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Protein

Zinc finger protein 709

Gene

ZNF709

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 709
Gene namesi
Name:ZNF709
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196826.7
HostDB:ENSG00000242852.6
HGNCiHGNC:20629 ZNF709
neXtProtiNX_Q8N972

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670469

Polymorphism and mutation databases

BioMutaiZNF709
DMDMi74760022

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002303121 – 641Zinc finger protein 709Add BLAST641

Proteomic databases

EPDiQ8N972
MaxQBiQ8N972
PaxDbiQ8N972
PeptideAtlasiQ8N972
PRIDEiQ8N972

PTM databases

iPTMnetiQ8N972
PhosphoSitePlusiQ8N972

Expressioni

Gene expression databases

BgeeiENSG00000196826
ExpressionAtlasiQ8N972 baseline and differential
GenevisibleiQ8N972 HS

Interactioni

Protein-protein interaction databases

BioGridi127845, 1 interactor
STRINGi9606.ENSP00000404127

Structurei

3D structure databases

ProteinModelPortaliQ8N972
SMRiQ8N972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144059
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N972
KOiK09228
OMAiYRRHMIM
OrthoDBiEOG091G02KC
PhylomeDBiQ8N972
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017125 Znf_PRDM5-like
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PIRSFiPIRSF037162 PRDM, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

Q8N972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVVFEDVA VNFTQEEWAL LGPSQKKLYR DVMQETFVNL ASIGENWEEK
60 70 80 90 100
NIEDHKNQGR KLRSHMVERL CERKEGSQFG ETISQTPNPK PNKKTFTRVK
110 120 130 140 150
PYECSVCGKD YMCHSSLNRH MRSHTEHRSY EYHKYGEKSY ECKECGKRFS
160 170 180 190 200
FRSSFRIHER THTGEKPYKC KQCGKAFSWP SSFQIHERTH TGEKPYECKE
210 220 230 240 250
CGKAFIYHTT FRGHMRMHTG EKPYKCKECG KTFSHPSSFR NHERTHSGEK
260 270 280 290 300
PYECKQCGKA FRYYQTFQIH ERTHTGEKPY QCKQCGKALS CPTSFRSHER
310 320 330 340 350
IHTGEKPYKC KKCGKAFSFP SSFRKHERIH TGEKPYDCKE CGKAFISLPS
360 370 380 390 400
YRRHMIMHTG NGPYKCKECG KAFDCPSSFQ IHERTHTGEK PYECKQCGKA
410 420 430 440 450
FSCSSSFRMH ERTHTGEKPH ECKQCGKAFS CSSSVRIHER THTGEKPYEC
460 470 480 490 500
KQCGKAFSCS SSFRMHERIH TGEKPYECKQ CGKAFSFSSS FRMHERTHTG
510 520 530 540 550
EKPYECKQCG KAFSCSSSFR MHERTHTGEK PYECKQCGKA FSCSSSIRIH
560 570 580 590 600
ERTHTGEKPY ECKQCGKAFS CSSSVRMHER THTGVKPYEC KQCDKAFSCS
610 620 630 640
RSFRIHERTH TGEKPYACQQ CGKAFKCSRS FRIHERVHSG E
Length:641
Mass (Da):74,652
Last modified:October 1, 2002 - v1
Checksum:i51BDA6D9D6DE0B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095600 mRNA Translation: BAC04584.1
AK290911 mRNA Translation: BAF83600.1
CH471106 Genomic DNA Translation: EAW84275.1
BC136746 mRNA Translation: AAI36747.1
BC136751 mRNA Translation: AAI36752.1
CCDSiCCDS42504.1
RefSeqiNP_689814.1, NM_152601.3
UniGeneiHs.631623

Genome annotation databases

EnsembliENST00000397732; ENSP00000380840; ENSG00000242852
GeneIDi163051
KEGGihsa:163051
UCSCiuc002mtv.5 human

Similar proteinsi

Entry informationi

Entry nameiZN709_HUMAN
AccessioniPrimary (citable) accession number: Q8N972
Secondary accession number(s): A8K4E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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