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Q8N9I0

- SYT2_HUMAN

UniProt

Q8N9I0 - SYT2_HUMAN

Protein

Synaptotagmin-2

Gene

SYT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone By similarity.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi169 – 1691Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi170 – 1701Calcium 1By similarity
    Metal bindingi170 – 1701Calcium 2By similarity
    Metal bindingi176 – 1761Calcium 1By similarity
    Metal bindingi228 – 2281Calcium 1By similarity
    Metal bindingi228 – 2281Calcium 2By similarity
    Metal bindingi229 – 2291Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi230 – 2301Calcium 1By similarity
    Metal bindingi230 – 2301Calcium 2By similarity
    Metal bindingi230 – 2301Calcium 3By similarity
    Metal bindingi233 – 2331Calcium 3By similarity
    Metal bindingi234 – 2341Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi236 – 2361Calcium 2By similarity
    Metal bindingi236 – 2361Calcium 3By similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: Ensembl
    2. calcium ion binding Source: Ensembl
    3. protein binding Source: UniProtKB
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. neurotransmitter secretion Source: Reactome
    2. synaptic transmission Source: Reactome

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_200782. Toxicity of botulinum toxin type B (BoNT/B).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-2
    Alternative name(s):
    Synaptotagmin II
    Short name:
    SytII
    Gene namesi
    Name:SYT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11510. SYT2.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Single-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesiclechromaffin granule membrane By similarity; Single-pass membrane protein By similarity
    Note: Synaptic vesicles and chromaffin granules.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chromaffin granule membrane Source: UniProtKB-SubCell
    3. endocytic vesicle membrane Source: Reactome
    4. integral component of membrane Source: UniProtKB-KW
    5. intracellular membrane-bounded organelle Source: HPA
    6. plasma membrane Source: Reactome
    7. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36291.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Synaptotagmin-2PRO_0000183942Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Modified residuei227 – 2271PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8N9I0.
    PRIDEiQ8N9I0.

    PTM databases

    PhosphoSiteiQ8N9I0.

    Expressioni

    Gene expression databases

    BgeeiQ8N9I0.
    CleanExiHS_SYT2.
    GenevestigatoriQ8N9I0.

    Organism-specific databases

    HPAiHPA030372.

    Interactioni

    Subunit structurei

    Homotetramer Probable. Interacts with stonin 2 By similarity. Interacts with SCAMP5.By similarity1 PublicationCurated

    Protein-protein interaction databases

    BioGridi126085. 4 interactions.
    IntActiQ8N9I0. 4 interactions.
    MINTiMINT-2810903.
    STRINGi9606.ENSP00000356236.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N9I0.
    SMRiQ8N9I0. Positions 138-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262VesicularSequence AnalysisAdd
    BLAST
    Topological domaini84 – 419336CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini141 – 242102C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 375104C2 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 379247Phospholipid bindingBy similarityAdd
    BLAST

    Domaini

    The first C2 domain mediates Ca2+-dependent phospholipid binding.By similarity
    The second C2 domain mediates interaction with Stonin 2.By similarity

