Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 454

Gene

ZNF454

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178187-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 454
Gene namesi
Name:ZNF454
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:21200. ZNF454.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178187.
PharmGKBiPA134974337.

Polymorphism and mutation databases

BioMutaiZNF454.
DMDMi269849529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476001 – 522Zinc finger protein 454Add BLAST522

Proteomic databases

PaxDbiQ8N9F8.
PeptideAtlasiQ8N9F8.
PRIDEiQ8N9F8.

PTM databases

iPTMnetiQ8N9F8.
PhosphoSitePlusiQ8N9F8.

Expressioni

Gene expression databases

BgeeiENSG00000178187.
CleanExiHS_ZNF454.

Organism-specific databases

HPAiHPA024556.

Interactioni

Protein-protein interaction databases

BioGridi130176. 4 interactors.
STRINGi9606.ENSP00000326249.

Structurei

3D structure databases

ProteinModelPortaliQ8N9F8.
SMRiQ8N9F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N9F8.
KOiK09228.
OMAiFCLDWMT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N9F8.
TreeFamiTF336820.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N9F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSHLPTMV QESVTFKDVA ILFTQEEWGQ LSPAQRALYR DVMLENYSNL
60 70 80 90 100
VSLGLLGPKP DTFSQLEKRE VWMPEDTPGG FCLDWMTMPA SKKSTVKAEI
110 120 130 140 150
PEEELDQWTI KERFSSSSHW KCASLLEWQC GGQEISLQRV VLTHPNTPSQ
160 170 180 190 200
ECDESGSTMS SSLHSDQSQG FQPSKNAFEC SECGKVFSKS STLNKHQKIH
210 220 230 240 250
NEKNANQKIH IKEKRYECRE CGKAFHQSTH LIHHQRIHTG EKPYECKECG
260 270 280 290 300
KAFSVSSSLT YHQKIHTGEK PFECNLCGKA FIRNIHLAHH HRIHTGEKPF
310 320 330 340 350
KCNICEKAFV CRAHLTKHQN IHSGEKPYKC NECGKAFNQS TSFLQHQRIH
360 370 380 390 400
TGEKPFECNE CGKAFRVNSS LTEHQRIHTG EKPYKCNECG KAFRDNSSFA
410 420 430 440 450
RHRKIHTGEK PYRCGLCEKA FRDQSALAQH QRIHTGEKPY TCNICEKAFS
460 470 480 490 500
DHSALTQHKR IHTREKPYKC KICEKAFIRS THLTQHQRIH TGEKPYKCNK
510 520
CGKAFNQTAN LIQHQRHHIG EK
Length:522
Mass (Da):60,008
Last modified:November 24, 2009 - v2
Checksum:i77713F1487E01B4F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059919152C → Y.2 PublicationsCorresponds to variant rs6867221dbSNPEnsembl.1
Natural variantiVAR_033568166D → A.3 PublicationsCorresponds to variant rs12719860dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094763 mRNA. Translation: BAC04418.1.
AK292317 mRNA. Translation: BAF85006.1.
AC104117 Genomic DNA. No translation available.
CH471165 Genomic DNA. Translation: EAW53822.1.
CH471165 Genomic DNA. Translation: EAW53823.1.
CH471165 Genomic DNA. Translation: EAW53824.1.
BC105061 mRNA. Translation: AAI05062.1.
BC112276 mRNA. Translation: AAI12277.1.
CCDSiCCDS4441.1.
RefSeqiNP_001171560.1. NM_001178089.2.
NP_001171561.1. NM_001178090.2.
NP_001310235.1. NM_001323306.1.
NP_872400.2. NM_182594.3.
UniGeneiHs.259441.

Genome annotation databases

EnsembliENST00000320129; ENSP00000326249; ENSG00000178187.
ENST00000519564; ENSP00000430354; ENSG00000178187.
GeneIDi285676.
KEGGihsa:285676.
UCSCiuc003mjo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094763 mRNA. Translation: BAC04418.1.
AK292317 mRNA. Translation: BAF85006.1.
AC104117 Genomic DNA. No translation available.
CH471165 Genomic DNA. Translation: EAW53822.1.
CH471165 Genomic DNA. Translation: EAW53823.1.
CH471165 Genomic DNA. Translation: EAW53824.1.
BC105061 mRNA. Translation: AAI05062.1.
BC112276 mRNA. Translation: AAI12277.1.
CCDSiCCDS4441.1.
RefSeqiNP_001171560.1. NM_001178089.2.
NP_001171561.1. NM_001178090.2.
NP_001310235.1. NM_001323306.1.
NP_872400.2. NM_182594.3.
UniGeneiHs.259441.

3D structure databases

ProteinModelPortaliQ8N9F8.
SMRiQ8N9F8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130176. 4 interactors.
STRINGi9606.ENSP00000326249.

PTM databases

iPTMnetiQ8N9F8.
PhosphoSitePlusiQ8N9F8.

Polymorphism and mutation databases

BioMutaiZNF454.
DMDMi269849529.

Proteomic databases

PaxDbiQ8N9F8.
PeptideAtlasiQ8N9F8.
PRIDEiQ8N9F8.

Protocols and materials databases

DNASUi285676.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320129; ENSP00000326249; ENSG00000178187.
ENST00000519564; ENSP00000430354; ENSG00000178187.
GeneIDi285676.
KEGGihsa:285676.
UCSCiuc003mjo.3. human.

Organism-specific databases

CTDi285676.
GeneCardsiZNF454.
HGNCiHGNC:21200. ZNF454.
HPAiHPA024556.
neXtProtiNX_Q8N9F8.
OpenTargetsiENSG00000178187.
PharmGKBiPA134974337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N9F8.
KOiK09228.
OMAiFCLDWMT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N9F8.
TreeFamiTF336820.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178187-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii285676.
PROiQ8N9F8.

Gene expression databases

BgeeiENSG00000178187.
CleanExiHS_ZNF454.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN454_HUMAN
AccessioniPrimary (citable) accession number: Q8N9F8
Secondary accession number(s): Q2M1P2, Q2M323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.