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Protein

Activating signal cointegrator 1 complex subunit 1

Gene

ASCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112126. ALKBH3 mediated reversal of alkylation damage.

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 1
Alternative name(s):
ASC-1 complex subunit p50
Trip4 complex subunit p50
Gene namesi
Name:ASCC1
ORF Names:CGI-18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24268. ASCC1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: Reactome
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Barrett esophagus (BE)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
See also OMIM:614266

Organism-specific databases

MalaCardsiASCC1.
MIMi614266. phenotype.
Orphaneti1232. Barrett esophagus.
PharmGKBiPA134974899.

Polymorphism and mutation databases

BioMutaiASCC1.
DMDMi50400556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Activating signal cointegrator 1 complex subunit 1PRO_0000050100Add
BLAST

Proteomic databases

EPDiQ8N9N2.
MaxQBiQ8N9N2.
PaxDbiQ8N9N2.
PRIDEiQ8N9N2.

PTM databases

iPTMnetiQ8N9N2.
PhosphoSiteiQ8N9N2.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ8N9N2.
CleanExiHS_ASCC1.
ExpressionAtlasiQ8N9N2. baseline and differential.
GenevisibleiQ8N9N2. HS.

Organism-specific databases

HPAiHPA038038.

Interactioni

Subunit structurei

Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129333EBI-10268317,EBI-355744

Protein-protein interaction databases

BioGridi119215. 38 interactions.
IntActiQ8N9N2. 17 interactions.
STRINGi9606.ENSP00000339404.

Structurei

3D structure databases

ProteinModelPortaliQ8N9N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 14863KHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2814. Eukaryota.
ENOG4111FMP. LUCA.
GeneTreeiENSGT00390000018119.
HOGENOMiHOG000261687.
HOVERGENiHBG050588.
InParanoidiQ8N9N2.
KOiK18666.
OMAiRCKEEFI.
OrthoDBiEOG7WQ7SJ.
PhylomeDBiQ8N9N2.
TreeFamiTF314479.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
3.90.1140.10. 1 hit.
InterProiIPR009210. ASCC1.
IPR004088. KH_dom_type_1.
IPR019510. Kinase-A_anchor_nucl_local_sig.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PfamiPF10469. AKAP7_NLS. 1 hit.
PF00013. KH_1. 1 hit.
[Graphical view]
PIRSFiPIRSF027019. Euk_LigT. 1 hit.
SUPFAMiSSF54791. SSF54791. 1 hit.
SSF55144. SSF55144. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9N2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLRPQLIR IDGRNYRKNP VQEQTYQHEE DEEDFYQGSM ECADEPCDAY
60 70 80 90 100
EVEQTPQGFR STLRAPSLLY NLIHLNTSND CGFQKITLDC QNIYTWKSRH
110 120 130 140 150
IVGKRGDTRK KIEMETKTSI SIPKPGQDGE IVITGQHRNG VISARTRIDV
160 170 180 190 200
LLDTFRRKQP FTHFLAFFLN EVEVQEGFLR FQEEVLAKCS MDHGVDSSIF
210 220 230 240 250
QNPKKLHLTI GMLVLLSEEE IQQTCEMLQQ CKEEFINDIS GGKPLEVEMA
260 270 280 290 300
GIEYMNDDPG MVDVLYAKVH MKDGSNRLQE LVDRVLERFQ ASGLIVKEWN
310 320 330 340 350
SVKLHATVMN TLFRKDPNAE GRYNLYTAEG KYIFKERESF DGRNILKSFA
360 370 380 390 400
LLPRLEYNDA ISAHCNLCLP GSSDSPASAS QVAGITGVSD AYSQSLPGKS
Length:400
Mass (Da):45,509
Last modified:October 1, 2002 - v1
Checksum:iDAD067C98CE71DDB
GO
Isoform 2 (identifier: Q8N9N2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-99: NLIHLNTSNDCGFQKITLDCQNIYTWKSR → K
     348-400: SFALLPRLEY...AYSQSLPGKS → LFENFYFGSL...YASCGQIDFS

