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Protein

Coiled-coil domain-containing protein 89

Gene

CCDC89

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179071-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 89
Alternative name(s):
Bc8 orange-interacting protein
Gene namesi
Name:CCDC89
Synonyms:BOIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26762. CCDC89.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179071.
PharmGKBiPA144596457.

Polymorphism and mutation databases

BioMutaiCCDC89.
DMDMi74729632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710241 – 374Coiled-coil domain-containing protein 89Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N998.
PeptideAtlasiQ8N998.
PRIDEiQ8N998.

PTM databases

iPTMnetiQ8N998.
PhosphoSitePlusiQ8N998.

Expressioni

Gene expression databases

BgeeiENSG00000179071.
CleanExiHS_CCDC89.

Organism-specific databases

HPAiHPA039351.
HPA040628.

Interactioni

Subunit structurei

Interacts with HEY1.By similarity

Protein-protein interaction databases

BioGridi128643. 11 interactors.
STRINGi9606.ENSP00000320649.

Structurei

3D structure databases

ProteinModelPortaliQ8N998.
SMRiQ8N998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 351Sequence analysisAdd BLAST332

Sequence similaritiesi

Belongs to the CCDC89 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHI9. Eukaryota.
ENOG4111GX6. LUCA.
GeneTreeiENSGT00390000016046.
HOGENOMiHOG000007171.
HOVERGENiHBG081050.
InParanoidiQ8N998.
OMAiLICILKR.
OrthoDBiEOG091G0KSH.
PhylomeDBiQ8N998.
TreeFamiTF333232.

Sequencei

Sequence statusi: Complete.

Q8N998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA
60 70 80 90 100
NLRGLSEEER SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE
110 120 130 140 150
LEEKMMQEAE KLKAQGEYSR KLEERFMTLA ANHELMLRFK DEYKSENIKL
160 170 180 190 200
REENEKLRLE NSSLFSQALK DEEAKVLQLT VRCEALTGEL ETLKERCAQD
210 220 230 240 250
ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH QQAVEQIAKA
260 270 280 290 300
EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL
310 320 330 340 350
EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA
360 370
FKKHSLDLLS KERELNGKLR HLSP
Length:374
Mass (Da):43,809
Last modified:October 1, 2002 - v1
Checksum:i161160AC06AC1491
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095478 mRNA. Translation: BAC04556.1.
BC044814 mRNA. Translation: AAH44814.1.
CCDSiCCDS8270.1.
RefSeqiNP_689936.1. NM_152723.2.
UniGeneiHs.376241.

Genome annotation databases

EnsembliENST00000316398; ENSP00000320649; ENSG00000179071.
GeneIDi220388.
KEGGihsa:220388.
UCSCiuc001pau.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095478 mRNA. Translation: BAC04556.1.
BC044814 mRNA. Translation: AAH44814.1.
CCDSiCCDS8270.1.
RefSeqiNP_689936.1. NM_152723.2.
UniGeneiHs.376241.

3D structure databases

ProteinModelPortaliQ8N998.
SMRiQ8N998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128643. 11 interactors.
STRINGi9606.ENSP00000320649.

PTM databases

iPTMnetiQ8N998.
PhosphoSitePlusiQ8N998.

Polymorphism and mutation databases

BioMutaiCCDC89.
DMDMi74729632.

Proteomic databases

PaxDbiQ8N998.
PeptideAtlasiQ8N998.
PRIDEiQ8N998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316398; ENSP00000320649; ENSG00000179071.
GeneIDi220388.
KEGGihsa:220388.
UCSCiuc001pau.2. human.

Organism-specific databases

CTDi220388.
GeneCardsiCCDC89.
HGNCiHGNC:26762. CCDC89.
HPAiHPA039351.
HPA040628.
neXtProtiNX_Q8N998.
OpenTargetsiENSG00000179071.
PharmGKBiPA144596457.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHI9. Eukaryota.
ENOG4111GX6. LUCA.
GeneTreeiENSGT00390000016046.
HOGENOMiHOG000007171.
HOVERGENiHBG081050.
InParanoidiQ8N998.
OMAiLICILKR.
OrthoDBiEOG091G0KSH.
PhylomeDBiQ8N998.
TreeFamiTF333232.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179071-MONOMER.

Miscellaneous databases

GenomeRNAii220388.
PROiQ8N998.

Gene expression databases

BgeeiENSG00000179071.
CleanExiHS_CCDC89.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD89_HUMAN
AccessioniPrimary (citable) accession number: Q8N998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.