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Q8N998

- CCD89_HUMAN

UniProt

Q8N998 - CCD89_HUMAN

Protein

Coiled-coil domain-containing protein 89

Gene

CCDC89

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 89
    Alternative name(s):
    Bc8 orange-interacting protein
    Gene namesi
    Name:CCDC89
    Synonyms:BOIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:26762. CCDC89.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596457.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Coiled-coil domain-containing protein 89PRO_0000271024Add
    BLAST

    Proteomic databases

    PaxDbiQ8N998.
    PRIDEiQ8N998.

    PTM databases

    PhosphoSiteiQ8N998.

    Expressioni

    Gene expression databases

    BgeeiQ8N998.
    CleanExiHS_CCDC89.
    GenevestigatoriQ8N998.

    Organism-specific databases

    HPAiHPA039351.

    Interactioni

    Subunit structurei

    Interacts with HEY1.By similarity

    Protein-protein interaction databases

    BioGridi128643. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N998.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili20 – 351332Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC89 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG77184.
    HOGENOMiHOG000007171.
    HOVERGENiHBG081050.
    InParanoidiQ8N998.
    OMAiLICILKR.
    OrthoDBiEOG7673B5.
    PhylomeDBiQ8N998.
    TreeFamiTF333232.

    Sequencei

    Sequence statusi: Complete.

    Q8N998-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA    50
    NLRGLSEEER SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE 100
    LEEKMMQEAE KLKAQGEYSR KLEERFMTLA ANHELMLRFK DEYKSENIKL 150
    REENEKLRLE NSSLFSQALK DEEAKVLQLT VRCEALTGEL ETLKERCAQD 200
    ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH QQAVEQIAKA 250
    EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL 300
    EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA 350
    FKKHSLDLLS KERELNGKLR HLSP 374
    Length:374
    Mass (Da):43,809
    Last modified:October 1, 2002 - v1
    Checksum:i161160AC06AC1491
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095478 mRNA. Translation: BAC04556.1.
    BC044814 mRNA. Translation: AAH44814.1.
    CCDSiCCDS8270.1.
    RefSeqiNP_689936.1. NM_152723.1.
    UniGeneiHs.376241.

    Genome annotation databases

    EnsembliENST00000316398; ENSP00000320649; ENSG00000179071.
    GeneIDi220388.
    KEGGihsa:220388.
    UCSCiuc001pau.1. human.

    Polymorphism databases

    DMDMi74729632.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095478 mRNA. Translation: BAC04556.1 .
    BC044814 mRNA. Translation: AAH44814.1 .
    CCDSi CCDS8270.1.
    RefSeqi NP_689936.1. NM_152723.1.
    UniGenei Hs.376241.

    3D structure databases

    ProteinModelPortali Q8N998.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128643. 1 interaction.

    PTM databases

    PhosphoSitei Q8N998.

    Polymorphism databases

    DMDMi 74729632.

    Proteomic databases

    PaxDbi Q8N998.
    PRIDEi Q8N998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316398 ; ENSP00000320649 ; ENSG00000179071 .
    GeneIDi 220388.
    KEGGi hsa:220388.
    UCSCi uc001pau.1. human.

    Organism-specific databases

    CTDi 220388.
    GeneCardsi GC11M085394.
    HGNCi HGNC:26762. CCDC89.
    HPAi HPA039351.
    neXtProti NX_Q8N998.
    PharmGKBi PA144596457.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77184.
    HOGENOMi HOG000007171.
    HOVERGENi HBG081050.
    InParanoidi Q8N998.
    OMAi LICILKR.
    OrthoDBi EOG7673B5.
    PhylomeDBi Q8N998.
    TreeFami TF333232.

    Miscellaneous databases

    GenomeRNAii 220388.
    NextBioi 91051.
    PROi Q8N998.

    Gene expression databases

    Bgeei Q8N998.
    CleanExi HS_CCDC89.
    Genevestigatori Q8N998.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neonatal skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse."
      Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S., Gessler M., Christophe D., Bellefroid E.J.
      Dev. Dyn. 228:716-725(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiCCD89_HUMAN
    AccessioniPrimary (citable) accession number: Q8N998
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3