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Protein

Probable RNA-binding protein EIF1AD

Gene

EIF1AD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role into cellular response to oxidative stress. Decreases cell proliferation.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein EIF1AD
Alternative name(s):
Eukaryotic translation initiation factor 1A domain-containing protein
Haponin
Gene namesi
Name:EIF1AD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175376.8
HGNCiHGNC:28147 EIF1AD
neXtProtiNX_Q8N9N8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84285
OpenTargetsiENSG00000175376
PharmGKBiPA162384553

Polymorphism and mutation databases

BioMutaiEIF1AD
DMDMi74729733

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141511 – 165Probable RNA-binding protein EIF1ADAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphothreonineCombined sources1
Modified residuei131PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei155PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9N8
MaxQBiQ8N9N8
PaxDbiQ8N9N8
PeptideAtlasiQ8N9N8
PRIDEiQ8N9N8

PTM databases

iPTMnetiQ8N9N8
PhosphoSitePlusiQ8N9N8

Expressioni

Tissue specificityi

Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.1 Publication

Gene expression databases

BgeeiENSG00000175376
CleanExiHS_EIF1AD
ExpressionAtlasiQ8N9N8 baseline and differential
GenevisibleiQ8N9N8 HS

Organism-specific databases

HPAiHPA054991
HPA058735

Interactioni

Subunit structurei

Interacts with GAPDH and STAT1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124012, 63 interactors
IntActiQ8N9N8, 23 interactors
MINTiQ8N9N8
STRINGi9606.ENSP00000309175

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 32Combined sources7
Beta strandi35 – 42Combined sources8
Beta strandi48 – 52Combined sources5
Beta strandi68 – 73Combined sources6
Beta strandi82 – 87Combined sources6
Helixi90 – 99Combined sources10
Helixi104 – 110Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGYNMR-A17-114[»]
ProteinModelPortaliQ8N9N8
SMRiQ8N9N8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N9N8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89S1-likePROSITE-ProRule annotationAdd BLAST85

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi6 – 12Nuclear localization signalSequence analysis7
Motifi56 – 65Nuclear localization signalSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 163Poly-Glu10

Sequence similaritiesi

Belongs to the EIF1AD family.Curated

Phylogenomic databases

eggNOGiKOG2925 Eukaryota
ENOG4111N6Z LUCA
GeneTreeiENSGT00390000011180
HOGENOMiHOG000007486
HOVERGENiHBG097893
InParanoidiQ8N9N8
KOiK15025
OMAiEMMEDDY
OrthoDBiEOG091G0TN4
PhylomeDBiQ8N9N8
TreeFamiTF314439

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
SMARTiView protein in SMART
SM00652 eIF1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N9N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQATKRKHV VKEVLGEHIV PSDQQQIVRV LRTPGNNLHE VETAQGQRFL
60 70 80 90 100
VSMPSKYRKN IWIKRGDFLI VDPIEEGEKV KAEISFVLCK DHVRSLQKEG
110 120 130 140 150
FWPEAFSEVA EKHNNRNRQT QPELPAEPQL SGEESSSEDD SDLFVNTNRR
160
QYHESEEESE EEEAA
Length:165
Mass (Da):19,053
Last modified:October 1, 2002 - v1
Checksum:i33FB5ACB777084B2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03785123D → N1 PublicationCorresponds to variant dbSNP:rs17849919Ensembl.1
Natural variantiVAR_037852159S → N. Corresponds to variant dbSNP:rs2276017Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094129 mRNA Translation: BAC04293.1
AK311891 mRNA Translation: BAG34832.1
CH471076 Genomic DNA Translation: EAW74478.1
BC005131 mRNA Translation: AAH05131.1
CCDSiCCDS8124.1
RefSeqiNP_001229410.1, NM_001242481.1
NP_001229411.1, NM_001242482.1
NP_001229412.1, NM_001242483.1
NP_001229413.1, NM_001242484.1
NP_001229414.1, NM_001242485.1
NP_001229415.1, NM_001242486.1
NP_115701.2, NM_032325.3
XP_016873901.1, XM_017018412.1
UniGeneiHs.425178

Genome annotation databases

EnsembliENST00000312234; ENSP00000309175; ENSG00000175376
ENST00000526451; ENSP00000436644; ENSG00000175376
ENST00000527249; ENSP00000435439; ENSG00000175376
ENST00000529964; ENSP00000435942; ENSG00000175376
ENST00000533544; ENSP00000434056; ENSG00000175376
GeneIDi84285
KEGGihsa:84285
UCSCiuc001ogm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEIF1A_HUMAN
AccessioniPrimary (citable) accession number: Q8N9N8
Secondary accession number(s): B2R4N5, Q9BSC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health