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Protein

Zinc finger protein 709

Gene

ZNF709

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180855-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 709
Gene namesi
Name:ZNF709
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20629. ZNF709.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196826.
ENSG00000242852.
PharmGKBiPA142670469.

Polymorphism and mutation databases

BioMutaiZNF709.
DMDMi74760022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002303121 – 641Zinc finger protein 709Add BLAST641

Proteomic databases

EPDiQ8N972.
MaxQBiQ8N972.
PaxDbiQ8N972.
PeptideAtlasiQ8N972.
PRIDEiQ8N972.

PTM databases

iPTMnetiQ8N972.
PhosphoSitePlusiQ8N972.

Expressioni

Gene expression databases

BgeeiENSG00000242852.
ExpressionAtlasiQ8N972. baseline and differential.
GenevisibleiQ8N972. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000404127.

Structurei

3D structure databases

ProteinModelPortaliQ8N972.
SMRiQ8N972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N972.
KOiK09228.
OMAiYRRHMIM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N972.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVVFEDVA VNFTQEEWAL LGPSQKKLYR DVMQETFVNL ASIGENWEEK
60 70 80 90 100
NIEDHKNQGR KLRSHMVERL CERKEGSQFG ETISQTPNPK PNKKTFTRVK
110 120 130 140 150
PYECSVCGKD YMCHSSLNRH MRSHTEHRSY EYHKYGEKSY ECKECGKRFS
160 170 180 190 200
FRSSFRIHER THTGEKPYKC KQCGKAFSWP SSFQIHERTH TGEKPYECKE
210 220 230 240 250
CGKAFIYHTT FRGHMRMHTG EKPYKCKECG KTFSHPSSFR NHERTHSGEK
260 270 280 290 300
PYECKQCGKA FRYYQTFQIH ERTHTGEKPY QCKQCGKALS CPTSFRSHER
310 320 330 340 350
IHTGEKPYKC KKCGKAFSFP SSFRKHERIH TGEKPYDCKE CGKAFISLPS
360 370 380 390 400
YRRHMIMHTG NGPYKCKECG KAFDCPSSFQ IHERTHTGEK PYECKQCGKA
410 420 430 440 450
FSCSSSFRMH ERTHTGEKPH ECKQCGKAFS CSSSVRIHER THTGEKPYEC
460 470 480 490 500
KQCGKAFSCS SSFRMHERIH TGEKPYECKQ CGKAFSFSSS FRMHERTHTG
510 520 530 540 550
EKPYECKQCG KAFSCSSSFR MHERTHTGEK PYECKQCGKA FSCSSSIRIH
560 570 580 590 600
ERTHTGEKPY ECKQCGKAFS CSSSVRMHER THTGVKPYEC KQCDKAFSCS
610 620 630 640
RSFRIHERTH TGEKPYACQQ CGKAFKCSRS FRIHERVHSG E
Length:641
Mass (Da):74,652
Last modified:October 1, 2002 - v1
Checksum:i51BDA6D9D6DE0B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095600 mRNA. Translation: BAC04584.1.
AK290911 mRNA. Translation: BAF83600.1.
CH471106 Genomic DNA. Translation: EAW84275.1.
BC136746 mRNA. Translation: AAI36747.1.
BC136751 mRNA. Translation: AAI36752.1.
CCDSiCCDS42504.1.
RefSeqiNP_689814.1. NM_152601.3.
UniGeneiHs.631623.

Genome annotation databases

EnsembliENST00000397732; ENSP00000380840; ENSG00000242852.
GeneIDi163051.
KEGGihsa:163051.
UCSCiuc002mtv.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095600 mRNA. Translation: BAC04584.1.
AK290911 mRNA. Translation: BAF83600.1.
CH471106 Genomic DNA. Translation: EAW84275.1.
BC136746 mRNA. Translation: AAI36747.1.
BC136751 mRNA. Translation: AAI36752.1.
CCDSiCCDS42504.1.
RefSeqiNP_689814.1. NM_152601.3.
UniGeneiHs.631623.

3D structure databases

ProteinModelPortaliQ8N972.
SMRiQ8N972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000404127.

PTM databases

iPTMnetiQ8N972.
PhosphoSitePlusiQ8N972.

Polymorphism and mutation databases

BioMutaiZNF709.
DMDMi74760022.

Proteomic databases

EPDiQ8N972.
MaxQBiQ8N972.
PaxDbiQ8N972.
PeptideAtlasiQ8N972.
PRIDEiQ8N972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397732; ENSP00000380840; ENSG00000242852.
GeneIDi163051.
KEGGihsa:163051.
UCSCiuc002mtv.5. human.

Organism-specific databases

CTDi163051.
GeneCardsiZNF709.
HGNCiHGNC:20629. ZNF709.
neXtProtiNX_Q8N972.
OpenTargetsiENSG00000196826.
ENSG00000242852.
PharmGKBiPA142670469.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N972.
KOiK09228.
OMAiYRRHMIM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N972.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180855-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163051.
PROiQ8N972.

Gene expression databases

BgeeiENSG00000242852.
ExpressionAtlasiQ8N972. baseline and differential.
GenevisibleiQ8N972. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN709_HUMAN
AccessioniPrimary (citable) accession number: Q8N972
Secondary accession number(s): A8K4E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.