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Protein

Immunoglobulin superfamily member 22

Gene

IGSF22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 22
Short name:
IgSF22
Gene namesi
Name:IGSF22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26750. IGSF22.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671662.

Polymorphism and mutation databases

BioMutaiIGSF22.
DMDMi146324946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Immunoglobulin superfamily member 22PRO_0000285255Add
BLAST

Proteomic databases

PeptideAtlasiQ8N9C0.
PRIDEiQ8N9C0.

PTM databases

iPTMnetiQ8N9C0.
PhosphoSiteiQ8N9C0.

Expressioni

Gene expression databases

BgeeiQ8N9C0.
CleanExiHS_IGSF22.
GenevisibleiQ8N9C0. HS.

Organism-specific databases

HPAiCAB026459.

Interactioni

Protein-protein interaction databases

BioGridi129517. 1 interaction.
IntActiQ8N9C0. 1 interaction.
MINTiMINT-7969147.

Structurei

3D structure databases

ProteinModelPortaliQ8N9C0.
SMRiQ8N9C0. Positions 67-157, 231-894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 15892Ig-like 1Add
BLAST
Domaini232 – 32291Ig-like 2Add
BLAST
Domaini418 – 50891Ig-like 3Add
BLAST
Domaini606 – 69691Ig-like 4Add
BLAST
Domaini703 – 79896Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini804 – 89895Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi163 – 22866Lys-richAdd
BLAST

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00840000129685.
HOGENOMiHOG000113015.
InParanoidiQ8N9C0.
OMAiTLTWNHS.
OrthoDBiEOG7GTT2T.
PhylomeDBiQ8N9C0.
TreeFamiTF351819.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTIHSRQML QEHVSMEFSS STTHVQTFSQ TTKIVGEEVV RRKSSSIVEF
60 70 80 90 100
FSLVTRSSNI PAGDSVPEFV EKPQPVTAPE GDKAVFRARV QGNAKPHISW
110 120 130 140 150
KRESGIPIKE SAKIFYDSIN KEHVLKLEPL TSDDSDNYKC IASNDHADAI
160 170 180 190 200
YTVSLLVTEG QEKMDFKKML KKRAPPAPKK KQKKVANEKE MLEILSKVPK
210 220 230 240 250
KDFEKVCMEY GFTDFRGLLR KLKEMKKKVE VEAIRILKPL EDKETKVDTT
260 270 280 290 300
VVFDCIMELK DPNVKMIWIK GTEPLRIQYS LGKYDVKQMG TKYMLVISNV
310 320 330 340 350
NMNDAGIYSL SVGDKRMSAE LTVLDEPLKF LGEMKPVKVT ERQTAVFEIR
360 370 380 390 400
LSKKEPNFVW KFNGKELKRD DKYEITVSED GLTHTLKIKD ARLSDSGEFS
410 420 430 440 450
AEAGNLVQKA QLTVDRIPIK FVSNLKNVRV KERSRACLEC ELTSKDVTLR
460 470 480 490 500
WKKDGQLLMH GTKYSMNHEG KRAELIIEDA QLSDGGEYTV VAMQDGDPTE
510 520 530 540 550
YYSTAIVTVE ERLATVKSGM SDVHAATGSP AELCVVLNDE KVEGVWLKDG
560 570 580 590 600
KEITDLPGMQ IVKQGAVHKL IFPSMGPEHE GKYTFRAKGT ESEASVFIAD
610 620 630 640 650
PPTIDPSVLE ALAAHAITVK VGHTAHIKVP FRGKPLPKVT WYKDGMEVTE
660 670 680 690 700
EERVSMERGE DQALLTISNC VREDSGLILL KLKNDHGSAT ATLHLSVLEP
710 720 730 740 750
PGFASQPQVT DVTKEAVTIT WNAPTQDGGA PVLGYIVERR KKGSNLWVPV
760 770 780 790 800
NKDPIQGTKC TVDGLLEDTE YEFRVIAVNK AGPGQPSVPS SSVVAKDPVK
810 820 830 840 850
PPGLVQDLHV SDSSNSSISL AWREPAEGDP PSGYILEMRA EDTKEWSKCT
860 870 880 890 900
KIPISGTCYT VGGLIERQKY FFRIRAVNEA GVGEPVELDK GVRAMPPPGL

TTT
Length:903
Mass (Da):100,400
Last modified:May 1, 2007 - v2
Checksum:i0564F44686C144F5
GO
Isoform 2 (identifier: Q8N9C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: L → LDRPKPPQGR...TEEVFAGNPI
     899-903: GLTTT → AAPKFDLSAR...SLQKKSKHLM

