TMEM102

Functionⁱ

Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.1 Publication

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
positive regulation of cell adhesion
Source: MGI
Inferred from direct assayⁱ
- 23620790
positive regulation of T cell chemotaxis Source: Ensembl
positive regulation of T cell migration
Source: MGI
Inferred from direct assayⁱ
- 23620790
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 17828305
regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
response to cytokine
Source: UniProtKB
Inferred from direct assayⁱ
- 17828305
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 17828305

Complete GO annotation...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 102 Alternative name(s): Common beta-chain associated protein Short name: CBAP
Gene namesⁱ	Name:TMEM102
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26722. TMEM102.

HGNCⁱ

HGNC:26722. TMEM102.

Subcellular locationⁱ

Cell membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction."
  Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F., Yen J.J.
  Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, TOPOLOGY.
; Single-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction."
  Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F., Yen J.J.
  Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, TOPOLOGY.

Note:

Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 260	ExtracellularSequence analysisAdd BLAST	260
Transmembraneⁱ	261 – 278	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	279 – 508	CytoplasmicSequence analysisAdd BLAST	230

GO - Cellular componentⁱ

cell surface
Source: UniProtKB
Inferred from direct assayⁱ
- 17828305
integral component of membrane Source: UniProtKB-KW
intracellular
Source: UniProtKB
Inferred from direct assayⁱ
- 17828305
mitochondrion Source: GOC
plasma membrane Source: UniProtKB-SubCell
protein complex
Source: MGI
Inferred from direct assayⁱ
- 23620790

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000181284.
PharmGKBⁱ	PA142670751.

Polymorphism and mutation databases

BioMutaⁱ	TMEM102.
DMDMⁱ	74729725.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000263648	1 – 508	Transmembrane protein 102Add BLAST		508

Proteomic databases

EPDⁱ	Q8N9M5.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N9M5.
PaxDbⁱ	Q8N9M5.
PeptideAtlas More...PeptideAtlasⁱ	Q8N9M5.
PRIDEⁱ	Q8N9M5.

PTM databases

iPTMnetⁱ	Q8N9M5.
PhosphoSitePlusⁱ	Q8N9M5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000181284.
CleanExⁱ	HS_TMEM102.
Genevisibleⁱ	Q8N9M5. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024433.

HPAⁱ

HPA024433.

Interactionⁱ

Subunit structureⁱ

Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.1 Publication

Protein-protein interaction databases

BioGridⁱ	129765. 6 interactors.
IntActⁱ	Q8N9M5. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1683538.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N9M5.
SMRⁱ	Q8N9M5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3963. Eukaryota. ENOG410XNRJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063769.
HOGENOMⁱ	HOG000154601.
HOVERGENⁱ	HBG094048.
InParanoidⁱ	Q8N9M5.
OMAⁱ	SHSWAGP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06D0.
PhylomeDBⁱ	Q8N9M5.
TreeFamⁱ	TF329089.

Family and domain databases

InterProⁱ	View protein in InterPro IPR024810. Mab-21_dom. IPR024806. TMEM102.
PANTHERⁱ	PTHR10656:SF51. PTHR10656:SF51. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03281. Mab-21. 1 hit.
SMARTⁱ	View protein in SMART SM01265. Mab-21. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N9M5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW 
        60         70         80         90        100
SDGPKPGADL LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD 
       110        120        130        140        150
LGHAPLGPYA RGPHYDAGFT LLVPMFSLDG TELQLDLESC YAQVCLPEMV 
       160        170        180        190        200
CGTPIREMWQ DCLGPPVPGA RDSIHRTESE ESSKDWQSSV DQPHSYVTEH 
       210        220        230        240        250
EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT KAAVESPVPK 
       260        270        280        290        300
PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT 
       310        320        330        340        350
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV 
       360        370        380        390        400
PGGGTERPCA SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT 
       410        420        430        440        450
RAAAPYLLRT LLYWACERLP ALYLARPENA GACCLGLLDE LGRVLEAGTL 
       460        470        480        490        500
PHYFLNGRQL RTGDDSAALL GELARLRGDP ARALRAAVEE AKVARKGGGL 

AGVGGGAH

Length:508

Mass (Da):54,175

Last modified:October 1, 2002 - v1

Checksum:ⁱ27B3FDC1C30E3406

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029595	110	A → V. Corresponds to variant dbSNP:rs3809718Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK094197 mRNA. Translation: BAC04306.1. CH471108 Genomic DNA. Translation: EAW90189.1. CH471108 Genomic DNA. Translation: EAW90190.1. BC046189 mRNA. Translation: AAH46189.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11104.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001307373.1. NM_001320444.1. NP_848613.1. NM_178518.2.
UniGeneⁱ	Hs.655662.