Show »
Length:357
Mass (Da):41,228
Checksum:iC25FA29C9BA16EDE
GO

Sequence cautioni

The sequence CAI15908.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111I → F (PubMed:12077347).Curated
Sequence conflicti11 – 111I → F (PubMed:10810093).Curated
Sequence conflicti240 – 2434SGGK → PGR (PubMed:12077347).Curated
Sequence conflicti240 – 2434SGGK → PGR (PubMed:10810093).Curated
Sequence conflicti250 – 2501A → P (PubMed:12077347).Curated
Sequence conflicti250 – 2501A → P (PubMed:10810093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341D → N.
Corresponds to variant rs11558719 [ dbSNP | Ensembl ].
VAR_061278
Natural varianti318 – 3181N → S Found in patients with Barrett esophagus. 1 Publication
Corresponds to variant rs146370051 [ dbSNP | Ensembl ].
VAR_066588

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei71 – 9929NLIHL…TWKSR → K in isoform 2. 4 PublicationsVSP_011007Add
BLAST
Alternative sequencei348 – 40053SFALL…LPGKS → LFENFYFGSLKLNSIHISQR FTVDSFGNYASCGQIDFS in isoform 2. 4 PublicationsVSP_011008Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013290 mRNA. Translation: AAG45476.1.
AF132952 mRNA. Translation: AAD27727.1.
AK094170 mRNA. Translation: BAC04299.1.
AK023436 mRNA. Translation: BAG51193.1.
AL607035, AC022392 Genomic DNA. Translation: CAI15907.1.
AL607035, AC022392 Genomic DNA. Translation: CAI15908.1. Sequence problems.
CH471083 Genomic DNA. Translation: EAW54444.1.
BC012291 mRNA. Translation: AAH12291.1.
CCDSiCCDS31219.1. [Q8N9N2-2]
CCDS55713.1. [Q8N9N2-1]
RefSeqiNP_001185727.1. NM_001198798.2. [Q8N9N2-2]
NP_001185728.1. NM_001198799.2. [Q8N9N2-1]
NP_001185729.1. NM_001198800.2. [Q8N9N2-2]
XP_006717936.1. XM_006717873.2. [Q8N9N2-2]
UniGeneiHs.500007.

Genome annotation databases

EnsembliENST00000317126; ENSP00000320461; ENSG00000138303. [Q8N9N2-2]
ENST00000317168; ENSP00000320810; ENSG00000138303. [Q8N9N2-2]
ENST00000342444; ENSP00000339404; ENSG00000138303. [Q8N9N2-1]
ENST00000394915; ENSP00000378373; ENSG00000138303. [Q8N9N2-1]
ENST00000394919; ENSP00000378377; ENSG00000138303. [Q8N9N2-2]
GeneIDi51008.
KEGGihsa:51008.
UCSCiuc001jst.3. human. [Q8N9N2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013290 mRNA. Translation: AAG45476.1.
AF132952 mRNA. Translation: AAD27727.1.
AK094170 mRNA. Translation: BAC04299.1.
AK023436 mRNA. Translation: BAG51193.1.
AL607035, AC022392 Genomic DNA. Translation: CAI15907.1.
AL607035, AC022392 Genomic DNA. Translation: CAI15908.1. Sequence problems.
CH471083 Genomic DNA. Translation: EAW54444.1.
BC012291 mRNA. Translation: AAH12291.1.
CCDSiCCDS31219.1. [Q8N9N2-2]
CCDS55713.1. [Q8N9N2-1]
RefSeqiNP_001185727.1. NM_001198798.2. [Q8N9N2-2]
NP_001185728.1. NM_001198799.2. [Q8N9N2-1]
NP_001185729.1. NM_001198800.2. [Q8N9N2-2]
XP_006717936.1. XM_006717873.2. [Q8N9N2-2]
UniGeneiHs.500007.

3D structure databases

ProteinModelPortaliQ8N9N2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119215. 38 interactions.
IntActiQ8N9N2. 17 interactions.
STRINGi9606.ENSP00000339404.

