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Protein

Palmitoyltransferase ZDHHC22

Gene

ZDHHC22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein localization to plasma membrane Source: UniProtKB
  • protein palmitoylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC22 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 22
Short name:
DHHC-22
Short name:
zDHHC22
Gene namesi
Name:ZDHHC22
Synonyms:C14orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000177108.5
HGNCiHGNC:20106 ZDHHC22
neXtProtiNX_Q8N966

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177108
PharmGKBiPA134952477

Polymorphism and mutation databases

BioMutaiZDHHC22
DMDMi126302620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129111 – 263Palmitoyltransferase ZDHHC22Add BLAST263

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8N966
PeptideAtlasiQ8N966
PRIDEiQ8N966
ProteomicsDBi72495

Expressioni

Gene expression databases

BgeeiENSG00000177108
CleanExiHS_ZDHHC22
ExpressionAtlasiQ8N966 baseline and differential
GenevisibleiQ8N966 HS

Organism-specific databases

HPAiHPA049471
HPA072213

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM59Q8IWR15EBI-10268111,EBI-10262539

Protein-protein interaction databases

BioGridi129607, 1 interactor
IntActiQ8N966, 4 interactors
STRINGi9606.ENSP00000318222

Structurei

3D structure databases

ProteinModelPortaliQ8N966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 131DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00730000111268
HOGENOMiHOG000082400
HOVERGENiHBG094179
InParanoidiQ8N966
KOiK18932
OMAiHSISQFF
OrthoDBiEOG091G10XR
PhylomeDBiQ8N966
TreeFamiTF342115

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR000731 SSD
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
PS50156 SSD, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALRLLNVV APAYFLCISL VTFVLQLFLF LPSMREDPAA ARLFSPALLH
60 70 80 90 100
GALFLFLSAN ALGNYVLVIQ NSPDDLGACQ GASARKTPCP SPSTHFCRVC
110 120 130 140 150
ARVTLRHDHH CFFTGNCIGS RNMRNFVLFC LYTSLACLYS MVAGVAYISA
160 170 180 190 200
VLSISFAHPL AFLTLLPTSI SQFFSGAVLG SEMFVILMLY LWFAIGLACA
210 220 230 240 250
GFCCHQLLLI LRGQTRHQVR KGVAVRARPW RKNLQEVFGK RWLLGLLVPM
260
FNVGSESSKQ QDK
Length:263
Mass (Da):29,100
Last modified:February 20, 2007 - v2
Checksum:i702A71D90A6F4C94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137 – 160CLYSM…FAHPL → QELTRGLRKEVAAGPAGPHV QCRK in BAC04590 (PubMed:14702039).CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095612 mRNA Translation: BAC04590.1
AK294840 mRNA Translation: BAH11901.1
AC007375 Genomic DNA No translation available.
BC117676 mRNA Translation: AAI17677.1
CCDSiCCDS45140.1
RefSeqiNP_777636.2, NM_174976.2
XP_006720182.1, XM_006720119.3
XP_011534963.1, XM_011536661.2
UniGeneiHs.525485

Genome annotation databases

EnsembliENST00000319374; ENSP00000318222; ENSG00000177108
GeneIDi283576
KEGGihsa:283576
UCSCiuc010asp.3 human

Similar proteinsi

Entry informationi

Entry nameiZDH22_HUMAN
AccessioniPrimary (citable) accession number: Q8N966
Secondary accession number(s): A6NH02, B7Z2L5, Q149P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 20, 2007
Last modified: June 20, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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