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Q8N9I9

- DTX3_HUMAN

UniProt

Q8N9I9 - DTX3_HUMAN

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Protein

Probable E3 ubiquitin-protein ligase DTX3

Gene

DTX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 20542RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. Notch signaling pathway Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase DTX3 (EC:6.3.2.-)
Alternative name(s):
Protein deltex-3
Short name:
Deltex3
RING finger protein 154
Gene namesi
Name:DTX3
Synonyms:RNF154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24457. DTX3.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Probable E3 ubiquitin-protein ligase DTX3PRO_0000219085Add
BLAST

Proteomic databases

MaxQBiQ8N9I9.
PaxDbiQ8N9I9.
PRIDEiQ8N9I9.

PTM databases

PhosphoSiteiQ8N9I9.

Expressioni

Gene expression databases

BgeeiQ8N9I9.
CleanExiHS_DTX3.
ExpressionAtlasiQ8N9I9. baseline and differential.
GenevestigatoriQ8N9I9.

Organism-specific databases

HPAiHPA059654.

Interactioni

Subunit structurei

Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi128203. 32 interactions.
IntActiQ8N9I9. 20 interactions.
STRINGi9606.ENSP00000338050.

Structurei

3D structure databases

ProteinModelPortaliQ8N9I9.
SMRiQ8N9I9. Positions 164-202, 211-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 15130Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Deltex family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 20542RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG84763.
GeneTreeiENSGT00440000035370.
HOGENOMiHOG000007352.
HOVERGENiHBG045495.
InParanoidiQ8N9I9.
KOiK06058.
OMAiCEDCITR.
OrthoDBiEOG7QNVKH.
PhylomeDBiQ8N9I9.
TreeFamiTF325526.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N9I9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI
60 70 80 90 100
DGETSDIYVL QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG
110 120 130 140 150
ELMGCLALGG GGEHPEMHRA GPPPLRAAPL LPPGARGLPP PPPPLPPPLP
160 170 180 190 200
PRLREEAEEQ ESTCPICLGE IQNAKTLEKC RHSFCEGCIT RALQVKKACP
210 220 230 240 250
MCGRFYGQLV GNQPQNGRML VSKDATLLLP SYEKYGTIVI QYVFPPGVQG
260 270 280 290 300
AEHPNPGVRY PGTTRVAYLP DCPEGNKVLT LFRKAFDQRL TFTIGTSMTT
310 320 330 340
GRPNVITWND IHHKTSCTGG PQLFGYPDPT YLTRVQEELR AKGITDD
Length:347
Mass (Da):37,988
Last modified:September 26, 2003 - v2
Checksum:iFDB4CDC982F1B707
GO
Isoform 2 (identifier: Q8N9I9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MSFVLSR → MPILSSSGSK

Note: No experimental confirmation available.

Show »
Length:350
Mass (Da):38,155
Checksum:i41ACDC6F899F99F3
GO

Sequence cautioni

The sequence CAD38593.2 differs from that shown. Reason: Intron retention.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MSFVLSR → MPILSSSGSK in isoform 2. 1 PublicationVSP_008354

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225126 mRNA. Translation: AAP57520.1.
AK092085 mRNA. Translation: BAC03801.1.
AK094385 mRNA. Translation: BAC04344.1.
AK128752 mRNA. Translation: BAG54727.1.
CH471054 Genomic DNA. Translation: EAW97033.1.
BC114441 mRNA. Translation: AAI14442.1.
BC114498 mRNA. Translation: AAI14499.1.
AL831941 mRNA. Translation: CAD38593.2. Sequence problems.
CCDSiCCDS41800.1. [Q8N9I9-1]
CCDS66410.1. [Q8N9I9-2]
RefSeqiNP_001273174.1. NM_001286245.1. [Q8N9I9-2]
NP_001273175.1. NM_001286246.1. [Q8N9I9-1]
NP_848597.1. NM_178502.3. [Q8N9I9-1]
XP_005268754.1. XM_005268697.1. [Q8N9I9-2]
XP_005268755.1. XM_005268698.1. [Q8N9I9-2]
XP_005268757.1. XM_005268700.1. [Q8N9I9-2]
XP_005268760.1. XM_005268703.1. [Q8N9I9-1]
UniGeneiHs.32374.