PTM databases

iPTMnetiQ8N9N2.
PhosphoSiteiQ8N9N2.

Polymorphism and mutation databases

BioMutaiASCC1.
DMDMi50400556.

Proteomic databases

EPDiQ8N9N2.
MaxQBiQ8N9N2.
PaxDbiQ8N9N2.
PRIDEiQ8N9N2.

Protocols and materials databases

DNASUi51008.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317126; ENSP00000320461; ENSG00000138303. [Q8N9N2-2]
ENST00000317168; ENSP00000320810; ENSG00000138303. [Q8N9N2-2]
ENST00000342444; ENSP00000339404; ENSG00000138303. [Q8N9N2-1]
ENST00000394915; ENSP00000378373; ENSG00000138303. [Q8N9N2-1]
ENST00000394919; ENSP00000378377; ENSG00000138303. [Q8N9N2-2]
GeneIDi51008.
KEGGihsa:51008.
UCSCiuc001jst.3. human. [Q8N9N2-1]

Organism-specific databases

CTDi51008.
GeneCardsiASCC1.
HGNCiHGNC:24268. ASCC1.
HPAiHPA038038.
MalaCardsiASCC1.
MIMi614215. gene.
614266. phenotype.
neXtProtiNX_Q8N9N2.
Orphaneti1232. Barrett esophagus.
PharmGKBiPA134974899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2814. Eukaryota.
ENOG4111FMP. LUCA.
GeneTreeiENSGT00390000018119.
HOGENOMiHOG000261687.
HOVERGENiHBG050588.
InParanoidiQ8N9N2.
KOiK18666.
OMAiRCKEEFI.
OrthoDBiEOG7WQ7SJ.
PhylomeDBiQ8N9N2.
TreeFamiTF314479.

Enzyme and pathway databases

ReactomeiR-HSA-112126. ALKBH3 mediated reversal of alkylation damage.

Miscellaneous databases

GenomeRNAii51008.
PROiQ8N9N2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N9N2.
CleanExiHS_ASCC1.
ExpressionAtlasiQ8N9N2. baseline and differential.
GenevisibleiQ8N9N2. HS.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
3.90.1140.10. 1 hit.
InterProiIPR009210. ASCC1.
IPR004088. KH_dom_type_1.
IPR019510. Kinase-A_anchor_nucl_local_sig.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PfamiPF10469. AKAP7_NLS. 1 hit.
PF00013. KH_1. 1 hit.
[Graphical view]
PIRSFiPIRSF027019. Euk_LigT. 1 hit.
SUPFAMiSSF54791. SSF54791. 1 hit.
SSF55144. SSF55144. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel transcription coactivator complex containing activating signal cointegrator 1."
    Jung D.-J., Sung H.-S., Goo Y.-W., Lee H.M., Park O.K., Jung S.-Y., Lim J., Kim H.-J., Lee S.-K., Kim T.S., Lee J.W., Lee Y.C.
    Mol. Cell. Biol. 22:5203-5211(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE, INTERACTION WITH ASCC2 AND ASCC3.
    Tissue: Cervix carcinoma.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Astrocyte and Placenta.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.
  7. "Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1."
    Almeida-Vega S., Catlow K., Kenny S., Dimaline R., Varro A.
    Am. J. Physiol. 296:G414-G423(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma."
    Orloff M., Peterson C., He X., Ganapathi S., Heald B., Yang Y.R., Bebek G., Romigh T., Song J.H., Wu W., David S., Cheng Y., Meltzer S.J., Eng C.
    JAMA 306:410-419(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BE, VARIANT SER-318.
  10. "DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."
    Dango S., Mosammaparast N., Sowa M.E., Xiong L.J., Wu F., Park K., Rubin M., Gygi S., Harper J.W., Shi Y.
    Mol. Cell 44:373-384(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALKHB3.

Entry informationi

Entry nameiASCC1_HUMAN
AccessioniPrimary (citable) accession number: Q8N9N2
Secondary accession number(s): Q5SW06
, Q5SW07, Q96EI8, Q9Y307
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.