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Protein

Zinc finger protein 454

Gene

ZNF454

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 454
Gene namesi
Name:ZNF454
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000178187.7
HGNCiHGNC:21200 ZNF454
neXtProtiNX_Q8N9F8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178187
PharmGKBiPA134974337

Polymorphism and mutation databases

BioMutaiZNF454
DMDMi269849529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476001 – 522Zinc finger protein 454Add BLAST522

Proteomic databases

PaxDbiQ8N9F8
PeptideAtlasiQ8N9F8
PRIDEiQ8N9F8

PTM databases

iPTMnetiQ8N9F8
PhosphoSitePlusiQ8N9F8

Expressioni

Gene expression databases

BgeeiENSG00000178187
CleanExiHS_ZNF454

Organism-specific databases

HPAiHPA024556

Interactioni

Protein-protein interaction databases

BioGridi130176, 4 interactors
STRINGi9606.ENSP00000326249

Structurei

3D structure databases

ProteinModelPortaliQ8N9F8
SMRiQ8N9F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N9F8
KOiK09228
OMAiFCLDWMT
OrthoDBiEOG091G02KC
PhylomeDBiQ8N9F8
TreeFamiTF336820

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q8N9F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSHLPTMV QESVTFKDVA ILFTQEEWGQ LSPAQRALYR DVMLENYSNL
60 70 80 90 100
VSLGLLGPKP DTFSQLEKRE VWMPEDTPGG FCLDWMTMPA SKKSTVKAEI
110 120 130 140 150
PEEELDQWTI KERFSSSSHW KCASLLEWQC GGQEISLQRV VLTHPNTPSQ
160 170 180 190 200
ECDESGSTMS SSLHSDQSQG FQPSKNAFEC SECGKVFSKS STLNKHQKIH
210 220 230 240 250
NEKNANQKIH IKEKRYECRE CGKAFHQSTH LIHHQRIHTG EKPYECKECG
260 270 280 290 300
KAFSVSSSLT YHQKIHTGEK PFECNLCGKA FIRNIHLAHH HRIHTGEKPF
310 320 330 340 350
KCNICEKAFV CRAHLTKHQN IHSGEKPYKC NECGKAFNQS TSFLQHQRIH
360 370 380 390 400
TGEKPFECNE CGKAFRVNSS LTEHQRIHTG EKPYKCNECG KAFRDNSSFA
410 420 430 440 450
RHRKIHTGEK PYRCGLCEKA FRDQSALAQH QRIHTGEKPY TCNICEKAFS
460 470 480 490 500
DHSALTQHKR IHTREKPYKC KICEKAFIRS THLTQHQRIH TGEKPYKCNK
510 520
CGKAFNQTAN LIQHQRHHIG EK
Length:522
Mass (Da):60,008
Last modified:November 24, 2009 - v2
Checksum:i77713F1487E01B4F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059919152C → Y2 PublicationsCorresponds to variant dbSNP:rs6867221Ensembl.1
Natural variantiVAR_033568166D → A3 PublicationsCorresponds to variant dbSNP:rs12719860Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094763 mRNA Translation: BAC04418.1
AK292317 mRNA Translation: BAF85006.1
AC104117 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53822.1
CH471165 Genomic DNA Translation: EAW53823.1
CH471165 Genomic DNA Translation: EAW53824.1
BC105061 mRNA Translation: AAI05062.1
BC112276 mRNA Translation: AAI12277.1
CCDSiCCDS4441.1
RefSeqiNP_001171560.1, NM_001178089.2
NP_001171561.1, NM_001178090.2
NP_001310235.1, NM_001323306.1
NP_872400.2, NM_182594.3
UniGeneiHs.259441

Genome annotation databases

EnsembliENST00000320129; ENSP00000326249; ENSG00000178187
ENST00000519564; ENSP00000430354; ENSG00000178187
GeneIDi285676
KEGGihsa:285676
UCSCiuc003mjo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN454_HUMAN
AccessioniPrimary (citable) accession number: Q8N9F8
Secondary accession number(s): Q2M1P2, Q2M323
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 24, 2009
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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