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Protein

Probable E3 ubiquitin-protein ligase DTX3

Gene

DTX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 205RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase DTX3 (EC:6.3.2.-)
Alternative name(s):
Protein deltex-3
Short name:
Deltex3
RING finger protein 154
Gene namesi
Name:DTX3
Synonyms:RNF154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24457. DTX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi196403.
OpenTargetsiENSG00000178498.
PharmGKBiPA134887936.

Polymorphism and mutation databases

DMDMi37077338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190851 – 347Probable E3 ubiquitin-protein ligase DTX3Add BLAST347

Proteomic databases

EPDiQ8N9I9.
MaxQBiQ8N9I9.
PaxDbiQ8N9I9.
PeptideAtlasiQ8N9I9.
PRIDEiQ8N9I9.
TopDownProteomicsiQ8N9I9-1. [Q8N9I9-1]

PTM databases

iPTMnetiQ8N9I9.
PhosphoSitePlusiQ8N9I9.

Expressioni

Gene expression databases

BgeeiENSG00000178498.
CleanExiHS_DTX3.
ExpressionAtlasiQ8N9I9. baseline and differential.
GenevisibleiQ8N9I9. HS.

Organism-specific databases

HPAiHPA059654.

Interactioni

Subunit structurei

Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE2KP610865EBI-2340258,EBI-473850

Protein-protein interaction databases

BioGridi128203. 34 interactors.
IntActiQ8N9I9. 21 interactors.
STRINGi9606.ENSP00000338050.

Structurei

3D structure databases

ProteinModelPortaliQ8N9I9.
SMRiQ8N9I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 151Pro-richAdd BLAST30

Sequence similaritiesi

Belongs to the Deltex family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 205RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410II0N. Eukaryota.
ENOG410Z2TC. LUCA.
GeneTreeiENSGT00440000035370.
HOGENOMiHOG000007352.
HOVERGENiHBG045495.
InParanoidiQ8N9I9.
KOiK06058.
OMAiLREEHHV.
OrthoDBiEOG091G06M5.
PhylomeDBiQ8N9I9.
TreeFamiTF325526.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9I9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI
60 70 80 90 100
DGETSDIYVL QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG
110 120 130 140 150
ELMGCLALGG GGEHPEMHRA GPPPLRAAPL LPPGARGLPP PPPPLPPPLP
160 170 180 190 200
PRLREEAEEQ ESTCPICLGE IQNAKTLEKC RHSFCEGCIT RALQVKKACP
210 220 230 240 250
MCGRFYGQLV GNQPQNGRML VSKDATLLLP SYEKYGTIVI QYVFPPGVQG
260 270 280 290 300
AEHPNPGVRY PGTTRVAYLP DCPEGNKVLT LFRKAFDQRL TFTIGTSMTT
310 320 330 340
GRPNVITWND IHHKTSCTGG PQLFGYPDPT YLTRVQEELR AKGITDD
Length:347
Mass (Da):37,988
Last modified:September 26, 2003 - v2
Checksum:iFDB4CDC982F1B707
GO
Isoform 2 (identifier: Q8N9I9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MSFVLSR → MPILSSSGSK

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):38,155
Checksum:i41ACDC6F899F99F3
GO

Sequence cautioni

The sequence CAD38593 differs from that shown. Intron retention.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0083541 – 7MSFVLSR → MPILSSSGSK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225126 mRNA. Translation: AAP57520.1.
AK092085 mRNA. Translation: BAC03801.1.
AK094385 mRNA. Translation: BAC04344.1.
AK128752 mRNA. Translation: BAG54727.1.
CH471054 Genomic DNA. Translation: EAW97033.1.
BC114441 mRNA. Translation: AAI14442.1.
BC114498 mRNA. Translation: AAI14499.1.
AL831941 mRNA. Translation: CAD38593.2. Sequence problems.
CCDSiCCDS41800.1. [Q8N9I9-1]
CCDS66410.1. [Q8N9I9-2]
RefSeqiNP_001273174.1. NM_001286245.1. [Q8N9I9-2]
NP_001273175.1. NM_001286246.1. [Q8N9I9-1]
NP_848597.1. NM_178502.3. [Q8N9I9-1]
XP_005268754.1. XM_005268697.1. [Q8N9I9-2]
XP_005268755.1. XM_005268698.1. [Q8N9I9-2]
XP_005268757.1. XM_005268700.1. [Q8N9I9-2]
XP_005268760.1. XM_005268703.1. [Q8N9I9-1]
XP_011536324.1. XM_011538022.2. [Q8N9I9-1]
UniGeneiHs.32374.

