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Protein

Protein SREK1IP1

Gene

SREK1IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible splicing regulator involved in the control of cellular survival.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 30CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SREK1IP1
Alternative name(s):
SFRS12-interacting protein 1
SREK1-interacting protein 1
Splicing regulatory protein of 18 kDa
Short name:
p18SRP
Gene namesi
Name:SREK1IP1
Synonyms:P18SRP, SFRS12IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153006.14
HGNCiHGNC:26716 SREK1IP1
neXtProtiNX_Q8N9Q2

Pathology & Biotechi

Organism-specific databases

DisGeNETi285672
OpenTargetsiENSG00000153006
PharmGKBiPA162402954

Polymorphism and mutation databases

BioMutaiSREK1IP1
DMDMi74729743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119221 – 155Protein SREK1IP1Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei96PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei146PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9Q2
MaxQBiQ8N9Q2
PaxDbiQ8N9Q2
PeptideAtlasiQ8N9Q2
PRIDEiQ8N9Q2

PTM databases

iPTMnetiQ8N9Q2
PhosphoSitePlusiQ8N9Q2

Expressioni

Inductioni

Down-regulated in the brains of Alzheimer disease patients.1 Publication

Gene expression databases

BgeeiENSG00000153006
CleanExiHS_SFRS12IP1
GenevisibleiQ8N9Q2 HS

Organism-specific databases

HPAiHPA045677
HPA062853

Interactioni

Subunit structurei

Interacts with SREK1/SFRS12.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi13017534 interactors.
IntActiQ8N9Q2 27 interactors.
STRINGi9606.ENSP00000427401

Structurei

3D structure databases

ProteinModelPortaliQ8N9Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 142Lys-richAdd BLAST67

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 30CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2985 Eukaryota
ENOG41124J3 LUCA
GeneTreeiENSGT00510000047710
HOVERGENiHBG104841
InParanoidiQ8N9Q2
OMAiKSKRGKH
OrthoDBiEOG091G13V4
PhylomeDBiQ8N9Q2
TreeFamiTF318225

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N9Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPGCNKDS VRAGCKKCGY PGHLTFECRN FLRVDPKRDI VLDVSSTSSE
60 70 80 90 100
DSDEENEELN KLQALQEKRI NEEEEKKKEK SKEKIKLKKK RKRSYSSSST
110 120 130 140 150
EEDTSKQKKQ KYQKKEKKKE KKSKSKKGKH HKKEKKKRKK EKHSSTPNSS

EFSRK
Length:155
Mass (Da):18,177
Last modified:October 1, 2002 - v1
Checksum:i9BABECE4783AFF27
GO

Sequence cautioni

The sequence AAI08717 differs from that shown. Reason: Frameshift at position 79.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094073 mRNA Translation: BAC04279.1
CH471137 Genomic DNA Translation: EAW51368.1
BC108716 mRNA Translation: AAI08717.1 Frameshift.
BC127085 mRNA Translation: AAI27086.1
BC127086 mRNA Translation: AAI27087.1
CCDSiCCDS34171.1
RefSeqiNP_776190.1, NM_173829.3
UniGeneiHs.69504

Genome annotation databases

EnsembliENST00000513458; ENSP00000427401; ENSG00000153006
GeneIDi285672
KEGGihsa:285672
UCSCiuc003jtk.4 human

Similar proteinsi

Entry informationi

Entry nameiSR1IP_HUMAN
AccessioniPrimary (citable) accession number: Q8N9Q2
Secondary accession number(s): Q32NC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome