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Q8N983

- RM43_HUMAN

UniProt

Q8N983 - RM43_HUMAN

Protein

39S ribosomal protein L43, mitochondrial

Gene

MRPL43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L43, mitochondrial
    Short name:
    L43mt
    Short name:
    MRP-L43
    Alternative name(s):
    Mitochondrial ribosomal protein bMRP36a
    Gene namesi
    Name:MRPL43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:14517. MRPL43.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30975.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 21539S ribosomal protein L43, mitochondrialPRO_0000030561
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ8N983.
    PaxDbiQ8N983.
    PRIDEiQ8N983.

    PTM databases

    PhosphoSiteiQ8N983.

    Expressioni

    Tissue specificityi

    High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with PEO1.1 Publication

    Gene expression databases

    ArrayExpressiQ8N983.
    BgeeiQ8N983.
    CleanExiHS_MRPL43.
    GenevestigatoriQ8N983.

    Interactioni

    Protein-protein interaction databases

    BioGridi124130. 17 interactions.
    IntActiQ8N983. 5 interactions.
    MINTiMINT-4132722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N983.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S25/L51 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG289823.
    HOVERGENiHBG056363.
    KOiK17424.
    OMAiGMRDFIE.
    PhylomeDBiQ8N983.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR007741. Ribosome/NADH_DH.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF05047. L51_S25_CI-B8. 1 hit.
    [Graphical view]
    SMARTiSM00916. L51_S25_CI-B8. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N983-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE    50
    VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL 100
    VQKLADQSGL DVIRIRKPFH TDNPSIQGQW HPFTNKPTTF RGLRPREVQD 150
    PAPAQDTGLR LSAVAPQILL PGWPDPPDLP TVDPISSSLT SAPAPMLSAV 200
    SCLPIVPALT TVCSA 215
    Length:215
    Mass (Da):23,431
    Last modified:October 1, 2002 - v1
    Checksum:i059C6E36FEB0D235
    GO
    Isoform 2 (identifier: Q8N983-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         177-215: PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → ISVQSSDLPWGNTHYRPEPLSSTTWL

    Show »
    Length:202
    Mass (Da):22,580
    Checksum:i30A1ACC6D3F30CA8
    GO
    Isoform 3 (identifier: Q8N983-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         156-164: DTGLRLSAV → CLLLGAVTL
         165-215: Missing.

    Show »
    Length:164
    Mass (Da):18,311
    Checksum:i8BBA76364E45CA58
    GO
    Isoform 4 (identifier: Q8N983-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         156-159: DTGL → VQAQ
         160-215: Missing.

    Show »
    Length:159
    Mass (Da):17,853
    Checksum:i3430B94F1152F375
    GO
    Isoform 5 (identifier: Q8N983-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...SSLGKYPLPS

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:235
    Mass (Da):25,862
    Checksum:iC47FD0F42CE0F80E
    GO
    Isoform 6 (identifier: Q8N983-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...DHCVLSVKAA

    Note: No experimental confirmation available.

    Show »
    Length:261
    Mass (Da):28,676
    Checksum:i4A4FAA0C31C80A5C
    GO

    Sequence cautioni

    The sequence BAB40861.1 differs from that shown. Reason: Frameshift at position 131.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei156 – 1649DTGLRLSAV → CLLLGAVTL in isoform 3. 1 PublicationVSP_011027
    Alternative sequencei156 – 1594DTGL → VQAQ in isoform 4. 2 PublicationsVSP_011029
    Alternative sequencei157 – 21559TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPNISSVIRSSLGKYPLPS in isoform 5. CuratedVSP_054092Add
    BLAST
    Alternative sequencei157 – 21559TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPTRPPHSGSYLILIDLCSS PYAVRSFLPPDCPCTDHCVL SVKAA in isoform 6. 1 PublicationVSP_054093Add
    BLAST
    Alternative sequencei160 – 21556Missing in isoform 4. 2 PublicationsVSP_011030Add
    BLAST
    Alternative sequencei165 – 21551Missing in isoform 3. 1 PublicationVSP_011028Add
    BLAST
    Alternative sequencei177 – 21539PDLPT…TVCSA → ISVQSSDLPWGNTHYRPEPL SSTTWL in isoform 2. 1 PublicationVSP_011026Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049656 mRNA. Translation: BAB40861.1. Frameshift.
    AK095556 mRNA. Translation: BAC04572.1.
    AK300237 mRNA. Translation: BAG62005.1.
    AL133215 Genomic DNA. No translation available.
    CH471066 Genomic DNA. Translation: EAW49795.1.
    CH471066 Genomic DNA. Translation: EAW49796.1.
    CH471066 Genomic DNA. Translation: EAW49797.1.
    CH471066 Genomic DNA. Translation: EAW49799.1.
    BC015905 mRNA. Translation: AAH15905.1.
    BC041165 mRNA. Translation: AAH41165.1.
    BC052639 mRNA. Translation: AAH52639.1.
    BC053373 mRNA. Translation: AAH53373.1.
    CCDSiCCDS7502.1. [Q8N983-1]
    CCDS7503.1. [Q8N983-2]
    CCDS7504.1. [Q8N983-6]
    CCDS7505.1. [Q8N983-4]
    RefSeqiNP_115488.2. NM_032112.2. [Q8N983-4]
    NP_789762.1. NM_176792.2. [Q8N983-1]
    NP_789763.1. NM_176793.1. [Q8N983-2]
    NP_789764.1. NM_176794.1. [Q8N983-6]
    XP_005270287.1. XM_005270230.1. [Q8N983-3]
    XP_005270288.1. XM_005270231.1. [Q8N983-4]
    XP_006718098.1. XM_006718035.1. [Q8N983-4]
    UniGeneiHs.421848.

