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Protein

Probable RNA-binding protein EIF1AD

Gene

EIF1AD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role into cellular response to oxidative stress. Decreases cell proliferation.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein EIF1AD
Alternative name(s):
Eukaryotic translation initiation factor 1A domain-containing protein
Haponin
Gene namesi
Name:EIF1AD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28147. EIF1AD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84285.
OpenTargetsiENSG00000175376.
PharmGKBiPA162384553.

Polymorphism and mutation databases

BioMutaiEIF1AD.
DMDMi74729733.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141511 – 165Probable RNA-binding protein EIF1ADAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphothreonineCombined sources1
Modified residuei131PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei155PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9N8.
MaxQBiQ8N9N8.
PaxDbiQ8N9N8.
PeptideAtlasiQ8N9N8.
PRIDEiQ8N9N8.

PTM databases

iPTMnetiQ8N9N8.
PhosphoSitePlusiQ8N9N8.

Expressioni

Tissue specificityi

Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.1 Publication

Gene expression databases

BgeeiENSG00000175376.
CleanExiHS_EIF1AD.
ExpressionAtlasiQ8N9N8. baseline and differential.
GenevisibleiQ8N9N8. HS.

Organism-specific databases

HPAiHPA054991.
HPA058735.

Interactioni

Subunit structurei

Interacts with GAPDH and STAT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BEND7Q8N7W2-23EBI-750700,EBI-10181188
CEP55D3DR373EBI-750700,EBI-10173536
GLYR1Q49A263EBI-750700,EBI-2804292
MEOX2A4D1273EBI-750700,EBI-10172134
SDCBPO005605EBI-750700,EBI-727004
SDCBP2Q9H1904EBI-750700,EBI-742426
STAT1P422244EBI-750700,EBI-1057697
STX11O755585EBI-750700,EBI-714135
TBC1D5B9A6K13EBI-750700,EBI-10217641
ZBTB14O438293EBI-750700,EBI-10176632
ZBTB8AQ96BR95EBI-750700,EBI-742740

Protein-protein interaction databases

BioGridi124012. 16 interactors.
IntActiQ8N9N8. 19 interactors.
MINTiMINT-1479911.
STRINGi9606.ENSP00000309175.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 32Combined sources7
Beta strandi35 – 42Combined sources8
Beta strandi48 – 52Combined sources5
Beta strandi68 – 73Combined sources6
Beta strandi82 – 87Combined sources6
Helixi90 – 99Combined sources10
Helixi104 – 110Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGYNMR-A17-114[»]
ProteinModelPortaliQ8N9N8.
SMRiQ8N9N8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N9N8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89S1-likePROSITE-ProRule annotationAdd BLAST85

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi6 – 12Nuclear localization signalSequence analysis7
Motifi56 – 65Nuclear localization signalSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 163Poly-Glu10

Sequence similaritiesi

Belongs to the EIF1AD family.Curated
Contains 1 S1-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2925. Eukaryota.
ENOG4111N6Z. LUCA.
GeneTreeiENSGT00390000011180.
HOGENOMiHOG000007486.
HOVERGENiHBG097893.
InParanoidiQ8N9N8.
KOiK15025.
OMAiTENQQIV.
OrthoDBiEOG091G0TN4.
PhylomeDBiQ8N9N8.
TreeFamiTF314439.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
[Graphical view]
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N9N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQATKRKHV VKEVLGEHIV PSDQQQIVRV LRTPGNNLHE VETAQGQRFL
60 70 80 90 100
VSMPSKYRKN IWIKRGDFLI VDPIEEGEKV KAEISFVLCK DHVRSLQKEG
110 120 130 140 150
FWPEAFSEVA EKHNNRNRQT QPELPAEPQL SGEESSSEDD SDLFVNTNRR
160
QYHESEEESE EEEAA
Length:165
Mass (Da):19,053
Last modified:October 1, 2002 - v1
Checksum:i33FB5ACB777084B2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03785123D → N.1 PublicationCorresponds to variant rs17849919dbSNPEnsembl.1
Natural variantiVAR_037852159S → N.Corresponds to variant rs2276017dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094129 mRNA. Translation: BAC04293.1.
AK311891 mRNA. Translation: BAG34832.1.
CH471076 Genomic DNA. Translation: EAW74478.1.
BC005131 mRNA. Translation: AAH05131.1.
CCDSiCCDS8124.1.
RefSeqiNP_001229410.1. NM_001242481.1.
NP_001229411.1. NM_001242482.1.
NP_001229412.1. NM_001242483.1.
NP_001229413.1. NM_001242484.1.
NP_001229414.1. NM_001242485.1.
NP_001229415.1. NM_001242486.1.
NP_115701.2. NM_032325.3.
XP_016873901.1. XM_017018412.1.
UniGeneiHs.425178.

