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Protein

Leucine-rich repeat-containing protein 57

Gene

LRRC57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 57
Gene namesi
Name:LRRC57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26719. LRRC57.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180979.
PharmGKBiPA142671516.

Polymorphism and mutation databases

BioMutaiLRRC57.
DMDMi74760039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002277782 – 239Leucine-rich repeat-containing protein 57Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ8N9N7.
MaxQBiQ8N9N7.
PaxDbiQ8N9N7.
PeptideAtlasiQ8N9N7.
PRIDEiQ8N9N7.

PTM databases

iPTMnetiQ8N9N7.
PhosphoSitePlusiQ8N9N7.

Expressioni

Gene expression databases

BgeeiENSG00000180979.
CleanExiHS_LRRC57.
ExpressionAtlasiQ8N9N7. baseline and differential.
GenevisibleiQ8N9N7. HS.

Organism-specific databases

HPAiHPA040894.

Interactioni

Protein-protein interaction databases

BioGridi129089. 6 interactors.
IntActiQ8N9N7. 1 interactor.
MINTiMINT-5003364.
STRINGi9606.ENSP00000326817.

Structurei

3D structure databases

ProteinModelPortaliQ8N9N7.
SMRiQ8N9N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 60LRR 1Add BLAST22
Repeati63 – 84LRR 2Add BLAST22
Repeati86 – 107LRR 3Add BLAST22
Repeati109 – 131LRR 4Add BLAST23
Repeati132 – 153LRR 5Add BLAST22
Repeati154 – 175LRR 6Add BLAST22
Repeati177 – 197LRR 7Add BLAST21
Repeati202 – 222LRR 8Add BLAST21

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000116557.
HOVERGENiHBG054710.
InParanoidiQ8N9N7.
OMAiDVAECPK.
OrthoDBiEOG091G08V6.
PhylomeDBiQ8N9N7.
TreeFamiTF326481.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N9N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP ADLQKLTSNL RTIDLSNNKI
60 70 80 90 100
ESLPPLLIGK FTLLKSLSLN NNKLTVLPDE ICNLKKLETL SLNNNHLREL
110 120 130 140 150
PSTFGQLSAL KTLSLSGNQL GALPPQLCSL RHLDVMDLSK NQIRSIPDSV
160 170 180 190 200
GELQVIELNL NQNQISQISV KISCCPRLKI LRLEENCLEL SMLPQSILSD
210 220 230
SQICLLAVEG NLFEIKKLRE LEGYDKYMER FTATKKKFA
Length:239
Mass (Da):26,754
Last modified:October 1, 2002 - v1
Checksum:i8CA6E06075D10E3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71N → S in CAD98097 (PubMed:17974005).Curated1
Sequence conflicti237K → N in BAC04451 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094131 mRNA. Translation: BAC04294.1.
AK094891 mRNA. Translation: BAC04451.1.
CR749223 mRNA. Translation: CAH18079.1.
BX538324 mRNA. Translation: CAD98097.1.
BC058935 mRNA. Translation: AAH58935.1.
CCDSiCCDS10089.1.
RefSeqiNP_694992.2. NM_153260.2.
UniGeneiHs.234681.

Genome annotation databases

EnsembliENST00000323443; ENSP00000326817; ENSG00000180979.
ENST00000397130; ENSP00000380319; ENSG00000180979.
ENST00000563454; ENSP00000455445; ENSG00000180979.
GeneIDi255252.
KEGGihsa:255252.
UCSCiuc001zqc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094131 mRNA. Translation: BAC04294.1.
AK094891 mRNA. Translation: BAC04451.1.
CR749223 mRNA. Translation: CAH18079.1.
BX538324 mRNA. Translation: CAD98097.1.
BC058935 mRNA. Translation: AAH58935.1.
CCDSiCCDS10089.1.
RefSeqiNP_694992.2. NM_153260.2.
UniGeneiHs.234681.

3D structure databases

ProteinModelPortaliQ8N9N7.
SMRiQ8N9N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129089. 6 interactors.
IntActiQ8N9N7. 1 interactor.
MINTiMINT-5003364.
STRINGi9606.ENSP00000326817.

PTM databases

iPTMnetiQ8N9N7.
PhosphoSitePlusiQ8N9N7.

Polymorphism and mutation databases

BioMutaiLRRC57.
DMDMi74760039.

Proteomic databases

EPDiQ8N9N7.
MaxQBiQ8N9N7.
PaxDbiQ8N9N7.
PeptideAtlasiQ8N9N7.
PRIDEiQ8N9N7.

Protocols and materials databases

DNASUi255252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323443; ENSP00000326817; ENSG00000180979.
ENST00000397130; ENSP00000380319; ENSG00000180979.
ENST00000563454; ENSP00000455445; ENSG00000180979.
GeneIDi255252.
KEGGihsa:255252.
UCSCiuc001zqc.4. human.

Organism-specific databases

CTDi255252.
GeneCardsiLRRC57.
HGNCiHGNC:26719. LRRC57.
HPAiHPA040894.
neXtProtiNX_Q8N9N7.
OpenTargetsiENSG00000180979.
PharmGKBiPA142671516.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000116557.
HOVERGENiHBG054710.
InParanoidiQ8N9N7.
OMAiDVAECPK.
OrthoDBiEOG091G08V6.
PhylomeDBiQ8N9N7.
TreeFamiTF326481.

Miscellaneous databases

ChiTaRSiLRRC57. human.
GeneWikiiLRRC57.
GenomeRNAii255252.
PROiQ8N9N7.

Gene expression databases

BgeeiENSG00000180979.
CleanExiHS_LRRC57.
ExpressionAtlasiQ8N9N7. baseline and differential.
GenevisibleiQ8N9N7. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC57_HUMAN
AccessioniPrimary (citable) accession number: Q8N9N7
Secondary accession number(s): Q7Z2Z6, Q8N1T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.