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Protein

Uncharacterized protein C12orf29

Gene

C12orf29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf29
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25322. C12orf29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485359.

Polymorphism and mutation databases

BioMutaiC12orf29.
DMDMi158706467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Uncharacterized protein C12orf29PRO_0000305272Add
BLAST

Proteomic databases

EPDiQ8N999.
MaxQBiQ8N999.
PaxDbiQ8N999.
PeptideAtlasiQ8N999.
PRIDEiQ8N999.

PTM databases

iPTMnetiQ8N999.
PhosphoSiteiQ8N999.

Expressioni

Gene expression databases

BgeeiENSG00000133641.
CleanExiHS_C12orf29.
ExpressionAtlasiQ8N999. baseline and differential.
GenevisibleiQ8N999. HS.

Organism-specific databases

HPAiHPA039663.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349358.

Structurei

3D structure databases

ProteinModelPortaliQ8N999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEPK. Eukaryota.
ENOG4110N6G. LUCA.
GeneTreeiENSGT00500000044938.
HOGENOMiHOG000057278.
HOVERGENiHBG107705.
InParanoidiQ8N999.
OMAiDGTCCYV.
OrthoDBiEOG091G09NV.
PhylomeDBiQ8N999.
TreeFamiTF328501.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N999-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRLGSVQRK MPCVFVTEVK EEPSSKREHQ PFKVLATETV SHKALDADIY
60 70 80 90 100
SAIPTEKVDG TCCYVTTYKD QPYLWARLDR KPNKQAEKRF KNFLHSKENP
110 120 130 140 150
KEFFWNVEED FKPAPECWIP AKETEQINGN PVPDENGHIP GWVPVEKNNK
160 170 180 190 200
QYCWHSSVVN YEFEIALVLK HHPDDSGLLE ISAVPLSDLL EQTLELIGTN
210 220 230 240 250
INGNPYGLGS KKHPLHLLIP HGAFQIRNLP SLKHNDLVSW FEDCKEGKIE
260 270 280 290 300
GIVWHCSDGC LIKVHRHHLG LCWPIPDTYM NSRPVIINMN LNKCDSAFDI
310 320
KCLFNHFLKI DNQKFVRLKD IIFDV
Length:325
Mass (Da):37,490
Last modified:October 2, 2007 - v2
Checksum:i348F2FB665137DAC
GO
Isoform 2 (identifier: Q8N999-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-38: PFKVLATE → ISHTFGLD
     39-325: Missing.

Show »
Length:38
Mass (Da):4,416
Checksum:iD2BB9CDD4F699045
GO
Isoform 3 (identifier: Q8N999-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MKRLGSVQRKMPCVFVTEVKEEPSSKREH → MSLPF
     140-140: P → PG

Show »
Length:302
Mass (Da):34,724
Checksum:i123638567219DCC9
GO

Sequence cautioni

The sequence AAH35136 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAH58014 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871E → K in AAH92422 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231P → L.1 Publication
Corresponds to variant rs11541954 [ dbSNP | Ensembl ].
VAR_035197
Natural varianti238 – 2381V → L.2 Publications
Corresponds to variant rs9262 [ dbSNP | Ensembl ].
VAR_035198

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929MKRLG…SKREH → MSLPF in isoform 3. 1 PublicationVSP_028316Add
BLAST
Alternative sequencei31 – 388PFKVLATE → ISHTFGLD in isoform 2. 2 PublicationsVSP_028317
Alternative sequencei39 – 325287Missing in isoform 2. 2 PublicationsVSP_028318Add
BLAST
Alternative sequencei140 – 1401P → PG in isoform 3. 1 PublicationVSP_028319

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095477 mRNA. Translation: BAC04555.1.
AL137488 mRNA. Translation: CAB70767.2.
BX537868 mRNA. Translation: CAD97870.1.
BX640968 mRNA. Translation: CAE45983.1.
BX648026 mRNA. Translation: CAH10541.1.
CH471054 Genomic DNA. Translation: EAW97411.1.
BC035136 mRNA. Translation: AAH35136.2. Sequence problems.
BC058014 mRNA. Translation: AAH58014.1. Sequence problems.
BC092422 mRNA. Translation: AAH92422.1.
CCDSiCCDS31866.1. [Q8N999-1]
PIRiT46472.
RefSeqiNP_001009894.2. NM_001009894.2. [Q8N999-1]
UniGeneiHs.591009.

