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Q8N998 (CCD89_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 89
Alternative name(s):
Bc8 orange-interacting protein
Gene names
Name:CCDC89
Synonyms:BOIP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with HEY1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1 By similarity.

Sequence similarities

Belongs to the CCDC89 family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Coiled-coil domain-containing protein 89
PRO_0000271024

Regions

Coiled coil20 – 351332 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8N998 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 161160AC06AC1491

FASTA37443,809
        10         20         30         40         50         60 
MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA NLRGLSEEER 

        70         80         90        100        110        120 
SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE LEEKMMQEAE KLKAQGEYSR 

       130        140        150        160        170        180 
KLEERFMTLA ANHELMLRFK DEYKSENIKL REENEKLRLE NSSLFSQALK DEEAKVLQLT 

       190        200        210        220        230        240 
VRCEALTGEL ETLKERCAQD ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH 

       250        260        270        280        290        300 
QQAVEQIAKA EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL 

       310        320        330        340        350        360 
EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA FKKHSLDLLS 

       370 
KERELNGKLR HLSP 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neonatal skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse."
Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S., Gessler M., Christophe D., Bellefroid E.J.
Dev. Dyn. 228:716-725(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095478 mRNA. Translation: BAC04556.1.
BC044814 mRNA. Translation: AAH44814.1.
RefSeqNP_689936.1. NM_152723.1.
UniGeneHs.376241.

3D structure databases

ProteinModelPortalQ8N998.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128643. 1 interaction.

PTM databases

PhosphoSiteQ8N998.

Polymorphism databases

DMDM74729632.

Proteomic databases

PaxDbQ8N998.
PRIDEQ8N998.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316398; ENSP00000320649; ENSG00000179071.
GeneID220388.
KEGGhsa:220388.
UCSCuc001pau.1. human.

Organism-specific databases

CTD220388.
GeneCardsGC11M085394.
HGNCHGNC:26762. CCDC89.
HPAHPA039351.
neXtProtNX_Q8N998.
PharmGKBPA144596457.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77184.
HOGENOMHOG000007171.
HOVERGENHBG081050.
InParanoidQ8N998.
OMALICILKR.
OrthoDBEOG7673B5.
PhylomeDBQ8N998.
TreeFamTF333232.

Gene expression databases

BgeeQ8N998.
CleanExHS_CCDC89.
GenevestigatorQ8N998.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi220388.
NextBio91051.
PROQ8N998.

Entry information

Entry nameCCD89_HUMAN
AccessionPrimary (citable) accession number: Q8N998
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM