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Q8N998

- CCD89_HUMAN

UniProt

Q8N998 - CCD89_HUMAN

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Protein
Coiled-coil domain-containing protein 89
Gene
CCDC89, BOIP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 89
Alternative name(s):
Bc8 orange-interacting protein
Gene namesi
Name:CCDC89
Synonyms:BOIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:26762. CCDC89.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1 By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Coiled-coil domain-containing protein 89
PRO_0000271024Add
BLAST

Proteomic databases

PaxDbiQ8N998.
PRIDEiQ8N998.

PTM databases

PhosphoSiteiQ8N998.

Expressioni

Gene expression databases

BgeeiQ8N998.
CleanExiHS_CCDC89.
GenevestigatoriQ8N998.

Organism-specific databases

HPAiHPA039351.

Interactioni

Subunit structurei

Interacts with HEY1 By similarity.

Protein-protein interaction databases

BioGridi128643. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N998.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili20 – 351332 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CCDC89 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG77184.
HOGENOMiHOG000007171.
HOVERGENiHBG081050.
InParanoidiQ8N998.
OMAiLICILKR.
OrthoDBiEOG7673B5.
PhylomeDBiQ8N998.
TreeFamiTF333232.

Sequencei

Sequence statusi: Complete.

Q8N998-1 [UniParc]FASTAAdd to Basket

« Hide

MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA    50
NLRGLSEEER SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE 100
LEEKMMQEAE KLKAQGEYSR KLEERFMTLA ANHELMLRFK DEYKSENIKL 150
REENEKLRLE NSSLFSQALK DEEAKVLQLT VRCEALTGEL ETLKERCAQD 200
ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH QQAVEQIAKA 250
EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL 300
EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA 350
FKKHSLDLLS KERELNGKLR HLSP 374
Length:374
Mass (Da):43,809
Last modified:October 1, 2002 - v1
Checksum:i161160AC06AC1491
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095478 mRNA. Translation: BAC04556.1.
BC044814 mRNA. Translation: AAH44814.1.
CCDSiCCDS8270.1.
RefSeqiNP_689936.1. NM_152723.1.
UniGeneiHs.376241.

Genome annotation databases

EnsembliENST00000316398; ENSP00000320649; ENSG00000179071.
GeneIDi220388.
KEGGihsa:220388.
UCSCiuc001pau.1. human.

Polymorphism databases

DMDMi74729632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095478 mRNA. Translation: BAC04556.1 .
BC044814 mRNA. Translation: AAH44814.1 .
CCDSi CCDS8270.1.
RefSeqi NP_689936.1. NM_152723.1.
UniGenei Hs.376241.

3D structure databases

ProteinModelPortali Q8N998.
ModBasei Search...

Protein-protein interaction databases

BioGridi 128643. 1 interaction.

PTM databases

PhosphoSitei Q8N998.

Polymorphism databases

DMDMi 74729632.

Proteomic databases

PaxDbi Q8N998.
PRIDEi Q8N998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316398 ; ENSP00000320649 ; ENSG00000179071 .
GeneIDi 220388.
KEGGi hsa:220388.
UCSCi uc001pau.1. human.

Organism-specific databases

CTDi 220388.
GeneCardsi GC11M085394.
HGNCi HGNC:26762. CCDC89.
HPAi HPA039351.
neXtProti NX_Q8N998.
PharmGKBi PA144596457.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77184.
HOGENOMi HOG000007171.
HOVERGENi HBG081050.
InParanoidi Q8N998.
OMAi LICILKR.
OrthoDBi EOG7673B5.
PhylomeDBi Q8N998.
TreeFami TF333232.

Miscellaneous databases

GenomeRNAii 220388.
NextBioi 91051.
PROi Q8N998.

Gene expression databases

Bgeei Q8N998.
CleanExi HS_CCDC89.
Genevestigatori Q8N998.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neonatal skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse."
    Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S., Gessler M., Christophe D., Bellefroid E.J.
    Dev. Dyn. 228:716-725(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCCD89_HUMAN
AccessioniPrimary (citable) accession number: Q8N998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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