Genome annotation databases

EnsembliENST00000356891; ENSP00000349358; ENSG00000133641. [Q8N999-1]
ENST00000453037; ENSP00000402018; ENSG00000133641. [Q8N999-2]
ENST00000550333; ENSP00000448194; ENSG00000133641. [Q8N999-2]
ENST00000552121; ENSP00000447327; ENSG00000133641. [Q8N999-2]
GeneIDi91298.
KEGGihsa:91298.
UCSCiuc001tao.4. human. [Q8N999-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095477 mRNA. Translation: BAC04555.1.
AL137488 mRNA. Translation: CAB70767.2.
BX537868 mRNA. Translation: CAD97870.1.
BX640968 mRNA. Translation: CAE45983.1.
BX648026 mRNA. Translation: CAH10541.1.
CH471054 Genomic DNA. Translation: EAW97411.1.
BC035136 mRNA. Translation: AAH35136.2. Sequence problems.
BC058014 mRNA. Translation: AAH58014.1. Sequence problems.
BC092422 mRNA. Translation: AAH92422.1.
CCDSiCCDS31866.1. [Q8N999-1]
PIRiT46472.
RefSeqiNP_001009894.2. NM_001009894.2. [Q8N999-1]
UniGeneiHs.591009.

3D structure databases

ProteinModelPortaliQ8N999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349358.

PTM databases

iPTMnetiQ8N999.
PhosphoSiteiQ8N999.

Polymorphism and mutation databases

BioMutaiC12orf29.
DMDMi158706467.

Proteomic databases

EPDiQ8N999.
MaxQBiQ8N999.
PaxDbiQ8N999.
PeptideAtlasiQ8N999.
PRIDEiQ8N999.

Protocols and materials databases

DNASUi91298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356891; ENSP00000349358; ENSG00000133641. [Q8N999-1]
ENST00000453037; ENSP00000402018; ENSG00000133641. [Q8N999-2]
ENST00000550333; ENSP00000448194; ENSG00000133641. [Q8N999-2]
ENST00000552121; ENSP00000447327; ENSG00000133641. [Q8N999-2]
GeneIDi91298.
KEGGihsa:91298.
UCSCiuc001tao.4. human. [Q8N999-1]

Organism-specific databases

CTDi91298.
GeneCardsiC12orf29.
HGNCiHGNC:25322. C12orf29.
HPAiHPA039663.
neXtProtiNX_Q8N999.
PharmGKBiPA143485359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEPK. Eukaryota.
ENOG4110N6G. LUCA.
GeneTreeiENSGT00500000044938.
HOGENOMiHOG000057278.
HOVERGENiHBG107705.
InParanoidiQ8N999.
OMAiDGTCCYV.
OrthoDBiEOG091G09NV.
PhylomeDBiQ8N999.
TreeFamiTF328501.

Miscellaneous databases

ChiTaRSiC12orf29. human.
GenomeRNAii91298.
PROiQ8N999.

Gene expression databases

BgeeiENSG00000133641.
CleanExiHS_C12orf29.
ExpressionAtlasiQ8N999. baseline and differential.
GenevisibleiQ8N999. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCL029_HUMAN
AccessioniPrimary (citable) accession number: Q8N999
Secondary accession number(s): Q569K5
, Q6AWA8, Q6PEK5, Q8IYQ5, Q9NT75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.