Genome annotation databases

EnsembliENST00000337737; ENSP00000338050; ENSG00000178498. [Q8N9I9-1]
ENST00000548198; ENSP00000447873; ENSG00000178498. [Q8N9I9-1]
ENST00000548804; ENSP00000449294; ENSG00000178498. [Q8N9I9-1]
ENST00000551632; ENSP00000448696; ENSG00000178498. [Q8N9I9-2]
GeneIDi196403.
KEGGihsa:196403.
UCSCiuc001sow.3. human. [Q8N9I9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225126 mRNA. Translation: AAP57520.1.
AK092085 mRNA. Translation: BAC03801.1.
AK094385 mRNA. Translation: BAC04344.1.
AK128752 mRNA. Translation: BAG54727.1.
CH471054 Genomic DNA. Translation: EAW97033.1.
BC114441 mRNA. Translation: AAI14442.1.
BC114498 mRNA. Translation: AAI14499.1.
AL831941 mRNA. Translation: CAD38593.2. Sequence problems.
CCDSiCCDS41800.1. [Q8N9I9-1]
CCDS66410.1. [Q8N9I9-2]
RefSeqiNP_001273174.1. NM_001286245.1. [Q8N9I9-2]
NP_001273175.1. NM_001286246.1. [Q8N9I9-1]
NP_848597.1. NM_178502.3. [Q8N9I9-1]
XP_005268754.1. XM_005268697.1. [Q8N9I9-2]
XP_005268755.1. XM_005268698.1. [Q8N9I9-2]
XP_005268757.1. XM_005268700.1. [Q8N9I9-2]
XP_005268760.1. XM_005268703.1. [Q8N9I9-1]
XP_011536324.1. XM_011538022.2. [Q8N9I9-1]
UniGeneiHs.32374.

3D structure databases

ProteinModelPortaliQ8N9I9.
SMRiQ8N9I9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128203. 34 interactors.
IntActiQ8N9I9. 21 interactors.
STRINGi9606.ENSP00000338050.

PTM databases

iPTMnetiQ8N9I9.
PhosphoSitePlusiQ8N9I9.

Polymorphism and mutation databases

DMDMi37077338.

Proteomic databases

EPDiQ8N9I9.
MaxQBiQ8N9I9.
PaxDbiQ8N9I9.
PeptideAtlasiQ8N9I9.
PRIDEiQ8N9I9.
TopDownProteomicsiQ8N9I9-1. [Q8N9I9-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337737; ENSP00000338050; ENSG00000178498. [Q8N9I9-1]
ENST00000548198; ENSP00000447873; ENSG00000178498. [Q8N9I9-1]
ENST00000548804; ENSP00000449294; ENSG00000178498. [Q8N9I9-1]
ENST00000551632; ENSP00000448696; ENSG00000178498. [Q8N9I9-2]
GeneIDi196403.
KEGGihsa:196403.
UCSCiuc001sow.3. human. [Q8N9I9-1]

Organism-specific databases

CTDi196403.
DisGeNETi196403.
GeneCardsiDTX3.
HGNCiHGNC:24457. DTX3.
HPAiHPA059654.
MIMi613142. gene.
neXtProtiNX_Q8N9I9.
OpenTargetsiENSG00000178498.
PharmGKBiPA134887936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0N. Eukaryota.
ENOG410Z2TC. LUCA.
GeneTreeiENSGT00440000035370.
HOGENOMiHOG000007352.
HOVERGENiHBG045495.
InParanoidiQ8N9I9.
KOiK06058.
OMAiLREEHHV.
OrthoDBiEOG091G06M5.
PhylomeDBiQ8N9I9.
TreeFamiTF325526.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii196403.
PROiQ8N9I9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178498.
CleanExiHS_DTX3.
ExpressionAtlasiQ8N9I9. baseline and differential.
GenevisibleiQ8N9I9. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTX3_HUMAN
AccessioniPrimary (citable) accession number: Q8N9I9
Secondary accession number(s): Q53ZZ2, Q8NAU6, Q8NDS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.