Note: Gene prediction based on EST data.
Show »
Length:1,326
Mass (Da):147,994
Checksum:iE7F3975084D7B9A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691F → L in BAC04488 (PubMed:14702039).Curated
Sequence conflicti210 – 2101Y → H in BAC04488 (PubMed:14702039).Curated
Sequence conflicti839 – 8391R → W in BAC04488 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → W Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064722
Natural varianti94 – 941A → P.
Corresponds to variant rs10832975 [ dbSNP | Ensembl ].
VAR_032000
Natural varianti130 – 1301L → R.
Corresponds to variant rs3740710 [ dbSNP | Ensembl ].
VAR_032001
Natural varianti414 – 4141V → I.1 Publication
Corresponds to variant rs10766494 [ dbSNP | Ensembl ].
VAR_032002
Natural varianti472 – 4721R → Q.1 Publication
Corresponds to variant rs4424652 [ dbSNP | Ensembl ].
VAR_032003
Natural varianti503 – 5031S → I.
Corresponds to variant rs3887899 [ dbSNP | Ensembl ].
VAR_032004
Natural varianti559 – 5591M → V.1 Publication
Corresponds to variant rs7125943 [ dbSNP | Ensembl ].
VAR_032005
Natural varianti677 – 6771L → F.
Corresponds to variant rs11024769 [ dbSNP | Ensembl ].
VAR_032006

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei698 – 6981L → LDRPKPPQGRVEFLELSGSC VHMKWKAPKDNGGRPVTQFI VERRAVGKKSWIKIGEVDGK VTNFSTNKVEEGKAYQFRIL AVNSEGVSDPLETEEVFAGN PI in isoform 2. CuratedVSP_047394
Alternative sequencei899 – 9035GLTTT → AAPKFDLSARLKSHMVVRAG TALCIHAAFSGSPPPDVIWQ KDGVPTKGRETITKSKNHSQ FLINSTKRSDSGVYRILLQN EFGEARYDIHVRVADFPRPP TNLRLFEEVPNTVTLTWNHS PDVQEDGEAHYIIMKRDAST ATWYTAAERVFSNKYTVTGL LPGRKYYFRVVARNEIGDSE PLDSRDTWLINKDQIQDLSA KLKPYEKKDWRHAPRFVTPL KPHTVLRGQDCTMTCAFLGN PRPTVTLYKGDVNITANSKF WYNSTSGVCTLVIPTCTLKD SGDYSVLVENELGKDRSSCT LTVYDKDDKSVVASITESLQ KKSKHLM in isoform 2. CuratedVSP_047395

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095113 mRNA. Translation: BAC04488.1.
AC103974 Genomic DNA. No translation available.
CCDSiCCDS41625.2. [Q8N9C0-2]
RefSeqiNP_775859.3. NM_173588.3.
UniGeneiHs.434152.

Genome annotation databases

EnsembliENST00000319338; ENSP00000322422; ENSG00000179057. [Q8N9C0-1]
ENST00000513874; ENSP00000421191; ENSG00000179057. [Q8N9C0-2]
GeneIDi283284.
KEGGihsa:283284.
UCSCiuc009yht.3. human. [Q8N9C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095113 mRNA. Translation: BAC04488.1.
AC103974 Genomic DNA. No translation available.
CCDSiCCDS41625.2. [Q8N9C0-2]
RefSeqiNP_775859.3. NM_173588.3.
UniGeneiHs.434152.

3D structure databases

ProteinModelPortaliQ8N9C0.
SMRiQ8N9C0. Positions 67-157, 231-894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129517. 1 interaction.
IntActiQ8N9C0. 1 interaction.
MINTiMINT-7969147.

PTM databases

iPTMnetiQ8N9C0.
PhosphoSiteiQ8N9C0.

Polymorphism and mutation databases

BioMutaiIGSF22.
DMDMi146324946.

Proteomic databases

PeptideAtlasiQ8N9C0.
PRIDEiQ8N9C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319338; ENSP00000322422; ENSG00000179057. [Q8N9C0-1]
ENST00000513874; ENSP00000421191; ENSG00000179057. [Q8N9C0-2]
GeneIDi283284.
KEGGihsa:283284.
UCSCiuc009yht.3. human. [Q8N9C0-1]

Organism-specific databases

CTDi283284.
GeneCardsiIGSF22.
HGNCiHGNC:26750. IGSF22.
HPAiCAB026459.
neXtProtiNX_Q8N9C0.
PharmGKBiPA142671662.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129685.
HOGENOMiHOG000113015.
InParanoidiQ8N9C0.
OMAiTLTWNHS.
OrthoDBiEOG7GTT2T.
PhylomeDBiQ8N9C0.
TreeFamiTF351819.

Miscellaneous databases

GenomeRNAii283284.
PROiQ8N9C0.

Gene expression databases

BgeeiQ8N9C0.
CleanExiHS_IGSF22.
GenevisibleiQ8N9C0. HS.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-414; GLN-472 AND VAL-559.
    Tissue: Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: VARIANT TRP-7.

Entry informationi

Entry nameiIGS22_HUMAN
AccessioniPrimary (citable) accession number: Q8N9C0
Secondary accession number(s): A6NNA0, D6RGV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.