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Q8N983

- RM43_HUMAN

UniProt

Q8N983 - RM43_HUMAN

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Protein

39S ribosomal protein L43, mitochondrial

Gene

MRPL43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L43, mitochondrial
Short name:
L43mt
Short name:
MRP-L43
Alternative name(s):
Mitochondrial ribosomal protein bMRP36a
Gene namesi
Name:MRPL43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14517. MRPL43.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 21539S ribosomal protein L43, mitochondrialPRO_0000030561
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ8N983.
PaxDbiQ8N983.
PRIDEiQ8N983.

PTM databases

PhosphoSiteiQ8N983.

Expressioni

Tissue specificityi

High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with PEO1.1 Publication

Gene expression databases

BgeeiQ8N983.
CleanExiHS_MRPL43.
ExpressionAtlasiQ8N983. baseline and differential.
GenevestigatoriQ8N983.

Interactioni

Protein-protein interaction databases

BioGridi124130. 30 interactions.
IntActiQ8N983. 5 interactions.
MINTiMINT-4132722.

Structurei

3D structure databases

ProteinModelPortaliQ8N983.
SMRiQ8N983. Positions 3-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S25/L51 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG289823.
GeneTreeiENSGT00390000015375.
HOVERGENiHBG056363.
InParanoidiQ8N983.
KOiK17424.
OMAiGMRDFIE.
PhylomeDBiQ8N983.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR007741. Ribosome/NADH_DH.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF05047. L51_S25_CI-B8. 1 hit.
[Graphical view]
SMARTiSM00916. L51_S25_CI-B8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N983-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE
60 70 80 90 100
VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL
110 120 130 140 150
VQKLADQSGL DVIRIRKPFH TDNPSIQGQW HPFTNKPTTF RGLRPREVQD
160 170 180 190 200
PAPAQDTGLR LSAVAPQILL PGWPDPPDLP TVDPISSSLT SAPAPMLSAV
210
SCLPIVPALT TVCSA
Length:215
Mass (Da):23,431
Last modified:October 1, 2002 - v1
Checksum:i059C6E36FEB0D235
GO
Isoform 2 (identifier: Q8N983-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-215: PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → ISVQSSDLPWGNTHYRPEPLSSTTWL

Show »
Length:202
Mass (Da):22,580
Checksum:i30A1ACC6D3F30CA8
GO
Isoform 3 (identifier: Q8N983-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-164: DTGLRLSAV → CLLLGAVTL
     165-215: Missing.

Show »
Length:164
Mass (Da):18,311
Checksum:i8BBA76364E45CA58
GO
Isoform 4 (identifier: Q8N983-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-159: DTGL → VQAQ
     160-215: Missing.

Show »
Length:159
Mass (Da):17,853
Checksum:i3430B94F1152F375
GO
Isoform 5 (identifier: Q8N983-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...SSLGKYPLPS

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:235
Mass (Da):25,862
Checksum:iC47FD0F42CE0F80E
GO
Isoform 6 (identifier: Q8N983-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...DHCVLSVKAA

Note: No experimental confirmation available.

Show »
Length:261
Mass (Da):28,676
Checksum:i4A4FAA0C31C80A5C
GO

Sequence cautioni

The sequence BAB40861.1 differs from that shown. Reason: Frameshift at position 131.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 1649DTGLRLSAV → CLLLGAVTL in isoform 3. 1 PublicationVSP_011027
Alternative sequencei156 – 1594DTGL → VQAQ in isoform 4. 2 PublicationsVSP_011029
Alternative sequencei157 – 21559TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPNISSVIRSSLGKYPLPS in isoform 5. CuratedVSP_054092Add
BLAST
Alternative sequencei157 – 21559TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPTRPPHSGSYLILIDLCSS PYAVRSFLPPDCPCTDHCVL SVKAA in isoform 6. 1 PublicationVSP_054093Add
BLAST
Alternative sequencei160 – 21556Missing in isoform 4. 2 PublicationsVSP_011030Add
BLAST
Alternative sequencei165 – 21551Missing in isoform 3. 1 PublicationVSP_011028Add
BLAST
Alternative sequencei177 – 21539PDLPT…TVCSA → ISVQSSDLPWGNTHYRPEPL SSTTWL in isoform 2. 1 PublicationVSP_011026Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049656 mRNA. Translation: BAB40861.1. Frameshift.
AK095556 mRNA. Translation: BAC04572.1.
AK300237 mRNA. Translation: BAG62005.1.
AL133215 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49795.1.
CH471066 Genomic DNA. Translation: EAW49796.1.
CH471066 Genomic DNA. Translation: EAW49797.1.
CH471066 Genomic DNA. Translation: EAW49799.1.
BC015905 mRNA. Translation: AAH15905.1.
BC041165 mRNA. Translation: AAH41165.1.
BC052639 mRNA. Translation: AAH52639.1.
BC053373 mRNA. Translation: AAH53373.1.
CCDSiCCDS7502.1. [Q8N983-1]
CCDS7503.1. [Q8N983-2]
CCDS7504.1. [Q8N983-6]
CCDS7505.1. [Q8N983-4]
RefSeqiNP_115488.2. NM_032112.2. [Q8N983-4]
NP_789762.1. NM_176792.2. [Q8N983-1]
NP_789763.1. NM_176793.1. [Q8N983-2]
NP_789764.1. NM_176794.1. [Q8N983-6]
XP_005270287.1. XM_005270230.1. [Q8N983-3]
XP_005270288.1. XM_005270231.1. [Q8N983-4]
XP_006718098.1. XM_006718035.1. [Q8N983-4]
UniGeneiHs.421848.

