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Protein

Protein BANP

Gene

BANP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6804759. Regulation of TP53 Activity through Association with Co-factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BANP
Alternative name(s):
BEN domain-containing protein 1
Btg3-associated nuclear protein
Scaffold/matrix-associated region-1-binding protein
Gene namesi
Name:BANP
Synonyms:BEND1, SMAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000172530.19.
HGNCiHGNC:13450. BANP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi54971.
OpenTargetsiENSG00000172530.
PharmGKBiPA134933411.

Polymorphism and mutation databases

BioMutaiBANP.
DMDMi308153628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979101 – 519Protein BANPAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei275N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N9N5.
MaxQBiQ8N9N5.
PaxDbiQ8N9N5.
PeptideAtlasiQ8N9N5.
PRIDEiQ8N9N5.

PTM databases

iPTMnetiQ8N9N5.
PhosphoSitePlusiQ8N9N5.

Expressioni

Tissue specificityi

Down-regulated in breast cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000172530.
CleanExiHS_BANP.
ExpressionAtlasiQ8N9N5. baseline and differential.
GenevisibleiQ8N9N5. HS.

Organism-specific databases

HPAiHPA047164.

Interactioni

Subunit structurei

Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAM15Q134443EBI-744695,EBI-77818
AFG1LQ8WV933EBI-744695,EBI-2865743
ALAS2P225573EBI-744695,EBI-2115743
ALAS2P22557-25EBI-11524452,EBI-12257000
BAG5Q9UL153EBI-744695,EBI-356517
C1orf94Q6P1W53EBI-744695,EBI-946029
C22orf39Q6P5X53EBI-744695,EBI-7317823
CAMK2DQ135573EBI-744695,EBI-351018
CCDC26Q8TAB73EBI-744695,EBI-10271580
CDKN1BP465273EBI-11524452,EBI-519280
CEP76Q8TAP63EBI-744695,EBI-742887
CFAP206Q8IYR03EBI-744695,EBI-749051
COL10A1Q036924EBI-11524452,EBI-2528309
DCDC2BA2VCK23EBI-744695,EBI-10173222
DNAJA4Q8WW22-23EBI-744695,EBI-10277181
EPHA10Q5JZY3-33EBI-744695,EBI-10244652
FAM117BQ6P1L53EBI-744695,EBI-3893327
FAM71CQ8NEG03EBI-744695,EBI-752049
FAM90A1Q86YD73EBI-744695,EBI-6658203
FHL2Q141923EBI-744695,EBI-701903
FOXR1Q6PIV23EBI-744695,EBI-10253815
GFM2Q969S93EBI-744695,EBI-2371750
ISCUQ9H1K13EBI-744695,EBI-1047335
L3MBTL3Q96JM73EBI-744695,EBI-2686809
LENG1Q96BZ83EBI-744695,EBI-726510
LGALS14Q8TCE93EBI-744695,EBI-10274069
LMO2P257913EBI-744695,EBI-739696
LMO3Q8TAP43EBI-744695,EBI-742259
LMO4P619683EBI-744695,EBI-2798728
LSM2Q9Y3333EBI-744695,EBI-347416
MAP2K1Q027503EBI-744695,EBI-492564
MAXP612443EBI-744695,EBI-751711
MGC4677Q53S703EBI-744695,EBI-10242717
MRPL28Q130843EBI-744695,EBI-723426
NEDD9Q145114EBI-744695,EBI-2108053
NRIP2Q9BQI93EBI-744695,EBI-3913975
PHF21AQ96BD53EBI-744695,EBI-745085
PID1Q7Z2X43EBI-744695,EBI-10256685
PIM1P113093EBI-744695,EBI-696621
POGZQ7Z3K35EBI-744695,EBI-1389308
POLDIP3Q8WUT13EBI-744695,EBI-10276663
POLR2LP628753EBI-744695,EBI-359527
PPIBP232843EBI-744695,EBI-359252
PPICP458773EBI-744695,EBI-953909
PPIFP304053EBI-744695,EBI-5544229
PRKAB2O437413EBI-744695,EBI-1053424
PRKCHQ9BVQ03EBI-744695,EBI-10299920
PSMD9O002333EBI-744695,EBI-750973
RAB3IPQ96QF03EBI-744695,EBI-747844
RBM39Q14498-33EBI-744695,EBI-6654703
RBPMSQ930623EBI-744695,EBI-740322
RIDAP527584EBI-11524452,EBI-1045080
SH3RF2Q08AM83EBI-744695,EBI-10225873
SH3RF2Q8TEC53EBI-744695,EBI-2130111
SLC16A3O154273EBI-744695,EBI-7600166
SNRPBP14678-23EBI-744695,EBI-372475
SP2Q020864EBI-744695,EBI-8651703
SPACA6W5XKT83EBI-744695,EBI-10176265
tmp_locus_54Q53NU33EBI-744695,EBI-10242677
TNXBP221054EBI-744695,EBI-2821024
TOX4O948423EBI-744695,EBI-948613
TP53P046373EBI-744695,EBI-366083
TRAF2Q129334EBI-744695,EBI-355744
TRAF4Q9BUZ44EBI-11524452,EBI-3650647
TROAPQ128153EBI-744695,EBI-2349743
XAGE1EQ9HD643EBI-744695,EBI-2340004
ZC2HC1CQ53FD03EBI-744695,EBI-740767
ZMIZ2Q8NF64-23EBI-744695,EBI-10182121
ZNF438Q7Z4V04EBI-11524452,EBI-11962468
ZNF488Q96MN93EBI-744695,EBI-948288
ZNF581Q9P0T43EBI-744695,EBI-745520

