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Protein

Leucine-rich repeat and transmembrane domain-containing protein 2

Gene

LRTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and transmembrane domain-containing protein 2
Gene namesi
Name:LRTM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:32443. LRTM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 310275ExtracellularSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Topological domaini332 – 37039CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671500.

Polymorphism and mutation databases

BioMutaiLRTM2.
DMDMi74760021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 370335Leucine-rich repeat and transmembrane domain-containing protein 2PRO_0000263686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N967.
PRIDEiQ8N967.

PTM databases

PhosphoSiteiQ8N967.

Expressioni

Gene expression databases

BgeeiQ8N967.
CleanExiHS_LRTM2.
ExpressionAtlasiQ8N967. baseline and differential.
GenevisibleiQ8N967. HS.

Organism-specific databases

HPAiHPA055094.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299194.

Structurei

3D structure databases

ProteinModelPortaliQ8N967.
SMRiQ8N967. Positions 33-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 6833LRRNTAdd
BLAST
Repeati69 – 9022LRR 1Add
BLAST
Repeati93 – 11422LRR 2Add
BLAST
Repeati117 – 13923LRR 3Add
BLAST
Repeati141 – 16222LRR 4Add
BLAST
Repeati165 – 18622LRR 5Add
BLAST
Domaini198 – 25255LRRCTAdd
BLAST

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129749.
HOGENOMiHOG000290674.
HOVERGENiHBG081938.
InParanoidiQ8N967.
OMAiWIALYAV.
OrthoDBiEOG718KCG.
PhylomeDBiQ8N967.
TreeFamiTF351114.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAPGSSPGQ RGRLALQWRQ VSWITCWIAL YAVEALPTCP FSCKCDSRSL
60 70 80 90 100
EVDCSGLGLT TVPPDVPAAT RTLLLLNNKL SALPSWAFAN LSSLQRLDLS
110 120 130 140 150
NNFLDRLPRS IFGDLTNLTE LQLRNNSIRT LDRDLLRHSP LLRHLDLSIN
160 170 180 190 200
GLAQLPPGLF DGLLALRSLS LRSNRLQNLD RLTFEPLANL QLLQVGDNPW
210 220 230 240 250
ECDCNLREFK HWMEWFSYRG GRLDQLACTL PKELRGKDMR MVPMEMFNYC
260 270 280 290 300
SQLEDENSSA GLDIPGPPCT KASPEPAKPK PGAEPEPEPS TACPQKQRHR
310 320 330 340 350
PASVRRAMGT VIIAGVVCGV VCIMMVVAAA YGCIYASLMA KYHRELKKRQ
360 370
PLMGDPEGEH EDQKQISSVA
Length:370
Mass (Da):41,158
Last modified:October 1, 2002 - v1
Checksum:i400F7EED850F0E84
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti161 – 1611D → N.
Corresponds to variant rs41276696 [ dbSNP | Ensembl ].
VAR_061679

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095610 mRNA. Translation: BAC04589.1.
AK124687 mRNA. Translation: BAG54068.1.
CH471116 Genomic DNA. Translation: EAW88921.1.
CH471116 Genomic DNA. Translation: EAW88922.1.
BC146894 mRNA. Translation: AAI46895.1.
BC146910 mRNA. Translation: AAI46911.1.
BC150568 mRNA. Translation: AAI50569.1.
CCDSiCCDS31726.1.
RefSeqiNP_001034118.1. NM_001039029.2.
NP_001157397.1. NM_001163925.1.
NP_001157398.1. NM_001163926.1.
XP_006719073.1. XM_006719010.1.
XP_011519317.1. XM_011521015.1.
XP_011519318.1. XM_011521016.1.
UniGeneiHs.585579.

Genome annotation databases

EnsembliENST00000299194; ENSP00000299194; ENSG00000166159.
ENST00000535041; ENSP00000444737; ENSG00000166159.
ENST00000543818; ENSP00000446278; ENSG00000166159.
GeneIDi654429.
KEGGihsa:654429.
UCSCiuc001qjt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095610 mRNA. Translation: BAC04589.1.
AK124687 mRNA. Translation: BAG54068.1.
CH471116 Genomic DNA. Translation: EAW88921.1.
CH471116 Genomic DNA. Translation: EAW88922.1.
BC146894 mRNA. Translation: AAI46895.1.
BC146910 mRNA. Translation: AAI46911.1.
BC150568 mRNA. Translation: AAI50569.1.
CCDSiCCDS31726.1.
RefSeqiNP_001034118.1. NM_001039029.2.
NP_001157397.1. NM_001163925.1.
NP_001157398.1. NM_001163926.1.
XP_006719073.1. XM_006719010.1.
XP_011519317.1. XM_011521015.1.
XP_011519318.1. XM_011521016.1.
UniGeneiHs.585579.

3D structure databases

ProteinModelPortaliQ8N967.
SMRiQ8N967. Positions 33-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299194.

PTM databases

PhosphoSiteiQ8N967.

Polymorphism and mutation databases

BioMutaiLRTM2.
DMDMi74760021.

Proteomic databases

PaxDbiQ8N967.
PRIDEiQ8N967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299194; ENSP00000299194; ENSG00000166159.
ENST00000535041; ENSP00000444737; ENSG00000166159.
ENST00000543818; ENSP00000446278; ENSG00000166159.
GeneIDi654429.
KEGGihsa:654429.
UCSCiuc001qjt.3. human.

Organism-specific databases

CTDi654429.
GeneCardsiLRTM2.
HGNCiHGNC:32443. LRTM2.
HPAiHPA055094.
neXtProtiNX_Q8N967.
PharmGKBiPA142671500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129749.
HOGENOMiHOG000290674.
HOVERGENiHBG081938.
InParanoidiQ8N967.
OMAiWIALYAV.
OrthoDBiEOG718KCG.
PhylomeDBiQ8N967.
TreeFamiTF351114.

Miscellaneous databases

GenomeRNAii654429.
NextBioi123980.
PROiQ8N967.

Gene expression databases

BgeeiQ8N967.
CleanExiHS_LRTM2.
ExpressionAtlasiQ8N967. baseline and differential.
GenevisibleiQ8N967. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiLRTM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N967
Secondary accession number(s): A7E2U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.