Genome annotation databases

Ensemblⁱ	ENST00000323206; ENSP00000315387; ENSG00000181284. ENST00000396568; ENSP00000379815; ENSG00000181284. ENST00000638427; ENSP00000491063; ENSG00000284228. ENST00000639387; ENSP00000491290; ENSG00000284228.
GeneIDⁱ	284114.
KEGGⁱ	hsa:284114.
UCSC genome browser More...UCSCⁱ	uc002ggx.1. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK094197 mRNA. Translation: BAC04306.1. CH471108 Genomic DNA. Translation: EAW90189.1. CH471108 Genomic DNA. Translation: EAW90190.1. BC046189 mRNA. Translation: AAH46189.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11104.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001307373.1. NM_001320444.1. NP_848613.1. NM_178518.2.
UniGeneⁱ	Hs.655662.

3D structure databases

ProteinModelPortalⁱ	Q8N9M5.
SMRⁱ	Q8N9M5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129765. 6 interactors.
IntActⁱ	Q8N9M5. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1683538.

PTM databases

iPTMnetⁱ	Q8N9M5.
PhosphoSitePlusⁱ	Q8N9M5.

Polymorphism and mutation databases

BioMutaⁱ	TMEM102.
DMDMⁱ	74729725.

Proteomic databases

EPDⁱ	Q8N9M5.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N9M5.
PaxDbⁱ	Q8N9M5.
PeptideAtlas More...PeptideAtlasⁱ	Q8N9M5.
PRIDEⁱ	Q8N9M5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000323206; ENSP00000315387; ENSG00000181284. ENST00000396568; ENSP00000379815; ENSG00000181284. ENST00000638427; ENSP00000491063; ENSG00000284228. ENST00000639387; ENSP00000491290; ENSG00000284228.
GeneIDⁱ	284114.
KEGGⁱ	hsa:284114.
UCSC genome browser More...UCSCⁱ	uc002ggx.1. human.

Organism-specific databases

CTDⁱ	284114.
GeneCardsⁱ	TMEM102.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26722. TMEM102.
Human Protein Atlas More...HPAⁱ	HPA024433.
MIMⁱ	613936. gene.
neXtProtⁱ	NX_Q8N9M5.
Open Targets More...OpenTargetsⁱ	ENSG00000181284.
PharmGKBⁱ	PA142670751.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3963. Eukaryota. ENOG410XNRJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063769.
HOGENOMⁱ	HOG000154601.
HOVERGENⁱ	HBG094048.
InParanoidⁱ	Q8N9M5.
OMAⁱ	SHSWAGP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06D0.
PhylomeDBⁱ	Q8N9M5.
TreeFamⁱ	TF329089.

Miscellaneous databases

GenomeRNAiⁱ	284114.
Protein Ontology More...PROⁱ	PR:Q8N9M5.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000181284.
CleanExⁱ	HS_TMEM102.
Genevisibleⁱ	Q8N9M5. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR024810. Mab-21_dom. IPR024806. TMEM102.
PANTHERⁱ	PTHR10656:SF51. PTHR10656:SF51. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03281. Mab-21. 1 hit.
SMARTⁱ	View protein in SMART SM01265. Mab-21. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM102_HUMAN
Accessionⁱ	Q8N9M5Primary (citable) accession number: Q8N9M5 Secondary accession number(s): D3DTP8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	October 1, 2002
	Last modified:	July 5, 2017
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N9M5 (TM102_HUMAN)

Your basket is currently empty.

Transmembrane protein 102

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