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5038.
    HOGENOMiHOG000232127.
    HOVERGENiHBG005010.
    InParanoidiQ8N9I0.
    OMAiCCIRRCC.
    OrthoDBiEOG78PV8W.
    PhylomeDBiQ8N9I0.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    [Graphical view]
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N9I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNIFKRNQE PIVAPATTTA TMPIGPVDNS TESGGAGESQ EDMFAKLKEK    50
    LFNEINKIPL PPWALIAIAV VAGLLLLTCC FCICKKCCCK KKKNKKEKGK 100
    GMKNAMNMKD MKGGQDDDDA ETGLTEGEGE GEEEKEPENL GKLQFSLDYD 150
    FQANQLTVGV LQAAELPALD MGGTSDPYVK VFLLPDKKKK YETKVHRKTL 200
    NPAFNETFTF KVPYQELGGK TLVMAIYDFD RFSKHDIIGE VKVPMNTVDL 250
    GQPIEEWRDL QGGEKEEPEK LGDICTSLRY VPTAGKLTVC ILEAKNLKKM 300
    DVGGLSDPYV KIHLMQNGKR LKKKKTTVKK KTLNPYFNES FSFEIPFEQI 350
    QKVQVVVTVL DYDKLGKNEA IGKIFVGSNA TGTELRHWSD MLANPRRPIA 400
    QWHSLKPEEE VDALLGKNK 419
    Length:419
    Mass (Da):46,872
    Last modified:October 17, 2006 - v2
    Checksum:iBE3855E9CDE2D76E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti310 – 3101V → G in BAC04354. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090672 mRNA. Translation: BAC03500.1.
    AK094430 mRNA. Translation: BAC04354.1.
    BC100814 mRNA. Translation: AAI00815.1.
    BC100815 mRNA. Translation: AAI00816.1.
    BC100817 mRNA. Translation: AAI00818.1.
    CCDSiCCDS1427.1.
    RefSeqiNP_001129976.1. NM_001136504.1.
    NP_796376.2. NM_177402.4.
    UniGeneiHs.25422.

    Genome annotation databases

    EnsembliENST00000367267; ENSP00000356236; ENSG00000143858.
    ENST00000367268; ENSP00000356237; ENSG00000143858.
    GeneIDi127833.
    KEGGihsa:127833.
    UCSCiuc001gye.3. human.

    Polymorphism databases

    DMDMi116242811.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090672 mRNA. Translation: BAC03500.1 .
    AK094430 mRNA. Translation: BAC04354.1 .
    BC100814 mRNA. Translation: AAI00815.1 .
    BC100815 mRNA. Translation: AAI00816.1 .
    BC100817 mRNA. Translation: AAI00818.1 .
    CCDSi CCDS1427.1.
    RefSeqi NP_001129976.1. NM_001136504.1.
    NP_796376.2. NM_177402.4.
    UniGenei Hs.25422.

    3D structure databases

    ProteinModelPortali Q8N9I0.
    SMRi Q8N9I0. Positions 138-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126085. 4 interactions.
    IntActi Q8N9I0. 4 interactions.
    MINTi MINT-2810903.
    STRINGi 9606.ENSP00000356236.

    Chemistry

    DrugBanki DB00042. Botulinum Toxin Type B.

    PTM databases

    PhosphoSitei Q8N9I0.

    Polymorphism databases

    DMDMi 116242811.

    Proteomic databases

    PaxDbi Q8N9I0.
    PRIDEi Q8N9I0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367267 ; ENSP00000356236 ; ENSG00000143858 .
    ENST00000367268 ; ENSP00000356237 ; ENSG00000143858 .
    GeneIDi 127833.
    KEGGi hsa:127833.
    UCSCi uc001gye.3. human.

    Organism-specific databases

    CTDi 127833.
    GeneCardsi GC01M202559.
    HGNCi HGNC:11510. SYT2.
    HPAi HPA030372.
    MIMi 600104. gene.
    neXtProti NX_Q8N9I0.
    PharmGKBi PA36291.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5038.
    HOGENOMi HOG000232127.
    HOVERGENi HBG005010.
    InParanoidi Q8N9I0.
    OMAi CCIRRCC.
    OrthoDBi EOG78PV8W.
    PhylomeDBi Q8N9I0.
    TreeFami TF315600.

    Enzyme and pathway databases

    Reactomei REACT_200782. Toxicity of botulinum toxin type B (BoNT/B).

    Miscellaneous databases

    ChiTaRSi SYT2. human.
    GeneWikii SYT2.
    GenomeRNAii 127833.
    NextBioi 82195.
    PROi Q8N9I0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N9I0.
    CleanExi HS_SYT2.
    Genevestigatori Q8N9I0.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    [Graphical view ]
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery."
      Han C., Chen T., Yang M., Li N., Liu H., Cao X.
      J. Immunol. 182:2986-2996(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCAMP5.

    Entry informationi

    Entry nameiSYT2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N9I0
    Secondary accession number(s): Q496K5, Q8NBE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3