    Genome annotation databases

    EnsembliENST00000299179; ENSP00000299179; ENSG00000055950. [Q8N983-2]
    ENST00000318325; ENSP00000315364; ENSG00000055950. [Q8N983-1]
    ENST00000318364; ENSP00000315948; ENSG00000055950. [Q8N983-4]
    ENST00000342071; ENSP00000339844; ENSG00000055950. [Q8N983-6]
    ENST00000370234; ENSP00000359254; ENSG00000055950. [Q8N983-3]
    ENST00000370236; ENSP00000359256; ENSG00000055950. [Q8N983-4]
    ENST00000370242; ENSP00000359262; ENSG00000055950. [Q8N983-7]
    GeneIDi84545.
    KEGGihsa:84545.
    UCSCiuc001kry.1. human. [Q8N983-1]
    uc001ksa.1. human.
    uc001ksb.1. human. [Q8N983-2]
    uc001ksc.3. human. [Q8N983-3]
    uc001ksd.1. human. [Q8N983-4]

    Polymorphism databases

    DMDMi50401603.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049656 mRNA. Translation: BAB40861.1 . Frameshift.
    AK095556 mRNA. Translation: BAC04572.1 .
    AK300237 mRNA. Translation: BAG62005.1 .
    AL133215 Genomic DNA. No translation available.
    CH471066 Genomic DNA. Translation: EAW49795.1 .
    CH471066 Genomic DNA. Translation: EAW49796.1 .
    CH471066 Genomic DNA. Translation: EAW49797.1 .
    CH471066 Genomic DNA. Translation: EAW49799.1 .
    BC015905 mRNA. Translation: AAH15905.1 .
    BC041165 mRNA. Translation: AAH41165.1 .
    BC052639 mRNA. Translation: AAH52639.1 .
    BC053373 mRNA. Translation: AAH53373.1 .
    CCDSi CCDS7502.1. [Q8N983-1 ]
    CCDS7503.1. [Q8N983-2 ]
    CCDS7504.1. [Q8N983-6 ]
    CCDS7505.1. [Q8N983-4 ]
    RefSeqi NP_115488.2. NM_032112.2. [Q8N983-4 ]
    NP_789762.1. NM_176792.2. [Q8N983-1 ]
    NP_789763.1. NM_176793.1. [Q8N983-2 ]
    NP_789764.1. NM_176794.1. [Q8N983-6 ]
    XP_005270287.1. XM_005270230.1. [Q8N983-3 ]
    XP_005270288.1. XM_005270231.1. [Q8N983-4 ]
    XP_006718098.1. XM_006718035.1. [Q8N983-4 ]
    UniGenei Hs.421848.

    3D structure databases

    ProteinModelPortali Q8N983.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124130. 17 interactions.
    IntActi Q8N983. 5 interactions.
    MINTi MINT-4132722.

    PTM databases

    PhosphoSitei Q8N983.

    Polymorphism databases

    DMDMi 50401603.

    Proteomic databases

    MaxQBi Q8N983.
    PaxDbi Q8N983.
    PRIDEi Q8N983.

    Protocols and materials databases

    DNASUi 84545.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299179 ; ENSP00000299179 ; ENSG00000055950 . [Q8N983-2 ]
    ENST00000318325 ; ENSP00000315364 ; ENSG00000055950 . [Q8N983-1 ]
    ENST00000318364 ; ENSP00000315948 ; ENSG00000055950 . [Q8N983-4 ]
    ENST00000342071 ; ENSP00000339844 ; ENSG00000055950 . [Q8N983-6 ]
    ENST00000370234 ; ENSP00000359254 ; ENSG00000055950 . [Q8N983-3 ]
    ENST00000370236 ; ENSP00000359256 ; ENSG00000055950 . [Q8N983-4 ]
    ENST00000370242 ; ENSP00000359262 ; ENSG00000055950 . [Q8N983-7 ]
    GeneIDi 84545.
    KEGGi hsa:84545.
    UCSCi uc001kry.1. human. [Q8N983-1 ]
    uc001ksa.1. human.
    uc001ksb.1. human. [Q8N983-2 ]
    uc001ksc.3. human. [Q8N983-3 ]
    uc001ksd.1. human. [Q8N983-4 ]

    Organism-specific databases

    CTDi 84545.
    GeneCardsi GC10M102737.
    HGNCi HGNC:14517. MRPL43.
    MIMi 611848. gene.
    neXtProti NX_Q8N983.
    PharmGKBi PA30975.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289823.
    HOVERGENi HBG056363.
    KOi K17424.
    OMAi GMRDFIE.
    PhylomeDBi Q8N983.

    Miscellaneous databases

    ChiTaRSi MRPL43. human.
    GenomeRNAii 84545.
    NextBioi 35466618.
    PROi Q8N983.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N983.
    Bgeei Q8N983.
    CleanExi HS_MRPL43.
    Genevestigatori Q8N983.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR007741. Ribosome/NADH_DH.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF05047. L51_S25_CI-B8. 1 hit.
    [Graphical view ]
    SMARTi SM00916. L51_S25_CI-B8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Tissue: Ovary, Pancreas, Skin and Uterus.
    6. Cited for: TISSUE SPECIFICITY, COREGULATION WITH PEO1.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM43_HUMAN
    AccessioniPrimary (citable) accession number: Q8N983
    Secondary accession number(s): B1AL06
    , B1AL07, B1AL09, B1AL10, C9J5Q3, D3DR71, Q5JW06, Q7Z719, Q7Z7H6, Q86XN1, Q9BYC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3