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Q8N9M5 (TM102_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 102
Alternative name(s):
Common beta-chain associated protein
Short name=CBAP
Gene names
Name:TMEM102
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. Ref.4

Subunit structure

Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2. Ref.4

Subcellular location

Cell membrane; Single-pass membrane protein. Note: Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments. Ref.4

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Transmembrane protein 102
PRO_0000263648

Regions

Topological domain1 – 260260Extracellular Potential
Transmembrane261 – 27818Helical; Potential
Topological domain279 – 508230Cytoplasmic Potential

Natural variations

Natural variant1101A → V.
Corresponds to variant rs3809718 [ dbSNP | Ensembl ].
VAR_029595

Sequences

Sequence LengthMass (Da)Tools
Q8N9M5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 27B3FDC1C30E3406

FASTA50854,175
        10         20         30         40         50         60 
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW SDGPKPGADL 

        70         80         90        100        110        120 
LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYA RGPHYDAGFT 

       130        140        150        160        170        180 
LLVPMFSLDG TELQLDLESC YAQVCLPEMV CGTPIREMWQ DCLGPPVPGA RDSIHRTESE 

       190        200        210        220        230        240 
ESSKDWQSSV DQPHSYVTEH EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT 

       250        260        270        280        290        300 
KAAVESPVPK PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT 

       310        320        330        340        350        360 
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV PGGGTERPCA 

       370        380        390        400        410        420 
SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT RAAAPYLLRT LLYWACERLP 

       430        440        450        460        470        480 
ALYLARPENA GACCLGLLDE LGRVLEAGTL PHYFLNGRQL RTGDDSAALL GELARLRGDP 

       490        500 
ARALRAAVEE AKVARKGGGL AGVGGGAH 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Glial tumor.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction."
Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F., Yen J.J.
Oncogene 27:1397-1403(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK094197 mRNA. Translation: BAC04306.1.
CH471108 Genomic DNA. Translation: EAW90189.1.
CH471108 Genomic DNA. Translation: EAW90190.1.
BC046189 mRNA. Translation: AAH46189.1.
CCDSCCDS11104.1.
RefSeqNP_848613.1. NM_178518.2.
XP_005256671.1. XM_005256614.1.
UniGeneHs.655662.

3D structure databases

ProteinModelPortalQ8N9M5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129765. 2 interactions.
IntActQ8N9M5. 1 interaction.
MINTMINT-1683538.
STRING9606.ENSP00000315387.

PTM databases

PhosphoSiteQ8N9M5.

Polymorphism databases

DMDM74729725.

Proteomic databases

MaxQBQ8N9M5.
PaxDbQ8N9M5.
PRIDEQ8N9M5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323206; ENSP00000315387; ENSG00000181284.
ENST00000396568; ENSP00000379815; ENSG00000181284.
GeneID284114.
KEGGhsa:284114.
UCSCuc002ggx.1. human.

Organism-specific databases

CTD284114.
GeneCardsGC17P007338.
HGNCHGNC:26722. TMEM102.
HPAHPA024433.
MIM613936. gene.
neXtProtNX_Q8N9M5.
PharmGKBPA142670751.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302599.
HOGENOMHOG000154601.
HOVERGENHBG094048.
InParanoidQ8N9M5.
OMASHSWAGP.
OrthoDBEOG7DNNTS.
PhylomeDBQ8N9M5.
TreeFamTF329089.

Gene expression databases

BgeeQ8N9M5.
CleanExHS_TMEM102.
GenevestigatorQ8N9M5.

Family and domain databases

InterProIPR024810. Mab-21_dom.
IPR024806. TMEM102.
[Graphical view]
PANTHERPTHR10656:SF11. PTHR10656:SF11. 1 hit.
PfamPF03281. Mab-21. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284114.
NextBio94554.
PROQ8N9M5.
SOURCESearch...

Entry information

Entry nameTM102_HUMAN
AccessionPrimary (citable) accession number: Q8N9M5
Secondary accession number(s): D3DTP8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM