UniProtKB - Q8N9M5 (TM102_HUMAN)
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Protein
Transmembrane protein 102
Gene
TMEM102
Organism
Homo sapiens (Human)
Status
Functioni
Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.1 Publication
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- positive regulation of cell adhesion Source: MGI
- positive regulation of T cell chemotaxis Source: Ensembl
- positive regulation of T cell migration Source: MGI
- regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
- regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- response to cytokine Source: UniProtKB
- signal transduction Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 102Alternative name(s): Common beta-chain associated protein Short name: CBAP |
Gene namesi | Name:TMEM102 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181284.2 |
HGNCi | HGNC:26722 TMEM102 |
MIMi | 613936 gene |
neXtProti | NX_Q8N9M5 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 260 | ExtracellularSequence analysisAdd BLAST | 260 | |
Transmembranei | 261 – 278 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 279 – 508 | CytoplasmicSequence analysisAdd BLAST | 230 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000181284 |
PharmGKBi | PA142670751 |
Polymorphism and mutation databases
BioMutai | TMEM102 |
DMDMi | 74729725 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263648 | 1 – 508 | Transmembrane protein 102Add BLAST | 508 |
Proteomic databases
EPDi | Q8N9M5 |
MaxQBi | Q8N9M5 |
PaxDbi | Q8N9M5 |
PeptideAtlasi | Q8N9M5 |
PRIDEi | Q8N9M5 |
PTM databases
iPTMneti | Q8N9M5 |
PhosphoSitePlusi | Q8N9M5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181284 |
CleanExi | HS_TMEM102 |
Genevisiblei | Q8N9M5 HS |
Organism-specific databases
HPAi | HPA024433 |
Interactioni
Subunit structurei
Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 12976515 interactors. |
IntActi | Q8N9M5 12 interactors. |
MINTi | Q8N9M5 |
Structurei
3D structure databases
ProteinModelPortali | Q8N9M5 |
SMRi | Q8N9M5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3963 Eukaryota ENOG410XNRJ LUCA |
GeneTreei | ENSGT00530000063769 |
HOGENOMi | HOG000154601 |
HOVERGENi | HBG094048 |
InParanoidi | Q8N9M5 |
OMAi | SHSWAGP |
OrthoDBi | EOG091G06D0 |
PhylomeDBi | Q8N9M5 |
TreeFami | TF329089 |
Family and domain databases
InterProi | View protein in InterPro IPR024810 Mab-21_dom IPR024806 TMEM102 |
PANTHERi | PTHR10656:SF48 PTHR10656:SF48, 1 hit |
Pfami | View protein in Pfam PF03281 Mab-21, 1 hit |
SMARTi | View protein in SMART SM01265 Mab-21, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8N9M5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW
60 70 80 90 100
SDGPKPGADL LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD
110 120 130 140 150
LGHAPLGPYA RGPHYDAGFT LLVPMFSLDG TELQLDLESC YAQVCLPEMV
160 170 180 190 200
CGTPIREMWQ DCLGPPVPGA RDSIHRTESE ESSKDWQSSV DQPHSYVTEH
210 220 230 240 250
EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT KAAVESPVPK
260 270 280 290 300
PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT
310 320 330 340 350
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV
360 370 380 390 400
PGGGTERPCA SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT
410 420 430 440 450
RAAAPYLLRT LLYWACERLP ALYLARPENA GACCLGLLDE LGRVLEAGTL
460 470 480 490 500
PHYFLNGRQL RTGDDSAALL GELARLRGDP ARALRAAVEE AKVARKGGGL
AGVGGGAH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029595 | 110 | A → V. Corresponds to variant dbSNP:rs3809718Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094197 mRNA Translation: BAC04306.1 CH471108 Genomic DNA Translation: EAW90189.1 CH471108 Genomic DNA Translation: EAW90190.1 BC046189 mRNA Translation: AAH46189.1 |
CCDSi | CCDS11104.1 |
RefSeqi | NP_001307373.1, NM_001320444.1 NP_848613.1, NM_178518.2 |
UniGenei | Hs.655662 |
Genome annotation databases
Ensembli | ENST00000323206; ENSP00000315387; ENSG00000181284 ENST00000396568; ENSP00000379815; ENSG00000181284 ENST00000638427; ENSP00000491063; ENSG00000284228 ENST00000639387; ENSP00000491290; ENSG00000284228 |
GeneIDi | 284114 |
KEGGi | hsa:284114 |
UCSCi | uc002ggx.1 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TM102_HUMAN | |
Accessioni | Q8N9M5Primary (citable) accession number: Q8N9M5 Secondary accession number(s): D3DTP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 25, 2018 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |