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Q8N983 (RM43_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L43, mitochondrial

Short name=L43mt
Short name=MRP-L43
Alternative name(s):
Mitochondrial ribosomal protein bMRP36a
Gene names
Name:MRPL43
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion Ref.1.

Tissue specificity

High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with PEO1. Ref.6

Sequence similarities

Belongs to the ribosomal protein S25/L51 family.

Sequence caution

The sequence BAB40861.1 differs from that shown. Reason: Frameshift at position 131.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement PubMed 11543634. Source: UniProtKB

   Cellular_componentmitochondrial ribosome

Non-traceable author statement PubMed 11543634. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

structural constituent of ribosome

Non-traceable author statement PubMed 11543634. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N983-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N983-2)

The sequence of this isoform differs from the canonical sequence as follows:
     177-215: PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → ISVQSSDLPWGNTHYRPEPLSSTTWL
Isoform 3 (identifier: Q8N983-3)

The sequence of this isoform differs from the canonical sequence as follows:
     156-164: DTGLRLSAV → CLLLGAVTL
     165-215: Missing.
Isoform 4 (identifier: Q8N983-4)

The sequence of this isoform differs from the canonical sequence as follows:
     156-159: DTGL → VQAQ
     160-215: Missing.
Isoform 5 (identifier: Q8N983-6)

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...SSLGKYPLPS
Note: No experimental confirmation available. Gene prediction based on EST data.
Isoform 6 (identifier: Q8N983-7)

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...DHCVLSVKAA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 21539S ribosomal protein L43, mitochondrialPRO_0000030561

Natural variations

Alternative sequence156 – 1649DTGLRLSAV → CLLLGAVTL in isoform 3.
VSP_011027
Alternative sequence156 – 1594DTGL → VQAQ in isoform 4.
VSP_011029
Alternative sequence157 – 21559TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPNISSVIRSSLGKYPLPS in isoform 5.
VSP_054092
Alternative sequence157 – 21559TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPTRPPHSGSYLILIDLCSS PYAVRSFLPPDCPCTDHCVL SVKAA in isoform 6.
VSP_054093
Alternative sequence160 – 21556Missing in isoform 4.
VSP_011030
Alternative sequence165 – 21551Missing in isoform 3.
VSP_011028
Alternative sequence177 – 21539PDLPT…TVCSA → ISVQSSDLPWGNTHYRPEPL SSTTWL in isoform 2.
VSP_011026

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 059C6E36FEB0D235

FASTA21523,431
        10         20         30         40         50         60 
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG 

        70         80         90        100        110        120 
VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL VQKLADQSGL DVIRIRKPFH 

       130        140        150        160        170        180 
TDNPSIQGQW HPFTNKPTTF RGLRPREVQD PAPAQDTGLR LSAVAPQILL PGWPDPPDLP 

       190        200        210 
TVDPISSSLT SAPAPMLSAV SCLPIVPALT TVCSA 

« Hide

Isoform 2 [UniParc].

Checksum: 30A1ACC6D3F30CA8
Show »

FASTA20222,580
Isoform 3 [UniParc].

Checksum: 8BBA76364E45CA58
Show »

FASTA16418,311
Isoform 4 [UniParc].

Checksum: 3430B94F1152F375
Show »

FASTA15917,853
Isoform 5 [UniParc].

Checksum: C47FD0F42CE0F80E
Show »

FASTA23525,862
Isoform 6 [UniParc].

Checksum: 4A4FAA0C31C80A5C
Show »

FASTA26128,676

References

« Hide 'large scale' references
[1]"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
Tissue: Brain.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
Tissue: Ovary, Pancreas, Skin and Uterus.
[6]"Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number."
Tyynismaa H., Sembongi H., Bokori-Brown M., Granycome C., Ashley N., Poulton J., Jalanko A., Spelbrink J.N., Holt I.J., Suomalainen A.
Hum. Mol. Genet. 13:3219-3227(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, COREGULATION WITH PEO1.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049656 mRNA. Translation: BAB40861.1. Frameshift.
AK095556 mRNA. Translation: BAC04572.1.
AK300237 mRNA. Translation: BAG62005.1.
AL133215 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49795.1.
CH471066 Genomic DNA. Translation: EAW49796.1.
CH471066 Genomic DNA. Translation: EAW49797.1.
CH471066 Genomic DNA. Translation: EAW49799.1.
BC015905 mRNA. Translation: AAH15905.1.
BC041165 mRNA. Translation: AAH41165.1.
BC052639 mRNA. Translation: AAH52639.1.
BC053373 mRNA. Translation: AAH53373.1.
CCDSCCDS7502.1. [Q8N983-1]
CCDS7503.1. [Q8N983-2]
CCDS7505.1. [Q8N983-4]
RefSeqNP_115488.2. NM_032112.2. [Q8N983-4]
NP_789762.1. NM_176792.2. [Q8N983-1]
NP_789763.1. NM_176793.1. [Q8N983-2]
NP_789764.1. NM_176794.1. [Q8N983-6]
XP_005270287.1. XM_005270230.1. [Q8N983-3]
XP_005270288.1. XM_005270231.1. [Q8N983-4]
XP_006718098.1. XM_006718035.1. [Q8N983-4]
UniGeneHs.421848.

3D structure databases

ProteinModelPortalQ8N983.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124130. 16 interactions.
IntActQ8N983. 5 interactions.
MINTMINT-4132722.

PTM databases

PhosphoSiteQ8N983.

Polymorphism databases

DMDM50401603.

Proteomic databases

MaxQBQ8N983.
PaxDbQ8N983.
PRIDEQ8N983.

Protocols and materials databases

DNASU84545.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299179; ENSP00000299179; ENSG00000055950. [Q8N983-2]
ENST00000318325; ENSP00000315364; ENSG00000055950. [Q8N983-1]
ENST00000318364; ENSP00000315948; ENSG00000055950. [Q8N983-4]
ENST00000342071; ENSP00000339844; ENSG00000055950.
ENST00000370234; ENSP00000359254; ENSG00000055950. [Q8N983-3]
ENST00000370236; ENSP00000359256; ENSG00000055950. [Q8N983-4]
ENST00000370242; ENSP00000359262; ENSG00000055950.
GeneID84545.
KEGGhsa:84545.
UCSCuc001kry.1. human. [Q8N983-1]
uc001ksb.1. human. [Q8N983-2]
uc001ksc.3. human. [Q8N983-3]
uc001ksd.1. human. [Q8N983-4]

Organism-specific databases

CTD84545.
GeneCardsGC10M102737.
HGNCHGNC:14517. MRPL43.
MIM611848. gene.
neXtProtNX_Q8N983.
PharmGKBPA30975.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289823.
HOVERGENHBG056363.
KOK17424.
OMAGMRDFIE.
PhylomeDBQ8N983.

Gene expression databases

ArrayExpressQ8N983.
BgeeQ8N983.
CleanExHS_MRPL43.
GenevestigatorQ8N983.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR007741. Ribosome/NADH_DH.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF05047. L51_S25_CI-B8. 1 hit.
[Graphical view]
SMARTSM00916. L51_S25_CI-B8. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPL43. human.
GenomeRNAi84545.
NextBio35466618.
PROQ8N983.
SOURCESearch...

Entry information

Entry nameRM43_HUMAN
AccessionPrimary (citable) accession number: Q8N983
Secondary accession number(s): B1AL06 expand/collapse secondary AC list , B1AL07, B1AL09, B1AL10, C9J5Q3, D3DR71, Q5JW06, Q7Z719, Q7Z7H6, Q86XN1, Q9BYC7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM