Q8N9N5 (BANP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein BANP

Alternative name(s):
BEN domain-containing protein 1
Btg3-associated nuclear protein
Scaffold/matrix-associated region-1-binding protein

Gene names

Name:	BANP
Synonyms:	BEND1, SMAR1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest By similarity. Ref.5
Subunit structure	Interacts with TP53 and CUX1/CDP By similarity. Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2. Ref.5
Subcellular location	Nucleus Ref.5.
Tissue specificity	Down-regulated in breast cancer cell lines. Ref.5
Sequence similarities	Belongs to the BANP/SMAR1 family. Contains 1 BEN domain.
Sequence caution	The sequence BAC04296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell cycle Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Disease	Tumor suppressor
Domain	Coiled coil
Ligand	DNA-binding
Molecular function	Chromatin regulator Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N9N5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N9N5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ
     425-446: Missing.

Isoform 3 (identifier: Q8N9N5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     25-36: VLENHVVTDEDE → MTREFVKRSIFL
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N9N5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Protein BANP		PRO_0000297910
Regions
	Domain	226 – 322	97	BEN
	Region	152 – 342	191	Interaction with CUX1 and HDAC1 By similarity
	Region	320 – 349	30	Necessary and sufficient for TP53 activation By similarity
	Region	342 – 393	52	DNA-binding By similarity
	Coiled coil	53 – 90	38	Potential
	Compositional bias	361 – 426	66	Gln-rich
Natural variations
	Alternative sequence	1 – 24	24	Missing in isoform 3.		VSP_027396
	Alternative sequence	25 – 36	12	VLENH…TDEDE → MTREFVKRSIFL in isoform 3.		VSP_027398
	Alternative sequence	54	1	K → KSFLYSINQ in isoform 2, isoform 3 and isoform 4.		VSP_027399
	Alternative sequence	114 – 152	39	Missing in isoform 2, isoform 3 and isoform 4.		VSP_027400
	Alternative sequence	392	1	V → VIPQ in isoform 2 and isoform 4.		VSP_027401
	Alternative sequence	425 – 446	22	Missing in isoform 2 and isoform 3.		VSP_027402
Experimental info
	Sequence conflict	338	1	P → S in BAA91244. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 521C53F367A3A29E	FASTA	519	56,494
	10 20 30 40 50 60 MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD PSIKTICLRL 70 80 90 100 110 120 DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS PLGATQTCNK VRCVVPQTTV 130 140 150 160 170 180 ILNNDRQNAI VAKMEDPLSN RAPDSLENVI SNAVPGRRQN TIVVKVPGQE DSHHEDGESG 190 200 210 220 230 240 SEASDSVSSC GQAGSQSIGS NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH 250 260 270 280 290 300 ISTNCRTAEK MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT 310 320 330 340 350 360 ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM STPPPASELP 370 380 390 400 410 420 QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV PQGEQVQITQ DSEGNLQIHH 430 440 450 460 470 480 VGQDGQLLEA TRIPCLLAPS VFKASSGQVL QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV 490 500 510 QYVQLAPVSD HTAGAQTAEA LQPTLQPEMQ LEHGAIQIQ
	Isoform 2 [UniParc]. Checksum: 9E4B4A8C287A4A34	FASTA	469	51,243
	10 20 30 40 50 60 MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD PSIKSFLYSI 70 80 90 100 110 120 NQTICLRLDS IEAKLQALEA TCKSLEEKLD LVTNKQHSPI QVPMVAGSPL GATQTCNKVR 130 140 150 160 170 180 CAVPGRRQNT IVVKVPGQED SHHEDGESGS EASDSVSSCG QAGSQSIGSN VTLITLNSEE 190 200 210 220 230 240 DYPNGTWLGD ENNPEMRVRC AIIPSDMLHI STNCRTAEKM ALTLLDYLFH REVQAVSNLS 250 260 270 280 290 300 GQGKHGKKQL DPLTIYGIRC HLFYKFGITE SDWYRIKQSI DSKCRTAWRR KQRGQSLAVK 310 320 330 340 350 360 SFSRRTPNSS SYCPSEPMMS TPPPASELPQ PQPQPQALHY ALANAQQVQI HQIGEDGQVQ 370 380 390 400 410 420 VIPQGHLHIA QVPQGEQVQI TQDSEGNLQI HHVGQDGQVL QGAQLIAVAS SDPAAAGVDG 430 440 450 460 SPLQGSDIQV QYVQLAPVSD HTAGAQTAEA LQPTLQPEMQ LEHGAIQIQ
	Isoform 3 [UniParc]. Checksum: 4C86E6B4AFD4B689	FASTA	442	48,404
