ID   RM43_HUMAN              Reviewed;         215 AA.
AC   Q8N983; B1AL09; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q9BYC7;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   05-MAY-2009, entry version 51.
DE   RecName: Full=39S ribosomal protein L43, mitochondrial;
DE            Short=L43mt;
DE            Short=MRP-L43;
DE   AltName: Full=Mitochondrial ribosomal protein bMRP36a;
DE   Flags: Precursor;
GN   Name=MRPL43;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND SUBCELLULAR LOCATION.
RX   MEDLINE=21293042; PubMed=11279069; DOI=10.1074/jbc.M100826200;
RA   Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA   Watanabe K.;
RT   "Structural compensation for the deficit of rRNA with proteins in the
RT   mammalian mitochondrial ribosome. Systematic analysis of protein
RT   components of the large ribosomal subunit from mammalian
RT   mitochondria.";
RL   J. Biol. Chem. 276:21724-21736(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC   TISSUE=Ovary, Pancreas, Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY, AND COREGULATION WITH PEO1.
RX   PubMed=15509589; DOI=10.1093/hmg/ddh342;
RA   Tyynismaa H., Sembongi H., Bokori-Brown M., Granycome C., Ashley N.,
RA   Poulton J., Jalanko A., Spelbrink J.N., Holt I.J., Suomalainen A.;
RT   "Twinkle helicase is essential for mtDNA maintenance and regulates
RT   mtDNA copy number.";
RL   Hum. Mol. Genet. 13:3219-3227(2004).
CC   -!- INTERACTION:
CC       P32121:ARRB2; NbExp=1; IntAct=EBI-1043145, EBI-714559;
CC       Q9NY93:DDX56; NbExp=1; IntAct=EBI-1043145, EBI-372376;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q8N983-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N983-2; Sequence=VSP_011026;
CC       Name=3;
CC         IsoId=Q8N983-3; Sequence=VSP_011027, VSP_011028;
CC       Name=4;
CC         IsoId=Q8N983-4; Sequence=VSP_011029, VSP_011030;
CC         Note=Ref.1 (BAB40861) sequence differs from that shown due to
CC         frameshifts in positions 131 and 210;
CC   -!- TISSUE SPECIFICITY: High relative levels in skeletal muscle and
CC       testis. Lower levels of expression in the heart, brain, placenta,
CC       lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary,
CC       small intestine, colon and leukocytes. Expression is coregulated
CC       with PEO1.
CC   -!- SIMILARITY: Belongs to the ribosomal protein S25/L51 family.
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DR   EMBL; AB049656; BAB40861.1; ALT_FRAME; mRNA.
DR   EMBL; AK095556; BAC04572.1; -; mRNA.
DR   EMBL; AL133215; CAI10919.1; -; Genomic_DNA.
DR   EMBL; AL133215; CAI10922.1; -; Genomic_DNA.
DR   EMBL; BC015905; AAH15905.1; -; mRNA.
DR   EMBL; BC041165; AAH41165.1; -; mRNA.
DR   EMBL; BC052639; AAH52639.1; -; mRNA.
DR   EMBL; BC053373; AAH53373.1; -; mRNA.
DR   IPI; IPI00428285; -.
DR   IPI; IPI00428286; -.
DR   IPI; IPI00428287; -.
DR   IPI; IPI00428288; -.
DR   RefSeq; NP_789762.1; -.
DR   RefSeq; NP_789763.1; -.
DR   UniGene; Hs.421848; -.
DR   IntAct; Q8N983; 2.
DR   PRIDE; Q8N983; -.
DR   Ensembl; ENSG00000055950; Homo sapiens.
DR   GeneID; 84545; -.
DR   GeneCards; GC10M102727; -.
DR   H-InvDB; HIX0009131; -.
DR   HGNC; HGNC:14517; MRPL43.
DR   MIM; 611848; gene.
DR   PharmGKB; PA30975; -.
DR   HOVERGEN; Q8N983; -.
DR   OMA; Q8N983; WGNTHYR.
DR   NextBio; 74406; -.
DR   ArrayExpress; Q8N983; -.
DR   Bgee; Q8N983; -.
DR   CleanEx; HS_MRPL43; -.
DR   GermOnline; ENSG00000055950; Homo sapiens.
DR   GO; GO:0005761; C:mitochondrial ribosome; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR   GO; GO:0006412; P:translation; NAS:UniProtKB.
DR   InterPro; IPR007741; Ribosome/NADH_DH.
DR   Pfam; PF05047; L51_S25_CI-B8; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Mitochondrion; Ribonucleoprotein;
KW   Ribosomal protein; Transit peptide.
FT   TRANSIT       1      ?       Mitochondrion (Potential).
FT   CHAIN         ?    215       39S ribosomal protein L43, mitochondrial.
FT                                /FTId=PRO_0000030561.
FT   VAR_SEQ     156    164       DTGLRLSAV -> CLLLGAVTL (in isoform 3).
FT                                /FTId=VSP_011027.
FT   VAR_SEQ     156    159       DTGL -> VQAQ (in isoform 4).
FT                                /FTId=VSP_011029.
FT   VAR_SEQ     160    215       Missing (in isoform 4).
FT                                /FTId=VSP_011030.
FT   VAR_SEQ     165    215       Missing (in isoform 3).
FT                                /FTId=VSP_011028.
FT   VAR_SEQ     177    215       PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA
FT                                -> ISVQSSDLPWGNTHYRPEPLSSTTWL (in isoform
FT                                2).
FT                                /FTId=VSP_011026.
SQ   SEQUENCE   215 AA;  23431 MW;  059C6E36FEB0D235 CRC64;
     MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG
     VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL VQKLADQSGL DVIRIRKPFH
     TDNPSIQGQW HPFTNKPTTF RGLRPREVQD PAPAQDTGLR LSAVAPQILL PGWPDPPDLP
     TVDPISSSLT SAPAPMLSAV SCLPIVPALT TVCSA
//