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Protein

Uncharacterized protein C19orf47

Gene

C19orf47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf47
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160392.13
HGNCiHGNC:26723 C19orf47
neXtProtiNX_Q8N9M1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160392
PharmGKBiPA145149543

Polymorphism and mutation databases

BioMutaiC19orf47
DMDMi74729722

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918601 – 422Uncharacterized protein C19orf47Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei280PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N9M1
MaxQBiQ8N9M1
PaxDbiQ8N9M1
PeptideAtlasiQ8N9M1
PRIDEiQ8N9M1
ProteomicsDBi72556
72557 [Q8N9M1-2]
72558 [Q8N9M1-3]

PTM databases

iPTMnetiQ8N9M1
PhosphoSitePlusiQ8N9M1

Expressioni

Gene expression databases

BgeeiENSG00000160392
CleanExiHS_C19orf47
ExpressionAtlasiQ8N9M1 baseline and differential
GenevisibleiQ8N9M1 HS

Organism-specific databases

HPAiHPA041843
HPA046309

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NTMQ9P1213EBI-2835503,EBI-4315078

Protein-protein interaction databases

BioGridi125997, 12 interactors
IntActiQ8N9M1, 11 interactors
STRINGi9606.ENSP00000463159

Structurei

3D structure databases

ProteinModelPortaliQ8N9M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi284 – 287Poly-Ser4
Compositional biasi395 – 398Poly-Ser4

Phylogenomic databases

eggNOGiKOG3930 Eukaryota
ENOG41121VM LUCA
GeneTreeiENSGT00390000005773
HOGENOMiHOG000111994
HOVERGENiHBG061253
InParanoidiQ8N9M1
OMAiQMDHAGT
OrthoDBiEOG091G0MLD
PhylomeDBiQ8N9M1
TreeFamiTF317361

Family and domain databases

InterProiView protein in InterPro
IPR013761 SAM/pointed_sf
SUPFAMiSSF47769 SSF47769, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMAALSLVA ACWGRAAADE SVQLPAAPGS SVRARETMVS VTMATSEWIQ
60 70 80 90 100
FFKEAGIPPG PAVNYAVMFV DNRIQKSMLL DLNKEIMNEL GVTVVGDIIA
110 120 130 140 150
ILKHAKVVHR QDMCKAATES VPCSPSPLAG EIRRGTSAAS RMITNSLNHD
160 170 180 190 200
SPPSTPPRRP DTSTSKISVT VSNKMAAKSA KATAALARRE EESLAVPAKR
210 220 230 240 250
RRVTAEMEGK YVINMPKGTT PRTRKILEQQ QAAKGLHRTS VFDRLGAETK
260 270 280 290 300
ADTTTGSKPT GVFSRLGATP ETDEDLAWDS DNDSSSSVLQ YAGVLKKLGR
310 320 330 340 350
GPAKASPQPA LTVKAKATSS ATTAAAPTLR RLALSSRSGL ERKPESLSKV
360 370 380 390 400
SIIKRLGAAA LVPEAQDSQV TSTKSKSSAE VKVTIKRTLV GPRGSSSSEG
410 420
LGAQMDHAGT VSVFKRLGRR TF
Length:422
Mass (Da):44,746
Last modified:October 1, 2002 - v1
Checksum:iEA532718B56E24DE
GO
Isoform 2 (identifier: Q8N9M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:355
Mass (Da):37,796
Checksum:iF0B0FD9EDF147BF0
GO
Isoform 3 (identifier: Q8N9M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Show »
Length:281
Mass (Da):29,752
Checksum:i21A265A1F298E6A4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262761 – 141Missing in isoform 3. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_0262751 – 67Missing in isoform 2. 2 PublicationsAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094207 mRNA Translation: BAC04311.1
AL834131 mRNA Translation: CAD38848.1
BC023623 mRNA Translation: AAH23623.1
BC027935 mRNA Translation: AAH27935.1
CCDSiCCDS58662.1 [Q8N9M1-1]
RefSeqiNP_001243369.1, NM_001256440.1 [Q8N9M1-1]
NP_001243370.1, NM_001256441.1
XP_016881784.1, XM_017026295.1 [Q8N9M1-3]
UniGeneiHs.631557

Genome annotation databases

EnsembliENST00000392035; ENSP00000375889; ENSG00000160392 [Q8N9M1-2]
ENST00000582783; ENSP00000463159; ENSG00000160392 [Q8N9M1-1]
GeneIDi126526
KEGGihsa:126526
UCSCiuc002onh.5 human [Q8N9M1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCS047_HUMAN
AccessioniPrimary (citable) accession number: Q8N9M1
Secondary accession number(s): Q8IZ33, Q8N0V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

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