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120308. 117 interactors.
CORUMiQ8N9N5.
IntActiQ8N9N5. 149 interactors.
MINTiMINT-4926337.
STRINGi9606.ENSP00000286122.

Structurei

3D structure databases

ProteinModelPortaliQ8N9N5.
SMRiQ8N9N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 322BENPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 342Interaction with CUX1 and HDAC1By similarityAdd BLAST191
Regioni320 – 349Necessary and sufficient for TP53 activationBy similarityAdd BLAST30
Regioni342 – 393DNA-bindingBy similarityAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 90Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi361 – 426Gln-richAdd BLAST66

Sequence similaritiesi

Belongs to the BANP/SMAR1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGMM. Eukaryota.
ENOG410Z2PJ. LUCA.
GeneTreeiENSGT00390000011116.
HOGENOMiHOG000015355.
HOVERGENiHBG107493.
InParanoidiQ8N9N5.
OMAiIISNAVP.
OrthoDBiEOG091G0JD3.
PhylomeDBiQ8N9N5.
TreeFamiTF331908.

Family and domain databases

InterProiView protein in InterPro
IPR018379. BEN_domain.
PfamiView protein in Pfam
PF10523. BEN. 1 hit.
SMARTiView protein in SMART
SM01025. BEN. 1 hit.
PROSITEiView protein in PROSITE
PS51457. BEN. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9N5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD
60 70 80 90 100
PSIKTICLRL DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS
110 120 130 140 150
PLGATQTCNK VRCVVPQTTV ILNNDRQNAI VAKMEDPLSN RAPDSLENVI
160 170 180 190 200
SNAVPGRRQN TIVVKVPGQE DSHHEDGESG SEASDSVSSC GQAGSQSIGS
210 220 230 240 250
NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH ISTNCRTAEK
260 270 280 290 300
MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT
310 320 330 340 350
ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM
360 370 380 390 400
STPPPASELP QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV
410 420 430 440 450
PQGEQVQITQ DSEGNLQIHH VGQDGQLLEA TRIPCLLAPS VFKASSGQVL
460 470 480 490 500
QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV QYVQLAPVSD HTAGAQTAEA
510
LQPTLQPEMQ LEHGAIQIQ
Length:519
Mass (Da):56,494
Last modified:October 5, 2010 - v3
Checksum:i521C53F367A3A29E
GO
Isoform 2 (identifier: Q8N9N5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ
     425-446: Missing.

Show »
Length:469
Mass (Da):51,243
Checksum:i9E4B4A8C287A4A34
GO
Isoform 3 (identifier: Q8N9N5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     25-36: VLENHVVTDEDE → MTREFVKRSIFL
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):48,404
Checksum:i4C86E6B4AFD4B689
GO
Isoform 4 (identifier: Q8N9N5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Show »
Length:491
Mass (Da):53,527
Checksum:iBA171D3BA87F731B
GO
Isoform 5 (identifier: Q8N9N5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → GTELWDI
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):54,243
Checksum:i377684337AFFEF27
GO
Isoform 6 (identifier: Q8N9N5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Show »
Length:466
Mass (Da):50,905
Checksum:i4704286351630810
GO
Isoform 7 (identifier: Q8N9N5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     392-392: V → VIPQ
     425-446: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):55,502
Checksum:i80ACD475B6F32D74
GO

Sequence cautioni

The sequence BAC04296 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123N → S in AK315535 (PubMed:14702039).Curated1
Sequence conflicti338P → S in BAA91244 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273961 – 24Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04355824V → GTELWDI in isoform 5. 1 Publication1
Alternative sequenceiVSP_02739825 – 36VLENH…TDEDE → MTREFVKRSIFL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02739954K → KSFLYSINQ in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_027400114 – 152Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_027401392V → VIPQ in isoform 2, isoform 4, isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_027402425 – 446Missing in isoform 2, isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000545 mRNA. Translation: BAA91244.1.
AK094158 mRNA. Translation: BAC04296.1. Different initiation.
AK125232 mRNA. Translation: BAG54171.1.
AK297945 mRNA. Translation: BAG60261.1.
AK315089 mRNA. Translation: BAG37554.1.
AK315535 mRNA. No translation available.
AC127455 Genomic DNA. No translation available.
AC134312 Genomic DNA. No translation available.
BC009424 mRNA. Translation: AAH09424.1.
CCDSiCCDS10966.2. [Q8N9N5-4]
CCDS42215.1. [Q8N9N5-2]
CCDS54052.1. [Q8N9N5-7]
CCDS54053.1. [Q8N9N5-6]
CCDS54054.1. [Q8N9N5-1]
CCDS54055.1. [Q8N9N5-5]
RefSeqiNP_001167010.1. NM_001173539.1.
NP_001167011.1. NM_001173540.1. [Q8N9N5-5]
NP_001167012.1. NM_001173541.1. [Q8N9N5-6]
NP_001167013.1. NM_001173542.1. [Q8N9N5-7]
NP_001167014.1. NM_001173543.1. [Q8N9N5-1]
NP_060339.2. NM_017869.3. [Q8N9N5-2]
NP_524576.2. NM_079837.2. [Q8N9N5-4]
UniGeneiHs.461705.

Genome annotation databases

EnsembliENST00000286122; ENSP00000286122; ENSG00000172530. [Q8N9N5-1]
ENST00000355022; ENSP00000347125; ENSG00000172530. [Q8N9N5-2]
ENST00000393207; ENSP00000376902; ENSG00000172530. [Q8N9N5-1]
ENST00000393208; ENSP00000376903; ENSG00000172530. [Q8N9N5-4]
ENST00000479780; ENSP00000432508; ENSG00000172530. [Q8N9N5-6]
ENST00000538234; ENSP00000444352; ENSG00000172530. [Q8N9N5-7]
ENST00000626016; ENSP00000487304; ENSG00000172530. [Q8N9N5-5]
GeneIDi54971.
KEGGihsa:54971.
UCSCiuc002fkp.4. human. [Q8N9N5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBANP_HUMAN
AccessioniPrimary (citable) accession number: Q8N9N5
Secondary accession number(s): A8MU25
, A8MX25, B2RCF7, B4DNJ9, F5GZM0, Q96GJ7, Q9NWY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: October 25, 2017
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families