	10 20 30 40 50 60 MTREFVKRSI FLPALKRQRL EINCQDPSIK SFLYSINQTI CLRLDSIEAK LQALEATCKS 70 80 90 100 110 120 LEEKLDLVTN KQHSPIQVPM VAGSPLGATQ TCNKVRCAVP GRRQNTIVVK VPGQEDSHHE 130 140 150 160 170 180 DGESGSEASD SVSSCGQAGS QSIGSNVTLI TLNSEEDYPN GTWLGDENNP EMRVRCAIIP 190 200 210 220 230 240 SDMLHISTNC RTAEKMALTL LDYLFHREVQ AVSNLSGQGK HGKKQLDPLT IYGIRCHLFY 250 260 270 280 290 300 KFGITESDWY RIKQSIDSKC RTAWRRKQRG QSLAVKSFSR RTPNSSSYCP SEPMMSTPPP 310 320 330 340 350 360 ASELPQPQPQ PQALHYALAN AQQVQIHQIG EDGQVQVGHL HIAQVPQGEQ VQITQDSEGN 370 380 390 400 410 420 LQIHHVGQDG QVLQGAQLIA VASSDPAAAG VDGSPLQGSD IQVQYVQLAP VSDHTAGAQT 430 440 AEALQPTLQP EMQLEHGAIQ IQ
	Isoform 4 [UniParc]. Checksum: BA171D3BA87F731B	FASTA	491	53,527
	10 20 30 40 50 60 MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD PSIKSFLYSI 70 80 90 100 110 120 NQTICLRLDS IEAKLQALEA TCKSLEEKLD LVTNKQHSPI QVPMVAGSPL GATQTCNKVR 130 140 150 160 170 180 CAVPGRRQNT IVVKVPGQED SHHEDGESGS EASDSVSSCG QAGSQSIGSN VTLITLNSEE 190 200 210 220 230 240 DYPNGTWLGD ENNPEMRVRC AIIPSDMLHI STNCRTAEKM ALTLLDYLFH REVQAVSNLS 250 260 270 280 290 300 GQGKHGKKQL DPLTIYGIRC HLFYKFGITE SDWYRIKQSI DSKCRTAWRR KQRGQSLAVK 310 320 330 340 350 360 SFSRRTPNSS SYCPSEPMMS TPPPASELPQ PQPQPQALHY ALANAQQVQI HQIGEDGQVQ 370 380 390 400 410 420 VIPQGHLHIA QVPQGEQVQI TQDSEGNLQI HHVGQDGQLL EATRIPCLLA PSVFKASSGQ 430 440 450 460 470 480 VLQGAQLIAV ASSDPAAAGV DGSPLQGSDI QVQYVQLAPV SDHTAGAQTA EALQPTLQPE 490 MQLEHGAIQI Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.
[4]	"Identification and molecular analysis of BANP." Birot A.-M., Duret L., Bartholin L., Santalucia B., Tigaud I., Magaud J.-P., Rouault J.-P. Gene 253:189-196(2000) [PubMed: 10940556] [Abstract] Cited for: IDENTIFICATION.
[5]	"Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex." Rampalli S., Pavithra L., Bhatt A., Kundu T.K., Chattopadhyay S. Mol. Cell. Biol. 25:8415-8429(2005) [PubMed: 16166625] [Abstract] Cited for: FUNCTION, INTERACTION WITH HDAC1, IDENTIFICATION IN A COMPLEX WITH HDAC1; SIN3A; SIN3B; RBL1 AND RBL2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000545 mRNA. Translation: BAA91244.1. AK094158 mRNA. Translation: BAC04296.1. Different initiation. AK125232 mRNA. Translation: BAG54171.1. AC127455 Genomic DNA. No translation available. AC134312 Genomic DNA. No translation available. BC009424 mRNA. Translation: AAH09424.1.
IPI	IPI00167773. IPI00218489. IPI00332572. IPI00853021.
RefSeq	NP_001167010.1. NM_001173539.1. NP_001167011.1. NM_001173540.1. NP_001167014.1. NM_001173543.1. NP_060339.2. NM_017869.3. NP_524576.2. NM_079837.2.
UniGene	Hs.461705.
3D structure databases
ProteinModelPortal	Q8N9N5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N9N5. 7 interactions.
STRING	Q8N9N5.
PTM databases
PhosphoSite	Q8N9N5.
Polymorphism databases
DMDM	308153628.
Proteomic databases
PRIDE	Q8N9N5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286122; ENSP00000286122; ENSG00000172530. ENST00000393207; ENSP00000376902; ENSG00000172530. ENST00000393208; ENSP00000376903; ENSG00000172530.
GeneID	54971.
KEGG	hsa:54971.
UCSC	uc002fkq.1. human.
Organism-specific databases
CTD	54971.
GeneCards	GC16P087984.
HGNC	HGNC:13450. BANP.
MIM	611564. gene.
neXtProt	NX_Q8N9N5.
PharmGKB	PA134933411.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000011116.
HOGENOM	HBG713656.
HOVERGEN	HBG107493.
InParanoid	Q8N9N5.
OMA	SINQTIC.
Gene expression databases
ArrayExpress	Q8N9N5.
Bgee	Q8N9N5.
CleanEx	HS_BANP.
Genevestigator	Q8N9N5.
Family and domain databases
InterPro	IPR018379. BEN_domain. [Graphical view]
Pfam	PF10523. BEN. 1 hit. [Graphical view]
SMART	SM01025. BEN. 1 hit. [Graphical view]
PROSITE	PS51457. BEN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	58210.
SOURCE	Search...

Entry information

Entry name

BANP_HUMAN

Accession

Primary (citable) accession number: Q8N9N5
Secondary accession number(s): A8MU25 , A8MX25, Q96GJ7, Q9NWY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.