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Protein

Zinc finger protein 565

Gene

ZNF565

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171832-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 565
Gene namesi
Name:ZNF565
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26726. ZNF565.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi147929.
OpenTargetsiENSG00000196357.
PharmGKBiPA134970652.

Polymorphism and mutation databases

DMDMi74760034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476551 – 539Zinc finger protein 565Add BLAST539

Proteomic databases

MaxQBiQ8N9K5.
PaxDbiQ8N9K5.
PeptideAtlasiQ8N9K5.
PRIDEiQ8N9K5.

PTM databases

iPTMnetiQ8N9K5.
PhosphoSitePlusiQ8N9K5.

Expressioni

Gene expression databases

BgeeiENSG00000196357.
CleanExiHS_ZNF565.
ExpressionAtlasiQ8N9K5. baseline and differential.
GenevisibleiQ8N9K5. HS.

Organism-specific databases

HPAiHPA044123.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306869.

Structurei

3D structure databases

ProteinModelPortaliQ8N9K5.
SMRiQ8N9K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 117KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N9K5.
KOiK09228.
OMAiNWEIMES.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N9K5.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGPWERWS LASHRLDAGL CTCPREESRE IRAGQIVLKA MAQGLVTFRD
60 70 80 90 100
VAIEFSLEEW KCLEPAQRDL YREVTLENFG HLASLGLSIS KPDVVSLLEQ
110 120 130 140 150
GKEPWMIAND VTGPWCPDLE SRCEKFLQKD IFEIGAFNWE IMESLKCSDL
160 170 180 190 200
EGSDFRADWE CEGQFERQVN EECYFKQVNV TYGHMPVFQH HTSHTVRQSR
210 220 230 240 250
ETGEKLMECH ECGKAFSRGS HLIQHQKIHT GEKPFGCKEC GKAFSRASHL
260 270 280 290 300
VQHQRIHTGE KPYDCKDCGK AFGRTSELIL HQRLHTGVKP YECKECGKTF
310 320 330 340 350
RQHSQLILHQ RTHTGEKPYV CKDCGKAFIR GSQLTVHRRI HTGARPYECK
360 370 380 390 400
ECGKAFRQHS QLTVHQRIHT GEKPYECKEC GKGFIHSSEV TRHQRIHSGE
410 420 430 440 450
KPYECKECGK AFRQHAQLTR HQRVHTGDRP YECKDCGKAF SRSSYLIQHQ
460 470 480 490 500
RIHTGDKPYE CKECGKAFIR VSQLTHHQRI HTCEKPYECR ECGMAFIRSS
510 520 530
QLTEHQRIHP GIKPYECREC GQAFILGSQL IEHYRIHTG
Length:539
Mass (Da):62,445
Last modified:October 1, 2014 - v2
Checksum:iCACB38F824A22856
GO
Isoform 2 (identifier: Q8N9K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):57,827
Checksum:i04470AA0EB11FA17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023938228I → T.1 PublicationCorresponds to variant rs4805162dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559651 – 40Missing in isoform 2. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057290 mRNA. Translation: BAG51897.1.
AK094310 mRNA. Translation: BAC04328.1.
AC008848 Genomic DNA. No translation available.
AC012617 Genomic DNA. No translation available.
BC068453 mRNA. Translation: AAH68453.1.
CCDSiCCDS12491.1. [Q8N9K5-2]
RefSeqiNP_001035939.1. NM_001042474.2. [Q8N9K5-2]
NP_689690.3. NM_152477.4. [Q8N9K5-2]
XP_011524814.1. XM_011526512.2. [Q8N9K5-2]
XP_011524816.1. XM_011526514.2. [Q8N9K5-2]
XP_016881830.1. XM_017026341.1. [Q8N9K5-2]
UniGeneiHs.596338.

Genome annotation databases

EnsembliENST00000304116; ENSP00000306869; ENSG00000196357. [Q8N9K5-2]
ENST00000355114; ENSP00000347234; ENSG00000196357. [Q8N9K5-1]
ENST00000392173; ENSP00000376013; ENSG00000196357. [Q8N9K5-2]
GeneIDi147929.
KEGGihsa:147929.
UCSCiuc002odn.4. human. [Q8N9K5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057290 mRNA. Translation: BAG51897.1.
AK094310 mRNA. Translation: BAC04328.1.
AC008848 Genomic DNA. No translation available.
AC012617 Genomic DNA. No translation available.
BC068453 mRNA. Translation: AAH68453.1.
CCDSiCCDS12491.1. [Q8N9K5-2]
RefSeqiNP_001035939.1. NM_001042474.2. [Q8N9K5-2]
NP_689690.3. NM_152477.4. [Q8N9K5-2]
XP_011524814.1. XM_011526512.2. [Q8N9K5-2]
XP_011524816.1. XM_011526514.2. [Q8N9K5-2]
XP_016881830.1. XM_017026341.1. [Q8N9K5-2]
UniGeneiHs.596338.

3D structure databases

ProteinModelPortaliQ8N9K5.
SMRiQ8N9K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306869.

PTM databases

iPTMnetiQ8N9K5.
PhosphoSitePlusiQ8N9K5.

Polymorphism and mutation databases

DMDMi74760034.

Proteomic databases

MaxQBiQ8N9K5.
PaxDbiQ8N9K5.
PeptideAtlasiQ8N9K5.
PRIDEiQ8N9K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304116; ENSP00000306869; ENSG00000196357. [Q8N9K5-2]
ENST00000355114; ENSP00000347234; ENSG00000196357. [Q8N9K5-1]
ENST00000392173; ENSP00000376013; ENSG00000196357. [Q8N9K5-2]
GeneIDi147929.
KEGGihsa:147929.
UCSCiuc002odn.4. human. [Q8N9K5-1]

Organism-specific databases

CTDi147929.
DisGeNETi147929.
GeneCardsiZNF565.
HGNCiHGNC:26726. ZNF565.
HPAiHPA044123.
neXtProtiNX_Q8N9K5.
OpenTargetsiENSG00000196357.
PharmGKBiPA134970652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N9K5.
KOiK09228.
OMAiNWEIMES.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N9K5.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171832-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF565. human.
GenomeRNAii147929.
PROiQ8N9K5.

Gene expression databases

BgeeiENSG00000196357.
CleanExiHS_ZNF565.
ExpressionAtlasiQ8N9K5. baseline and differential.
GenevisibleiQ8N9K5. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN565_HUMAN
AccessioniPrimary (citable) accession number: Q8N9K5
Secondary accession number(s): B3KQ35, Q6NUS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2014
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.