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Protein

Leucine-rich repeat and transmembrane domain-containing protein 2

Gene

LRTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and transmembrane domain-containing protein 2
Gene namesi
Name:LRTM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166159.10
HGNCiHGNC:32443 LRTM2
neXtProtiNX_Q8N967

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 310ExtracellularSequence analysisAdd BLAST275
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 370CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166159
PharmGKBiPA142671500

Polymorphism and mutation databases

BioMutaiLRTM2
DMDMi74760021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000026368636 – 370Leucine-rich repeat and transmembrane domain-containing protein 2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N967
PeptideAtlasiQ8N967
PRIDEiQ8N967

PTM databases

iPTMnetiQ8N967
PhosphoSitePlusiQ8N967

Expressioni

Gene expression databases

BgeeiENSG00000166159
CleanExiHS_LRTM2
ExpressionAtlasiQ8N967 baseline and differential
GenevisibleiQ8N967 HS

Organism-specific databases

HPAiHPA055094

Interactioni

Protein-protein interaction databases

BioGridi576379, 7 interactors
STRINGi9606.ENSP00000299194

Structurei

3D structure databases

ProteinModelPortaliQ8N967
SMRiQ8N967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 68LRRNTAdd BLAST33
Repeati69 – 90LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 139LRR 3Add BLAST23
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Domaini198 – 252LRRCTAdd BLAST55

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00880000137863
HOGENOMiHOG000290674
HOVERGENiHBG081938
InParanoidiQ8N967
OMAiIPGPPCT
OrthoDBiEOG091G0KOT
PhylomeDBiQ8N967
TreeFamiTF351114

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAPGSSPGQ RGRLALQWRQ VSWITCWIAL YAVEALPTCP FSCKCDSRSL
60 70 80 90 100
EVDCSGLGLT TVPPDVPAAT RTLLLLNNKL SALPSWAFAN LSSLQRLDLS
110 120 130 140 150
NNFLDRLPRS IFGDLTNLTE LQLRNNSIRT LDRDLLRHSP LLRHLDLSIN
160 170 180 190 200
GLAQLPPGLF DGLLALRSLS LRSNRLQNLD RLTFEPLANL QLLQVGDNPW
210 220 230 240 250
ECDCNLREFK HWMEWFSYRG GRLDQLACTL PKELRGKDMR MVPMEMFNYC
260 270 280 290 300
SQLEDENSSA GLDIPGPPCT KASPEPAKPK PGAEPEPEPS TACPQKQRHR
310 320 330 340 350
PASVRRAMGT VIIAGVVCGV VCIMMVVAAA YGCIYASLMA KYHRELKKRQ
360 370
PLMGDPEGEH EDQKQISSVA
Length:370
Mass (Da):41,158
Last modified:October 1, 2002 - v1
Checksum:i400F7EED850F0E84
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061679161D → N. Corresponds to variant dbSNP:rs41276696Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095610 mRNA Translation: BAC04589.1
AK124687 mRNA Translation: BAG54068.1
CH471116 Genomic DNA Translation: EAW88921.1
CH471116 Genomic DNA Translation: EAW88922.1
BC146894 mRNA Translation: AAI46895.1
BC146910 mRNA Translation: AAI46911.1
BC150568 mRNA Translation: AAI50569.1
CCDSiCCDS31726.1
RefSeqiNP_001034118.1, NM_001039029.2
NP_001157397.1, NM_001163925.1
NP_001157398.1, NM_001163926.1
XP_011519317.1, XM_011521015.1
UniGeneiHs.585579

Genome annotation databases

EnsembliENST00000299194; ENSP00000299194; ENSG00000166159
ENST00000535041; ENSP00000444737; ENSG00000166159
ENST00000543818; ENSP00000446278; ENSG00000166159
GeneIDi654429
KEGGihsa:654429
UCSCiuc001qjt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRTM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N967
Secondary accession number(s): A7E2U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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