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Protein

Protein SREK1IP1

Gene

SREK1IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible splicing regulator involved in the control of cellular survival.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3018CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SREK1IP1
Alternative name(s):
SFRS12-interacting protein 1
SREK1-interacting protein 1
Splicing regulatory protein of 18 kDa
Short name:
p18SRP
Gene namesi
Name:SREK1IP1
Synonyms:P18SRP, SFRS12IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26716. SREK1IP1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402954.

Polymorphism and mutation databases

BioMutaiSREK1IP1.
DMDMi74729743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Protein SREK1IP1PRO_0000311922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei96 – 961PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei146 – 1461PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9Q2.
MaxQBiQ8N9Q2.
PaxDbiQ8N9Q2.
PeptideAtlasiQ8N9Q2.
PRIDEiQ8N9Q2.

PTM databases

iPTMnetiQ8N9Q2.
PhosphoSiteiQ8N9Q2.

Expressioni

Inductioni

Down-regulated in the brains of Alzheimer disease patients.1 Publication

Gene expression databases

BgeeiENSG00000153006.
CleanExiHS_SFRS12IP1.
ExpressionAtlasiQ8N9Q2. baseline and differential.
GenevisibleiQ8N9Q2. HS.

Organism-specific databases

HPAiHPA045677.
HPA062853.

Interactioni

Subunit structurei

Interacts with SREK1/SFRS12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
hCG_1744368A0A024RA763EBI-10268630,EBI-10180729
HSD17B14Q9BPX13EBI-10268630,EBI-742664
NME1P155313EBI-10268630,EBI-741141
PPCDCQ96CD23EBI-10268630,EBI-724333
RBM39Q144983EBI-10268630,EBI-395290
SDCBPO005603EBI-10268630,EBI-727004
SDCBP2Q9H1903EBI-10268630,EBI-742426
STAC3Q96MF23EBI-10268630,EBI-745680

Protein-protein interaction databases

BioGridi130175. 27 interactions.
IntActiQ8N9Q2. 12 interactions.
STRINGi9606.ENSP00000427401.

Structurei

3D structure databases

ProteinModelPortaliQ8N9Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi76 – 14267Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3018CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2985. Eukaryota.
ENOG41124J3. LUCA.
GeneTreeiENSGT00510000047710.
HOVERGENiHBG104841.
InParanoidiQ8N9Q2.
OMAiKSKRGKH.
OrthoDBiEOG091G13V4.
PhylomeDBiQ8N9Q2.
TreeFamiTF318225.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N9Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPGCNKDS VRAGCKKCGY PGHLTFECRN FLRVDPKRDI VLDVSSTSSE
60 70 80 90 100
DSDEENEELN KLQALQEKRI NEEEEKKKEK SKEKIKLKKK RKRSYSSSST
110 120 130 140 150
EEDTSKQKKQ KYQKKEKKKE KKSKSKKGKH HKKEKKKRKK EKHSSTPNSS

EFSRK
Length:155
Mass (Da):18,177
Last modified:October 1, 2002 - v1
Checksum:i9BABECE4783AFF27
GO

Sequence cautioni

The sequence AAI08717 differs from that shown. Reason: Frameshift at position 79. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094073 mRNA. Translation: BAC04279.1.
CH471137 Genomic DNA. Translation: EAW51368.1.
BC108716 mRNA. Translation: AAI08717.1. Frameshift.
BC127085 mRNA. Translation: AAI27086.1.
BC127086 mRNA. Translation: AAI27087.1.
CCDSiCCDS34171.1.
RefSeqiNP_776190.1. NM_173829.3.
UniGeneiHs.69504.

Genome annotation databases

EnsembliENST00000513458; ENSP00000427401; ENSG00000153006.
GeneIDi285672.
KEGGihsa:285672.
UCSCiuc003jtk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094073 mRNA. Translation: BAC04279.1.
CH471137 Genomic DNA. Translation: EAW51368.1.
BC108716 mRNA. Translation: AAI08717.1. Frameshift.
BC127085 mRNA. Translation: AAI27086.1.
BC127086 mRNA. Translation: AAI27087.1.
CCDSiCCDS34171.1.
RefSeqiNP_776190.1. NM_173829.3.
UniGeneiHs.69504.

3D structure databases

ProteinModelPortaliQ8N9Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130175. 27 interactions.
IntActiQ8N9Q2. 12 interactions.
STRINGi9606.ENSP00000427401.

PTM databases

iPTMnetiQ8N9Q2.
PhosphoSiteiQ8N9Q2.

Polymorphism and mutation databases

BioMutaiSREK1IP1.
DMDMi74729743.

Proteomic databases

EPDiQ8N9Q2.
MaxQBiQ8N9Q2.
PaxDbiQ8N9Q2.
PeptideAtlasiQ8N9Q2.
PRIDEiQ8N9Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000513458; ENSP00000427401; ENSG00000153006.
GeneIDi285672.
KEGGihsa:285672.
UCSCiuc003jtk.4. human.

Organism-specific databases

CTDi285672.
GeneCardsiSREK1IP1.
HGNCiHGNC:26716. SREK1IP1.
HPAiHPA045677.
HPA062853.
neXtProtiNX_Q8N9Q2.
PharmGKBiPA162402954.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2985. Eukaryota.
ENOG41124J3. LUCA.
GeneTreeiENSGT00510000047710.
HOVERGENiHBG104841.
InParanoidiQ8N9Q2.
OMAiKSKRGKH.
OrthoDBiEOG091G13V4.
PhylomeDBiQ8N9Q2.
TreeFamiTF318225.

Miscellaneous databases

ChiTaRSiSREK1IP1. human.
GenomeRNAii285672.
PROiQ8N9Q2.

Gene expression databases

BgeeiENSG00000153006.
CleanExiHS_SFRS12IP1.
ExpressionAtlasiQ8N9Q2. baseline and differential.
GenevisibleiQ8N9Q2. HS.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSR1IP_HUMAN
AccessioniPrimary (citable) accession number: Q8N9Q2
Secondary accession number(s): Q32NC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.