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Q8N9I9

- DTX3_HUMAN

UniProt

Q8N9I9 - DTX3_HUMAN

Protein

Probable E3 ubiquitin-protein ligase DTX3

Gene

DTX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (26 Sep 2003)
      Previous versions | rss
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    Functioni

    Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context By similarity. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri164 – 20542RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. Notch signaling pathway Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Notch signaling pathway, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX3 (EC:6.3.2.-)
    Alternative name(s):
    Protein deltex-3
    Short name:
    Deltex3
    RING finger protein 154
    Gene namesi
    Name:DTX3
    Synonyms:RNF154
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24457. DTX3.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887936.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Probable E3 ubiquitin-protein ligase DTX3PRO_0000219085Add
    BLAST

    Proteomic databases

    MaxQBiQ8N9I9.
    PaxDbiQ8N9I9.
    PRIDEiQ8N9I9.

    PTM databases

    PhosphoSiteiQ8N9I9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N9I9.
    BgeeiQ8N9I9.
    CleanExiHS_DTX3.
    GenevestigatoriQ8N9I9.

    Organism-specific databases

    HPAiHPA059654.

    Interactioni

    Subunit structurei

    Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi128203. 23 interactions.
    IntActiQ8N9I9. 20 interactions.
    STRINGi9606.ENSP00000338050.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N9I9.
    SMRiQ8N9I9. Positions 164-202, 211-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi122 – 15130Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Deltex family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri164 – 20542RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG84763.
    HOGENOMiHOG000007352.
    HOVERGENiHBG045495.
    InParanoidiQ8N9I9.
    KOiK06058.
    OMAiCEDCITR.
    OrthoDBiEOG7QNVKH.
    PhylomeDBiQ8N9I9.
    TreeFamiTF325526.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N9I9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI    50
    DGETSDIYVL QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG 100
    ELMGCLALGG GGEHPEMHRA GPPPLRAAPL LPPGARGLPP PPPPLPPPLP 150
    PRLREEAEEQ ESTCPICLGE IQNAKTLEKC RHSFCEGCIT RALQVKKACP 200
    MCGRFYGQLV GNQPQNGRML VSKDATLLLP SYEKYGTIVI QYVFPPGVQG 250
    AEHPNPGVRY PGTTRVAYLP DCPEGNKVLT LFRKAFDQRL TFTIGTSMTT 300
    GRPNVITWND IHHKTSCTGG PQLFGYPDPT YLTRVQEELR AKGITDD 347
    Length:347
    Mass (Da):37,988
    Last modified:September 26, 2003 - v2
    Checksum:iFDB4CDC982F1B707
    GO
    Isoform 2 (identifier: Q8N9I9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MSFVLSR → MPILSSSGSK

    Note: No experimental confirmation available.

    Show »
    Length:350
    Mass (Da):38,155
    Checksum:i41ACDC6F899F99F3
    GO

    Sequence cautioni

    The sequence CAD38593.2 differs from that shown. Reason: Intron retention.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MSFVLSR → MPILSSSGSK in isoform 2. 1 PublicationVSP_008354

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY225126 mRNA. Translation: AAP57520.1.
    AK092085 mRNA. Translation: BAC03801.1.
    AK094385 mRNA. Translation: BAC04344.1.
    AK128752 mRNA. Translation: BAG54727.1.
    CH471054 Genomic DNA. Translation: EAW97033.1.
    BC114441 mRNA. Translation: AAI14442.1.
    BC114498 mRNA. Translation: AAI14499.1.
    AL831941 mRNA. Translation: CAD38593.2. Sequence problems.
    CCDSiCCDS41800.1. [Q8N9I9-1]
    CCDS66410.1. [Q8N9I9-2]
    RefSeqiNP_001273174.1. NM_001286245.1. [Q8N9I9-2]
    NP_001273175.1. NM_001286246.1. [Q8N9I9-1]
    NP_848597.1. NM_178502.3. [Q8N9I9-1]
    XP_005268754.1. XM_005268697.1. [Q8N9I9-2]
    XP_005268755.1. XM_005268698.1. [Q8N9I9-2]
    XP_005268757.1. XM_005268700.1. [Q8N9I9-2]
    XP_005268760.1. XM_005268703.1. [Q8N9I9-1]
    UniGeneiHs.32374.

