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Protein

Palmitoyltransferase ZDHHC22

Gene

ZDHHC22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC22 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 22
Short name:
DHHC-22
Short name:
zDHHC22
Gene namesi
Name:ZDHHC22
Synonyms:C14orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20106. ZDHHC22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952477.

Polymorphism and mutation databases

BioMutaiZDHHC22.
DMDMi126302620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Palmitoyltransferase ZDHHC22PRO_0000212911Add
BLAST

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8N966.
PRIDEiQ8N966.

Expressioni

Gene expression databases

BgeeiENSG00000177108.
CleanExiHS_ZDHHC22.
ExpressionAtlasiQ8N966. baseline and differential.
GenevisibleiQ8N966. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM59Q8IWR13EBI-10268111,EBI-10262539

Protein-protein interaction databases

BioGridi129607. 1 interaction.
IntActiQ8N966. 1 interaction.
STRINGi9606.ENSP00000318222.

Structurei

3D structure databases

ProteinModelPortaliQ8N966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 13151DHHCPROSITE-ProRule annotationAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00730000111268.
HOGENOMiHOG000082400.
HOVERGENiHBG094179.
InParanoidiQ8N966.
KOiK18932.
OMAiGSESCKQ.
OrthoDBiEOG091G10XR.
PhylomeDBiQ8N966.
TreeFamiTF342115.

Family and domain databases

InterProiIPR000731. SSD.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
PS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALRLLNVV APAYFLCISL VTFVLQLFLF LPSMREDPAA ARLFSPALLH
60 70 80 90 100
GALFLFLSAN ALGNYVLVIQ NSPDDLGACQ GASARKTPCP SPSTHFCRVC
110 120 130 140 150
ARVTLRHDHH CFFTGNCIGS RNMRNFVLFC LYTSLACLYS MVAGVAYISA
160 170 180 190 200
VLSISFAHPL AFLTLLPTSI SQFFSGAVLG SEMFVILMLY LWFAIGLACA
210 220 230 240 250
GFCCHQLLLI LRGQTRHQVR KGVAVRARPW RKNLQEVFGK RWLLGLLVPM
260
FNVGSESSKQ QDK
Length:263
Mass (Da):29,100
Last modified:February 20, 2007 - v2
Checksum:i702A71D90A6F4C94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 16024CLYSM…FAHPL → QELTRGLRKEVAAGPAGPHV QCRK in BAC04590 (PubMed:14702039).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095612 mRNA. Translation: BAC04590.1.
AK294840 mRNA. Translation: BAH11901.1.
AC007375 Genomic DNA. No translation available.
BC117676 mRNA. Translation: AAI17677.1.
CCDSiCCDS45140.1.
RefSeqiNP_777636.2. NM_174976.2.
XP_006720182.1. XM_006720119.3.
XP_011534963.1. XM_011536661.2.
UniGeneiHs.525485.

Genome annotation databases

EnsembliENST00000319374; ENSP00000318222; ENSG00000177108.
GeneIDi283576.
KEGGihsa:283576.
UCSCiuc010asp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095612 mRNA. Translation: BAC04590.1.
AK294840 mRNA. Translation: BAH11901.1.
AC007375 Genomic DNA. No translation available.
BC117676 mRNA. Translation: AAI17677.1.
CCDSiCCDS45140.1.
RefSeqiNP_777636.2. NM_174976.2.
XP_006720182.1. XM_006720119.3.
XP_011534963.1. XM_011536661.2.
UniGeneiHs.525485.

3D structure databases

ProteinModelPortaliQ8N966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129607. 1 interaction.
IntActiQ8N966. 1 interaction.
STRINGi9606.ENSP00000318222.

Polymorphism and mutation databases

BioMutaiZDHHC22.
DMDMi126302620.

Proteomic databases

PaxDbiQ8N966.
PRIDEiQ8N966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319374; ENSP00000318222; ENSG00000177108.
GeneIDi283576.
KEGGihsa:283576.
UCSCiuc010asp.3. human.

Organism-specific databases

CTDi283576.
GeneCardsiZDHHC22.
HGNCiHGNC:20106. ZDHHC22.
neXtProtiNX_Q8N966.
PharmGKBiPA134952477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00730000111268.
HOGENOMiHOG000082400.
HOVERGENiHBG094179.
InParanoidiQ8N966.
KOiK18932.
OMAiGSESCKQ.
OrthoDBiEOG091G10XR.
PhylomeDBiQ8N966.
TreeFamiTF342115.

Miscellaneous databases

ChiTaRSiZDHHC22. human.
GenomeRNAii283576.
PROiQ8N966.

Gene expression databases

BgeeiENSG00000177108.
CleanExiHS_ZDHHC22.
ExpressionAtlasiQ8N966. baseline and differential.
GenevisibleiQ8N966. HS.

Family and domain databases

InterProiIPR000731. SSD.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
PS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH22_HUMAN
AccessioniPrimary (citable) accession number: Q8N966
Secondary accession number(s): A6NH02, B7Z2L5, Q149P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.