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Protein

Transmembrane protein 102

Gene

TMEM102

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of cell adhesion Source: MGI
  • positive regulation of T cell chemotaxis Source: Ensembl
  • positive regulation of T cell migration Source: MGI
  • regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
  • regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  • response to cytokine Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 102
Alternative name(s):
Common beta-chain associated protein
Short name:
CBAP
Gene namesi
Name:TMEM102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26722. TMEM102.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 260260ExtracellularSequence AnalysisAdd
BLAST
Transmembranei261 – 27818HelicalSequence AnalysisAdd
BLAST
Topological domaini279 – 508230CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670751.

Polymorphism and mutation databases

BioMutaiTMEM102.
DMDMi74729725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Transmembrane protein 102PRO_0000263648Add
BLAST

Proteomic databases

MaxQBiQ8N9M5.
PaxDbiQ8N9M5.
PRIDEiQ8N9M5.

PTM databases

PhosphoSiteiQ8N9M5.

Expressioni

Gene expression databases

BgeeiQ8N9M5.
CleanExiHS_TMEM102.
GenevisibleiQ8N9M5. HS.

Organism-specific databases

HPAiHPA024433.

Interactioni

Subunit structurei

Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.1 Publication

Protein-protein interaction databases

BioGridi129765. 6 interactions.
IntActiQ8N9M5. 1 interaction.
MINTiMINT-1683538.
STRINGi9606.ENSP00000315387.

Structurei

3D structure databases

ProteinModelPortaliQ8N9M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302599.
GeneTreeiENSGT00530000063769.
HOGENOMiHOG000154601.
HOVERGENiHBG094048.
InParanoidiQ8N9M5.
OMAiSHSWAGP.
OrthoDBiEOG7DNNTS.
PhylomeDBiQ8N9M5.
TreeFamiTF329089.

Family and domain databases

InterProiIPR024810. Mab-21_dom.
IPR024806. TMEM102.
[Graphical view]
PANTHERiPTHR10656:SF11. PTHR10656:SF11. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N9M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW
60 70 80 90 100
SDGPKPGADL LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD
110 120 130 140 150
LGHAPLGPYA RGPHYDAGFT LLVPMFSLDG TELQLDLESC YAQVCLPEMV
160 170 180 190 200
CGTPIREMWQ DCLGPPVPGA RDSIHRTESE ESSKDWQSSV DQPHSYVTEH
210 220 230 240 250
EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT KAAVESPVPK
260 270 280 290 300
PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT
310 320 330 340 350
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV
360 370 380 390 400
PGGGTERPCA SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT
410 420 430 440 450
RAAAPYLLRT LLYWACERLP ALYLARPENA GACCLGLLDE LGRVLEAGTL
460 470 480 490 500
PHYFLNGRQL RTGDDSAALL GELARLRGDP ARALRAAVEE AKVARKGGGL

AGVGGGAH
Length:508
Mass (Da):54,175
Last modified:October 1, 2002 - v1
Checksum:i27B3FDC1C30E3406
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101A → V.
Corresponds to variant rs3809718 [ dbSNP | Ensembl ].
VAR_029595

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094197 mRNA. Translation: BAC04306.1.
CH471108 Genomic DNA. Translation: EAW90189.1.
CH471108 Genomic DNA. Translation: EAW90190.1.
BC046189 mRNA. Translation: AAH46189.1.
CCDSiCCDS11104.1.
RefSeqiNP_848613.1. NM_178518.2.
XP_005256671.1. XM_005256614.1.
XP_011522100.1. XM_011523798.1.
UniGeneiHs.655662.

Genome annotation databases

EnsembliENST00000323206; ENSP00000315387; ENSG00000181284.
ENST00000396568; ENSP00000379815; ENSG00000181284.
GeneIDi284114.
KEGGihsa:284114.
UCSCiuc002ggx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094197 mRNA. Translation: BAC04306.1.
CH471108 Genomic DNA. Translation: EAW90189.1.
CH471108 Genomic DNA. Translation: EAW90190.1.
BC046189 mRNA. Translation: AAH46189.1.
CCDSiCCDS11104.1.
RefSeqiNP_848613.1. NM_178518.2.
XP_005256671.1. XM_005256614.1.
XP_011522100.1. XM_011523798.1.
UniGeneiHs.655662.

3D structure databases

ProteinModelPortaliQ8N9M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129765. 6 interactions.
IntActiQ8N9M5. 1 interaction.
MINTiMINT-1683538.
STRINGi9606.ENSP00000315387.

PTM databases

PhosphoSiteiQ8N9M5.

Polymorphism and mutation databases

BioMutaiTMEM102.
DMDMi74729725.

Proteomic databases

MaxQBiQ8N9M5.
PaxDbiQ8N9M5.
PRIDEiQ8N9M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323206; ENSP00000315387; ENSG00000181284.
ENST00000396568; ENSP00000379815; ENSG00000181284.
GeneIDi284114.
KEGGihsa:284114.
UCSCiuc002ggx.1. human.

Organism-specific databases

CTDi284114.
GeneCardsiGC17P007338.
HGNCiHGNC:26722. TMEM102.
HPAiHPA024433.
MIMi613936. gene.
neXtProtiNX_Q8N9M5.
PharmGKBiPA142670751.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302599.
GeneTreeiENSGT00530000063769.
HOGENOMiHOG000154601.
HOVERGENiHBG094048.
InParanoidiQ8N9M5.
OMAiSHSWAGP.
OrthoDBiEOG7DNNTS.
PhylomeDBiQ8N9M5.
TreeFamiTF329089.

Miscellaneous databases

GenomeRNAii284114.
NextBioi94554.
PROiQ8N9M5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N9M5.
CleanExiHS_TMEM102.
GenevisibleiQ8N9M5. HS.

Family and domain databases

InterProiIPR024810. Mab-21_dom.
IPR024806. TMEM102.
[Graphical view]
PANTHERiPTHR10656:SF11. PTHR10656:SF11. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Glial tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction."
    Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F., Yen J.J.
    Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, TOPOLOGY.

Entry informationi

Entry nameiTM102_HUMAN
AccessioniPrimary (citable) accession number: Q8N9M5
Secondary accession number(s): D3DTP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.