    Genome annotation databases

    EnsembliENST00000337737; ENSP00000338050; ENSG00000178498. [Q8N9I9-1]
    ENST00000548198; ENSP00000447873; ENSG00000178498. [Q8N9I9-1]
    ENST00000548478; ENSP00000448224; ENSG00000178498.
    ENST00000548804; ENSP00000449294; ENSG00000178498. [Q8N9I9-1]
    ENST00000551632; ENSP00000448696; ENSG00000178498. [Q8N9I9-2]
    GeneIDi196403.
    KEGGihsa:196403.
    UCSCiuc001sov.1. human. [Q8N9I9-1]

    Polymorphism databases

    DMDMi37077338.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY225126 mRNA. Translation: AAP57520.1 .
    AK092085 mRNA. Translation: BAC03801.1 .
    AK094385 mRNA. Translation: BAC04344.1 .
    AK128752 mRNA. Translation: BAG54727.1 .
    CH471054 Genomic DNA. Translation: EAW97033.1 .
    BC114441 mRNA. Translation: AAI14442.1 .
    BC114498 mRNA. Translation: AAI14499.1 .
    AL831941 mRNA. Translation: CAD38593.2 . Sequence problems.
    CCDSi CCDS41800.1. [Q8N9I9-1 ]
    CCDS66410.1. [Q8N9I9-2 ]
    RefSeqi NP_001273174.1. NM_001286245.1. [Q8N9I9-2 ]
    NP_001273175.1. NM_001286246.1. [Q8N9I9-1 ]
    NP_848597.1. NM_178502.3. [Q8N9I9-1 ]
    XP_005268754.1. XM_005268697.1. [Q8N9I9-2 ]
    XP_005268755.1. XM_005268698.1. [Q8N9I9-2 ]
    XP_005268757.1. XM_005268700.1. [Q8N9I9-2 ]
    XP_005268760.1. XM_005268703.1. [Q8N9I9-1 ]
    UniGenei Hs.32374.

    3D structure databases

    ProteinModelPortali Q8N9I9.
    SMRi Q8N9I9. Positions 164-202, 211-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128203. 23 interactions.
    IntActi Q8N9I9. 20 interactions.
    STRINGi 9606.ENSP00000338050.

    PTM databases

    PhosphoSitei Q8N9I9.

    Polymorphism databases

    DMDMi 37077338.

    Proteomic databases

    MaxQBi Q8N9I9.
    PaxDbi Q8N9I9.
    PRIDEi Q8N9I9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337737 ; ENSP00000338050 ; ENSG00000178498 . [Q8N9I9-1 ]
    ENST00000548198 ; ENSP00000447873 ; ENSG00000178498 . [Q8N9I9-1 ]
    ENST00000548478 ; ENSP00000448224 ; ENSG00000178498 .
    ENST00000548804 ; ENSP00000449294 ; ENSG00000178498 . [Q8N9I9-1 ]
    ENST00000551632 ; ENSP00000448696 ; ENSG00000178498 . [Q8N9I9-2 ]
    GeneIDi 196403.
    KEGGi hsa:196403.
    UCSCi uc001sov.1. human. [Q8N9I9-1 ]

    Organism-specific databases

    CTDi 196403.
    GeneCardsi GC12P057998.
    HGNCi HGNC:24457. DTX3.
    HPAi HPA059654.
    MIMi 613142. gene.
    neXtProti NX_Q8N9I9.
    PharmGKBi PA134887936.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84763.
    HOGENOMi HOG000007352.
    HOVERGENi HBG045495.
    InParanoidi Q8N9I9.
    KOi K06058.
    OMAi CEDCITR.
    OrthoDBi EOG7QNVKH.
    PhylomeDBi Q8N9I9.
    TreeFami TF325526.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GenomeRNAii 196403.
    NextBioi 89461.
    PROi Q8N9I9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N9I9.
    Bgeei Q8N9I9.
    CleanExi HS_DTX3.
    Genevestigatori Q8N9I9.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity."
      Takeyama K., Aguiar R.C.T., Gu L., He C., Freeman G.J., Kutok J.L., Aster J.C., Shipp M.A.
      J. Biol. Chem. 278:21930-21937(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IN VITRO UBIQUITIN LIGASE ACTIVITY, SUBUNIT.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Teratocarcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-201 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiDTX3_HUMAN
    AccessioniPrimary (citable) accession number: Q8N9I9
    Secondary accession number(s): Q53ZZ2, Q8NAU6, Q8NDS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: September 26, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3