Q8N9M5 (TM102_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 102

Alternative name(s):
Common beta-chain associated protein
Short name=CBAP

Gene names

Name:

TMEM102

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. Ref.4
Subunit structure	Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2. Ref.4
Subcellular location	Cell membrane; Single-pass membrane protein. Note: Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments. Ref.4

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of T cell migration Inferred from direct assay PubMed 23620790. Source: MGI positive regulation of cell adhesion Inferred from direct assay PubMed 23620790. Source: MGI regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Inferred from direct assay Ref.4. Source: UniProtKB response to cytokine Inferred from direct assay Ref.4. Source: UniProtKB signal transduction Inferred from direct assay Ref.4. Source: UniProtKB
Cellular_component	cell surface Inferred from direct assay Ref.4. Source: UniProtKB integral component of membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from direct assay Ref.4. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell protein complex Inferred from direct assay PubMed 23620790. Source: MGI
Molecular_function	protein binding Inferred from physical interaction Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Transmembrane protein 102		PRO_0000263648
Regions
	Topological domain	1 – 260	260	Extracellular Potential
	Transmembrane	261 – 278	18	Helical; Potential
	Topological domain	279 – 508	230	Cytoplasmic Potential
Natural variations
	Natural variant	110	1	A → V. Corresponds to variant rs3809718 [ dbSNP | Ensembl ].		VAR_029595

Sequences

	Sequence		Length	Mass (Da)
	Q8N9M5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 27B3FDC1C30E3406	FASTA	508	54,175
	10 20 30 40 50 60 MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW SDGPKPGADL 70 80 90 100 110 120 LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYA RGPHYDAGFT 130 140 150 160 170 180 LLVPMFSLDG TELQLDLESC YAQVCLPEMV CGTPIREMWQ DCLGPPVPGA RDSIHRTESE 190 200 210 220 230 240 ESSKDWQSSV DQPHSYVTEH EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT 250 260 270 280 290 300 KAAVESPVPK PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT 310 320 330 340 350 360 TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV PGGGTERPCA 370 380 390 400 410 420 SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT RAAAPYLLRT LLYWACERLP 430 440 450 460 470 480 ALYLARPENA GACCLGLLDE LGRVLEAGTL PHYFLNGRQL RTGDDSAALL GELARLRGDP 490 500 ARALRAAVEE AKVARKGGGL AGVGGGAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Glial tumor.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction." Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F., Yen J.J. Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK094197 mRNA. Translation: BAC04306.1. CH471108 Genomic DNA. Translation: EAW90189.1. CH471108 Genomic DNA. Translation: EAW90190.1. BC046189 mRNA. Translation: AAH46189.1.
CCDS	CCDS11104.1.
RefSeq	NP_848613.1. NM_178518.2. XP_005256671.1. XM_005256614.1.
UniGene	Hs.655662.
3D structure databases
ProteinModelPortal	Q8N9M5.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	129765. 2 interactions.
IntAct	Q8N9M5. 1 interaction.
MINT	MINT-1683538.
STRING	9606.ENSP00000315387.
PTM databases
PhosphoSite	Q8N9M5.
Polymorphism databases
DMDM	74729725.
Proteomic databases
MaxQB	Q8N9M5.
PaxDb	Q8N9M5.
PRIDE	Q8N9M5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323206; ENSP00000315387; ENSG00000181284. ENST00000396568; ENSP00000379815; ENSG00000181284.
GeneID	284114.
KEGG	hsa:284114.
UCSC	uc002ggx.1. human.
Organism-specific databases
CTD	284114.
GeneCards	GC17P007338.
HGNC	HGNC:26722. TMEM102.
HPA	HPA024433.
MIM	613936. gene.
neXtProt	NX_Q8N9M5.
PharmGKB	PA142670751.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302599.
HOGENOM	HOG000154601.
HOVERGEN	HBG094048.
InParanoid	Q8N9M5.
OMA	SHSWAGP.
OrthoDB	EOG7DNNTS.
PhylomeDB	Q8N9M5.
TreeFam	TF329089.
Gene expression databases
Bgee	Q8N9M5.
CleanEx	HS_TMEM102.
Genevestigator	Q8N9M5.
Family and domain databases
InterPro	IPR024810. Mab-21_dom. IPR024806. TMEM102. [Graphical view]
PANTHER	PTHR10656:SF11. PTHR10656:SF11. 1 hit.
Pfam	PF03281. Mab-21. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284114.
NextBio	94554.
PRO	Q8N9M5.
SOURCE	Search...

Entry information

Entry name

TM102_HUMAN

Accession

Primary (citable) accession number: Q8N9M5
Secondary accession number(s): D3DTP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 1, 2002
Last modified:	July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.