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Protein

Zinc finger protein 557

Gene

ZNF557

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 557
Gene namesi
Name:ZNF557
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28632. ZNF557.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866521.

Polymorphism and mutation databases

BioMutaiZNF557.
DMDMi68566211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Zinc finger protein 557PRO_0000047647Add
BLAST

Proteomic databases

EPDiQ8N988.
MaxQBiQ8N988.
PaxDbiQ8N988.
PeptideAtlasiQ8N988.
PRIDEiQ8N988.

PTM databases

iPTMnetiQ8N988.
PhosphoSiteiQ8N988.

Expressioni

Gene expression databases

BgeeiENSG00000130544.
CleanExiHS_ZNF557.
GenevisibleiQ8N988. HS.

Organism-specific databases

HPAiHPA003151.
HPA029291.

Interactioni

Protein-protein interaction databases

BioGridi122606. 10 interactions.
IntActiQ8N988. 5 interactions.
MINTiMINT-1195052.
STRINGi9606.ENSP00000252840.

Structurei

3D structure databases

ProteinModelPortaliQ8N988.
SMRiQ8N988. Positions 36-76, 136-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N988.
KOiK09228.
OMAiKLHVFRK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N988.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N988-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVLPPTA ASQREGHTEG GELVNELLKS WLKGLVTFED VAVEFTQEEW
60 70 80 90 100
ALLDPAQRTL YRDVMLENCR NLASLGNQVD KPRLISQLEQ EDKVMTEERG
110 120 130 140 150
ILSGTCPDVE NPFKAKGLTP KLHVFRKEQS RNMKMERNHL GATLNECNQC
160 170 180 190 200
FKVFSTKSSL TRHRKIHTGE RPYGCSECGK SYSSRSYLAV HKRIHNGEKP
210 220 230 240 250
YECNDCGKTF SSRSYLTVHK RIHNGEKPYE CSDCGKTFSN SSYLRPHLRI
260 270 280 290 300
HTGEKPYKCN QCFREFRTQS IFTRHKRVHT GEGHYVCNQC GKAFGTRSSL
310 320 330 340 350
SSHYSIHTGE YPYECHDCGR TFRRRSNLTQ HIRTHTGEKP YTCNECGKSF
360 370 380 390 400
TNSFSLTIHR RIHNGEKSYE CSDCGKSFNV LSSVKKHMRT HTGKKPYECN
410 420
YCGKSFTSNS YLSVHTRMHN RQM
Length:423
Mass (Da):48,627
Last modified:July 5, 2005 - v2
Checksum:iB9B98806E91AFD85
GO
Isoform 2 (identifier: Q8N988-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: A → ALSSLFPA

Show »
Length:430
Mass (Da):49,343
Checksum:i3875A8152D9FC546
GO

Sequence cautioni

The sequence AAH58040 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC04567 differs from that shown. Reason: Frameshift at position 23. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 111A → ALSSLFPA in isoform 2. 1 PublicationVSP_014515

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095524 mRNA. Translation: BAC04567.1. Sequence problems.
BC003020 mRNA. Translation: AAH03020.1.
BC058040 mRNA. Translation: AAH58040.1. Sequence problems.
CCDSiCCDS42485.1. [Q8N988-2]
CCDS45945.1. [Q8N988-1]
RefSeqiNP_001037852.1. NM_001044387.1. [Q8N988-2]
NP_001037853.1. NM_001044388.1. [Q8N988-1]
NP_077317.2. NM_024341.2. [Q8N988-2]
UniGeneiHs.591380.

Genome annotation databases

EnsembliENST00000252840; ENSP00000252840; ENSG00000130544. [Q8N988-2]
ENST00000414706; ENSP00000404065; ENSG00000130544. [Q8N988-1]
GeneIDi79230.
KEGGihsa:79230.
UCSCiuc002mga.4. human. [Q8N988-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095524 mRNA. Translation: BAC04567.1. Sequence problems.
BC003020 mRNA. Translation: AAH03020.1.
BC058040 mRNA. Translation: AAH58040.1. Sequence problems.
CCDSiCCDS42485.1. [Q8N988-2]
CCDS45945.1. [Q8N988-1]
RefSeqiNP_001037852.1. NM_001044387.1. [Q8N988-2]
NP_001037853.1. NM_001044388.1. [Q8N988-1]
NP_077317.2. NM_024341.2. [Q8N988-2]
UniGeneiHs.591380.

3D structure databases

ProteinModelPortaliQ8N988.
SMRiQ8N988. Positions 36-76, 136-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122606. 10 interactions.
IntActiQ8N988. 5 interactions.
MINTiMINT-1195052.
STRINGi9606.ENSP00000252840.

PTM databases

iPTMnetiQ8N988.
PhosphoSiteiQ8N988.

Polymorphism and mutation databases

BioMutaiZNF557.
DMDMi68566211.

Proteomic databases

EPDiQ8N988.
MaxQBiQ8N988.
PaxDbiQ8N988.
PeptideAtlasiQ8N988.
PRIDEiQ8N988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252840; ENSP00000252840; ENSG00000130544. [Q8N988-2]
ENST00000414706; ENSP00000404065; ENSG00000130544. [Q8N988-1]
GeneIDi79230.
KEGGihsa:79230.
UCSCiuc002mga.4. human. [Q8N988-1]

Organism-specific databases

CTDi79230.
GeneCardsiZNF557.
HGNCiHGNC:28632. ZNF557.
HPAiHPA003151.
HPA029291.
neXtProtiNX_Q8N988.
PharmGKBiPA134866521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N988.
KOiK09228.
OMAiKLHVFRK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N988.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79230.
PROiQ8N988.

Gene expression databases

BgeeiENSG00000130544.
CleanExiHS_ZNF557.
GenevisibleiQ8N988. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN557_HUMAN
AccessioniPrimary (citable) accession number: Q8N988
Secondary accession number(s): Q6PEJ3, Q9BTZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.