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Q8N9M5

- TM102_HUMAN

UniProt

Q8N9M5 - TM102_HUMAN

Protein

Transmembrane protein 102

Gene

TMEM102

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. positive regulation of cell adhesion Source: MGI
    3. positive regulation of T cell migration Source: MGI
    4. regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
    5. response to cytokine Source: UniProtKB
    6. signal transduction Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 102
    Alternative name(s):
    Common beta-chain associated protein
    Short name:
    CBAP
    Gene namesi
    Name:TMEM102
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26722. TMEM102.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass membrane protein 1 Publication
    Note: Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular Source: UniProtKB
    4. plasma membrane Source: UniProtKB-SubCell
    5. protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670751.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Transmembrane protein 102PRO_0000263648Add
    BLAST

    Proteomic databases

    MaxQBiQ8N9M5.
    PaxDbiQ8N9M5.
    PRIDEiQ8N9M5.

    PTM databases

    PhosphoSiteiQ8N9M5.

    Expressioni

    Gene expression databases

    BgeeiQ8N9M5.
    CleanExiHS_TMEM102.
    GenevestigatoriQ8N9M5.

    Organism-specific databases

    HPAiHPA024433.

    Interactioni

    Subunit structurei

    Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.1 Publication

    Protein-protein interaction databases

    BioGridi129765. 2 interactions.
    IntActiQ8N9M5. 1 interaction.
    MINTiMINT-1683538.
    STRINGi9606.ENSP00000315387.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N9M5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 260260ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini279 – 508230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei261 – 27818HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302599.
    HOGENOMiHOG000154601.
    HOVERGENiHBG094048.
    InParanoidiQ8N9M5.
    OMAiSHSWAGP.
    OrthoDBiEOG7DNNTS.
    PhylomeDBiQ8N9M5.
    TreeFamiTF329089.

    Family and domain databases

    InterProiIPR024810. Mab-21_dom.
    IPR024806. TMEM102.
    [Graphical view]
    PANTHERiPTHR10656:SF11. PTHR10656:SF11. 1 hit.
    PfamiPF03281. Mab-21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N9M5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW    50
    SDGPKPGADL LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD 100
    LGHAPLGPYA RGPHYDAGFT LLVPMFSLDG TELQLDLESC YAQVCLPEMV 150
    CGTPIREMWQ DCLGPPVPGA RDSIHRTESE ESSKDWQSSV DQPHSYVTEH 200
    EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT KAAVESPVPK 250
    PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT 300
    TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV 350
    PGGGTERPCA SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT 400
    RAAAPYLLRT LLYWACERLP ALYLARPENA GACCLGLLDE LGRVLEAGTL 450
    PHYFLNGRQL RTGDDSAALL GELARLRGDP ARALRAAVEE AKVARKGGGL 500
    AGVGGGAH 508
    Length:508
    Mass (Da):54,175
    Last modified:October 1, 2002 - v1
    Checksum:i27B3FDC1C30E3406
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101A → V.
    Corresponds to variant rs3809718 [ dbSNP | Ensembl ].
    VAR_029595

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094197 mRNA. Translation: BAC04306.1.
    CH471108 Genomic DNA. Translation: EAW90189.1.
    CH471108 Genomic DNA. Translation: EAW90190.1.
    BC046189 mRNA. Translation: AAH46189.1.
    CCDSiCCDS11104.1.
    RefSeqiNP_848613.1. NM_178518.2.
    XP_005256671.1. XM_005256614.1.
    UniGeneiHs.655662.

    Genome annotation databases

    EnsembliENST00000323206; ENSP00000315387; ENSG00000181284.
    ENST00000396568; ENSP00000379815; ENSG00000181284.
    GeneIDi284114.
    KEGGihsa:284114.
    UCSCiuc002ggx.1. human.

    Polymorphism databases

    DMDMi74729725.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094197 mRNA. Translation: BAC04306.1 .
    CH471108 Genomic DNA. Translation: EAW90189.1 .
    CH471108 Genomic DNA. Translation: EAW90190.1 .
    BC046189 mRNA. Translation: AAH46189.1 .
    CCDSi CCDS11104.1.
    RefSeqi NP_848613.1. NM_178518.2.
    XP_005256671.1. XM_005256614.1.
    UniGenei Hs.655662.

    3D structure databases

    ProteinModelPortali Q8N9M5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129765. 2 interactions.
    IntActi Q8N9M5. 1 interaction.
    MINTi MINT-1683538.
    STRINGi 9606.ENSP00000315387.

    PTM databases

    PhosphoSitei Q8N9M5.

    Polymorphism databases

    DMDMi 74729725.

    Proteomic databases

    MaxQBi Q8N9M5.
    PaxDbi Q8N9M5.
    PRIDEi Q8N9M5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323206 ; ENSP00000315387 ; ENSG00000181284 .
    ENST00000396568 ; ENSP00000379815 ; ENSG00000181284 .
    GeneIDi 284114.
    KEGGi hsa:284114.
    UCSCi uc002ggx.1. human.

    Organism-specific databases

    CTDi 284114.
    GeneCardsi GC17P007338.
    HGNCi HGNC:26722. TMEM102.
    HPAi HPA024433.
    MIMi 613936. gene.
    neXtProti NX_Q8N9M5.
    PharmGKBi PA142670751.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302599.
    HOGENOMi HOG000154601.
    HOVERGENi HBG094048.
    InParanoidi Q8N9M5.
    OMAi SHSWAGP.
    OrthoDBi EOG7DNNTS.
    PhylomeDBi Q8N9M5.
    TreeFami TF329089.

    Miscellaneous databases

    GenomeRNAii 284114.
    NextBioi 94554.
    PROi Q8N9M5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N9M5.
    CleanExi HS_TMEM102.
    Genevestigatori Q8N9M5.

    Family and domain databases

    InterProi IPR024810. Mab-21_dom.
    IPR024806. TMEM102.
    [Graphical view ]
    PANTHERi PTHR10656:SF11. PTHR10656:SF11. 1 hit.
    Pfami PF03281. Mab-21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Glial tumor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction."
      Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F., Yen J.J.
      Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiTM102_HUMAN
    AccessioniPrimary (citable) accession number: Q8N9M5
    Secondary accession number(s): D3DTP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3