Genome annotation databases

EnsembliENST00000312234; ENSP00000309175; ENSG00000175376.
ENST00000526451; ENSP00000436644; ENSG00000175376.
ENST00000527249; ENSP00000435439; ENSG00000175376.
ENST00000529964; ENSP00000435942; ENSG00000175376.
ENST00000533544; ENSP00000434056; ENSG00000175376.
GeneIDi84285.
KEGGihsa:84285.
UCSCiuc001ogm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094129 mRNA. Translation: BAC04293.1.
AK311891 mRNA. Translation: BAG34832.1.
CH471076 Genomic DNA. Translation: EAW74478.1.
BC005131 mRNA. Translation: AAH05131.1.
CCDSiCCDS8124.1.
RefSeqiNP_001229410.1. NM_001242481.1.
NP_001229411.1. NM_001242482.1.
NP_001229412.1. NM_001242483.1.
NP_001229413.1. NM_001242484.1.
NP_001229414.1. NM_001242485.1.
NP_001229415.1. NM_001242486.1.
NP_115701.2. NM_032325.3.
XP_016873901.1. XM_017018412.1.
UniGeneiHs.425178.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGYNMR-A17-114[»]
ProteinModelPortaliQ8N9N8.
SMRiQ8N9N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124012. 16 interactors.
IntActiQ8N9N8. 19 interactors.
MINTiMINT-1479911.
STRINGi9606.ENSP00000309175.

PTM databases

iPTMnetiQ8N9N8.
PhosphoSitePlusiQ8N9N8.

Polymorphism and mutation databases

BioMutaiEIF1AD.
DMDMi74729733.

Proteomic databases

EPDiQ8N9N8.
MaxQBiQ8N9N8.
PaxDbiQ8N9N8.
PeptideAtlasiQ8N9N8.
PRIDEiQ8N9N8.

Protocols and materials databases

DNASUi84285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312234; ENSP00000309175; ENSG00000175376.
ENST00000526451; ENSP00000436644; ENSG00000175376.
ENST00000527249; ENSP00000435439; ENSG00000175376.
ENST00000529964; ENSP00000435942; ENSG00000175376.
ENST00000533544; ENSP00000434056; ENSG00000175376.
GeneIDi84285.
KEGGihsa:84285.
UCSCiuc001ogm.3. human.

Organism-specific databases

CTDi84285.
DisGeNETi84285.
GeneCardsiEIF1AD.
HGNCiHGNC:28147. EIF1AD.
HPAiHPA054991.
HPA058735.
neXtProtiNX_Q8N9N8.
OpenTargetsiENSG00000175376.
PharmGKBiPA162384553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2925. Eukaryota.
ENOG4111N6Z. LUCA.
GeneTreeiENSGT00390000011180.
HOGENOMiHOG000007486.
HOVERGENiHBG097893.
InParanoidiQ8N9N8.
KOiK15025.
OMAiTENQQIV.
OrthoDBiEOG091G0TN4.
PhylomeDBiQ8N9N8.
TreeFamiTF314439.

Miscellaneous databases

ChiTaRSiEIF1AD. human.
EvolutionaryTraceiQ8N9N8.
GenomeRNAii84285.
PROiQ8N9N8.

Gene expression databases

BgeeiENSG00000175376.
CleanExiHS_EIF1AD.
ExpressionAtlasiQ8N9N8. baseline and differential.
GenevisibleiQ8N9N8. HS.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
[Graphical view]
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF1A_HUMAN
AccessioniPrimary (citable) accession number: Q8N9N8
Secondary accession number(s): B2R4N5, Q9BSC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.