Genome annotation databases

EnsembliENST00000337737; ENSP00000338050; ENSG00000178498. [Q8N9I9-1]
ENST00000548198; ENSP00000447873; ENSG00000178498. [Q8N9I9-1]
ENST00000548478; ENSP00000448224; ENSG00000178498.
ENST00000548804; ENSP00000449294; ENSG00000178498. [Q8N9I9-1]
ENST00000551632; ENSP00000448696; ENSG00000178498. [Q8N9I9-2]
GeneIDi196403.
KEGGihsa:196403.
UCSCiuc001sov.1. human. [Q8N9I9-1]

Polymorphism databases

DMDMi37077338.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225126 mRNA. Translation: AAP57520.1 .
AK092085 mRNA. Translation: BAC03801.1 .
AK094385 mRNA. Translation: BAC04344.1 .
AK128752 mRNA. Translation: BAG54727.1 .
CH471054 Genomic DNA. Translation: EAW97033.1 .
BC114441 mRNA. Translation: AAI14442.1 .
BC114498 mRNA. Translation: AAI14499.1 .
AL831941 mRNA. Translation: CAD38593.2 . Sequence problems.
CCDSi CCDS41800.1. [Q8N9I9-1 ]
CCDS66410.1. [Q8N9I9-2 ]
RefSeqi NP_001273174.1. NM_001286245.1. [Q8N9I9-2 ]
NP_001273175.1. NM_001286246.1. [Q8N9I9-1 ]
NP_848597.1. NM_178502.3. [Q8N9I9-1 ]
XP_005268754.1. XM_005268697.1. [Q8N9I9-2 ]
XP_005268755.1. XM_005268698.1. [Q8N9I9-2 ]
XP_005268757.1. XM_005268700.1. [Q8N9I9-2 ]
XP_005268760.1. XM_005268703.1. [Q8N9I9-1 ]
UniGenei Hs.32374.

3D structure databases

ProteinModelPortali Q8N9I9.
SMRi Q8N9I9. Positions 164-202, 211-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128203. 32 interactions.
IntActi Q8N9I9. 20 interactions.
STRINGi 9606.ENSP00000338050.

PTM databases

PhosphoSitei Q8N9I9.

Polymorphism databases

DMDMi 37077338.

Proteomic databases

MaxQBi Q8N9I9.
PaxDbi Q8N9I9.
PRIDEi Q8N9I9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337737 ; ENSP00000338050 ; ENSG00000178498 . [Q8N9I9-1 ]
ENST00000548198 ; ENSP00000447873 ; ENSG00000178498 . [Q8N9I9-1 ]
ENST00000548478 ; ENSP00000448224 ; ENSG00000178498 .
ENST00000548804 ; ENSP00000449294 ; ENSG00000178498 . [Q8N9I9-1 ]
ENST00000551632 ; ENSP00000448696 ; ENSG00000178498 . [Q8N9I9-2 ]
GeneIDi 196403.
KEGGi hsa:196403.
UCSCi uc001sov.1. human. [Q8N9I9-1 ]

Organism-specific databases

CTDi 196403.
GeneCardsi GC12P057998.
HGNCi HGNC:24457. DTX3.
HPAi HPA059654.
MIMi 613142. gene.
neXtProti NX_Q8N9I9.
PharmGKBi PA134887936.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84763.
GeneTreei ENSGT00440000035370.
HOGENOMi HOG000007352.
HOVERGENi HBG045495.
InParanoidi Q8N9I9.
KOi K06058.
OMAi CEDCITR.
OrthoDBi EOG7QNVKH.
PhylomeDBi Q8N9I9.
TreeFami TF325526.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GenomeRNAii 196403.
NextBioi 89461.
PROi Q8N9I9.
SOURCEi Search...

Gene expression databases

Bgeei Q8N9I9.
CleanExi HS_DTX3.
ExpressionAtlasi Q8N9I9. baseline and differential.
Genevestigatori Q8N9I9.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity."
    Takeyama K., Aguiar R.C.T., Gu L., He C., Freeman G.J., Kutok J.L., Aster J.C., Shipp M.A.
    J. Biol. Chem. 278:21930-21937(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IN VITRO UBIQUITIN LIGASE ACTIVITY, SUBUNIT.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-201 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiDTX3_HUMAN
AccessioniPrimary (citable) accession number: Q8N9I9
Secondary accession number(s): Q53ZZ2, Q8NAU6, Q8NDS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3