Genome annotation databases

EnsembliENST00000299179; ENSP00000299179; ENSG00000055950. [Q8N983-2]
ENST00000318325; ENSP00000315364; ENSG00000055950. [Q8N983-1]
ENST00000318364; ENSP00000315948; ENSG00000055950. [Q8N983-4]
ENST00000342071; ENSP00000339844; ENSG00000055950. [Q8N983-6]
ENST00000370234; ENSP00000359254; ENSG00000055950. [Q8N983-3]
ENST00000370236; ENSP00000359256; ENSG00000055950. [Q8N983-4]
ENST00000370242; ENSP00000359262; ENSG00000055950. [Q8N983-7]
GeneIDi84545.
KEGGihsa:84545.
UCSCiuc001kry.1. human. [Q8N983-1]
uc001ksa.1. human.
uc001ksb.1. human. [Q8N983-2]
uc001ksc.3. human. [Q8N983-3]
uc001ksd.1. human. [Q8N983-4]
uc010qpu.1. human.

Polymorphism databases

DMDMi50401603.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049656 mRNA. Translation: BAB40861.1 . Frameshift.
AK095556 mRNA. Translation: BAC04572.1 .
AK300237 mRNA. Translation: BAG62005.1 .
AL133215 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49795.1 .
CH471066 Genomic DNA. Translation: EAW49796.1 .
CH471066 Genomic DNA. Translation: EAW49797.1 .
CH471066 Genomic DNA. Translation: EAW49799.1 .
BC015905 mRNA. Translation: AAH15905.1 .
BC041165 mRNA. Translation: AAH41165.1 .
BC052639 mRNA. Translation: AAH52639.1 .
BC053373 mRNA. Translation: AAH53373.1 .
CCDSi CCDS7502.1. [Q8N983-1 ]
CCDS7503.1. [Q8N983-2 ]
CCDS7504.1. [Q8N983-6 ]
CCDS7505.1. [Q8N983-4 ]
RefSeqi NP_115488.2. NM_032112.2. [Q8N983-4 ]
NP_789762.1. NM_176792.2. [Q8N983-1 ]
NP_789763.1. NM_176793.1. [Q8N983-2 ]
NP_789764.1. NM_176794.1. [Q8N983-6 ]
XP_005270287.1. XM_005270230.1. [Q8N983-3 ]
XP_005270288.1. XM_005270231.1. [Q8N983-4 ]
XP_006718098.1. XM_006718035.1. [Q8N983-4 ]
UniGenei Hs.421848.

3D structure databases

ProteinModelPortali Q8N983.
SMRi Q8N983. Positions 3-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124130. 30 interactions.
IntActi Q8N983. 5 interactions.
MINTi MINT-4132722.

PTM databases

PhosphoSitei Q8N983.

Polymorphism databases

DMDMi 50401603.

Proteomic databases

MaxQBi Q8N983.
PaxDbi Q8N983.
PRIDEi Q8N983.

Protocols and materials databases

DNASUi 84545.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299179 ; ENSP00000299179 ; ENSG00000055950 . [Q8N983-2 ]
ENST00000318325 ; ENSP00000315364 ; ENSG00000055950 . [Q8N983-1 ]
ENST00000318364 ; ENSP00000315948 ; ENSG00000055950 . [Q8N983-4 ]
ENST00000342071 ; ENSP00000339844 ; ENSG00000055950 . [Q8N983-6 ]
ENST00000370234 ; ENSP00000359254 ; ENSG00000055950 . [Q8N983-3 ]
ENST00000370236 ; ENSP00000359256 ; ENSG00000055950 . [Q8N983-4 ]
ENST00000370242 ; ENSP00000359262 ; ENSG00000055950 . [Q8N983-7 ]
GeneIDi 84545.
KEGGi hsa:84545.
UCSCi uc001kry.1. human. [Q8N983-1 ]
uc001ksa.1. human.
uc001ksb.1. human. [Q8N983-2 ]
uc001ksc.3. human. [Q8N983-3 ]
uc001ksd.1. human. [Q8N983-4 ]
uc010qpu.1. human.

Organism-specific databases

CTDi 84545.
GeneCardsi GC10M102737.
HGNCi HGNC:14517. MRPL43.
MIMi 611848. gene.
neXtProti NX_Q8N983.
PharmGKBi PA30975.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289823.
GeneTreei ENSGT00390000015375.
HOVERGENi HBG056363.
InParanoidi Q8N983.
KOi K17424.
OMAi GMRDFIE.
PhylomeDBi Q8N983.

Miscellaneous databases

ChiTaRSi MRPL43. human.
GenomeRNAii 84545.
NextBioi 35466618.
PROi Q8N983.
SOURCEi Search...

Gene expression databases

Bgeei Q8N983.
CleanExi HS_MRPL43.
ExpressionAtlasi Q8N983. baseline and differential.
Genevestigatori Q8N983.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR007741. Ribosome/NADH_DH.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF05047. L51_S25_CI-B8. 1 hit.
[Graphical view ]
SMARTi SM00916. L51_S25_CI-B8. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Ovary, Pancreas, Skin and Uterus.
  6. Cited for: TISSUE SPECIFICITY, COREGULATION WITH PEO1.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM43_HUMAN
AccessioniPrimary (citable) accession number: Q8N983
Secondary accession number(s): B1AL06
, B1AL07, B1AL09, B1AL10, C9J5Q3, D3DR71, Q5JW06, Q7Z719, Q7Z7H6, Q86XN1, Q9BYC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3