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Q8N9K5 (ZN565_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 565
Gene names
Name:ZNF565
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Zinc finger protein 565
PRO_0000047655

Regions

Domain6 – 7772KRAB
Zinc finger167 – 18923C2H2-type 1
Zinc finger195 – 21723C2H2-type 2
Zinc finger223 – 24523C2H2-type 3
Zinc finger251 – 27323C2H2-type 4
Zinc finger279 – 30123C2H2-type 5
Zinc finger307 – 32923C2H2-type 6
Zinc finger335 – 35723C2H2-type 7
Zinc finger363 – 38523C2H2-type 8
Zinc finger391 – 41323C2H2-type 9
Zinc finger419 – 44123C2H2-type 10
Zinc finger447 – 46923C2H2-type 11
Zinc finger475 – 49723C2H2-type 12

Natural variations

Natural variant1881I → T. Ref.2
Corresponds to variant rs4805162 [ dbSNP | Ensembl ].
VAR_023938

Sequences

Sequence LengthMass (Da)Tools
Q8N9K5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 04470AA0EB11FA17

FASTA49957,827
        10         20         30         40         50         60 
MAQGLVTFRD VAIEFSLEEW KCLEPAQRDL YREVTLENFG HLASLGLSIS KPDVVSLLEQ 

        70         80         90        100        110        120 
GKEPWMIAND VTGPWCPDLE SRCEKFLQKD IFEIGAFNWE IMESLKCSDL EGSDFRADWE 

       130        140        150        160        170        180 
CEGQFERQVN EECYFKQVNV TYGHMPVFQH HTSHTVRQSR ETGEKLMECH ECGKAFSRGS 

       190        200        210        220        230        240 
HLIQHQKIHT GEKPFGCKEC GKAFSRASHL VQHQRIHTGE KPYDCKDCGK AFGRTSELIL 

       250        260        270        280        290        300 
HQRLHTGVKP YECKECGKTF RQHSQLILHQ RTHTGEKPYV CKDCGKAFIR GSQLTVHRRI 

       310        320        330        340        350        360 
HTGARPYECK ECGKAFRQHS QLTVHQRIHT GEKPYECKEC GKGFIHSSEV TRHQRIHSGE 

       370        380        390        400        410        420 
KPYECKECGK AFRQHAQLTR HQRVHTGDRP YECKDCGKAF SRSSYLIQHQ RIHTGDKPYE 

       430        440        450        460        470        480 
CKECGKAFIR VSQLTHHQRI HTCEKPYECR ECGMAFIRSS QLTEHQRIHP GIKPYECREC 

       490 
GQAFILGSQL IEHYRIHTG

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-188.
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK094310 mRNA. Translation: BAC04328.1.
BC068453 mRNA. Translation: AAH68453.1.
IPIIPI00396028.
RefSeqNP_001035939.1. NM_001042474.1.
NP_689690.3. NM_152477.3.
UniGeneHs.596338.

3D structure databases

ProteinModelPortalQ8N9K5.
ModBaseSearch...

PTM databases

PhosphoSiteQ8N9K5.

Polymorphism databases

DMDM74760034.

Proteomic databases

PaxDbQ8N9K5.
PRIDEQ8N9K5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304116; ENSP00000306869; ENSG00000196357.
ENST00000392173; ENSP00000376013; ENSG00000196357.
GeneID147929.
KEGGhsa:147929.
UCSCuc002odn.3. human.

Organism-specific databases

CTD147929.
GeneCardsGC19M036673.
HGNCHGNC:26726. ZNF565.
HPAHPA044123.
neXtProtNX_Q8N9K5.
PharmGKBPA134970652.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8N9K5.
KOK09228.
OrthoDBEOG45X7W0.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8N9K5.
BgeeQ8N9K5.
CleanExHS_ZNF565.
GenevestigatorQ8N9K5.
GermOnlineENSG00000196357. Homo sapiens.

Family and domain databases

Gene3D3.30.160.60. 12 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMSSF109640. Krueppel-associated_box. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF565. human.
GenomeRNAi147929.
NextBio85770.

Entry information

Entry nameZN565_HUMAN
AccessionPrimary (citable) accession number: Q8N9K5
Secondary accession number(s): Q6NUS2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

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