnsembl.1
Natural variantiVAR_042902428D → G.1 PublicationCorresponds to variant rs2022923dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0332611 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_033262100 – 107EFLKLAQL → MLGNTENW in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093906 mRNA. Translation: BAC04249.1.
AP000424 Genomic DNA. No translation available.
AP001205 Genomic DNA. No translation available.
BC031260 mRNA. Translation: AAH31260.1.
CCDSiCCDS6288.1. [Q8N9S9-1]
RefSeqiNP_689841.3. NM_152628.3. [Q8N9S9-1]
XP_005250872.1. XM_005250815.3. [Q8N9S9-2]
UniGeneiHs.567758.

Genome annotation databases

EnsembliENST00000311812; ENSP00000312368; ENSG00000174226. [Q8N9S9-1]
ENST00000428383; ENSP00000405024; ENSG00000174226. [Q8N9S9-2]
GeneIDi169166.
KEGGihsa:169166.
UCSCiuc003yjr.4. human. [Q8N9S9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093906 mRNA. Translation: BAC04249.1.
AP000424 Genomic DNA. No translation available.
AP001205 Genomic DNA. No translation available.
BC031260 mRNA. Translation: AAH31260.1.
CCDSiCCDS6288.1. [Q8N9S9-1]
RefSeqiNP_689841.3. NM_152628.3. [Q8N9S9-1]
XP_005250872.1. XM_005250815.3. [Q8N9S9-2]
UniGeneiHs.567758.

3D structure databases

ProteinModelPortaliQ8N9S9.
SMRiQ8N9S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127977. 1 interactor.
IntActiQ8N9S9. 4 interactors.
STRINGi9606.ENSP00000312368.

Protein family/group databases

TCDBi9.A.3.1.2. the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family.

PTM databases

iPTMnetiQ8N9S9.
PhosphoSitePlusiQ8N9S9.

Polymorphism and mutation databases

BioMutaiSNX31.
DMDMi269849658.

Proteomic databases

PaxDbiQ8N9S9.
PRIDEiQ8N9S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311812; ENSP00000312368; ENSG00000174226. [Q8N9S9-1]
ENST00000428383; ENSP00000405024; ENSG00000174226. [Q8N9S9-2]
GeneIDi169166.
KEGGihsa:169166.
UCSCiuc003yjr.4. human. [Q8N9S9-1]

Organism-specific databases

CTDi169166.
DisGeNETi169166.
GeneCardsiSNX31.
HGNCiHGNC:28605. SNX31.
HPAiHPA024284.
HPA053466.
neXtProtiNX_Q8N9S9.
OpenTargetsiENSG00000174226.
PharmGKBiPA162404313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ8N9S9.
KOiK17937.
OMAiRVKCWQV.
OrthoDBiEOG091G0BES.
PhylomeDBiQ8N9S9.
TreeFamiTF318398.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174226-MONOMER.

Miscellaneous databases

GenomeRNAii169166.
PROiQ8N9S9.

Gene expression databases

BgeeiENSG00000174226.
CleanExiHS_SNX31.
ExpressionAtlasiQ8N9S9. baseline and differential.
GenevisibleiQ8N9S9. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX31_HUMAN
AccessioniPrimary (citable) accession number: Q8N9S9
Secondary accession number(s): C9J6L9, Q8N0U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.