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Protein

Protein FAM133A

Gene

FAM133A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM133A
Gene namesi
Name:FAM133A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26748. FAM133A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386125.

Polymorphism and mutation databases

BioMutaiFAM133A.
DMDMi74751120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Protein FAM133APRO_0000287619Add
BLAST

Proteomic databases

EPDiQ8N9E0.
PaxDbiQ8N9E0.
PRIDEiQ8N9E0.

PTM databases

iPTMnetiQ8N9E0.
PhosphoSiteiQ8N9E0.

Expressioni

Gene expression databases

BgeeiQ8N9E0.
CleanExiHS_FAM133A.
GenevisibleiQ8N9E0. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEND7Q8N7W2-23EBI-10268158,EBI-10181188
CEP70Q8NHQ13EBI-10268158,EBI-739624
NOS1APO750523EBI-10268158,EBI-780467
PRR13Q9NZ813EBI-10268158,EBI-740924
SDCBP2Q9H1903EBI-10268158,EBI-742426
STAC3Q96MF23EBI-10268158,EBI-745680
THAP1Q9NVV93EBI-10268158,EBI-741515
TRIM23P364063EBI-10268158,EBI-740098

Protein-protein interaction databases

BioGridi130395. 8 interactions.
IntActiQ8N9E0. 8 interactions.
STRINGi9606.ENSP00000318974.

Structurei

3D structure databases

ProteinModelPortaliQ8N9E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 240196Lys-richAdd
BLAST
Compositional biasi82 – 198117Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM133 family.Curated

Phylogenomic databases

eggNOGiENOG410IY68. Eukaryota.
ENOG41123P0. LUCA.
GeneTreeiENSGT00730000111097.
HOGENOMiHOG000059590.
HOVERGENiHBG088046.
InParanoidiQ8N9E0.
OMAiKNHSHKS.
OrthoDBiEOG7MSMRZ.
PhylomeDBiQ8N9E0.
TreeFamiTF350193.

Family and domain databases

InterProiIPR026766. Fam133.
[Graphical view]
PANTHERiPTHR31911. PTHR31911. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N9E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRDNRVAY MNPIAMARWR GPTQSVGPTI QDYLNRPRPT WEEVKKQLEN
60 70 80 90 100
KKTGSKALAE FEEKMNENWK KELEKSREKL LSGNESSSKK RERKKKRKKK
110 120 130 140 150
SCRSSSSSSS SDSSSSSSDS EDEEKKQGKR RKKKKNRSYK SSQSSTHESE
160 170 180 190 200
SESKESVKKK KKSKDETEKE KDVRSLSKKR KKSYPDDKPL SSESSSESDY
210 220 230 240
EEDVQAKKKR RCEEREQAKE KVKKKKKKQH KKHSKKKKKK SGSSHKSR
Length:248
Mass (Da):28,941
Last modified:October 1, 2002 - v1
Checksum:iDB18B8F3FABFBAF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671E → K.
Corresponds to variant rs34123774 [ dbSNP | Ensembl ].
VAR_053907

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094978 mRNA. Translation: BAC04467.1.
AL009173 Genomic DNA. Translation: CAI42611.1.
BC113387 mRNA. Translation: AAI13388.1.
BC113385 mRNA. Translation: AAI13386.1.
CCDSiCCDS14466.1.
RefSeqiNP_001164580.1. NM_001171109.1.
NP_001164581.1. NM_001171110.1.
NP_001164582.1. NM_001171111.1.
NP_775969.1. NM_173698.2.
XP_006724704.1. XM_006724641.2.
XP_011529227.1. XM_011530925.1.
XP_011529228.1. XM_011530926.1.
XP_011529229.1. XM_011530927.1.
XP_011529230.1. XM_011530928.1.
XP_011529231.1. XM_011530929.1.
XP_011529232.1. XM_011530930.1.
XP_011529233.1. XM_011530931.1.
UniGeneiHs.110069.

Genome annotation databases

EnsembliENST00000322139; ENSP00000318974; ENSG00000179083.
ENST00000332647; ENSP00000362169; ENSG00000179083.
GeneIDi286499.
KEGGihsa:286499.
UCSCiuc004efr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094978 mRNA. Translation: BAC04467.1.
AL009173 Genomic DNA. Translation: CAI42611.1.
BC113387 mRNA. Translation: AAI13388.1.
BC113385 mRNA. Translation: AAI13386.1.
CCDSiCCDS14466.1.
RefSeqiNP_001164580.1. NM_001171109.1.
NP_001164581.1. NM_001171110.1.
NP_001164582.1. NM_001171111.1.
NP_775969.1. NM_173698.2.
XP_006724704.1. XM_006724641.2.
XP_011529227.1. XM_011530925.1.
XP_011529228.1. XM_011530926.1.
XP_011529229.1. XM_011530927.1.
XP_011529230.1. XM_011530928.1.
XP_011529231.1. XM_011530929.1.
XP_011529232.1. XM_011530930.1.
XP_011529233.1. XM_011530931.1.
UniGeneiHs.110069.

3D structure databases

ProteinModelPortaliQ8N9E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130395. 8 interactions.
IntActiQ8N9E0. 8 interactions.
STRINGi9606.ENSP00000318974.

PTM databases

iPTMnetiQ8N9E0.
PhosphoSiteiQ8N9E0.

Polymorphism and mutation databases

BioMutaiFAM133A.
DMDMi74751120.

Proteomic databases

EPDiQ8N9E0.
PaxDbiQ8N9E0.
PRIDEiQ8N9E0.

Protocols and materials databases

DNASUi286499.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322139; ENSP00000318974; ENSG00000179083.
ENST00000332647; ENSP00000362169; ENSG00000179083.
GeneIDi286499.
KEGGihsa:286499.
UCSCiuc004efr.3. human.

Organism-specific databases

CTDi286499.
GeneCardsiFAM133A.
HGNCiHGNC:26748. FAM133A.
neXtProtiNX_Q8N9E0.
PharmGKBiPA162386125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY68. Eukaryota.
ENOG41123P0. LUCA.
GeneTreeiENSGT00730000111097.
HOGENOMiHOG000059590.
HOVERGENiHBG088046.
InParanoidiQ8N9E0.
OMAiKNHSHKS.
OrthoDBiEOG7MSMRZ.
PhylomeDBiQ8N9E0.
TreeFamiTF350193.

Miscellaneous databases

GenomeRNAii286499.
NextBioi96242.
PROiQ8N9E0.

Gene expression databases

BgeeiQ8N9E0.
CleanExiHS_FAM133A.
GenevisibleiQ8N9E0. HS.

Family and domain databases

InterProiIPR026766. Fam133.
[Graphical view]
PANTHERiPTHR31911. PTHR31911. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiF133A_HUMAN
AccessioniPrimary (citable) accession number: Q8N9E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.