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Protein

Uncharacterized protein C19orf47

Gene

C19orf47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf47
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26723. C19orf47.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149543.

Polymorphism and mutation databases

BioMutaiC19orf47.
DMDMi74729722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Uncharacterized protein C19orf47PRO_0000291860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei126 – 1261PhosphoserineCombined sources
Modified residuei280 – 2801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N9M1.
MaxQBiQ8N9M1.
PaxDbiQ8N9M1.
PRIDEiQ8N9M1.

PTM databases

iPTMnetiQ8N9M1.
PhosphoSiteiQ8N9M1.

Expressioni

Gene expression databases

BgeeiQ8N9M1.
CleanExiHS_C19orf47.
ExpressionAtlasiQ8N9M1. baseline and differential.
GenevisibleiQ8N9M1. HS.

Organism-specific databases

HPAiHPA041843.
HPA046309.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NTMQ9P1213EBI-2835503,EBI-4315078

Protein-protein interaction databases

BioGridi125997. 12 interactions.
IntActiQ8N9M1. 10 interactions.
MINTiMINT-5192748.
STRINGi9606.ENSP00000463159.

Structurei

3D structure databases

ProteinModelPortaliQ8N9M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi284 – 2874Poly-Ser
Compositional biasi395 – 3984Poly-Ser

Phylogenomic databases

eggNOGiKOG3930. Eukaryota.
ENOG41121VM. LUCA.
GeneTreeiENSGT00390000005773.
HOGENOMiHOG000111994.
HOVERGENiHBG061253.
InParanoidiQ8N9M1.
OMAiGAQMDHA.
OrthoDBiEOG769ZJS.
PhylomeDBiQ8N9M1.
TreeFamiTF317361.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR013761. SAM/pointed.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMAALSLVA ACWGRAAADE SVQLPAAPGS SVRARETMVS VTMATSEWIQ
60 70 80 90 100
FFKEAGIPPG PAVNYAVMFV DNRIQKSMLL DLNKEIMNEL GVTVVGDIIA
110 120 130 140 150
ILKHAKVVHR QDMCKAATES VPCSPSPLAG EIRRGTSAAS RMITNSLNHD
160 170 180 190 200
SPPSTPPRRP DTSTSKISVT VSNKMAAKSA KATAALARRE EESLAVPAKR
210 220 230 240 250
RRVTAEMEGK YVINMPKGTT PRTRKILEQQ QAAKGLHRTS VFDRLGAETK
260 270 280 290 300
ADTTTGSKPT GVFSRLGATP ETDEDLAWDS DNDSSSSVLQ YAGVLKKLGR
310 320 330 340 350
GPAKASPQPA LTVKAKATSS ATTAAAPTLR RLALSSRSGL ERKPESLSKV
360 370 380 390 400
SIIKRLGAAA LVPEAQDSQV TSTKSKSSAE VKVTIKRTLV GPRGSSSSEG
410 420
LGAQMDHAGT VSVFKRLGRR TF
Length:422
Mass (Da):44,746
Last modified:October 1, 2002 - v1
Checksum:iEA532718B56E24DE
GO
Isoform 2 (identifier: Q8N9M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:355
Mass (Da):37,796
Checksum:iF0B0FD9EDF147BF0
GO
Isoform 3 (identifier: Q8N9M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Show »
Length:281
Mass (Da):29,752
Checksum:i21A265A1F298E6A4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 141141Missing in isoform 3. 1 PublicationVSP_026276Add
BLAST
Alternative sequencei1 – 6767Missing in isoform 2. 2 PublicationsVSP_026275Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094207 mRNA. Translation: BAC04311.1.
AL834131 mRNA. Translation: CAD38848.1.
BC023623 mRNA. Translation: AAH23623.1.
BC027935 mRNA. Translation: AAH27935.1.
CCDSiCCDS58662.1. [Q8N9M1-1]
RefSeqiNP_001243369.1. NM_001256440.1. [Q8N9M1-1]
NP_001243370.1. NM_001256441.1.
XP_011524763.1. XM_011526461.1. [Q8N9M1-3]
UniGeneiHs.631557.

Genome annotation databases

EnsembliENST00000392035; ENSP00000375889; ENSG00000160392. [Q8N9M1-2]
ENST00000582783; ENSP00000463159; ENSG00000160392. [Q8N9M1-1]
GeneIDi126526.
KEGGihsa:126526.
UCSCiuc002onh.5. human. [Q8N9M1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094207 mRNA. Translation: BAC04311.1.
AL834131 mRNA. Translation: CAD38848.1.
BC023623 mRNA. Translation: AAH23623.1.
BC027935 mRNA. Translation: AAH27935.1.
CCDSiCCDS58662.1. [Q8N9M1-1]
RefSeqiNP_001243369.1. NM_001256440.1. [Q8N9M1-1]
NP_001243370.1. NM_001256441.1.
XP_011524763.1. XM_011526461.1. [Q8N9M1-3]
UniGeneiHs.631557.

3D structure databases

ProteinModelPortaliQ8N9M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125997. 12 interactions.
IntActiQ8N9M1. 10 interactions.
MINTiMINT-5192748.
STRINGi9606.ENSP00000463159.

PTM databases

iPTMnetiQ8N9M1.
PhosphoSiteiQ8N9M1.

Polymorphism and mutation databases

BioMutaiC19orf47.
DMDMi74729722.

Proteomic databases

EPDiQ8N9M1.
MaxQBiQ8N9M1.
PaxDbiQ8N9M1.
PRIDEiQ8N9M1.

Protocols and materials databases

DNASUi126526.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392035; ENSP00000375889; ENSG00000160392. [Q8N9M1-2]
ENST00000582783; ENSP00000463159; ENSG00000160392. [Q8N9M1-1]
GeneIDi126526.
KEGGihsa:126526.
UCSCiuc002onh.5. human. [Q8N9M1-1]

Organism-specific databases

CTDi126526.
GeneCardsiC19orf47.
H-InvDBHIX0202777.
HGNCiHGNC:26723. C19orf47.
HPAiHPA041843.
HPA046309.
neXtProtiNX_Q8N9M1.
PharmGKBiPA145149543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3930. Eukaryota.
ENOG41121VM. LUCA.
GeneTreeiENSGT00390000005773.
HOGENOMiHOG000111994.
HOVERGENiHBG061253.
InParanoidiQ8N9M1.
OMAiGAQMDHA.
OrthoDBiEOG769ZJS.
PhylomeDBiQ8N9M1.
TreeFamiTF317361.

Miscellaneous databases

ChiTaRSiC19orf47. human.
GenomeRNAii126526.
PROiQ8N9M1.

Gene expression databases

BgeeiQ8N9M1.
CleanExiHS_C19orf47.
ExpressionAtlasiQ8N9M1. baseline and differential.
GenevisibleiQ8N9M1. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR013761. SAM/pointed.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Glial tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lung.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND SER-126, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCS047_HUMAN
AccessioniPrimary (citable) accession number: Q8N9M1
Secondary accession number(s): Q8IZ33, Q8N0V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.