Q8N998 (CCD89_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 89

Alternative name(s):
Bc8 orange-interacting protein

Gene names

Name:	CCDC89
Synonyms:	BOIP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with HEY1 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1 By similarity.
Sequence similarities	Belongs to the CCDC89 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Coiled-coil domain-containing protein 89		PRO_0000271024
Regions
	Coiled coil	20 – 351	332	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8N998 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 161160AC06AC1491	FASTA	374	43,809
	10 20 30 40 50 60 MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA NLRGLSEEER 70 80 90 100 110 120 SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE LEEKMMQEAE KLKAQGEYSR 130 140 150 160 170 180 KLEERFMTLA ANHELMLRFK DEYKSENIKL REENEKLRLE NSSLFSQALK DEEAKVLQLT 190 200 210 220 230 240 VRCEALTGEL ETLKERCAQD ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH 250 260 270 280 290 300 QQAVEQIAKA EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL 310 320 330 340 350 360 EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA FKKHSLDLLS 370 KERELNGKLR HLSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neonatal skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse." Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S., Gessler M., Christophe D., Bellefroid E.J. Dev. Dyn. 228:716-725(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK095478 mRNA. Translation: BAC04556.1. BC044814 mRNA. Translation: AAH44814.1.
IPI	IPI00167663.
RefSeq	NP_689936.1. NM_152723.1.
UniGene	Hs.376241.
3D structure databases
HSSP	HSSP built from PDB template 1B68 based on UniProtKB P02649.
ProteinModelPortal	Q8N998.
ModBase	Search...
PTM databases
PhosphoSite	Q8N998.
Polymorphism databases
DMDM	74729632.
Proteomic databases
PaxDb	Q8N998.
PRIDE	Q8N998.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316398; ENSP00000320649; ENSG00000179071.
GeneID	220388.
KEGG	hsa:220388.
UCSC	uc001pau.1. human.
Organism-specific databases
CTD	220388.
GeneCards	GC11M085394.
HGNC	HGNC:26762. CCDC89.
HPA	HPA039351.
neXtProt	NX_Q8N998.
PharmGKB	PA144596457.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77184.
HOGENOM	HOG000007171.
HOVERGEN	HBG081050.
InParanoid	Q8N998.
OMA	LICILKR.
OrthoDB	EOG4RBQK2.
PhylomeDB	Q8N998.
Gene expression databases
Bgee	Q8N998.
CleanEx	HS_CCDC89.
Genevestigator	Q8N998.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	220388.
NextBio	91051.

Entry information

Entry name

CCD89_HUMAN

Accession

Primary (citable) accession number: Q8N998

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.